Let this be the Last Medical Oxygen Crisis in India

The problem is not a shortage of medical oxygen but the supply chain of delivering it to the patient bedside in a hospital. A routine site at all major Indian hospitals is the large oxygen cylinders delivering oxygen to patients at the bedside, says Dr. Joseph Chalil.

International media is filled with headlines such as “Indian COVID-19 Patients Die as Ventilators Run Out of Oxygen” and showing images of people with empty oxygen cylinders crowding refilling facilities in Uttar Pradesh for their relatives in hospitals. The last such news was from Pakistan in December 2020 when six COVID-19 patients died in Khyber teaching hospital in Peshawar.

India has a daily production capacity of at least 7,100 tons of oxygen, including for industrial use, which appears to be more than enough to meet current demand. The problem is not a shortage of medical oxygen but the supply chain of delivering it to the patient bedside in a hospital. A routine site at all major Indian hospitals is the large oxygen cylinders delivering oxygen to patients at the bedside. Yet this is something you never see in a western hospital. All American hospitals have central piping, which delivers oxygen to the patient bedside from a Pressure Swing Adsorption (PSA) Oxygen Plant attached to each hospital. This is one of the building permit requirements for a new hospital in the USA. Medical oxygen can easily be manufactured from surrounding air.

Among the most significant challenges early in the COVID-19 Pandemic was the shortage of essential supplies like personal protective equipment (PPE) and ventilators. These products are tied to supply chains that stretch worldwide, and the Pandemic highlighted their fragility and susceptibility to significant disruptions. As China, a leading global exporter, dealt with the Pandemic in its early days, it was forced to shut down manufacturing, leaving the rest of the world scrambling to address its rapidly shifting supply needs.

Prime Minister Narendra Modi has also given a call for self-reliance – an ‘Aatmanirbhar Bharat’ where he talks of integrating India with the world moving away from isolation but from a position of internal strength. The aim is to make India and its citizens independent and self-reliant in all senses. Mr. Modi further outlined five pillars of Aatma Nirbhar Bharat – Economy, Infrastructure, System, Vibrant Demography, and Demand. India demonstrated its ability to go from producing zero PPE kits pre- COVID to producing millions of kits and exporting them today as a result of the COVID-19 Pandemic. Let us also make our hospitals self-reliant in Medical Oxygen production.

A vision for the future of health-conscious manufacturing

A supply chain that depends on domestic manufacturing is part of our strategic healthcare plan for the future. In the book *Beyond the COVID-19 Pandemic*, we outline a 33-33-33 Buy Local Policy, which involves increased purchases of local products while allowing purchasers flexibility to tap into the global marketplace. In the plan, healthcare systems would be required to buy 33% of their products locally within their region, 33% of their products within the country, and 33% from outside. This policy aims to create a flexible supply chain that could be ramped up to deal with emergencies.

Self-reliance has always been an Indian (The Swadeshi Movement) virtue and the key to India’s success and development. Suppose one supply chain is cut off due to war, natural disaster, or bioterrorism; there are other options to maintain and sustain supply chains. This will also ensure that the dependency on one particular source for anything essential is minimized. Domestic manufacturing is vital for job creation and a strong economy, and it’s also essential for national security.

AirSep Corporation of New York has installed PSA Medical Oxygen Systems in more than 4,500 hospitals in nearly 50 countries worldwide, including several hospitals in India, to meet their central pipeline and other oxygen needs. These generators and plants operate automatically to supply patient, surgical, and critical care units in medical facilities, military field hospitals, on-site emergency preparedness centers, and disaster-relief efforts. There are several other manufacturers with similar technologies.

Supply chain policy does not have to be an all-or-nothing proposition. That is to say, we should neither import everything nor should we import nothing. Currently, however, we are too reliant on imports in some areas, which hurt us during the early days of this Pandemic. More steps must be taken to create reserves of supplies and manufacturing capacity, similar to the U.S. strategic oil reserves or the Indian strategic food reserves.

India should invest in mobile containerized, turnkey packaged oxygen systems that are ideal for locations where a compressed air supply is limited or unavailable. These units can be truck mounted and moved to areas of shortage or pandemic hot spots. Containerized units can also be used for military applications as well. The oxygen generator within a containerized unit produces oxygen from an air compressor that is included in the package. These rugged systems can perform in extreme temperatures, high humidity conditions, and at high elevations.

Let this be the Last Medical Oxygen Crisis in India. Let us not scramble our resources; purchasing compressed liquid oxygen from Russia or China, which at best is a temporary fix but will arrive too late for our patients’ bedside in Delhi. Let us retrofit our hospitals with central oxygen piping
and support installing hospital oxygen plants and backup systems. Domestic production policies of all medical supplies will lead to job creation and positively impact the environment, reducing the distance oxygen and other supplies must travel from manufacturer to end-user. Local production is also a necessary part of national defense in a world where bioterrorism is an ever-present possibility—the military, for its part, has demonstrated the importance of not centralizing any aspect of its supply chain to one region or country.

India can lead the way globally by building supply chains that incorporate local manufacturing that can be ramped up to address critical needs. This goal recognizes that global supply chains can be broken, and alternatives need to be in place. When countries take these lessons and models to heart and use them to craft policy, their citizens can benefit from a common-sense approach that empowers us to mitigate challenges—everything from a natural disaster or political upheaval to a once-in-a-100-year pandemic.

(Prof. (Dr.) Joseph M. Chalil is an Adjunct Professor & Chair of the Complex Health Systems advisory board at Nova Southeastern University’s School of Business; Chairman of the Indo-American Press Club, and The Universal News Network publisher. He recently published a Best Seller Book – “Beyond the COVID-19 Pandemic: Envisioning a Better World by Transforming the Future of Healthcare.”)

AAPI Coordinates Efforts to Help India As Covid Ravages Communities

As AAPI is leading several efforts to support, coordinate and reach the much needed help in this hour of need, leading international media, including the Washington Post, The New York Times and CNN have recognized AAPI among the major resource groups to reach help India as people are impacted by Covid as never been in human history.

India has seen a cataclysmic coronavirus surge over the past week, reporting nearly 350,000 new coronavirus cases per day, with the real figure probably much higher. The spike in infections has led to deadly shortages of oxygen, ambulances and hospital beds. Countries around the world have pledged to send aid in the form of medical supplies and vaccine doses, but urgent requests for ventilators and intensive care unit beds continue to flood social media.

“Thanks to you, the generous and compassionate members, and others as well, AAPI has been able and continues to make progress in its efforts to deal with an unfolding and out of control COVID 19 crises in India,” said Dr. Sudhakar Jonnalagadda, President, AAPI here today.  “As we pledged, we are able to very quickly secure the much needed and in demand O2 concentrators through our reliable and committed partner (SEWA International). We have shipped by air freight, the first batch of 1,000 of the O2 Concentrators on 4/29/21.”

Stating that AAPI in collaboration with its partners on ground in India “have identified destinations based on urgency and acute need for the medical equipment to be able to serve and save as many lives as quickly, and to prevent avoidable catastrophe for the simple lack of O2,” Dr. Jonnalagadda said, “We have no doubt, this is just the beginning of a long road ahead. We are assessing the situation on the ground constantly and coordinating with various local task forces and teams.”

Dr. Sajani Shah, Chair of AAPI BOT, said, “We have a team of volunteers and support and guidance of experienced leaders, who have come forward to enable and empower our efforts to curtail this crisis. We urge all of you to stay engaged and connect with us whenever you have any good suggestions and feedback to help us understand the ground realities quickly and fully. So, we can be more effective and efficient to tackle the problems.”

Educating the public and the physicians in India is vital to combat the virus,” says Dr. Anupama Gotimukula, President-Elect of AAPI. She has reached out to the Indian media across the platform offering regular series of educational materials to be published in India for the use and implementation of effective ways to treat patients who are mpacted by Covid.

“On behalf of AAPI leadership, we would like to have a series of educational messages to the communities on Covid to address the concerns of the public and medical community during the pandemic time as we recognize our role is to educate communities. Through this voluntary project from our members, we can help educate the people first. Allay their fears. Explain and educate them about the disease and on ways to combat the virus.”

Dr. Ravi Kolli, Vice President of AAPI, while expressing gratitude to AAPI members, “request you to continue your support and contributions to take our activities to the next level of helping secure much needed ventilators, which will also be critically scarce as the morbidity and hospitalization surge, out matching the supplies.  Again, we want to reiterate that all of you, the members of AAPI inspire and motivate us and you are the true wind beneath our wings in this movement. We will leave no stone unturned to seek solutions and rise to the occasion. Let us all do our duty and be a beacon of hope and resolve to maintain the momentum to conquer the Himalayan challenge ahead of us.”

As India’s health-care system buckles under pressure, American Association of Physicians of Indian Origin (AAPI), the largest ethnic medical organization in the United States , representing the over 80,000 strong Indian American physician community in the US, has risen to the occasion and is leading several efforts to support, coordinate and reach the much needed help in this hour of need. Some of the leading international media, including the Washington Post, The New York Times and CNN have recognized AAPI and have urged AAPI among some of the major resource groups to reach help to the communities across India as they are impacted by Covid as never been in human history.

“Indeed a proud moment for AAPI,” said Dr. Amit Chakrabarthy, Secretary of AAPI. “The tireless efforts of the AAPI leadership and members, who have spent sleepless nights coordinating relief efforts for  India has been recognized by the prestigious New York Times as the second most prominent international organization in this effort (after UNICEF)!!! This is a proud moment for all of us.  Please continue to support and donate at aapiusa.org.”

Dr. Jonnalagadda announced that “AAPI is facilitating interaction between US and Indian doctors to advise them about the evidence based protocols to treat COVID-19 patients. We evaluated 3 HIPPA compliant telehealth platforms to treat patients in India. AAPI is also working on relaxing the restrictions on US physicians to treat patients in India. I want to thank Dr. Anupama Gotiumukaua, Dr. Ravi Kolli, Dr. Amit Chakrabarthy and Dr. Satiheesh Kathula for their efforts in coordinating various sources and resources in this fight against the pandemic.”

In its efforts to serve as a physician on humanitarian grounds to help patients in India, AAPI has identified and facilitates the following platforms/links to those who want the Telehealth established platforms: http://Mdtok.com/dr/Covid and www.eGobalDoctors.com

AAPI encourages using this route because they give global malpractice coverage: They offer free service for 1-3 months for our physicians to help Indian patients, as  these platforms serve and help become every Indian American physician to be a registered physician in India, by renewing your India licenses ASAP and can start your services; Getting more info from different resources as well to get our services reach Indian patients  as every resource is being tapped to help India in this crisis situation.

AAPI is in constant touch with Indian Embassy, Indian Health Minister Dr. Harsh Vardhan to see how best “we can help our motherland during this horrific pandemic. AAPI has written to a letter Prime Minister of India, Shri. Narendra Modi to lock down the country to contain the spread of the virus, and to ramp up the vaccinations.”

“AAPI has been in the forefront to help India to combat the pandemic,” said Dr. Satheesh Kathula, Treasurer of India. “Thousands of people, both members of AAPI and non-members have come forward to donate money by putting trust in AAPI. We will try our best to be transparent and make sure that your donations will make some impact. I really want to thank all the donors who supported us unconditionally.”

It’s devastating to see millions of people are being impacted by Covid in India, especially many of the friends and families of AAPI members are suffering from Covid disease and dying now. In this context, AAPI would like to help India big way, said Dr. Jonnalagadda: “AAPI is collaborating with UNICEF, SEWA International and other like minded organizations.  AAPI is also urging all Community leaders to educate their members to be on Alert to avoid spread of the virus.” For more information on AAPI and its efforts to coordinate services for the people of India, please visit: www.aapiusa.org

India Sets Record As Covid Cases Cross 400,000 Daily

India has recorded more than 19 million cases of coronavirus – second only to the US. It has also confirmed more than 215,000 deaths, though the real toll is thought to be far higher. Experts have cited low testing rates and the number of people dying at home, especially in rural areas, as contributing factors to under-reported figures.

India became the first country in the world to report over 4 lakh COVID cases in a single day. Country reported of 4,01,993 new COVID-19 cases and 3,523 deaths on May 1st. Total caseload of the country stood at 1,91,64,969. Death toll of India mounted to 2,11,853. Currently there are 32,68,710 active cases in country. According to Indian Council of Medical Research, up to April 30, 28,83,37,385 samples have been tested for COVID-19. Vaccination drive for citizens between 18-44 years age bracket will begin from today. So far, 15,49,89,635 vaccine doses have been inoculated.

Maharashtra reported 62,919 infections, followed by Karnataka (48,296), and Kerala (37,199). Maharashtra also recorded 828 casualties, followed by Delhi (375) and Uttar Pradesh (332). The country has so far reported a total of 1,91,63,488 cases and 2,11,778 deaths.
As many as 19,20,107 samples were tested on April 29 (results of which were made available on April 30). This is the first instance when daily tests have crossed the 19 lakh-mark. On April 28, 17.68 lakh samples were tested. A total of 28.64 crore tests have been conducted in the country from the beginning of the pandemic until April 29.

Around 22.24 lakh vaccination shots were given in the 24 hours ending 7 a.m. on April 30, which is only 31,267 doses more than what was recorded in the previous 24 hours. The daily vaccination rate has decreased significantly in the second half of April compared to the first. Between April 1 and 14, India administered 35.26 lakh doses on an average every day. However, between April 15-29, the average daily doses given fell to just 25.16 lakh. Cumulatively, 15,00,20,648 vaccine doses had been administered until 7 a.m. on April 30.
India continues to register the highest number of average daily cases in the world, according to Our World in Data. Until April 28, the country recorded 3.49 lakh daily cases. With 52,679 average daily cases, the U.S. was a distant second. Three other countries in the list included France (27,250), Germany (20,788) and Canada (7,980).

Several nations, including the United States, the United Kingdom, China, Japan, have pledged sustained support to India as hospitals in the country scramble for resources. The country received the first batch of Covid supplies from the US on Friday.
India crossed the grim milestone of 1.50 crore on April 19. According to the Indian Council of Medical Research (ICMR), 28,83,37,385 samples have been tested up to April 30, of which 19,45,299 were done on Friday.
India’s coronavirus cases may peak in the next 2 two weeks, according to a mathematical model of a team of scientists advising the government, news agency Reuters reported. “Our belief is that by next week, the daily new cases nationwide would have peaked,” M Vidyasagar, head of a government-appointed group of scientists modelling the trajectory of infections, told Reuters.

Pfizer Says, Covid Oral Pill Could Be Ready By Year-End

US-based pharmaceutical major Pfizer’s Chief Executive Officer Albert Bourla said that the company’s Covid-19 oral antiviral pill, which is in early-stage trials, could be ready by the end of the year, the media reported.

According to CNBC, the company, which developed the first authorised Covid-19 vaccine in the US with German drugmaker BioNTech, began an early-stage clinical trial for testing a new antiviral therapy for Covid-19 in March.

The drug is part of a class of medicines called protease inhibitors and works by inhibiting an enzyme that the virus needs to replicate in human cells.

“If clinical trials go well and the Food and Drug Administration (FDA) approves it, the drug could be distributed across the US by the end of the year,” Bourla told CNBC.

Protease inhibitors are used to treat other viral pathogens such as HIV and hepatitis C, the report said.

Last month, the pharmaceutical giant asked the US Food and Drug Administration (FDA) to expand the Emergency Use Authorisation (EUA) for its Covid-19 vaccine to include children ages 12 to 15.

The request to expand emergency use comes just days after Pfizer released data demonstrating its vaccine was 100 per cent effective and well-tolerated by the younger group.

Pfizer is also working on its vaccine for 6-month to 11-year-old children.

A recent study, published in the journal Science, showed that a single dose of Pfizer-BioNTech vaccines against Covid may boost immunity against the Covid-19 variants, only in people who were previously infected with the deadly virus.

In people who have not previously been infected and have so far only received one dose of vaccine, the immune response to variants of concern may be insufficient, the study indicated. (IANS)

Dr. Parag Mehta Elected President-Elect of the Medical Society of New York

Internist Parag Mehta, MD, was elected President-Elect of the Medical Society of the State of New York (MSSNY) on May xx. Dr. Mehta is the Senior Vice Chairman of the Department of Medicine and the Chief Medical Information Officer at NewYork-Presbyterian Brooklyn Methodist Hospital (NYPBMH). In addition, he is an Associate Professor of Clinical Medicine at Weill Cornell Medicine.

A graduate of NHL Medical College in Ahmedabad, India, Dr. Mehta completed his residency in OB/GYN at NHL Medical College and his Internal Medicine residency at NewYork-Presbyterian Brooklyn Methodist Hospital in Brooklyn, New York. He is Board Certified in Internal Medicine, Hospice and Palliative Care, and Integrative and Holistic Medicine. He has taken courses in Health Information Technology from Cornell University and Artificial Intelligence from MIT Sloan School of Management.

An active member of organized medicine, Dr. Mehta is the Governor for the New York Chapter of the American College of Physicians (NYACP) for Brooklyn, Queens, and Staten Island. In addition to MSSNY and NYACP, he is a member of AMA, Kings County Medical Society, American Association of Physicians of Indian Origin, and Indian Medical Association.  In 2011, NYACP awarded him its highest honor, the Laureate Award, to recognize his extraordinary contributions in governance, quality, public policy, and education. As a Physician Wellbeing Champion, he promotes wellness and engages in the discussion through every opportunity, including grand rounds.

Dr. Mehta’s many contributions to MSSNY include service as Councilor, Assistant Treasurer, Vice President, Commissioner of the Membership Division, Chair of the Future Task Force for Infrastructure/Organization, Chair of the International Medical Graduate Committee, and Young Physician Councilor. He presently serves as Vice President of MSSNY and as a New York Delegate to the American Medical Association.

Dr. Mehta has been involved with implementing EHR at NewYork-Presbyterian Brooklyn Methodist Hospital for the last 16 years and has helped the institution reach HIMSS Level 7. In this role, he brings IT and clinicians together to improve the user’s experience based on the user’s input.

Dr. Mehta lives in Manhasset Hills with his wife, Isha Mehta, MD, Chief of Gynecology at Elmhurst Hospital, and is a founder of “A Stitch in Time,” an organization that treats gynecological conditions at no cost to women around the world. They have two daughters, Ruju, an environmental engineer, and Setu, a pre-med student at Harvard College.

Founded in 1807, the Medical Society of the State of New York is the state’s principal non-profit professional organization for physicians, residents, and medical students of all specialties. Its mission is to represent the interests of patients and physicians to assure quality healthcare services for all.

Dr. Himanshu Pandya Honored By World Peace & Diplomacy Organization

(Long Island, NY: May 1st, 2021) “It gives me tremendous pleasure to share the good news of getting one of the most prestigious awards on April 30: World Peace & Diplomacy Organization, an organization, working towards the agenda of The United Nations, has honored me with “ILLUSTRIOUS HUMANITARIAN SERVICE HONOR,” Dr. Himnashu Pandya announced here.

Past President at American association of physicians of Indian Origin, Queens Long Island. (AAPIQLI), Dr. Pandya is an internist in Floral Park, New York and is affiliated with North Shore University Hospital. He received his medical degree from B. J. Medical College Ahmedabad and has been in practice between 11-20 years.

“We are honored to share the title of ‘Illustrious Humanitarian Service Honor’ with Dr. Himanshu Pandya, who would take forward the initiative of spreading Peace and Harmony for promoting humanity through sustainable leadership,” World Peace & Diplomacy Organization stated on its web portal about the honor bestowed on Dr. Pamdya.

Dr. Pandya in his response said: “Considering my Work in the US and India since March 2020 due to the Covid pandemic, including COVID and blood tests at patients’ homes, a concept of the home hospital to treat Covid patients at home in the US and India, vaccination help, and providing free of the cost telehealth in the rural areas in India. The award was given at a virtual ceremony on the auspicious day of World Peace and Humanitarian Summit 2021 with several International dignitaries, including Princess Sanyogita Atres,  Friederike Irina Bruning, Apostle Victoria Samusongha, etc.  My journey and fight against Covid will continue.”

WPDO is a not-for-profit organization, working diligently towards United Nations prime agenda of maintaining global peace by humanitarian means. United Nations – Economic & Social Council (ECOSOC) has recently Granted its parent organization, Confederation of Indian Healthcare Foundation (CIHF) “Special Consultative Status” which enables it to become the voice of various non-member NGOs.

Breathe India Campaign: “We helped Delhi, now we expand to UP!”

Four days back, we got together to do something for India in such an unprecedented crisis. Something as basic as oxygen seemed the bottleneck. We decided to get the concentrators for Delhi. We collaborated with SaveLife foundation, and started this fundraiser. We just wanted to get as many concentrators as we could. While we set up a vague number of 250 concentrators, little did we think on whether it was achievable.

Today, we are proud to share that we have been able to raise a whopping Rs. 2.41 Cr (as of 4PM, 30th April) from the campaign. We have already confirmed orders for 185 concentrators and are finalizing the other 65 concentrators as I write. We expect the shipments to start arriving in Delhi from May 07-May 10th. The concentrators will be distributed to Delhi hospitals and COVID Care Centers based on the need in close coordination with the Delhi government. The remaining proceeds (about ~0.6Cr) will be utilized for buying more concentrators and other medical equipments.

We are now more motivated to expand our campaign to other geographies and ensure that the help reaches there. For the purpose, starting 5PM, April 30th, we are collaborating with Right Walk Foundation, a Lucknow-based NGO which works with slum communities in eleven districts of UP. Right Walk Foundation will use the proceeds gained (after 5PM, April 30th) from the campaign in buying concentrators, cylinders, oximeter and other medical equipments as required. A collaboration with Right Walk will enable use to reach out to the less-privileged communities of UP.

A sincere thanks to SaveLife foundation for the tremendously smooth efforts in our phase-1 of the campaign. You inspire us, you really do!

It has just been the five of us, supported by a lovely community of yours. We are reaching out again for helping us achieve our targets in UP. The overall campaign target is being raised to 4Cr. We are confident that the outpouring support we have received will force us to raise this target further.

An important thing to keep in mind for foreign donors: Please transfer as much funds as you can through Indian accounts: they can be more quickly disbursed!

Keep following the page for more updates. All the documents (our update, SLF/RWF update, POs, Product Specifications), etc. can now be accessed at: https://drive.google.com/drive/u/1/folders/1Nm8ntSk_FuzklPBF82eSLdrAnl8DRJza

Thanks for all the love you have showered on us. Ashutosh Ranka graduated with a B.Tech in Materials Science and Engineering from IIT Kanpur in 2016. He is currently pursuing MPA from London School Of Economics. His previous work experience includes working with McKinsey & Delhi Government. Isha Agrawal graduated with a BT-MT degree in Electrical Engineering from IIT Kanpur in 2016. She has been working as an Analog Design Engineer in Texas Instruments for the past 5 years.
Nikhil Asati graduated with a B.Tech degree in Materials Science and Engineering from IIT Kanpur in 2017. He is currently working as a consultant with EXL Services.

Kavya Eluru graduated with a MSc. in  Mathematics and Scientific Computing from IIT Kanpur in 2014. She is currently working in the Business Finance Team in Udaan. Her previous experience includes working in EdTech & Construction Industry.  Randhir Shah graduated with a BT-MT degree in Mechanical Engineering  from IIT Kanpur in 2014. He is currently working as a Senior Field Engineer and Customer Engagement Coordinator in Schlumberger, Mumbai for the last 7 years.

Since its inception, RightWalk has prioritized Social Inclusion, and this has remained the hallmark of its practice. At RightWalk, everyone is a Public Policy Entrepreneur who envisions “Social Inclusion,” and cognizes that Public Policy Advocacy is important for the change we wish to see. We have been perpetual in improving the laws, the policies and the systems that impact inclusion and the communities we serve, giving us an opportunity to be one among the most persuasive and compelling messengers of social inclusion on the planet. We have strong network with public and social eco-system manifested by our strong ties with National Informatic Center-UP, WB and Jharkhand, Microsoft Research, Stanford University, Central Square Foundation, and UNICEF who are some of our technology, strategic and thought partners.

SaveLIFE Foundation (SLF) is an award-winning non-profit, non-governmental organization committed to saving lives in India since 2008. When COVID-19 hit India in 2020, in particular the capital city-state of Delhi, SLF’s traditional expertise in emergency medical response, first-responder training, and data analytics directly intersected with the needs imposed by the novel virus. Given its existing relationship (through a working MOU) with the Government of Delhi, SLF was immediately requested to help address these problems for the State and people of Delhi. SLF has since helped optimize State’s ambulance service reach people faster, increase the capacity of the emergency response system, and provide direct relief to those affected the most by the pandemic by providing over 10,000 PPE kits for frontline health workers, 80,000 meals for the needy affected by the national lockdown, 60 additional ambulances for the City of Delhi and 100 sanitization machines for ambulances carrying COVID positive patients.

Gujarati Seniors of Chicago Honor Dr. Mehboob Kapadia for Covid-19 Vaccination Camps

Gujarati Seniors of Chicago was established in 2019 under the Presidentship of Praful Shah. Due to the recent Pandemic, it had curtailed its activities. They have approximately 250 members. On Saturday, May 01, 2021, from 11:00 AM to 3:00 PM, Gujarati Seniors of Chicago had organized an entertainment cum social program to recognize Dr. Kapadia’s community service to help seniors during the Covid-19 pandemic. The event was held at Swaminarayan Temple, 1020 Bapa Road, Streamwood, IL.

In the beginning all attending members were given lunch tokens. Membership renewals as well as New Members were enrolled.

Bharat Thakkar, addressing the audience, informed Members to celebrate Gujarat Day along with Ram Navmi and Mother’s Day. To commemorate Mother’s Day all mothers present were given flowers. Birthday cards were given to all those who had their Birthday this month. He also outlined ensuing programs.

Mahen Patel introduced Dr. Mehboob Kapadia who was felicítated for arranging Vaccinations camps at many places and serving the community.  A plaque encasing the Recognition and Appreciation letter from the Governor of Illinois was presented to Dr. Kapadia as token of love from Gujarati Seniors of Chicago.

The Appreciation letter from the Governor concluded: “On behalf of the people of the State of Illinois, it is my pleasure to thank you for your ongoing work of Vaccination. Your dedication and leadership have created a lasting impact in your community and you have been an asset to all of Illinois in our collaboration to overcome the Pandemic. “J.B. Pritzker, Hon. Governor of Illinois.

Dr. Kapadia in his reciprocal speech deliberated various facets of Covid- 19, its variants, in depth comparison of various vaccines, their importance and dangers, inter relationship of each type, highlighted dangers and their effects.  Due to efforts of his team, they have already vaccinated more than 100,000 people and target to administer at least 1 million shots at the earliest possible. He warned not to take it lightly till all the variants come under control.

Dr Kapadia and his wife Seema Kapadia thanked each member of the team including Gujarati Seniors of Chicago team who made the vaccination camp a huge success. Dr Kapadia mentioned how his wife Seema Kapadia and his sons have been a driving force behind all these campaigns to ensure smooth execution. He added that Ms. Seema Kapadia has been present at many vaccination camps from the beginning till the end to ensure a safe, timely and equitable administration of the vaccine.

Sumptuous Gujarati Lunch prepared by Swaminarayan Temple was enjoyed along with enjoyable music. Shaila Khedkar and Abdul Gafoor of Sursangam performed at Gujarati Seniors Day celebration. Shaila Khedkar is a versatile singer and well-known for her melodious singing of all types of songs like bhajans, Garba and Bollywood songs. She has been performing in Chicago and other cities for various functions. Her Latajis songs are very much appreciated by the audience!

She and Mr. Gafoor started with bhajans- payoji and Sukh ke Sab, and then rendered old and new songs. Some of her solos included Satyam Shivam Sundaram, Tumhi Mere, Ruk Ja Raat, Tu Kitni Acchi hai, Ankhiyo Ke, E dil Muze, and Ashaji’s dance Medley. After a few old movie songs by Gafoor ji (Rafi and Kumar Sanu hits) they sang few old and new duets including. ye Raat, Ude Jab, Sagar Kinare, itna na, Tuze Dekha, Shyam Teri, humko Hamise. They delighted the audience with their melodious singing.

Politics of Pandemic in India

Current Covid-19 (Corona) situation in India is quite grave. There is no denying that the mistakes were made on multiple fronts which resulted into Corona taking awful tolls across the country. The central government’s errors were compounded by the State governments (govt). During the first corona-wave when the central-govt took over all the precautionary elements into its own hand, the State-govts cried out loud labeling it as ‘authoritarian’ or ‘dictatorial’. The central-govt ultimately gave in to their demands in the last quarter of 2020 and provided them instead, enough funds to fight this beastly virus. The money was supposed to be used for PPT kits, essential medicines, setting up bed-facilities and to procure Oxygen-equipment but nothing of that sort happened. The States showed complete laxity to take any proactive step, the moment they felt that Corona was receding. No one knows what the States did with their money. Maharashtra Govt in particular, which had 1/3 of cases and 1/4 of deaths started shutting down the bed facilities. When India was basking in the praise of the western world as the ‘role model’ for the containment of Corona, the Central and the State govts should have collectively started preparations for the impending second wave of the pandemic. This did not happen. Although in democracy, the elections are inevitable come what may, there should have been complete clamp down on rallies, however unrealistic this may sound. The central-govt should not have permitted any religious gatherings (including ‘Kumbh-Mela’ – April 2021), processions to take place, although Corona had started taking enormous tolls weeks before (February-March 2021) such gatherings. The collective lapses sent wrong signals to the public. Nevertheless, the fatal expansion of Corona squarely rests with ‘the public at large’. People not only disregarded the severity of Corona by not following mandated safety precautions, but also, started all their routine activities and celebrations, as if it did not exist. This had deadly consequences.

Covid-19 is a global phenomenon but in India it is being tossed around like a political football whose ultimate goal is, not only to project how the country is on the brink of ‘Armageddon’, but also, to emphasize how inept and insensitive the current administration is. The major players in this game are the opposition political parties and their surrogates. Scores of leading opposition political leaders who are now clamoring for vaccines, had earlier not only mocked the idea of vaccination, but also, had floated vigorous anti-vaccine campaign. The current shortage of ‘oxygen’ has everything to do with the lethargy of the State-govts. The Central-govt had sectioned 162 oxygen generating PSA plants for strategic areas across India but the States collectively set only 33 plants and blamed the Central-govt for their own ineptitude. Make no mistake, in this game, some national and international Medias are also involved. Instead of reporting positive inspiring stories, they mass-marketed unflattering, exaggerated or sometimes even fake stories. The international Media has converged on India’s plight as if it is the biggest calamity the world has ever witnessed. When China, the birthplace of Covid-19 and the global capital of misinformation, recently planted a mischievous tweet on the social-media, it was summarily condemned by a major news organization in U.S. We all know how a leading New York tabloid, couple of weeks back, used a picture of a roadside dead body from some gas leakage somewhere, to support their claim, ‘how the people in India are dying on the streets’. This is not an isolated incidence. Scandal-sniffing notorious British press isn’t less offensive either. The international media-cartel has never publicized the complicity of their own govts in the current crisis. As per WHO, 87% of vaccines have been cornered by high-income countries and only 0.2% of vaccines have gone to poor countries. The Indian ‘netizens’ who also now include numerous private TV channels, have proved themselves equal to so-called ‘yellow journalism’ by exposing all the falsification and putting it against rock-solid proofs. When, opposition parties are harping on the sorry conditions in the country, it is worth noting that none of their cadre or party-workers are seen anywhere helping out the masses. In their stark absence, the people have taken things into their own hands. At this moment, lot of caregiving is being done by numerous social or religious local organizations. All these organizations are collectively providing hundreds of thousands of meals to the needy people; setting up thousands of beds and acquiring necessary equipment & medications, where possible. Spearheading these efforts, nationwide, are RSS, VHP volunteers.

It is true that the healthcare system in India is simply overwhelmed at this moment by Corona cases. At the same time, it is very essential to analyze whether the current tragic phase is as ‘cataclysmic’ as the Media, think-tanks, and the govt-bashing pseudo-secular activists have made it out to be. When the western media is so eager to call the situation in India as ‘genocide’ or ‘criminal act’ without any regards to journalistic decency, where were they with the same verbalism when 3,500-4,000 people were dying each day in U.S. amid hundreds of thousands of covid cases? Let’s take a break and have comparative study with hard numbers. As of now, populations of India, USA, U.K. and ‘European Union (EU)’ are respectively 1,391 Million, 332.60 Million, 68.18 Million and 447 Million. As of May 1,2021, the Corona cases they have are 19.60 Million, 32.80 Million, 4.4 Million and 30.29 Million. The death tolls are respectively 216,000, 576,700, 151,200 and 679,000. In short, statistically, although U.S. population is less than 1/4 of India, it had 11 TIMES more deaths and 7 TIMES more corona cases. In U.K., although the population is measly 4.77% of India, it had 14.32 TIMES more deaths and 4.54 TIMES more Corona cases and though ‘EU’ population is less than 1/3 of India, it has 9.68 TIMES more deaths and 4.77 TIMES more Corona cases. Although the pandemic numbers of the highly developed countries look shocking in comparison to India, they are in no way comforting to what is unfolding in India, now. Each life is precious. The whole objective of this numerical exercise is only to put Indian pandemic in global perspective. It’s not just India, even developed nations like Canada, England and so many European countries are currently struggling with the acute shortage of vaccines and medical facilities. (My nephew is ER-Chief in a Toronto Hospital and one of my closest friends is overseeing a Hospital in London). Needless to say, the question that pops up in one’s mind is – ‘why then, the western world is finding Indian pandemic so monstrous when they themselves have fared so badly’ in reality? The reason being – India’s formidable stature as a rising world power under the leadership of PM N. Modi. This is their way of pointing out India’s vulnerability. Dr. Gautam Sen of ‘London School of Economics’ says, (as per the report that is available) – ”a professional international campaign has been launched in the context of Covid crisis in India in the hope of delegitimizing the Modi Govt and weaken it fatally … the goal is to instigate rejection of BJP in the forthcoming elections.”

India produces 70% of the world’s vaccine and a major chunk of generic drugs that U.S. needs. Even before under Trump administration, United States (U.S.) relations with China had started deteriorating, the American consumer-giants had already started eyeing India as the alternative manufacturing hub for their goods. By this time India had established itself as one of the biggest consumer markets in the world. When the new U.S. President Joe Biden bought 600 million dosages to play vaccine-diplomacy, his administration wasn’t fully aware of how much U.S. depended on India. During Trump administration, when U.S. badly needed millions of ‘Hydroxychloroquine’ dosages, it was India who had come to U.S. rescue.  When President Biden prematurely arrested raw material supply for Vaccine production in India, it took his administration some time to realize what a blunder he had made. As numerous countries started coming to India’s aid, it not only reflected badly on U.S. as a selfish, isolationist country, but also, presented a Public-Relation nightmare for the U.S. giants doing business with India. There is no doubt that PM Modi and his team charmed the new President and smoothen out diplomatic wrinkles but that wasn’t the only reason why Biden administration reversed its earlier decision. The tripping point that delivered the goods in India’s favor came in the third week of April. during an emergency meeting of U.S. Secretary of State, Antony Blinken with 135 CEOs of major U.S. conglomerates. The CEOs reportedly convinced the new Administration that if the U.S. didn’t reciprocate India’s earlier goodwill gesture, it would have disastrous economic repercussions, especially when nationalistic fervor running so high in India. Moreover, lately PM Modi’s new motto of ‘Atmanirbhar Bharat’ (self-reliant, self-sufficient, with self-esteem – India) had become worrisome to them. Nevertheless, the pandemic situation in India is definitely a matter of great concern which needs global efforts. Afterall one-fifth of the humanity and the world’s largest consumer clientele is at stake. In U.S., Indian diaspora is raising lot of funds through various organizations to fight Corona in India. Organizations, like ‘Sewa International’, ‘VHP of America’, ‘BAPS’, ‘Ekal V. Foundation’, ‘Share & Care’, ‘AAPI’ have collectively raised millions of dollars. Various American groups and organizations are also busy raising quite bit of money for India. It is very comforting to know that the people around the world are motivated to help India. One World! One Humanity! One Objective!

Indians Reach Out With Helping Hands As COVID Spirals

Even the darkest cloud, it is said, has a silver lining. And because most oft-quoted cliches are rooted in reality, myriad acts of kindness, be it home-cooked meals for the ill or arranging an oxygen cylinder, are shining through India’s gravest health emergency.

As India reports upwards of 3.5 lakh fresh Covid cases a day, people infected and isolated find that succour is close at hand sometimes neighbours and other times a faceless name on social media reaching out to help in any which way. Just so they can, without any motive in mind.

From people offering to run errands and home kitchens delivering meals to organisations and individuals stepping in to supply oxygen cylinders, oximeters and the like, the goodness runs like an undercurrent through the tragic times.

And so, realising that entire families are in quarantine in many homes in her city and there is no one to cook nourishing meals for them, Chennai’s Rama Parthasarathy opened up her kitchen on April 14, Tamil New Year Day. The 61-year-old dishes out healthy preparations all vegetarian and sends the food through portals like Dunzo or Porter for a nominal fee.

The inspiration for Rama’s Kitchen, she said, came when her son Aravindh’s friend asked if she could food to the home quarantined as they are not in a position to cook at home.

The story is replicated in umpteen localities across the length and breadth of the country from Chennai to Chandigarh. Lists of home kitchens and thali meals, sometimes at a nominal price and other times free, have been circulating on WhatsApp groups, Twitter and other social media platforms.

Community kitchens have opened up in gated communities. In many places, including Mumbai and Gurgaon, neighbours have set up a roster system to ensure that all quarantined families in their complexes are provided food.

Help comes in many shapes and sizes. Gopi’s e-rickshaw in Lucknow is one of them. With cases rising in the Uttar Pradesh capital, the 45-year-old hasn’t been getting much business but is busy helping those in Shivaji Nagar locality. He gets milk, newspapers and vegetables for those who can’t move out from their homes, and often medicines and even X-Ray reports and the like.

Raja and Shakeel, who run a cycle shop in Lucknow, are also doing their bit, helping people in Sarojinidevi Dharamshala lane with their daily errands. Sometimes, they also go to the nearest post office and banks either to withdraw or deposit money or update the passbook of residents in their area.

They have a kindred spirit in Noida-based activist Kiran Verma who earlier this month posted on Twitter and Facebook that he owned “a humble Maruti Suzuki Esteem in good condition and completely sanitised”.

“If any person, (willing to #DonateBlood or plasma) is finding it difficult to travel around NCR for blood donation. OR don’t have access to good food, I promise to drop you safe (with a smiling face) at a blood bank or provide food at your doorstep,” said the founder of blood donation initiative ‘Simply Blood’.

“The motivation is simply that these are very difficult times and I just wanted to encourage more people to come forward and show that we all are together in this tough time,” he told PTI earlier this month.

Several people are working through their organizations.

In Hyderabad, Azhar Maqsusi, who formed the Sani Welfare Association in 2012, arranges for cooked food to the poor as well as rations and medicines for them.

“The food distribution is continuing daily and is being distributed to 1,000 people. We are also arranging for medicines for those who cannot afford them,” Maqsusi told PTI.

Given the rising number of COVID-19 cases, he has also started the ‘Wall of Face Mask’ at the Dabeerpura flyover to provide free face masks to the people.

And in Chandigarh, H S Sabharwal, a trustee of the Guru Ka Langar Eye hospital, said home quarantined corona patients are being given oxygen cylinders, oxygen concentration machines and oximeters free of charge.

We wanted to serve people who are in need of help during COVID-19 pandemic, said Sabharwal.

Hundreds of miles away, in Kolkata, mountaineer Satyarup Siddhanta and climber and model Madhabilata Mitra are among those who have been working to help COVID-19 patients in West Bengal.

Their Covid Care Network has over 400 members, including several doctors, across the state. The helpline number (1800-889-1819) raises awareness about the disease, counsels people and gives information on how and where to get admitted if the need arises.

Besides, Siddhantha and his colleagues also operate an ambulance, with aid from the state government, to ferry patients from home to hospitals.

We have been doing this since last June and there has been a massive response. And now with this surge, there are at least 40-50 calls daily,” Siddhantha told PTI.

The Rajasthani Health Foundation in Chennai is similarly helping with a dedicated team of doctors and nurses at a quarantine facility.

The facility, for those who are asymptomatic or have mild symptoms without comorbidities, is meant mostly for economically weaker sections in one-room homes. Food, medicines, oximeters, masks and sanitisers are part of the deal.

“We get about 500 calls per day now on an average. Where are the facilities for so many,” asked Jagadish Prasad Sharma, chairperson of the Foundation.

In Rajasthan, the Narayan Seva Sansthan in Udaipur is among the NGOs working to help people with masks and food.

The NSS Mitra task force’ will be at the forefront in case of any crisis or calamity, said Prashant Agarwal, president of the NGO.

The outreach, sometimes from random strangers, is of huge help. Ask Atreyee Das, a fashion designer by profession, who lives alone in Gurgaon.

After I tested positive for COVID-19, I was feeling really helpless and scared, being away from home and living alone. At one point, my oxygen saturation level dropped to 94-95, which frightened me and forced e to think of consulting a doctor, said Das, who hails from Kolkata.

I reached out to a friend who asked for help on Twitter. Several people, including doctors, responded. Finally, I was able to speak to a doctor from Lucknow, Dr Saurabh Kumar Singh. Even though I am an absolute stranger, Dr Singh helped me in every possible way by prescribing medicines, diet and informing me of the Dos and Don’ts for a COVID patient, she said.

Good samaritans all, whether working in their individual capacities or through their organisations. As COVID continues its relentless march, they are also India’s Covid heroes.

On Wednesday, India saw a record single-day rise of 3,60,960 coronavirus cases, which pushed the total tally to 1,79,97,267 (17.9 million/1.79 crores), while the death toll crossed two lakh following 3,293 fresh fatalities, according to Union health ministry data.

(Courtesy:https://www.eastmojo.com/national-news/2021/04/29/the-good-people-do-indians-reach-out-with-helping-hands-as-covid-spirals/)

Coronavirus Live Updates in India- 3k+ Covid Deaths Daily – Global Humanitarian Aid Flows

Coronavirus Cases:20.6 millions – Deaths:223 k – Recovered:16.6 m – 7 day daily average: 365k – Deaths during the last 24 hours: 3449  (Daily change in India from JHU CSSE COVID-19 Data)

Sarcastically the story is narrated as “Born in China, Corona grew up in the United States. Later studying in Italy followed by a diploma from England. Now he has become the biggest businessman in India. This is history” 

In fact the history is punishing Indians with its dance of death. Adding scary 386,452 new cases, India now has reported more than 20.36 million since the pandemic began, second only to the United States. The Health Ministry on Friday also reported 3,499 deaths in the last 24 hours, bringing the total to 223,959. Experts believe both figures are an undercounted. During the year-long corona war, there was no proper planning against this catastrophe, and India is struggling badly with the uncontrollable spread and deaths everyday. The Covid situation in India remains severe, with more than 385,000 new infections registered daily.

Researchers believe there could be a number of factors at work in the surge, including the B.1.1.7 variant from the United Kingdom and the B.1.617 variant from India; relaxed restrictions that led people to mingle, including at political rallies and religious observances; and low vaccine coverage.

Delhi hospitals cry for help amid oxygen shortage, Madhukar Rainbow Children’s Hospital in Malviya Nagar on Sunday sounded an alarm about their depleting stocks around noon, saying 50 people, including four newborns, were “at risk”.

Hear the latest news from Bangalore: Twenty-four patients died at a government hospital in Karnataka due to lack of oxygen. The tragedy took place at the Chamarajanagar District Hospital on Sunday night. Battling an acute shortage of oxygen, some hospitals on Sunday sent out desperate SOS calls to authorities to replenish their dwindling stocks, even requesting the government to shift out its patients.

India sees another face of what happened in the United States a year ago. President Trump was accused of mishandling the Covid pandemic crisis turned to a huge blow to the United States of America. Though Trump could expedite the invention of effective vaccines,  with Biden’s sympathy and support  more than 200 million people have been vaccinated and are returning to normal life in a country that has been devastated by death.

U.S. White House’s chief health adviser and pathologist Anthony Fauci has called for a lockdown in India to avoid covid cases. He said that an emergency shutdown for a few weeks would put an end to the spread of Covid in India.

 

On April 26th American President Biden tweeted ”Today, I spoke with Prime Minister Narendra Modi and pledged America’s full support to provide emergency assistance and resources in the fight against Covid-19. India was there for us, and we will be there for them”.

As an immediate gesture the U.S. began supplying rapid virus test kits and oxygen to India, and some materials to expedite its domestic production of COVID-19 vaccines.

Additionally, a CDC team of public health experts is also expected to help Indian health officials, to slow the spread of the virus. Vice President Kamila Harris, who is of Indian descent, alerts India a “great tragedy”. She emphasized America’s “longstanding, decades-long relationship” with the country in providing U.S. aid to help alleviate some of the crisis there.

Indian Prime Minister Modi conveyed his “heartfelt appreciation” for the offer of assistance and support from the US government . He reiterated India’s commitment to contain the Covid pandemic globally through Vaccine Maitri, and its participation in Covax and the Quad Vaccine Initiatives.

Beijing, also has made a direct offer to help India Chinese Foreign ministry spokesperson Hua Chunying said that Beijing is concerned about the “grave situation” in India, and is ready to help India.” Chinese Ambassador Sun Weidong assured that Beijing will encourage Chinese firms to facilitate medical supplies to India. Despite the conflicts between the two countries followed by an year-long border standoff that has clouded the bilateral relationships ”

Russia has also offered to help India to combat the alarming Covid crisis. According to Russian Ambassador NikolavKudashev “ India can get immediate help with vaccines, raw materials and supply resources. Two Russian commercial flights have already landed in India with Covid-19 emergency aid. Russia on its humanitarian assistance to India, is delivering additional Lung Ventilation equipments, Bedside Monitors, Masks, Sputnik V vaccines etc by early May 2021”.

 The Supreme Court on Friday asked the Centre why it could not vaccinate the entire Indian population against Covid-19 free of cost under the National Immunisation Programme.”

Instantly, Equipments for the oxygen generation plant was transported to Dimapur, Nagaland by an IAF IL 76: Indian Air Force.  Many Indian hospitals are not installed with central oxygen delivery pipelines; instead, inpidual oxygen cylinders are needed for each patient.

While 60% of people there are fully vaccinated due to expert planning in countries like Israel, only 5% of people in India, the largest producer of the vaccine, have yet completed both doses of vaccination.

As at May 1, 2021 India has so far administered at least 154,211,511 doses of Covid vaccines. Assuming that every person needs 2 doses, that is enough to have vaccinated about 5.6% of the country’s population.

As my friend laments, with so many people dying of starvation for life without hospitals, projects like the Central Vista project are moving ahead with the construction of the new Rs 20,000 crore parliament building. Without realizing the seriousness of the matter, and a carefree life led to a degree of arrogance; with the tacit approval of a bunch of power-hungry people, all the political parties’ election rallies, ceremonies, Kumbh Mela, Holi, and other religious celebrations were discretely allowed, We all laughed and nodded.

We went on excursions, went to weddings, deaths, and festivals. The laws were weakened, and all politicians and governments took our protective umbrella. As a result, we can not even go out to live today. Our children are not even adequately educated and are looking forward to an unanswered future. Elderly parents say goodbye to the world, not even taking a last look at their children abroad.Indian Government, go ahead with an immediate national emergency if needed, we need to save our country.

With a responsible heart for the social existence, there is only one prayer and one request. It is not too late yet. Save lives, get vaccinated as soon as the vaccine is available. A humble request to everyone, especially those who have not been vaccinated, make it a habit to go out only in absolutely unavoidable situations. Go out only to live and keep alive.”Make SMS, the slogan of your life- Sanitizer, Mask, Social Distancing”.

US Lifts Ban On Exports Of Key Ingredients To Manufacture Covid Vaccine To India

With the Covid-19 surge crippling the healthcare system in India, the US, which had earlier said its primacy was for its citizens, changed its stance and has lifted export controls on raw materials for vaccines that were put in place in February.

With the Covid-19 surge crippling the healthcare system, hectic diplomacy is on with major countries for urgent supply of vaccines, oxygen-related equipment such as tankers, ventilators and other critical life-saving devices. The US, which had earlier said its primacy was for its citizens, changed its stance on lifting export controls on raw materials for vaccines that were put in place in February, following repeated requests from Indian officials and the Serum Institute of India.

A lethal, fast-paced second wave of the coronavirus pandemic has brought India’s health care systems to the verge of collapse and is putting millions of lives and livelihoods at risk, wrote Ramanan Laxminarayan, an economist and epidemiologist, in The New York Times. According to The Wall Street Journal, hospitals in New Delhi and other hard-hit cities have been turning away patients and running low on oxygen, beds, and other medical supplies.

After declining, the Biden-Harris administration has finally agreed to provide it raw materials for vaccines that had previously been under export controls, as well as other key material. A White House statement said that National Security Advisor Jake Sullivan spoke by phone on Sunday with his Indian counterpart, Ajit Doval, and expressed “deep sympathy for the people of India following the recent spike in Covid-19 cases”, and affirmed America’s solidarity with India.

“Just as India sent assistance to the United States as our hospitals were strained early in the pandemic, the United States is determined to help India in its time of need. To this end, the United States is working around the clock to deploy available resources and supplies, it said.

“The United States has identified sources of specific raw material urgently required for Indian manufacture of the Covishield vaccine that will immediately be made available for India. To help treat Covid-19 patients and protect front-line health workers in India, the United States has identified supplies of therapeutics, rapid diagnostic test kits, ventilators, and Personal Protective Equipment (PPE) that will immediately be made available for India,” it read.

Many in Washington DC’s political and business elite are in favor of helping India, sources said. On Saturday, the US Chamber of Commerce made a vocal pitch, calling on the White House to release “the millions of AstraZeneca vaccine doses in storage” — apart from life-saving equipment — to India, Brazil, and other nations hit hard by the pandemic.

Several US lawmakers have expressed concern over the sudden spike in COVID-19 cases in India and have urged the Biden administration to provide all necessary help to the country. “We have the resources to help, and other people need it; that makes it our moral obligation to do so,” Democratic Senator Edward Markey said in a tweet.

Congressman Gregory Meeks, Chairman of House Foreign Affairs Committee, said he was concerned about the situation in India. “Sending my thoughts and support to our friends in India fighting this terrible second wave of the COVID19 pandemic,” he said Congresswoman Haley Stevens said that her thoughts are with the people of India during this devastating COVID-19 surge.

Indian American Congressman Ro Khanna, while sharing a tweet from eminent public health expert Ashish K Jha, said, “India is in the throes of a horrendous COVID surge.
Horrendous. They are struggling to get more people vaccinated. We are sitting on 35-40 million doses of AstraZeneca vaccine Americans will never use. Can we please give or lend them to India? Like, maybe now? It’ll help. A lot,” Jha had said.

On Friday, US Health Secretary Matt Hancock tweeted, “Heartbreaking scenes from India… We stand ready to help fight this awful virus.” Top medical advisor to the US President Dr Anthony Fauci also said the CDC (Centers for Disease Control and Prevention) was in talks with Indian counterparts for technical assistance, adding, “we’re trying to help in any way we can”. “Obviously they need to get their people vaccinated because that’s the only way we’re going to turn that around,” Dr Fauci said.

White House spokesperson Jen Psaki said the US is “working closely with Indian officials at political and experts’ level for ways to help address the crisis”. For a month now, vaccine manufacturers and upstream suppliers have been reporting shortage of raw and packaging materials, critical consumables and equipment. Over time, such shortages can lead to shortage of vaccines and impact delivery commitments, as well as delay regulatory clearances for some products, experts said.

UK to Send Raw Materials to India

The UK will be sending more than 600 pieces of vital medical equipment to India to support it in fight against Covid-19, the UK government announced. The assistance package, funded by the Foreign, Commonwealth & Development Office, includes ventilators and oxygen concentrators from surplus stocks. The Department of Health and Social Care have worked closely with the NHS, as well as suppliers and manufacturers in the UK to identify reserve life-saving equipment that can be sent to India.

Recently, India has been reporting high number of Covid-19 cases and deaths while several reports of shortage of oxygen are also coming. The first shipment of equipment has already justify the UK and it will be arriving to India in the early hours of Tuesday. Further shipments are due to follow later this week.

In total, nine airline container loads of supplies, including 495 oxygen concentrators, 120 non-invasive ventilators and 20 manual ventilators, will be sent to the country this week. This equipment will be crucial in helping to save the lives of the most vulnerable in India. The oxygen concentrators, for example, can extract oxygen from the air in the atmosphere so that it can be provided to patients, taking the strain off hospital oxygen systems and allowing oxygen to be provided in situations where hospital oxygen supplies have run out.

Indian American Groups Offer Help to India

Several Indian-American groups have started raising funds to urgently airlift medical supplies including oxygen to help India in its fight against coronavirus.

“In the past week, we have been receiving nothing but mind numbing news from many countries around the world, particularly in India, the land of our birth,” stated Dr. Sudhakar Jonnalgadda, President of American Association of Physicians of Indian Origin (APPI) the largest ethnic medical organization in the country. Pointing to the fact that the statistics are chilling,

Dr. Sudhakar Jonnalagadda, while referring to the several proactive steps in educating their members and the general public about the disease, the preventive steps that needs to be taken at this time and most importantly, they are using all their contacts and resources at the hospital administrative and government levels to facilitate treatment protocols to be in place at the various hospitals in the US and in India, urged AAPI members and the general public to step up and donate generously as India, our motherland is facing one of the most serious health crisis in decades. “This is the time for immediate AAPI action. As doctors, we all share a visceral urge to do something about it,” he added.

“This is truly a humanitarian crisis of apocalyptic proportions which needs an immediate response,” wrote Indian-American Mike Sikand, chairman Oceanport Democratic Committee in New Jersey to Senator Robert Menendez, Chairman of the Senate Foreign Relations Committee. “Another step that you could take is to help increase hospital bed capacity in India by providing equipment and financial assistance to set up makeshift hospitals or even sending USS Mercy to help India deal with this crisis,” Sikand said in the letter to Menendez.

GOPIO Thanks President Biden and Appeals to Release AstraZeneca Vaccines to India

Global Organization of People of Indian Origin (GOPIO) thanked US President Joe Biden for his announcement of USA sending raw materials for COVID-19 vaccines, medical equipment and protective gear to help India respond to a massive surge in coronavirus infections.  India is going through a grim situation now in Covid Pandemic infection and deaths. The latest report says that the new infections are about 350,000 and deaths about 3,000 per day.

GOPIO Chairman Dr. Thomas Abraham said that in the last three months, India acted as a global leader in sending vaccines to many countries. However, with the sudden unexpected Covid-19 outbreak, India needs an enormous quantity of vaccines for its 1.3 billion population. As a close ally of India, our country must help India in this grave situation.

“We appeal to you to send AstraZeneca vaccines which are stored by US manufacturers in their warehouses since the US is yet to authorize its use here while it has been used in India,” Dr. Abraham appealed in his letter to President Biden. GOPIO also requested President Biden to facilitate manufacturing of other vaccines in India so that the global demand can be met sooner.

AAPI Begins Campaign For Medical Oxygen, Tele-Consult & Educational Webinars to Help Combat Covid -19 In India

(Chicago, IL: April 27th, 2021) “In the past week, we have been receiving nothing but mind numbing news from many countries around the world, particularly in India, the land of our birth,” stated Dr. Sudhakar Jonnalgadda, President of American Association of Physicians of Indian Origin (APPI) the largest ethnic medical organization in the country. Pointing to the fact that the statistics are chilling,

Dr. Sudhakar Jonnalagadda, while referring to the several proactive steps in educating their members and the general public about the disease, the preventive steps that needs to be taken at this time and most importantly, they are using all their contacts and resources at the hospital administrative and government levels to facilitate treatment protocols to be in place at the various hospitals in the US and in India, urged AAPI members and the general public to step up and donate generously as India, our motherland is facing one of the most serious health crisis in decades. “This is the time for immediate AAPI action. As doctors, we all share a visceral urge to do something about it,” he added.

Dr. Jonnalagadda said, “We have located a source manufacturer that supplies Oxygen concentrators each of which can save several lives in India. The cost of each unit is around $500.00. The Indian Embassy and Consulates have been extremely helpful, and will assist in the rapid shipping and customs regulations of these lifesaving units.

Dr. Jonnalagadda announced that “AAPI with the collaboration of numerous members/Chapters has placed orders for securing and delivering oxygen concentrators for 200 units to be delivered direct to hospitals in India with the help of SEWA  International, a reliable non-profit organization”

Describing the current trend/spike in Covid cases in India as “the worst nightmare” Dr. Sajni Shah, Chair of AAPI BOT pointed out, “This is a far cry from the picture a few months ago about our motherland India, which depicted the virus to be on the decline.”

Dr. Anupama Gotimukula, President-Elect, who is leading the AAPI Initiative to help and support plans to help the physicians and the people in India, at the conclusion of the brain storming session with hundreds of AAPI members, said: “Thank you and it was good to listen to every  physician from US and India how to execute our professional services to patients in India.” Summarizing the deliberations, Dr. Gotimukula said: 1. Groups of physicians will form smaller groups with Indian physicians in your own state/region, and do it yourselves in your own language, and can use the model that are already in place for Tele-Consult. The Google sheet prepared by AAPI has the list of volunteers and we will update it regularly. 2. We have 3 Telehealth platforms that have been identified and it is a free service to physicians from India/US and patients; 1. EglobalDoctors.com; 2. http://Mdtok.com; and, 3. Click2clinic.com. Apps are available on iOS and Android.

In addition, with the purpose of educating AAPI members and their counterparts in India,  AAPI is organizing educational webinars with small group of doctors on zoom. Dr. Gotimukula urged the physician fraternity of the need to educate your communities of the need to double masking and for “everyone must take the vaccine to reduce the intensity of disease if we become Covid positive.”  AAPI is offering MD-To-MD zoom chats and discussions about one’s patients, disease, course of medicines, and progress daily 7-8 am IST/9:30-10:30 am EST

Dr. Ravi Kolli, Vice President of AAPI said, “It is particularly painful and frightening, that the sudden widespread and intense shortage of the basic commodity we take for granted at all levels of management of this deadly disease, both at home, in an ambulance or at the health care facility  — that of OXYGEN. AAPI members have risen upto the occasion and are offering the much needed services to their motherland in several ways, individually and collectively.”

Dr. Amit Chakrabarty, Secretary of SAAPI said, “The AAPI Executive Committee, the Board of Trustees, and the AAPI Charitable Foundation are working together to get the initial order of two hundred units immediately, to jump start our response. he detailed about the exciting project, tele-consulting services for Indian doctors. “We had an officers’ meeting discussing the pros and cons of Covid tele consulting services and especially liability issues.  We are extremely delighted about the overwhelming response to this.”

Dr. Satheesh Kathula, Treasurer of AAPI said, “Time is of the essence and we need to act fast to save lives. I strongly urge each AAPI member to please rise to the occasion and contribute money and time generously to help the needy. Dr. Kathula thanked all the volunteers and tele-health platform companies for sharing platforms and offering services at no cost to AAPI members, Indian doctors and patients for treating COVID-19. For more details, please visit: AAPI website: www.appiusa.org

As Covid Strikes India Hard, Narendra Modi’s Image Sinks

The pandemic is killing thousands daily, crushing India’s modest health system, causing crippling shortages of doctors, nurses, medicines, even oxygen. If last week witnessed Narendra Modi government’s biggest crisis, it’s only become bigger since.

The second wave of Covid-19, with the spiraling cases and deaths across cities and towns, making India currently the world’s worst pandemic-affected country, have now dented India’s Prime Minister Narendra Modi’s image in India and around the world for the poor vision, poor planning, and mismanagement of the most deadly virus in over a century.

The pandemic is killing thousands daily, crushing India’s modest health system, causing crippling shortages of doctors, nurses, medicines, even oxygen. If last week witnessed Narendra Modi government’s biggest crisis, it’s only become bigger since. It threatens to grow bigger over the next several weeks, healthcare experts say.

With over 350,000 new coronavirus cases daily and more than 2,000 people dying every 24 hours, the situation has become too tumultuous for Modi, the leader of Hindutva or Hindu nationhood. The daily increase in cases has forced many Indians to raise their eyebrows about the governance efficiency of Modi, hitherto considered the superhero and a catalyst of good governance.

Modi’s government has faced criticism that it let its guard down, allowed big religious and political gatherings to take place when India’s cases plummeted to below 10,000 a day and did not plan on building up the healthcare systems. Hospitals and doctors have put out urgent notices that they were unable to cope with the rush of patients.

India’s total tally of infections stands at 16.96 million and deaths 192,311 after 2,767 more died overnight, health ministry data showed. In the last month alone, daily cases have gone up eight times and deaths by 10 times. Health experts say the death count is probably far higher.

India’s surge is expected to peak in mid-May with the daily count of infections reaching half a million, the Indian Express said citing an internal government assessment. V.K. Paul, a COVID-task force leader, made the presentation during a meeting with Modi and state chief ministers and said that the health infrastructure in heavily populated states is not adequate enough to cope, according to the media reports.

The Guardian, a popular Western publication wrote in an editorial this week: “At the beginning of March, the Hindu nationalist government of Narendra Modi claimed the country was in Covid-19’s “endgame”. India is now in a living hell. A new “double mutant” variant, named B.1.617, has emerged in a devastating coronavirus second wave which has seen hospitals run out of beds and oxygen. Mortuaries are so full that bodies are justify to decompose at home. Charities warn that the dead risk being justify on the streets.”

The second wave of cases has been made more deadly by oxygen shortages in hospitals. An investigation by Indian news website Scroll.in revealed that the country’s government waited until October 2020, eight months after the pandemic began, to invite bids for a $27 million contract to place oxygen generation systems inside more than 150 district hospitals. Six months later, most still aren’t up and running. Several states across the nation have expressed despair as most hospitals have run short of Oxygen.

“India is in the ICU and those who put her there now spend their time trying to shift the blame. The change from ‘victory’ over Covid to gasping for oxygen began in the last week of January this year when the Prime Minister proudly declared that India had not only defeated the pandemic but had been an inspiration for other countries. He then proceeded to personally oversee vaccine exports to needy countries and his Minister of External Affairs boasted about it. After this ‘victory’, the Prime Minister and Home Minister spent their time organizing a blitzkrieg of election rallies in West Bengal and Assam without wearing masks and while exhorting large crowds to gather,” wrote columnist Tavleen Singh in The Indian Express.

If you’ve been tempted to think the pandemic is over, journalist Rana Ayyub’s reporting from India will prove you sorely mistaken. “If the apocalypse had an image,” she writes for TIME, “it would be the hospitals of India.” India’s sheer volume of cases is contributing to that unimaginable death toll, but there are extenuating factors, too. Oxygen supplies are running out across the country, in part because the Indian government waited until October 2020 to seek contracts for installing oxygen generation systems in many hospitals, Ayyub reports. Some are still not working today, leaving critically ill patients without the thing they need most as their lungs fail.

A recent story in TIME magazine titled, “’This Is Hell.’ Prime Minister Modi’s Failure to Lead Is Deepening India’s COVID-19 Crisis” pointed out how India has mismanaged and sent misleading messages. “The Uttarakhand chief minister declared on March 20, “nobody will be stopped in the name of COVID-19 as we are sure the faith in God will overcome the fear of the virus.” It wasn’t until mid-April that Hindu nationalist Prime Minister Narendra Modi tweeted that participation in the pilgrimage should be kept “symbolic” to combat the pandemic. Is it any wonder that the festival has become a super-spreader event?”

But the statement by Modi came too late. Mega political rallies in poll bound states, led by Modi himself and his party leaders in several states has been stated to be instrumental in spiking the covid cases across India. Hundreds of thousands of Hindu devotees showed up each day for a dip in the Ganges as part of the Kumbh Mela pilgrimage in Haridwar, Uttarakhand. Millions of worshippers have participated in the weeks-long festival since the first day of bathing on March 11, despite clear evidence that thousands are testing positive for the virus after attending. In the space of just a few days in mid-April, more than 1,600 cases were confirmed among devotees. In March, when the second wave was already underway, state leaders from the ruling Bharatiya Janata Party (BJP) published full-page ads in national newspapers telling worshippers it was “clean” and “safe” to attend.

Last week, as India reported the highest number of daily cases of anywhere in the world, the ruling Bharatiya Janata Party tweeted a video of one of Modi’s political rallies. Alongside Modi was his close confidante and home minister, Amit Shah. In theory, Shah should have been in the capital, coordinating with various state governments on how to deal with the devastating spike in COVID-19 cases over the past few weeks. Instead, Shah has been holding roadshows with thousands of joyous crowds on the streets of West Bengal which is in the midst of elections to the state Assembly. “Since January, Modi has organized mass political rallies in various states and has allowed religious events like the Kumbh Mela to go ahead, while his party continued with its dog-whistle campaigns against Indian minorities,” TIME reported.

The Guardian wrote: “Like Donald Trump, Mr Modi would not give up campaigning while the pandemic raged. India went ahead with five state elections in April, and an unmasked Mr Modi held huge rallies. Mr Modi’s brand of Indian exceptionalism bred complacency. A presumption of national greatness has led to a lack of preparedness, most notably in vaccine production.”

“The country has been too complacent and relaxed for too long. Now we are paying the price for that negligence,” Archbishop Prakash Mallavarapu, chairman of the Healthcare Commission of the Catholic Bishops’ Conference of India (CBCI), told the Register.  “There has been certainly a big lapse from the complacent government and the general public, paying scant regard for the social-distance norms while the state machinery ignored enforcing norms,” said Archbishop Mallavarapu, whose Visakhapatnam Archdiocese in located in the state of Andhra on the east coast of India.

TIME criticized states that are attempting to hide the death rate. “In the state of Uttar Pradesh workers were pictured covering the crematorium with tin sheets. Priyanka Gandhi, of the opposition Congress party, accused local authorities of hiding the truth.” In Gujarat, the Prime Minister’s home state, crematoriums are burning day and night, while the state refuses to acknowledge the high number of deaths. The Gujarat high court has demanded the state government reveal the accurate count of COVID-19 patients and deaths,” TIME pointed out.

Jesuit Father Cedric Prakash, an internationally known social activist based in Modi’s home state of Gujarat, was much more unsparing is his choice of words, when asked for his reaction to the calamity that has gripped the nation. “Absolutely abominable,” Father Prakash described the situation on the ground in Gujarat. Among over two dozen Christians who have died of COVID in Gujarat were five of his Jesuit confreres, who died on April 17 alone. A week earlier, another eminent Jesuit, Father Varghese Paul, former president of the Indian Catholic Press Association and mentor of dozens of writers in Gujarat, also died of COVID at the age of 78.

“The government is blatantly lying on official figures of the grim reality,” said Father Prakash, endorsing the media reports that exposed the underreporting of deaths in Gujarat and several other Indian states. “They play down deaths and the number of infected by the pandemic.” While the Gujarat government acknowledged only 78 deaths on April 16, national daily The Hindu reported cremation of 689 bodies in seven cities alone under COVID protocol in the state, in an article titled, “COVID-19 Deaths in Gujarat Far Exceed Government Figures.”

“The situation is miserable here. Many are dying. I know an entire Christian family that has been wiped out. One of our young bishops is also in hospital with COVID,” Bishop Chacko Thottumarickal of Indore, in Madhya Pradesh state in central India, told the Register.  “The media reports here routinely challenge the government death figures, with some networks challenging the actual figures to be several times higher,” said Bishop Thottumarickal, the former chairman of the Office for Communication of the Federation of Asian Bishops’ Conferences.

After The Wire news portal published an article titled, “Varanasi: Cremation, Burial Grounds Show About 50% of COVID-19 Deaths Aren’t Officially Recorded,” Prime Minister Modi called a meeting of top officials of Varanasi, as he personally represents the Hindu holy city in the Indian Parliament.

In the race to produce and secure vaccines for the 1.4 Billion Indians, Modi regime failed miserably. India invested too little in vaccine against Covid production. While epidemiologists, specialists and opposition leaders have long urged Modi to give approvals for foreign vaccines, the decision to give emergency use license to the Russian manufactured Sputnik V vaccine was only taken in the second week of April. Against the skepticism for vaccines by a vast majority of Indian, Modi government has done too little to reinforce public health messaging. In West Bengal, where Modi himself has been campaigning, the BJP Chief has advocated drinking cow urine to treat COVID-19.

The net result of all these is: People are dying in their hundreds in India because of a lack of medical oxygen and other supplies in the country’s overloaded hospitals. The healthcare system is collapsing as India records more than 350,000 new coronavirus cases each day and thousands lose their lives daily.

“The Indian prime minister suffers from overconfidence in his own instincts and pooh-poohs expert advice,” The Guardian wrote. “His ministers turned on a former Congress prime minister for daring to offer them counsel just before he was admitted to hospital with Covid this week.” Guardian was referring to the recommendations suggested by Manmohan Singh, former Prime Minister of India.

As this COVID-19 “tsunami” floods across the nation, a chorus of protest has erupted from opposition parties, social-action networks and the media, challenging the government’s lack of foresight. One of the most prominent is a report by The Times that accuses the BJP government led by Prime Minister Narendra Modi of “floundering” in the face of the giant surge in cases. Another media account accuses the Indian government of indulging in “vaccine diplomacy” by exporting more than 60 million COVID vaccines to 84 countries at the cost of Indian citizens while the country’s own vaccination centers are crippled by vaccine shortages.

 “This is the first time Modi has been on the receiving end and he may have to pay a political price. It is also the first time that India has experienced a catastrophe of such magnitude,” a political analysts wrote recently. “Thus, it may not be wrong to suggest that it would be far from easy for Modi to remake and reshape the politics of the Bharatiya Janata Party (BJP), say some skeptics. And the skepticism has come not without good reason.”

His critics are already predicting doomsday. Many have gone vocal demanding the prime minister’s resignation. On social media and in general discussions, the refrain is that the limit of good governance under Modi has been reached. At this critical juncture in its history, Indians have been justify to fend for themselves.

We Know More As To How The Vaccines Work

COVID-19 vaccines teach our immune systems how to recognize and fight the virus that causes COVID-19. It typically takes two weeks after vaccination for the body to build protection (immunity) against the virus that causes COVID-19. That means it is possible a person could still get COVID-19 before or just after vaccination and then get sick because the vaccine did not have enough time to provide protection.  People are considered fully protected two weeks after their second dose of the Pfizer-BioNTech or Moderna COVID-19 vaccine, or two weeks after the single-dose Johnson & Johnson’s Janssen COVID-19 vaccine, CDC has stated.

Studies have shown that several vaccines are highly effective in preventing people getting seriously ill from Covid-19. Now, early results from a survey in the UK suggest two commonly used vaccines — the Pfizer-BioNTech and AstraZeneca shots — can significantly reduce infections.

Twenty-one days after the first vaccine, odds of a new Covid-19 infection were reduced by 65%, according to results from the COVID-19 Infection Survey, coordinated by the University of Oxford, the Office of National Statistics and the Department for Health and Social Care. The largest reductions in odds were seen after a second dose, it said.

The numbers appeared more promising for the prevention of symptomatic infections. The odds of testing positive and self-reporting symptoms were reduced by 90% after the second dose. And vaccination was just as effective in the vulnerable over-75 age group as it was in younger people.

Two studies highlighting the results were posted as pre-prints and have not been peer-reviewed. They analysed 1.6 million test results from nose and throat swabs taken from more than 373,000 people between December and the start of April.

But experts advise people to continue with Covid prevention measures, as some infections will still be transmitted, particularly when large numbers of the population have had just one dose in a two-dose regimen or haven’t been vaccinated at all. Although infections are at a record high, lives are being saved in countries with effective immunization programs.

Although COVID-19 vaccines are effective at keeping you from getting sick, scientists are still learning how well vaccines prevent you from spreading the virus that causes COVID-19 to others, even if you do not have symptoms. Early data show the vaccines do help keep people with no symptoms from spreading COVID-19, but we are learning more as more people get vaccinated.

We’re also still learning how long COVID-19 vaccines protect people. For these reasons, people who have been fully vaccinated against COVID-19 should keep taking precautions in public places, until we know more, like wearing a mask, staying 6 feet apart from others, avoiding crowds and poorly ventilated spaces, and washing your hands often.

CDC Panel Allows J&J Vaccine for COVID-19 To Resume

A committee of the U.S. Centers for Disease Control (CDC) has decided to lift the temporary hold on using the COVID-19 vaccine made by Johnson & Johnson/Janssen as of April 23rd. The U.S. Food and Drug Administration (FDA) and CDC had temporarily halted vaccination with the J&J shot on April 13 after six reports of unusual blood clots in the brain occurred among nearly 7 million people vaccinated with the shot in the U.S.

Within hours, CDC director Dr. Rochelle Walensky accepted the panel’s recommendation and FDA officials said vaccinations could resume immediately. “The American public should feel reassured by the safety protocols we have in place for COVID-19 vaccines,” said Walensky at a briefing following the committee’s decision.

The panel of 15 independent experts was under some pressure to make a decision about the safety of the vaccine, which is the only single-shot vaccine for COVID-19 currently authorized in the U.S. But after an initial meeting on April 14, the group decided it needed more information.

Over the past week, an additional nine cases of unusual blood clots, called cerebral venous sinus thrombosis (CVST) were reported, bringing the total so far to 15 cases. All 15 have occurred in women, and most were in their 30s. However, since that’s still among several million people who had recently been vaccinated with the shot, CDC vaccine-safety experts still felt the overall risk is very small.

To put those 15 cases in context, Dr. Sara Oliver, from the CDC’s National Center for Immunization and Respiratory Diseases, and her team presented data from models they constructed to estimate how the 11-day pause in using the J&J vaccine affected COVID-19 cases, hospitalizations and death. The models showed that if the vaccine were reinstated for all adults over age 18 years, there would be 26 to 45 additional cases of the rare blood clots side effects over the next six months, but 800 to 3,500 fewer admissions to the ICU and anywhere from 600 to 1,400 fewer deaths. If officials restricted the vaccine only to people over age 50—which might make sense given that younger people are more at risk of the clotting side effect— they would expect two to three additional cases of clotting compared to 300 to 1,000 fewer ICU admissions and 40 to 250 fewer deaths.

J&J representatives at the meeting reiterated that the vaccine starts protecting people against disease within days of administration, and that data from the company’s clinical trials showed it was 85% efficacious in protecting people from severe COVID-19, including against new variants of the virus. The company favored adding a warning label about the risk of clotting, similar to the way the risk of anaphylaxis is now included in the label for the mRNA vaccines from Pfizer-BioNTech and Moderna.

Nearly 286.1 million doses of the COVID-19 vaccine have been shipped to various U.S. states as of this afternoon, of which 222.3 million doses have been administered thus far, according to TIME’s vaccine tracker. About 27.5% of Americans have been completely vaccinated. A single dose of either the AstraZeneca-Oxford University or Pfizer-BioNTech vaccine may provide protection against COVID-19 for at least 10 weeks, Oxford researchers reported during a press briefing.

As Pandemic Surges, World Anger Rises Over U.S. Vaccine Abundance

A long-simmering debate over the glaring gap in vaccine access — largely between rich and poor countries, but among some developed nations, too — is now boiling over, with global figures and national leaders decrying the vaccine plenty in a few nations and the relative drought almost everywhere else.

African nations such as Namibia and Kenya are denouncing a “vaccine apartheid,” while others are calling for policy changes in Washington and a broader rethink of the intellectual property and trademark laws that govern vaccine manufacturing in global pandemics. “It’s outrageous ethically, morally, scientifically,” said Maria Van Kerkhove, an epidemiologist with the World Health Organization, on global vaccine inequities. “We have all the kindling to start fires everywhere,” she said in an interview. “We’re sitting on a powder keg.”

It is happening at a demarcation point in the pandemic. In some countries with high vaccination rates — including the United States, Britain and Israel — coronavirus numbers are decreasing or plateauing. But globally, the number of new cases per week has nearly doubled since February, according to the WHO, particularly as some nations in the developing world witness their highest infection rates yet.

“Many countries still have no vaccines whatsoever,” said Rob Yates, executive director of the Center for Universal Health at Chatham House, a London-based think tank. “You’re seeing much anger, and I think it’s justified.” The surging numbers come as a chain reaction of vaccine nationalism is hindering the flow of doses to poorer nations through Covax, a WHO-backed effort to distribute vaccines around the world.

India, a massive vaccine maker — mostly producing the AstraZeneca formula — has largely stopped exporting as its own surge worsens, dealing a major setback to the slow Covax rollout. The global initiative had expected 71 percent of its initial doses to come from India’s Serum Institute, the country’s largest vaccine maker. But so far, Covax has delivered 43 million doses of its 2 billion-dose goal this year.

As an organization that works with South Asians in the United States, SAALT calls upon the Biden Harris Administration and Congress to take immediate action to address the global health crisis unfolding in India and across South Asia as a result of the COVID–19 pandemic.  India has been averaging over 2,000 reported COVID-19 related deaths daily since late March.

The head of the World Health Organization is calling India’s surge in coronavirus cases “beyond heartbreaking” and says the U.N. agency has dispatched critical supplies to the subcontinent, including thousands of portable oxygen machines that help patients breathe.

WHO director-general Tedros Adhanom Ghebreyesus said the agency has redeployed more than 2,000 staff to support India’s response. Among the supplies the agency has sent are pre-made mobile field hospitals and lab supplies, he said.

India’s Second Wave Of Covid-19 Crisis Is Catastrophic

India reported 273,810 new Covid-19 infections and 1,619 deaths—both highest single-day spikes. That takes the active Covid-19 caseload tally up to nearly 2 million.

India, which was reporting less than 15,000 cases a day just last month, has been seeing over 200,000 Covid-19 infections a day since April 15. On April 19th alone, India reported 273,810 new Covid-19 infections and 1,619 deaths—both highest single-day spikes. That takes the active Covid-19 caseload tally up to nearly 2 million.

The current wave started in the western states of Maharashtra and Gujarat and has now engulfed almost the entire country. Delhi, for instance, had only around 2,800 new infections on April 1, and active infections stood at 10,498. Yesterday, it recorded 25,462 infections and an active caseload of 74,941. That amounts to a 900% increase in new infections and a 700% increase in active cases in just 18 days.

India has now recorded more than 15 million infections and more than 178,000 deaths. Experts agree that even these figures are likely undercounts. New Delhi imposed a weeklong lockdown Monday night to prevent the collapse of the Indian capital’s health system, which authorities said had been pushed to its limit amid an explosive surge in coronavirus cases.

In scenes familiar from surges elsewhere, ambulances catapulted from one hospital to another, trying to find an empty bed over the weekend, while patients lined up outside of medical facilities waiting to be let in. Ambulances also idled outside of crematoriums, carrying half a dozen dead bodies each. In an effort to combat crisis, India announced that it would soon expand its vaccination campaign to all adults. “People keep arriving, in an almost collapsing situation,” said Dr. Suresh Kumar, who heads Lok Nayak Jai Prakash Narayan Hospital, one of New Delhi’s largest hospitals for treating COVID-19 patients.

Meanwhile, election campaigns are continuing in West Bengal state in eastern India, amid an alarming increase there as well, and experts fear that crowded rallies could fuel the spread of the virus. Top leaders of the ruling Bhartiya Janta Party, including Prime Minister Narendra Modi, have campaigned heavily to win polls in the region.

By contrast, in New Delhi, officials have begun to impose stringent measures again. The Indian capital was shut down over the weekend, but now authorities are extending that for a week: All shops and factories will close, except for those that provide essential services, like grocery stores. People are not supposed to leave their homes, except for a handful of reasons, like seeking medical care. They will be allowed to travel to airports or train stations — a difference from the last lockdown when thousands of migrant workers were forced to walk to their home villages.

That harsh lockdown last year, which lasted months, justify deep scars. Politicians have since been reticent to even mention the word. When similar measures were imposed in Mahrashtra state, home to the financial capital of Mumbai, in recent days, officials refused to call it a lockdown. Those restrictions are to last 15 days.

India is not alone. Several places in the world are seeing deepening crises, including Brazil and France, spurred in part by new variants. More than a year into the pandemic, deaths are on the rise again worldwide, running at nearly 12,000 per day on average, and new cases are climbing, too. Over the weekend, the global death toll passed a staggering 3 million people.

Biden Administration Urges All Americans To Get Vaccinated

The Biden administration has suggested that every single American adult is eligible for a vaccine as of April 19. The White House stressed how important those shots are to beating back the pandemic — especially in recent weeks, as the more transmissible B-117 variant has rapidly become the most dominant and new cases hover near 70,000 per day.

“All roads to defeating the pandemic go through the path of successfully and quickly vaccinating the country,” White House COVID adviser Andy Slavitt said at a White House briefing on last week.

The good news is the U.S. has an ample supply of vaccines, even with the recent pause of Johnson & Johnson vaccines. More than one-third of the total population has already gotten one shot, while 80% of the highest-risk demographic, adults 65 and older, has received one shot. The remaining states that haven’t opened eligibility to all adults do so on April 19.

“I am proud of the progress we’ve made,” Centers for Disease Control and Prevention Director Dr. Rochelle Walensky said at the briefing. “But we must continue to get many more people vaccinated.”

That’s because vaccinations are still nowhere near where they need to be to hit “herd immunity,” and quickly-spreading, potentially deadlier variants such as the B-117, first discovered in the U.K., have taken hold in the U.S.

The latest CDC data shows that it accounted for 44% of cases during the last week of March, but Walensky said on Friday that the number is “certainly higher” now than then.

In Michigan, which currently has the most cases per population in the country, the number of B-117 cases has doubled since the last week of March. Nationwide, cases, hospitalizations and deaths continue to tick up. Just four weeks ago, the seven-day average of cases was around 53,000. As of Friday, it was just below 70,000.

Hospitalizations had also increased 5-8% since the week before, and deaths were over 700 people a day for the third day in a row, Walensky said.

“The increasing trends in cases, hospitalizations, and deaths are very concerning, and they threaten the progress we’ve already made,” she said.

For its part, the White House announced it will be investing $1.7 billion to do more genomic sequencing and identify variant spread, which the U.S. was woefully unprepared to do a few months ago. The funding will come from the American Rescue Plan, the nearly $2 trillion coronavirus relief package that Biden recently signed into law.

“Our ability to spot variants as they emerge and spread is vital, particularly as we aim to get ahead of dangerous variants before they emerge, as they are in the Midwest right now,” Slavitt said.

“Right now, these variants account for nearly half of all COVID-19 cases in the United States. And we need more capacity in our public health system to identify and track these mutations,” he said.

The White House coronavirus response team also warned that loosening restrictions was contributing to the spread, and urged people to mask-up, wash their hands and get vaccinated.

“Some of these increases are as a result of relaxed prevention efforts in states across the country, such as relaxed mask mandates or loosened restrictions on indoor restaurant seating,” Walensky said.

U.S. Surgeon General Vivek Murthy Says, Additional Funds To Places Hit disproportionately by COVID-19

U.S. Surgeon General Vivek Murthy has said the U.S. was increasing funding to areas that had been hit disproportionately by COVID-19, including $4 billion in funding to the Indian Health System. Though the IHS has impressively distributed 1 million vaccines in Indian Country, recent data showed that American Indians and Alaska Natives suffered devastating loss when the pandemic was at its worst.

According to a recent CDC report, they were 3.5 times more likely to get COVID than white people and more than four times as likely to be hospitalized as a result of COVID-19.

Murthy said the steady increase in cases over the last month had him more concerned than the J&J pause, which was put into place on Tuesday after the CDC and FDA found that out of the nearly 7 million people who got the J&J shot, at least 6 patients suffered blood clots roughly 6-13 days afterward.

The pause could last at least a few more weeks, according to an independent CDC advisory panel that on Wednesday decided to wait and see if more patients developed symptoms before recommending next steps on the vaccine.

“As much attention as the J&J news has received though, what I’m most concerned about, the numbers which are most on my mind are the rising cases and hospitalizations among those who are not vaccinated,” Murthy said.

He underscored the positive news, however, which is that the U.S. is one of the few countries in the world with three vaccine options and hundreds of millions of doses.

“We’re really fortunate to have highly effective vaccines and a system that’s working day and night to keep us safe. It gives me faith that we will make it through this pandemic together,” Murthy said.

All Americans age 16 and up can now get a Covid-19 vaccine. But the challenge is getting enough people to roll up their sleeves so we can finally quash this pandemic.  “The vaccine is the most important pathway to ending this pandemic. That means we’ve got to get everyone in our country vaccinated,” US Surgeon General Dr. Vivek Murthy said Monday.

“Now what we’ve got to do is No. 1: Get the vaccine. No. 2: Turn around and look at our family and friends and ask if they’re going to get vaccinated. If they need help, that’s what we’ve got to do.”

About 40% of the US population — more than 132 million people — have received at least one dose of the Covid-19 vaccine and about 26% of the population — more than 85 million — are fully vaccinated, according to the Centers for Disease Control and Prevention.

Nearly 212 million doses have been administered in the US, with an average of 3 million shots per day, the CDC said. It’s critical for those age 16 and up to get vaccinated before new, more contagious strains emerge — just like the B.1.1.7 variant did.

First Ever Human-Monkey Embryos Created To Help Produce Organs For Transplants

Scientists have successfully created the first embryos containing both human and monkey cells, an important step in helping researchers find ways to produce organs for transplants. The results of the groundbreaking experiment, published Thursday in the journal Cell, describe the first mixed-species embryos known as chimeras.

The research team in China was led by Juan Carlos Izpisua Belmonte, who has previously experimented with human and pig embryos. The team injected 25 human stem cells into the embryos of macaque monkeys.

“My first question is: Why?” said Kirstin Matthews, a fellow for science and technology at Rice University’s Baker Institute. “I think the public is going to be concerned, and I am as well, that we’re just kind of pushing forward with science without having a proper conversation about what we should or should not do.”

Still, the scientists who conducted the research, and some other bioethicists defended the experiment. “This is one of the major problems in medicine — organ transplantation,” said Juan Carlos Izpisua Belmonte, a professor in the Gene Expression Laboratory of the Salk Institute for Biological Sciences in La Jolla, Calif., and a co-author of the Cell study. “The demand for that is much higher than the supply.”

“I don’t see this type of research being ethically problematic,” said Insoo Hyun, a bioethicist at Case Western Reserve University and Harvard University. “It’s aimed at lofty humanitarian goals.”

Thousands of people die every year in the United States waiting for an organ transplant, Hyun noted. So, in recent years, some researchers in the U.S. and beyond have been injecting human stem cells into sheep and pig embryos to see if they might eventually grow human organs in such animals for transplantation.

But so far, that approach hasn’t worked. So Belmonte teamed up with scientists in China and elsewhere to try something different. The researchers injected 25 cells known as induced pluripotent stem cells from humans — commonly called iPS cells — into embryos from macaque monkeys, which are much more closely genetically related to humans than are sheep and pigs.

After one day, the researchers reported, they were able to detect human cells growing in 132 of the embryos and were able study the embryos for up to 19 days. That enabled the scientists to learn more about how animal cells and human cells communicate, an important step toward eventually helping researchers find new ways to grow organs for transplantation in other animals, Belmonte said.

“This knowledge will allow us to go back now and try to re-engineer these pathways that are successful for allowing appropriate development of human cells in these other animals,” Belmonte told NPR. “We are very, very excited.”

Such mixed-species embryos are known as chimeras, named for the fire-breathing creature from Greek mythology that is part lion, part goat and part snake.

“Our goal is not to generate any new organism, any monster,” Belmonte said. “And we are not doing anything like that. We are trying to understand how cells from different organisms communicate with one another.”

In addition, Belmonte said he hopes this kind of work could lead to new insights into early human development, aging and the underlying causes of cancer and other disease.

However, there are several concerns that using human cells in this way could produce animals that have human sperm or eggs. “Nobody really wants monkeys walking around with human eggs and human sperm inside them,” said Hank Greely, a Stanford University bioethicist who co-wrote an article in the same issue of the journal that critiques the line of research while noting that this particular study was ethically done. “Because if a monkey with human sperm meets a monkey with human eggs, nobody wants a human embryo inside a monkey’s uterus.”

Belmonte acknowledges the ethical concerns. But he stresses that his team has no intention of trying to create animals with the part-human, part-monkey embryos, or even to try to grow human organs in such a closely related species. He said his team consulted closely with bioethicists, including Greely.

Greely said he hopes the work will spur a more general debate about how far scientists should be allowed to go with this kind of research. “I don’t think we’re on the edge of beyond the Planet of the Apes. I think rogue scientists are few and far between. But they’re not zero,” Greely said. “So I do think it’s an appropriate time for us to start thinking about, ‘Should we ever let these go beyond a petri dish?’ “

For several years, the National Institutes of Health has been weighing the idea of lifting a ban on funding for this kind of research but has been waiting for new guidelines, which are expected to come out next month, from the International Society for Stem Cell Research.

The notion of using organs from animals for transplants has also long raised concerns about spreading viruses from animals to humans. So, if the current research comes to fruition, steps would have to be taken to reduce that infection risk, scientists said, such as carefully sequestering animals used for that purpose and screening any organs used for transplantation.

“Alone But Not Lonely – Living In The Reality Of New Normal,” An Insightful Event Held By GOPIO-Manhattan

(New York, NY: April 20, 2021) Isolation due to COVID-19 has reshaped the face of humanity. While the world faces great uncertainty with the coronavirus’ strength waxing and waning, the “new normal” has included extended periods of lockdown. With restrictions tied to the coronavirus outbreak leaving millions confined to their homes, everyone is feeling the effects of extended periods of quarantine on the body and mind. One major outcome of sustained solitude is being stuck in loneliness. Human beings are inherently social creatures, and the experience of loneliness can cause profound damage, including impairments in well-being, productivity, creativity, focus, as well as psychological harms and shortened life-spans.

In this context, a timely discussion by an experts’ panel organized virtually by GOPIO-Manhattan on “Alone But Not Lonely – Living In The Reality Of New Normal” on Friday, April 16th, 2021, was attended by hundreds of participants from around the world and broadcast live via Facebook.

The panel of experts included: Dr. Lipi Roy, an internal medicine physician board certified in addiction medicine as well as an MSNBC and NBC News Medical Contributor; Dr. Shuvendu Sen, a pioneer in multiple collaborations leading to superior Institutional performances, has been credited for adopting dynamic and innovative measures to foster higher productivity, employment, and education; Dr. Taruna Chakravorty, a Visiting Professor at Hans Raj College in New Delhi, India, where she teaches Spanish; and, Dr. Arnab Ghosh, physician-scientist is a medical oncologist who specializes in hematopoietic stem cell transplantation, with focus of research being making tumor immunotherapy more effective. During a lively and inspiring discussion they shared their wisdom thoughts with anecdotes and real life experiences.

Dr. Lipi Roy, who is a sought-after, charismatic speaker and media personality with mission to educate and empower the public to make healthy decisions through addiction awareness, nutrition, and mindfulness, said, “The past year been very difficult as the Covid pandemic has affected us in unique and universal ways.” Stating that most people have been “isolated from routine life, the pandemic has affected our normal ways of life.” Recalling how a year ago in April 2020, everything was shut down, with Streets empty, turning out crowded cities into Ghost town, “It’s been a very tough year for all of us. Many of us had to start collecting unemployment benefits, which is a new experience for many. This pandemic has been devastating. And it was a tough go for most of us in many ways,” she added.

Dr. Roy reminded the audience that “We are all social beings. We thrive on social connections. This need transcends all barriers universally.”  While admitting that “Pandemic has affected people differently.” Dr. Roy pointed out: “There are tools within each of us that we can use. We have ways to connect with people. Practicing Meditation, deep breathing. Watching comedies, and talking to people” are effective ways to combat loneliness, Dr. Roy said and added, “Love is the biggest game changer.”

In his address, Dr. Shuvendu Sen, an Ambassador of the New Jersey Re-entry Commission, who contributes to the behavioral and medical health of the formerly incarcerated female population, and a best-selling author of the book, Why Buddha Never Had Alzheimer’s: A Holistic Treatment Approach through Meditation, Yoga and the Arts, thanked GOPIO for its contributions to enhance Indian values and for the many accomplishments. Dr. Sen reminded the audience that “This is not the first time it has happened. The world has experienced similar calamities, changing our well structures lifestyles.  We have seen it time and time again. However, whenever we have been hurt, humanity is tremendously powerful to resurface from the dust.”

While so many of us have experienced the feelings of doom during the pandemic, we have had the HOPE that humanity will come out of that even stronger, Dr. Sen said.  Sharing his own personal experiences, Dr. Sen said, My hope came not from scriptures, but from my patients whom I treat every-day. They showed me the Strength of humanity. They gave me hope through their personal stories, which have been very compelling and moving.” Stating that his “mission is to use holistic medicine, using one’s inner strength, Dr. Sen said, “This is an opportunity to regain our strength and to rediscover ourselves. We need to appreciate the goodness and the strength in ourselves.”

Dr. Sen shared about how physician burn out and public distrust have impacted his life. He admitted that when the pandemic broke out, there were uncertainties of the treatment modalities. At the beginning of the pandemic, physicians were fearing for their own lives and were unable to support and help patients. “You have to take care of yourself first before taking care of others.” He stressed the need for “Friendship, fellowship and honesty.” Dr. Sen concluded by saying, “We have every reason is to be optimistic. Optimism is the opium” for a better more fulfilling life, he said.  He mentioned about the National Suicide Prevention Lifeline available to all in the USA that one can call 1 (800) 273 TALK (8255) and talk to a person and get the help they need.

Dr. Taruna Chakravorty, wife of former Consul General in New York, Ambassador Sandeep Chakravorty,  a life coach, motivational speaker and healer, said, she loves to work with people of all ages, helping them to live their lives happily and joyously.  Her mantra is “The human spirit is meant to soar the skies in jouful abandon, free from fear, full of love and compassion.” Dr. Taruna Chakravorty shared her knowledge about this state of being which is not elusive after all. Her mantra is “Happiness is yours to experience and is well within the reach of us all.”

“We forget to be grateful for the many things that we have in our lives,” Dr. Chakravorty said. “Our sense of gratitude builds positivity within us. There is no need looking for something outwards, but look inwards,” she said and the way to the inward journey is through “Meditation that leads to inner sense of peace.” According to her, When we can give to others, and when we can do something good to others, and when are instrumental in giving love and compassion to others, we find that inner peace and joy. “The more you give, the more you receive,” she said.

Dr. Chakravorty shared about her own personal story of she and her family transitioning from New York to Delhi during the pandemic and how it has impacted her family. In the face of losing one’s dear ones in life and the many challenges, especially while living in a virtual world and the many anxious moments in life we face, Dr. Chakravorty stressed the importance “to look inward rather than outward, by prating the techniques in mediation. Experience for yourself about the brilliance of how meditation impacts us.

Be conscious of what make you happy and uplifts you. And you can impact and help all around you. It is in our hands and we need to make the decision. Being happy is a conscious choice.” she stressed.

Dr. Arnab Ghosh, whose goal is to develop strategies in preclinical models and translate them into clinical studies, was instrumental in putting together the panelists. Dr. Ghosh said, The objective of the discussion is “Sharing knowledge and empowering the community, while learning how the pandemic t has impacted the community. And the focus is on people’s life stories and how they have been personally impacted.” He suggested that “doing simple things like wearing masks and distancing and learning how one behavior affects me and the society at large. We are all in this together. Science has given us the hope.”

There were several video presentations by people as to how they have been impacted by Covid and how they have coped with the pandemic. Dr. Asha Samant, the International Coordinator of GOPIO in her introduction shared about the series of panel discussions the GOPIO Manhattan Chapter has initiated with the objective of educating the public.

Dr. Thomas Abraham, Chairman of GOPIO International reminded the audience who for over a year, we are homebound. He said, Vaccination gives us hope. He commended the US government for the great roll out of the vaccination. “We are grateful to Dr. Ghosh, who has become a great assets to the Chapter.” He thanked Vimal Goyal and Asha Samant and the GOPIO Manhattan leadership, especially Shivender Sofat, GOPIO Manhattan President.

Mr. Sofat thanked the panelists and participants to the timely and very important discussion on COVID and on ways to live the new reality after Covid pandemic has impacted all. He shared about some of the initiatives by the Chapter in the recent past, especially the political and community engagement, supporting the student population and Community Feeding every month organized by the Chapter. He urged the community to support the initiative by being a volunteer and or a sponsor. Dr. Vimal Goyal proposed vote of thanks.

Call National Suicide Prevention Lifeline for those needing assistance: 1 (800) 273 TALK (8255)

Molnupiravir New Drug Gives Hope In Trials Against Coronavirus

Over the last year, several drugs have either been developed or tested to treat coronavirus. Now there’s another that’s showing some promise.  Molnupiravir is an antiviral drug in clinical trials.

In an interview with molecular epidemiologist Dr. Jill Roberts says the way that it works is it messes up viral replication. It’s shown some use against other viruses such as SARS and MERS.

Dr. Roberts says during an animal study on ferrets, they tried to get coronavirus to spread, and it wouldn’t. So while it’s a treatment designed to prevent hospitalizations and deaths, it also seems to prevent transmission.

While there is no timetable about when this would be available, it could be promising for future viruses or pandemics.  “This is a great tool to have to be able to know for future viruses maybe if we get a mutant that actually circumvents the vaccines, this drug will still work.”

Dr. Roberts says now that Merck is behind it, it has the resources to do a big enough trial to send to the FDA to get Emergency Use Authorization or even full authorization.

A couple of other positives she pointed out with this drug: it can also be used for people who do not want to get a vaccine or don’t have the resources to get shots. And, this is a pill, unlike other treatments right now that are IVs and have to be given at a treatment center.

It would be a pill, exquisitely calibrated to target SARS-CoV-2, with tolerable side effects and a low price tag. And it would work just as well as those antibody treatments that require an hourlong intravenous infusion, but it would come in a handy packet patients could take home.

“We’re looking for something I could give everyone in an urgent care setting who comes in with exposure or a positive test,” said Nathaniel Erdmann, an infectious disease specialist at the University of Alabama at Birmingham Hospital who treats Covid-19. “An easy, oral, safe drug.”

NIH Director Francis Collins called his “dream”: a highly effective pill that can be given immediately after diagnosis.“It’s just a damn long pathway,” Collins said in an interview. First scientists have to find molecular vulnerability in a virus, and then comes the process of screening hundreds of thousands of would-be drugs to find the few that latch onto that target. Then medicinal chemists get to work on honing a Goldilocks molecule that balances power, specificity, and safety, and if everything goes well in the Petri dish, there’s still months of animal testing to do before a single human being can take a pill in a clinical trial.

“But I will tell you that this is an extremely high priority for Tony Fauci and Francis Collins and the Biden administration, to work with these companies to try to make sure that we speed this up,” Collins said. “Because this pandemic is going to be with us — even with great vaccines — and people are going to get sick.”

There is hope, even in the short term. Any day now, Merck is expected to present pivotal data on an oral treatment akin to remdesivir. Behind that is a treatment from Atea Pharmaceuticals, first developed for hepatitis C virus, which could have pivotal results in the coming months. Neither is purpose-built for the virus that causes Covid-19, but experts said the treatments could still tick many of the boxes of a hoped-for antiviral.

Perhaps most promising is a novel antiviral from Pfizer, a drug engineered specifically for the virus SARS-CoV-2 that entered its first clinical trial last month.

New Jersey-based Merck acquired the drug, MK-7110, through its $425 million acquisition of privately held biopharmaceutical company OncoImmune late last year. An interim analysis of clinical trial data suggested the drug improved the chances of recovery for the sickest patients with Covid-19 and reduced the risk of death or respiratory failure.

Sumit K. Chanda-Led Team Spots Genes That Fight Covid Infection

A team of US scientists, led by an Indian-origin researcher at Sanford Burnham Prebys have identified a set of human genes that fight SARS-CoV-2 infection, the virus that causes COVID-19. Knowing which genes help control viral infection can greatly assist researchers’ understanding of factors that affect disease severity and also suggest possible therapeutic options. The genes in question are related to interferons, the body’s frontline virus fighters. The study was published in the journal Molecular Cell

According to Sumit K. Chanda, professor and director of the Immunity and Pathogenesis Programme at Sanford Burnham Prebys Medical Discovery Institute, the scientists have gained new insights into how the virus exploits the human cells it invades.  “We are still searching for its Achille’s Heel so that we can develop optimal antivirals,” Chanda said in a paper published in the journal Molecular Cell.

Knowing which genes help control viral infection can greatly assist researchers’ understanding of factors that affect disease severity and also suggest possible therapeutic options.  The genes in question are related to interferons, the body’s frontline virus fighters.

“We wanted to gain a better understanding of the cellular response to SARS-CoV-2, including what drives a strong or weak response to infection,” says Sumit K. Chanda, Ph.D., professor and director of the Immunity and Pathogenesis Program at Sanford Burnham Prebys and lead author of the study. “We’ve gained new insights into how the virus exploits the human cells it invades, but we are still searching for its Achille’s heel so that we can develop optimal antivirals.”

Soon after the start of the pandemic, clinicians found that a weak interferon response to SARS-CoV-2 infection resulted in some of the more severe cases of COVID-19. This knowledge led Chanda and his collaborators to search for the human genes that are triggered by interferons, known as interferon-stimulated genes (ISGs), which act to limit SARS-CoV-2 infection.

Based on knowledge gleaned from SARS-CoV-1, the virus that caused a deadly, but relatively brief, outbreak of disease from 2002 to 2004, and knowing that it was similar to SARS-CoV-2, the investigators were able to develop laboratory experiments to identify the ISGs that control viral replication in COVID-19.

“We found that 65 ISGs controlled SARS-CoV-2 infection, including some that inhibited the virus’ ability to enter cells, some that suppressed manufacture of the RNA that is the virus’s lifeblood, and a cluster of genes that inhibited assembly of the virus,” says Chanda. “What was also of great interest was the fact that some of the ISGs exhibited control across unrelated viruses, such as seasonal flu, West Nile and HIV, which leads to AIDS.”

“We identified eight ISGs that inhibited both SARS-CoV-1 and CoV-2 replication in the subcellular compartment responsible for protein packaging, suggesting this vulnerable site could be exploited to clear viral infection,” says Laura Martin-Sancho, Ph.D., a senior postdoctoral associate in the Chanda lab and first author of this study. “This is important information, but we still need to learn more about the biology of the virus and investigate if genetic variability within these ISGs correlates with COVID-19 severity.”

This knowledge led Chanda and his collaborators to search for the human genes that are triggered by interferons, known as interferon-stimulated genes (ISGs), which act to limit SARS-CoV-2 infection.

“We found that 65 ISGs controlled SARS-CoV-2 infection, including some that inhibited the virus’ ability to enter cells, some that suppressed manufacture of the RNA that is the virus’s lifeblood, and a cluster of genes that inhibited assembly of the virus,” Chanda explained.

“What was also of great interest was the fact that some of the ISGs exhibited control across unrelated viruses, such as seasonal flu, West Nile and HIV, which leads to AIDS”.

The team also identified eight ISGs that inhibited both SARS-CoV-1 and CoV-2 replication in the subcellular compartment responsible for protein packaging, suggesting this vulnerable site could be exploited to clear viral infection.

“This is important information, but we still need to learn more about the biology of the virus and investigate if genetic variability within these ISGs correlates with Covid-19 severity,” said Laura Martin-Sancho, a senior postdoctoral associate in the Chanda lab.  As a next step, the researchers will look at the biology of SARS-CoV-2 variants that continue to evolve and threaten vaccine efficacy.

India’s Second Covid-19 Wave Is Much Worse Than The First

India records one of the highest new infections as Covid-19 last week. Vaccinations, a mammoth task in such a large nation, are dangerously behind schedule. Hospital beds are running short.

When the coronavirus first struck India last year, the country enforced one of the world’s strictest national lockdowns. The warning was clear: A fast spread in a population of 1.3 billion would be devastating. The new wave will hurt global efforts and vaccine supplies, experts say. Researchers are scrambling to assess whether new coronavirus variants are playing a role in India.

 India on Saturday reported a daily record of 145,384 new infections as Covid-19 raced out of control. Deaths, while still relatively low, are rising. Vaccinations, a mammoth task in such a large nation, are dangerously behind schedule. Hospital beds are running short.

This second wave is much, much worse than the first one, so it is not just cities like Mumbai and Delhi that have started imposing curfews and lockdowns. Smaller cities like Lucknow, Kanpur, Varanasi and Raipur are enforcing curbs as well, and these will, as they did last time, serve mostly to hurt the economy and not control the pandemic. Already migrant workers are beginning to flee because their jobs have gone. It was one of these fleeing migrants who had the best comment to make on what is happening.

Parts of the country are reinforcing lockdowns. Scientists are rushing to track new strains, including the more hazardous variants found in Britain and South Africa, that may be hastening the spread. But the authorities have declared contact tracing in some places to be simply impossible.

India cannot afford to fall behind in the vaccination race because the whole world now knows that the only way to defeat Covid-19 is by vaccinating as many people as possible, as soon as possible. So, when high officials in the Government of India declare that only those who ‘need’ vaccinations should be given them, they seem either to be covering up for the serious shortage of vaccines or to be totally removed from reality. Every government in the world today is centering its fight against the pandemic on massive vaccination programs so that there can be some sort of return to normal times by the middle of this year. Only in India do we seem to continue believing that the way forward is to scale up testing.

Something has gone very wrong. And it could be because the Prime Minister and his advisors continue to invest their faith in centrally planning the vaccination strategy. Why are state governments not allowed to procure as many vaccines as they want from whoever they want? Why are they not being allowed to decide the price of these vaccines so that Indians who can afford to pay a full price should be allowed to? Why is the Government of India not distributing among state governments the Rs 35,000 crore set aside for vaccinations in this year’s national Budget? Why are private hospitals not being allowed to play a much bigger role than they have so far? Why is the Serum Institute not already being given the

The truth is that things have clearly gone very, very wrong with our vaccination strategy and nobody in the Government of India seems ready to acknowledge this. Gimmicks like a ‘Vaccination Utsav’ will not work. What is needed urgently is a comprehensive review and a whole new strategy, but who is going to do this when the two men who make the big decisions for India are both totally immersed in the campaign for West Bengal. Winning Bengal or any other state will mean nothing if the war against the pandemic is lost.

The double mutant variant of the coronavirus first identified in India has been classified officially as B.1.617, The Hindu reports, separating it from the UK (B.1.1.7) and South Africa variants (B.1.351).  B.1.617 has two specific mutations that have not been seen together in other variants, namely E484Q and L452R.

The variant has been found in circulation in Maharashtra, which is in the throes of a second wave of the Covid-19. It has since been found in California, US.  India’s health officials had previously said there is no proof yet that the variant is causing the resurgence in cases in the country.

The mutations E484Q and L452R, found on the receptor-binding domain of the virus, possess traits that are worrying.  L452R, also found in the California variant, has been shown to make the virus more transmissible.  E484Q is closely related to the E484K mutation, which has been found in the South African (B.1.351) and Brazilian (P.1 and P.2) variants and is less susceptible to neutralizing antibodies. The Indian variant has these two mutations at the same time.

“What we don’t know is how those [two mutations] will behave when they’re put in the same virus,” Dr. Benjamin Pinsky, director of the Clinical Virology Laboratory at Stanford University, tells the LA Times. “There’s a reasonable amount of information about those [two mutations] individually. But will it be worse if they’re together? We don’t really know how they’re going to interact.”

US Halts Johnson & Johnson Vaccinations After Rare Clotting Cases

The US Federal health officials called for a halt in the use of the company’s coronavirus vaccine while they study serious illnesses that developed in six American women.Johnson & Johnson’s coronavirus vaccine came to a sudden halt across the country on Tuesday after federal health agencies called for a pause in the vaccine’s use as they examine a rare blood-clotting disorder that emerged in six recipients.
All six were women between the ages of 18 and 48, and all developed the illness within one to three weeks of vaccination. One woman in Virginia died, and a second woman in Nebraska has been hospitalized in critical condition.

More than seven million people in the United States have received Johnson & Johnson shots so far, and another 10 million doses have been shipped out to the states, according to data from the Centers for Disease Control and Prevention.“We are recommending a pause in the use of this vaccine out of an abundance of caution,” Dr. Peter Marks, the director of the Food and Drug Administration’s Center for Biologics Evaluation and Research, and Dr. Anne Schuchat, the principal deputy director of the C.D.C., said in a joint statement. “Right now, these adverse events appear to be extremely rare.”

The following statement is attributed to Dr. Peter Marks, director of the FDA’s Center for Biologics Evaluation and Research and Dr. Anne Schuchat, Principal Deputy Director of the CDC:As of April 12, more than 6.8 million doses of the Johnson & Johnson (Janssen) vaccine have been administered in the U.S. CDC and FDA are reviewing data involving six reported U.S. cases of a rare and severe type of blood clot in individuals after receiving the J&J vaccine. In these cases, a type of blood clot called cerebral venous sinus thrombosis (CVST) was seen in combination with low levels of blood platelets (thrombocytopenia). All six cases occurred among women between the ages of 18 and 48, and symptoms occurred 6 to 13 days after vaccination. Treatment of this specific type of blood clot is different from the treatment that might typically be administered. Usually, an anticoagulant drug called heparin is used to treat blood clots. In this setting, administration of heparin may be dangerous, and alternative treatments need to be given.

CDC will convene a meeting of the Advisory Committee on Immunization Practices (ACIP) on Wednesday to further review these cases and assess their potential significance. FDA will review that analysis as it also investigates these cases. Until that process is complete, we are recommending a pause in the use of this vaccine out of an abundance of caution. This is important, in part, to ensure that the health care provider community is aware of the potential for these adverse events and can plan for proper recognition and management due to the unique treatment required with this type of blood clot.

Right now, these adverse events appear to be extremely rare. COVID-19 vaccine safety is a top priority for the federal government, and we take all reports of health problems following COVID-19 vaccination very seriously. People who have received the J&J vaccine who develop severe headache, abdominal pain, leg pain, or shortness of breath within three weeks after vaccination should contact their health care provider. Health care providers are asked to report adverse events to the Vaccine Adverse Event Reporting System at https://vaers.hhs.gov/reportevent.html.

CDC and FDA will provide additional information and answer questions later today at a media briefing. A recordingExternal Link Disclaimer of that media call is available on the FDA’s YouTube channel.The FDA, an agency within the U.S. Department of Health and Human Services, protects the public health by assuring the safety, effectiveness, and security of human and veterinary drugs, vaccines and other biological products for human use, and medical devices. The agency also is responsible for the safety and security of our nation’s food supply, cosmetics, dietary supplements, products that give off electronic radiation, and for regulating tobacco products.

Study Finds, Moderna Vax Has More Side Effects Than Pfizer/Biontech

In a first, a new study has pointed out that those taking the Moderna vaccine have reported more side effects than people who get the Pfizer/BioNTech jabs. The study, published in the journal JAMA, analysed reports collected via a Centers for Disease Control and Prevention (CDC) programme called v-safe that tracks side effects in vaccine recipients. A total of 3,643,918 people were enrolled in v-safe and completed at least one health survey within seven days following their first vaccine dose before February 21, and 1,920,872 v-safe participants reported receiving a second vaccine dose and completed at least one daily health survey within seven days following the second dose. Nearly 70 per cent of those said they had some kind of injection site reaction, like pain or swelling, and half had generalised reaction like fatigue or chills.

“A greater percentage of participants who received the Moderna vaccine, compared with the Pfizer-BioNTech vaccine, reported reactogenicity; this pattern was more pronounced after the second dose,” the researchers noted. Reactogenicity refers to a subset of reactions that occur soon after vaccination. People who got a Moderna shot were more likely to have a side effect — 73 per cent had an injection site reaction, compared with 65 per cent of people who had a Pfizer/BioNTech dose.

Nearly 51 per cent of Moderna recipients had full-body symptoms, compared with 48 per cent of people who got the Pfizer/BioNTech shot. The gap widened after the second dose. Almost 82 per cent of people getting their second Moderna shot had injection site pain versus just under 69 per cent of people with Pfizer/BioNTech, reports The Verge. “Overall, 74 per cent of people said they had general reactions after their Moderna shot, compared with 64 per cent of people getting Pfizer/BioNTech,” the report said on Tuesday.

People over 65 were also less likely to have side effects than people under 65, regardless of which vaccine they received. “Data from millions of v-safe participants indicate that injection site pain is common after both the first and second doses of either mRNA-based vaccine,” the study noted. Systemic reactions, including fatigue, headache, myalgia, chills, fever, and joint pain, occurred in participants after the first dose, although they were more frequently reported after the second dose among both Pfizer-BioNTech and Moderna vaccine recipients. (IANS)

Trainings for Sikh Awareness at Major Hospital System

April 9, 2021 (Philadelphia, PA) — Sikh Coalition Legal Client and Community Services Manager Aasees Kaur facilitated a virtual presentation on Sikhism in partnership with Jefferson Health. The interactive session covered the basics of the Sikh faith and community, and was attended by at least 50 Jefferson clinical health team members, including doctors, nurses, techs, med students, and others.

Jefferson Health is a network of five hospitals in Philadelphia and New Jersey; with almost 1,000 licensed beds between them, the facilities also serve as teaching hospitals for Thomas Jefferson University. For the last two years, the Sikh Coalition has been working with the Jefferson Health team to provide information about the Sikh faith and community, as well as recommending best practices for respectfully engaging Sikh patients and visitors; this relationship-building work facilitated the training opportunity.

Yesterday’s training follows another successful presentation, specifically for security personnel regarding the Sikh articles of faith, delivered by the Sikh Coalition’s legal team in August of 2020. Both trainings were recorded, and the footage will be made available to thousands of Jefferson employees at future orientations; additionally, the Sikh Coalition has been invited back to give this Sikh awareness training on an annual basis.

“It is important for current and future medical professionals to understand the needs of diverse communities to provide a culturally competent environment of care,” said Kaur. “The Sikh Coalition continues to offer our training services to a wide range of public and private organizations to raise Sikh awareness across society and ensure that Sikhs are able to practice their faith without issue in all aspects of their daily lives.”

If you are affiliated with a healthcare network and would like to facilitate a Sikh awareness presentation for your team, please contact us at community@sikhcoalition.org. In addition to facilitating these presentations, the Sikh Coalition has increased our work with healthcare providers in the past year given the COVID-19 pandemic. Working with the North American Sikh Medical and Dental Association, we have fought to ensure that Sikh healthcare providers on the frontlines are able to maintain their articles of faith and have access to the personal protective equipment (PPE) they need; we also produced a guide to Sikhi for non-Sikh healthcare providers, and continue to curate COVID-19 vaccine safety and availability information along with partner organizations.

AAPI Elects New Leaders For 2021-22 And Beyond

(Chicago, IL: April 11, 2021) “We have successfully concluded our elections for the year 2021-22 for AAPI leadership positions,” Dr. Sudhakar Jonnalagadda, current President of AAPI announced. “I am happy to announce that members of American Association of Physicians of Indian Origin (AAPI) have voted for the first time electronically and have elected a new and dynamic team to lead AAPI, the largest ethnic medical organization in the United States in the coming year and beyond.”

While announcing the elections results after months long campaigning for several offices to the national body and regional chapters, Dr. Seema Arora, Chief Election Officer, 2021 said, Dr. Anjana Samadder has been elected as the Vice President of AAPI, Dr. Satheesh Kathula was elected Secretary and Dr. Krishan Kumar was elected Treasurer of AAPI for the year 20-21. Dr. Sapna Aggarwal, Dr. Lokesh Edara, and Dr. Srinagesh Paluvoi were elected to AAPI’s Board of Trustees for a two-year term.

“AAPI electoral process has concluded successfully and the results are being announced today. Today I feel very satisfied that we, the election committee, were able to do our Job right in providing a very FAIR election to everyone, following all bylaws, while dealing with big CHALLENGES in implementation of this new ELECTRONIC PROCESS, taking extra security precautions, anti-hacking measures,  fixing glitches, resolving disputes, anxieties, and concerns of the members,” Dr. Arora added. She thanked the election committee members, Dr. Ranga Reddy, Dr. Sharad Lakhanpal, Dr. Surendra Purohit and Dr. Surekha Rao and the entire Executive committee led by Dr. Jonnalgadda for making this election smooth and transparent. .

Dr. Sajani Shah, the current BOT Chair thanked the Election Committee for their meticulous planning and organizing the elections with integrity and fairness. She said, “I congratulate the winners and the new leadership who are entrusted with the responsibility of leading it in the year 2021-22 and beyond. I wish them the very best and my whole-hearted support.”

“As the incoming President of AAPI, I would like to congratulate my incoming new team for the fiscal year 2021-22,” said Dr. Anupama Gotimukula, who will be the President of AAPI in the year 2021-22. “I’m very honored, privileged and consider myself fortunate to be bestowed with the responsibility of leading the nearly four decades old organization with the cooperation and collaboration of an excellent group of dedicated, hardworking, and loyal officers and executive committee members who are with me to take AAPI to new heights.”

Dr. Gotimukula will have Dr. Ravi Kolli- President –Elect; Dr. Anjana Samaddar- Vice President; Dr. Satish Kathula- Secretary; Dr. Krishan Kumar- Treasurer; Dr. Kusum Punjabi- Chair, Board of Trustees; Dr. Sowmya Neravetla- President, Young Physicians Section; and, Dr. Ayesha Singh, President, Medical Student/Residents & Fellows Section. “AAPI is fortunate to have more women representation in 2021-22 year and the team is excited working towards strengthening the  goals and mission of AAPI and to visualize AAPI a healthcare leader in US and globally and work in the best interests of our Physicians and our Communities,” added Dr. Gotimukula.

While congratulating the newly elected leaders to the Executive Committee, Dr. Ravi Kolli, the President-Elect in 2021-22 said here in a statement: “I want to congratulate all the winners of election. I want to specially thank all the candidates for their passion and dedication to serve AAPI and regardless of the outcome, we need you as a valuable team member of our beloved AAPI.  We will work together to promote our values of professionalism, collegiality, excellence in patient care and enhance AAPI’s reputation as a premiere professional organization offering educational programs and advocacy.”

Dr. Anajana Samadder, who won the election to be the next Vice President of AAPI, said, “I am humbled and honored to be bestowed with this responsibility and will work to the greatest of my abilities to reach our goals, addressing the challenges, and advance the issues important to our members. This win belongs to all our members for trusting our vision of growth & progress. Thank you for choosing me as your representative and with team work, transparency, and greater member participation we will be able to achieve our target. The journey has just started and there is lot of work to be done. I hope to receive your continued support and love “

Dr. Satheesh Kathula, Secretary-Elect of AAPI said, “I would like to thank all AAPI members from the bottom of my heart for this honor and assure that I will sincerely work for the betterment of our beloved organization, AAPI. Once again, I thank everyone for the opportunity to serve.” He expressed gratitude to the Election Committee Team, who “successfully organized this election, for the first time electronically with great participation from members.”

Dr. Krishan Kumar, the newly elected Treasurer of AAPI said, “I am honored to be elected as the Treasurer of national AAPI. As an organization, AAPI is committed to increasing young physicians’ knowledge base, enhancing their careers, and empowering them to play a key role in healthcare advocacy and community service. I will continue my dedicated work of several years helping fulfil our mission.”

In his message, the current Secretary of AAPI, Dr. Amit Chakrabarty said, “I am thankful to my Supporters who gave me their precious vote honoring my 25 years of service for AAPI. I will soon finish my tenure as your secretary and I take with me all your wishes, and memories.  Everything is life is a learning opportunity, and I have learned a lot from this election. I will take this wisdom with me forever to the future. I congratulate all the winners. I wish Anjana the best of luck as she moves forward with her position.”

The growing influence of physicians of Indian heritage is evident, as increasingly physicians of Indian origin hold critical positions in the healthcare, academic, research and administrative positions across the nation. We the physicians of Indian origin are proud of our great achievements and contributions to our motherland, India, our adopted land, the US and in a very significant way to the transformation of the Indo-US relations.

Serving 1 in every 7 patients in the US, AAPI members care for millions of patients every day, while several of them have risen to hold high flying jobs, shaping the policies and programs and inventions that shape the landscape of healthcare in the US and around the  world.

Dr. Jonnalagadda, while reminding the members of AAPI said, “Since its inception in 1982, AAPI has been in the forefront, representing a conglomeration of more than 80,000 practicing physicians in the United States, seeking to be the united voice of the physicians of Indian origin, I hope and wish that the new Team under Dr. Gotimukula will continue the noble mission and strengthen our efforts to make AAPI reach greater heights.”  For more details, please visit: www.appiusa,org

 

 

AAPI ELECTIONS 2021 – RESULTS

The following are the Executive Committee and Board of Trustees for the year 2021-22.

President Dr. Anupama Gotimukula
President-Elect Dr. Ravi Kolli
Vice President Dr. Anjana Samadder
Secretary Dr. Satheesh Kathula
Treasurer Dr. Krishan Kumar
Immediate Past President Dr. Sudhakar Jonnalagadda
Chair, AAPI Board of Trustees Dr. Kusum Punjabi
President, AAPI YPS Dr. Soumya Neravetla
President, AAPI MSRF Dr. Ayesha Singh
Regional Director, Pacific Region Dr. Sujeeth Punnam
Regional Director, Mountain Region TBA
Regional Director, NW Central Region Dr. Raghuveer Kura
Regional Director, SW Central Region Dr. Roshan Shah
Regional Director, NE Central-I Region Dr. Meher Medavaram
Regional Director, NE Central-II Region Dr. Dharmesh Gandhi
Regional Director, SE Central Region Dr. Shirishkumar Patel
Regional Director, New England Region Dr. Subbarao Bollepalli
Regional Director, Mid Atlantic-I Region Dr. Raj Bhayani
Regional Director Mid Atlantic-II Region Dr. Vasu Singh
Regional Director, South Atlantic Region TBA
Regional Director, South Region Dr. Malti Mehta
Board of Trustee Dr. Kusum Punjabi (Chair)
Board of Trustee Dr. Mukesh Nigam
Board of Trustee Dr. Tarak Vasavada
Board of Trustee Dr. Jagdish Gupta
Board of Trustee Dr. Raghu Lolabhattu
Board of Trustee Dr. V. Ranga
Board of Trustee Dr. Sapna Aggarwal
Board of Trustee Dr. Lokesh Edara
Board of Trustee Dr. Srinagesh Paluvoi
Immediate Past BOT Chair Dr. Sajani Shah
YPS Representative on Board Dr. Ami Baxi
MSRF Representative on Board Dr. Kinjal Solanki

Tired Of Lockdowns, UK To Treat Covid Like Seasonal Flu

Lockdowns will likely become a thing of the past once England emerges from restrictions in June, Professor Chris Whitty has said, as he suggested Britain will treat coronavirus like the flu in the future. England’s chief medical officer said the UK would have to learn to live with the virus, noting that up to 25,000 people can die in a bad flu year without the figure hitting the headlines. “It is clear we are going to have to manage it, at some point, rather like we manage the flu. Here is a seasonal, very dangerous disease that kills thousands of people and society has chosen a particular way round it,” he said.

Speaking at a Royal Society of Medicine webinar, said the government would only be forced to “pull the alarm cord” if a dangerous new strain suddenly started to spread, but that it was “not realistic” to think Covid variants could be kept out of the country. Whitty said the government’s ambition was to shrink Covid deaths to the lowest level possible, but warned that society would not tolerate sweeping restrictions to prevent similar numbers of deaths to those from seasonal flu.

“We need to work out some balance which actually keeps it at a low level, minimises deaths as best we can, but in a way that the population tolerates, through medical countermeasures like vaccines and in due course drugs, which mean you can minimise mortality while not maximising the economic and social impacts on our fellow citizens.”

Boris Johnson has repeatedly stated that his roadmap for leaving lockdown will provide a “cautious but irreversible” path to “reclaiming our freedoms”. The rapid rollout of the UK’s largest vaccination programme has begun to bear fruit in pushing down infections, hospitalisations and deaths from coronavirus.

Daily Covid cases in the UK have plummeted in recent months from a record 81,570 on 29 December to 4,479 in the past 24 hours. Deaths and hospitalisations have also fallen dramatically, with the number of patients currently in hospital with Covid at just 10 per cent the level of the peak of the second wave. Today was the 18th day in a row that the UK has recorded coronavirus-related deaths in the double digits, marking a dramatic drop from 19 January when 1,362 Covid fatalities were reported in a single day.

Pfizer’s COVID-19 Vaccine Shows ‘100% Efficacy’ In Adolescents

The COVID vaccine made by Pfizer and BioNTech appears to work in children as young as 12 years old. That news comes from results from a study the company conducted in volunteers aged 12 to 15, reports here suggest

The vaccine was 100% effective in protecting against symptomatic disease in a study of more than 2,200 children, the companies said. Researchers also didn’t find any safety concerns. The Pfizer-BioNTech vaccine was safe and effective in adolescents as young as 12, the drug companies announced in a joint news release last week.

New clinical trials showed that Pfizer’s COVID-19 vaccine elicits “100% efficacy and robust antibody responses” in adolescents from 12 to 15 years old, the drug company announced last week. The trial included 2,260 participants; the results are even better than earlier responses from participants ages 16 to 25.

Pfizer and its vaccine partner BioNTech said they will submit the results “as soon as possible” to the U.S. Food and Drug Administration and the European Medicines Agency, asking regulators to expand their authorizations for the vaccine’s use in young people.

Pfizer will submit the data “in the coming weeks,” Pfizer CEO and Chairman Albert Bourla said in a news release about the trial. Calling the results encouraging, he added that the company is acting “with the hope of starting to vaccinate this age group before the start of the next school year.”

The Covid-19 vaccine from Pfizer Inc. and BioNTech SE safely protects children between the ages of 12 and 15, the companies said, results likely to lead to inoculations within that age group before this summer.

Data from a trial of the vaccine in nearly 2,300 people between the ages of 12 and 15 will be submitted to the Food and Drug Administration in the coming weeks, with the hope that vaccinations could begin before the next school year.

“Across the globe, we are longing for a normal life. This is especially true for our children. The initial results we have seen in the adolescent studies suggest that children are particularly well protected by vaccination,” said Ugur Sahin, chief executive of BioNTech, the German company that developed the vaccine in partnership with U.S. pharmaceutical giant Pfizer.

The findings, though expected, were much anticipated by parents, health authorities and school officials. They have been waiting for signs on when vaccines that adults have been getting could also be made available to children.

Like other authorized vaccines, the Pfizer-BioNTech shot hasn’t yet been cleared for use in adolescents under 16 years of age. Health experts say children will need to be vaccinated for a population to move past pandemic restrictions, like masking and physical distancing.

The vaccine was 100% effective at preventing symptomatic illness within the trial, with 18 cases of covid-19 in the group that received a placebo and none in the group that received the vaccine, the companies said. The vaccine triggered immune responses that were even more robust than those seen in young adults.

The data is the beginning of what many families, eager for normalcy to return, have been waiting to see. The Pfizer-BioNTech vaccine is currently authorized by the FDA for emergency use for people 16 and older. If regulators extend the authorization to younger age groups, Pfizer chief executive Albert Bourla said that vaccinations could begin before the school year.

Last week, Pfizer-BioNTech also started a trial in younger children, ages 6 months to 11 years. That trial will step down in age, establishing a safe dose first in children 5 to 11, then in 2- to 5-year-olds and then in children from 6 months to 2 years.

U.S. biotech firm Moderna is also conducting similar trials to test its coronavirus vaccine in teenagers and young children. Its vaccine is authorized by the FDA for emergency use for people over age 18.

Moderna, whose COVID-19 vaccine is authorized for people 18 and older in the U.S., is also testing its vaccine in adolescents; it announced a trial of around 3,000 participants from 12 to 18 years old in December. Moderna also said earlier this month it had administered the first doses of its vaccine to young children in a separate study that involves kids from 6 months to less than 12 years old.

Johnson & Johnson, whose vaccine got U.S. authorization one month ago, has also been moving to include children in clinical trials. The company will test the vaccine in only a small number of adolescents initially, with plans to expand the study if it is shown to be safe, according to a spokesperson at Janssen, the Johnson & Johnson subsidiary that developed the vaccine.

Covid Was Third Leading Cause Of Death In US In 2020

COVID-19 was the third-underlying cause of death in 2020 after heart disease and cancer, the Centers for Disease Control and Prevention confirmed on Wednesday.

Reports published in the CDC’s Morbidity and Mortality Weekly Report sheds new light on the approximately 375,000 U.S. deaths attributed to COVID-19 last year, and highlights the pandemic’s disproportionate impact on communities of color — a point CDC Director Rochelle Walensky emphasized at a White House COVID-19 Response Team briefing last week.

She said deaths related to COVID-19 were higher among American Indian and Alaskan Native persons, Hispanics, Blacks and Native Hawaiian and Pacific Islander persons than whites. She added that “among nearly all of these ethnic and racial minority groups, the COVID-19 related deaths were more than double the death rate of non-Hispanic white persons.”

Covid-19 was the third leading cause of death in the US in 2020, behind heart disease and cancer, according to a new study of the US Centers for Disease Control and Prevention (CDC).

The Covid-19 pandemic caused approximately 375,000 deaths in the US during 2020. The Covid-19 death rate was the highest among Hispanics, the study published on Wednesday, revealed, Xinhua reported. Covid-19 death rates were the lowest among children aged 1 to 4 years and 5 to 14 years, and the highest among those aged over 85 years. Meanwhile, the age-adjusted Covid-19 associated death rate among males was higher than that among females, according to the study.

The total number of deaths occurred in the country in 2020 was 3,358,814, an increase of 15.9 per cent over the previous year, according to the CDC. The deadliest weeks of 2020 were at the beginning of the pandemic in April and then in the middle of the holiday surge in late December, the study showed. (IANS)

BAPS Charities Vaccination Drive Helps Over 1,000

Chicago IL: The COVID-19 pandemic continues to wreak havoc on communities across the globe. Thanks to the effort put forth by scientists, researchers, doctors, among many others, vaccines have been developed that have shown evidence of generating strong immune responses against the COVID-19 virus. As the scientific community and public officials have emphasized, widespread vaccination is an essential pillar of battling the COVID-19 pandemic.

 BAPS Charities organized a COVID-19 Vaccination Drive in Bartlett, Illinois on April 01, 2021, in collaboration with Prism Health Lab. A total of 1,111 vaccine doses were administered to essential workers and adults with underlying health conditions in just one day.

 Volunteers from BAPS Charities ensured that all participants’ vaccination experience was orderly and safe by providing social distancing, sanitization, and translation services. Medical staff from Prism Health Lab also carried out the vaccination registration, delivery of vaccines and offered post-vaccination care. “It is a passion for our volunteers to give back, and we’re grateful to have Prism Health as a partner in this vaccine drive,” said Yagnesh Patel, a BAPS Charities volunteer. The recipients of the vaccine appreciated the seamless organization of the vaccination process. Dr. Mehbub Kapadia, Medical Director of Prism Health Lab, said, “I am so thankful to the BAPS Charities volunteers for putting this event together in only two days. This event is one of the best events we have done, among the over 100 drives we have done so far.”

Rachel L, a local resident stated, “I am getting vaccinated for the loved ones in my family, for those that I am encountering, just to save a life, to protect those who I love.”

BAPS Charities has supported local communities during these trying times by battling the misinformation surrounding COVID-19 vaccines and providing vaccination infrastructure. Similar Vaccination Drives have been planned at over 30 cities throughout North America wherein thousands of community residents will get easy access to vaccines.

 BAPS Charities has actively served the community, particularly frontline workers, first responders, community support organizations, medical centers and the underserved since the onset of the pandemic. BAPS Charities has provided over 110,000 pieces of personal protective equipment, donated $180,000 in financial assistance and prepared and delivered over 80,000 meals to those battling the Coronavirus for all. For further details about the above efforts and information regarding supporting the ongoing BAPS Charities COVID-19, visit the following links.

Fully Vaccinated Americans Can Travel

Americans who are fully vaccinated against Covid-19 can safely travel at home and abroad, as long as they take basic precautions like wearing masks, federal health officials announced on Friday, a long-awaited change from the dire government warnings that have kept many millions home for the past year.

In announcing the change at a White House news conference, officials from the Centers for Disease Control and Prevention stressed that they preferred that people avoid travel. But they said growing evidence of the real-world effectiveness of the vaccines — which have been given to more than 100 million Americans — suggested that inoculated people could do so “at low risk to themselves.”
The shift in the C.D.C.’s official stance comes at a moment of both hope and peril in the pandemic. The pace of vaccinations has been rapidly accelerating across the country, and the number of deaths has been declining.

Yet cases are increasing significantly in many states as new variants of the coronavirus spread through the country. Just last Monday, Dr. Rochelle P. Walensky, the C.D.C. director, warned of a potential fourth wave if states and cities continued to loosen public health restrictions, telling reporters that she had feelings of “impending doom.”

Updated Information for Travelers
Fully vaccinated travelers are less likely to get and spread COVID-19. However, international travel poses additional risks and even fully vaccinated travelers are at increased risk for getting and possibly spreading new COVID-19 variants.
CDC recommends delaying international travel until you are fully vaccinated.

If you are fully vaccinated with an FDA-authorized vaccine:You should continue to follow CDC’s recommendations for traveling safely and get tested 3-5 days after travel.
You do NOT need to get tested before leaving United States unless your destination requires it.
You do NOT need to self-quarantine after arriving in the United States.
International Travel Recommendations for Fully Vaccinated People

Have You Been Fully Vaccinated?
People are considered fully vaccinated:
2 weeks after their second dose in a 2-dose series, such as the Pfizer or Moderna vaccines, or
2 weeks after a single-dose vaccine, such as Johnson & Johnson’s Janssen vaccine
If you don’t meet these requirements, you are NOT fully vaccinated. Keep taking all precautions until you are fully vaccinated.
If you have a condition or are taking medication that weakens your immune system, you may NOT be fully protected even if you are fully vaccinated. Talk to your healthcare provider. Even after vaccination, you may need to continue taking all precautions.


Before you travel
oMake sure you understand and follow all airline and destination requirements related to travel, testing, or quarantine, which may differ from U.S. requirements. If you do not follow your destination’s requirements, you may be denied entry and required to return to the United States.
oCheck the current COVID-19 situation in your destination.
While you are traveling:
oWear a mask over your nose and mouth. Masks are required on planes, buses, trains, and other forms of public transportation traveling into, within, or out of the United States and in U.S. transportation hubs such as airports and stations.

oAvoid crowds and stay at least 6 feet/2 meters (about 2 arm lengths) from anyone who is not traveling with you.
oWash your hands often or use hand sanitizer (with at least 60% alcohol).
Before you arrive in the United States:
oAll air passengers coming to the United States, including U.S. citizens and fully vaccinated people, are required to have a negative COVID-19 test result no more than 3 days before travel or documentation of recovery from COVID-19 in the past 3 months before they board a flight to the United States.
After travel:
oGet tested with a viral test 3-5 days after travel.
oSelf-monitor for COVID-19 symptoms; isolate and get tested if you develop symptoms.
oFollow all state and local recommendations or requirements after travel.

As Corona Rate Spikes, President Biden, CDC Director Caution Nation

Scientists tracking the spread of COVID-19 in the U.S. have said that there’s plenty to be worried about. Cases are rising across the country, especially in the Northeast and Midwest. Public health experts are worried that the country is headed for a fourth major spike.

It’s the last news anyone wants to hear: one year after the United States was slammed with its first wave of COVID-19—which was followed by even worse second and third waves—public health experts are worried that the country is headed for a fourth major spike. Scientists tracking the spread of COVID-19 in the U.S. have said that there’s plenty to be worried about. Cases are rising across the country, especially in the Northeast and Midwest.

President Joe Biden has made a plea to the nation’s governors as the US faces the possibility of another wave of Covid-19 infections. “I’m reiterating my call for every governor, mayor, and local leader to maintain and reinstate the mask mandate. Please. This is not politics. Reinstate the mandate if you let it down,” Biden said during remarks on the state of vaccinations this week.

The plea comes as some states have lifted requirements for face coverings, as well as guidance on restaurant capacity and other measures, and cases have again begun to rise. Last week, the administration called on states to slow the relaxation of Covid guidelines.

Much of America’s recent progress against Covid-19 has been erased as new infections jump nationwide.  Now the director of the Centers for Disease Control and Prevention said she’s afraid of what will happen next. “What we’ve seen over the last week or so is a steady rise of cases,” said CDC Director Dr. Rochelle Walensky on Monday. “I know that travel is up, and I just worry that we will see the surges that we saw over the summer and over the winter again.”

The U.S. is facing “impending doom” as daily Covid-19 cases begin to rebound once again, threatening to send more people to the hospital even as vaccinations accelerate nationwide, the head of the Centers for Disease Control and Prevention said. The troubling B.1.1.7 variant strain is spreading more rapidly in the US. That strain isn’t just more contagious, health experts say. It appears to be deadlier as well.

During a White House coronavirus briefing yesterday, Rochelle Walensky, the new director of the U.S. Centers for Disease Control and Prevention, begged Americans to keep following public health guidelines amid alarming upticks in cases, hospitalizations and deaths. “Right now, I’m scared,” she said.

And the combination of young, carefree revelers and states ditching safety mandates has helped send the country backward, said Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases. “What we’re likely seeing is because of things like spring break and pulling back on the mitigation methods that you’ve seen now,” Fauci told CBS’ “Face the Nation” on Sunday.

Biden also renewed calls for Americans to wear masks, framing the choice as a “patriotic duty.” “I need the American people do their part as well. Mask up, mask up. It’s a patriotic duty. It’s the only way we ever get back to normal,” he said. With a nod to the role of the private sector, Biden also suggested businesses should also require the use of masks. “The failure to take this virus seriously precisely what got us to this mess in the first place, risk more cases, more deaths,” he said.

Dr. Rochelle Walensky, director of the US Centers for Disease Control and Prevention, said she would be conveying Biden’s message to governors on Tuesday after she warned of “impending doom” over concerns about another wave of Covid-19 cases.

“With regard to the surging, we are working closely with the states. I will be speaking with the governors tomorrow to try and reinforce the need for current restrictions to not open up,” Walensky said earlier Monday. “I think what we’ll do on masking will really depend on where we are 30 days from now.”

It’s not the federal government, but “the private sector” that will likely create and store data for Covid-19 vaccine passports, Andy Slavitt, the White House’s senior adviser for Covid-19 response, said on Monday.

Vaccine passports are a way for people to prove they have been vaccinated against Covid-19. “The government here is not viewing its role as the place to create a passport, nor a place to hold the data of citizens. We view this as something that the private sector is doing, and will do,” Slavitt said during a virtual White House briefing.

Instead, the Biden administration is working to develop a set of standards for such a vaccine passport program or database. “What’s important to us, and we’re leading an interagency process right now to go through these details, are that some important criteria be met with these credentials. Number one, that there is equitable access — that means whether or not people have access to technology or whether they don’t. It’s also important that we recognize that there are still many, many millions and millions of Americans that have not yet been vaccinated. So that’s a fundamental equity issue,” he said.

“Privacy of the information, security of the information, and a marketplace of solutions are all things that are part of what we believe in, as is the ability for people to access this free, and in multiple languages,” Slavitt said. “So, I think you will see more from us as we complete our interagency process. But this not slowing down the process in any way.”

He went on to describe why the government will be involved in the process.  “The core here is that Americans, like people around the world who are vaccinated, will want to be able to demonstrate that vaccination in various forms,” Slavitt said. “This is going to hit all parts of society, so naturally the government is involved.”

The great news is all three vaccines being distributed in the US appear to work well against the B.1.1.7 strain. But with only 15.8% of the US population fully vaccinated — and anti-vaxxers and vaccine hesitancy preventing America from returning to normal faster — it’s time for a reality check.  “Now is one of those times when I have to share the truth, and I have to hope and trust you will listen,” Walensky said.

“I’m going to reflect on the recurring feeling I have of impending doom … We have so much to look forward to, so much promise and potential of where we are and so much reason for hope. But right now, I’m scared.”

Before she became CDC director, Walensky was on the front lines of the pandemic, witnessing some patients die from Covid-19.  “I know what it’s like as a physician to stand in that patient room — gowned, gloved, masked, shielded — and to be the last person to touch someone else’s loved one, because they are not able to be there,” she said.  The US has come “such a long way,” Walensky said, pleading with all Americans to keep masking up and “hold on a little while longer” as more people get vaccinated.  Young people are fueling much of this new surge

At least 27 states have averaged at least 10% more cases each day this past week compared to the previous week, according to Johns Hopkins University.  “A lot of the spread is happening among younger people,” said Dr. Ashish Jha, dean of the Brown University School of Public Health. “That’s the group that is moving around, kind of relaxing, getting infected.”

And some state governors and local officials recently relaxed safety mandates, despite warnings from health experts to keep them in place a bit longer.  “We’re weeks away from a point where we can begin to do these things a bit more safely,” Jha said. “But I think states have just moved too fast.”

The U.S. is recording a weekly average of 63,239 new Covid-19 cases per day, a 16% increase compared with a week ago, according to a CNBC analysis of data compiled by Johns Hopkins University. Daily cases are now growing by at least 5% in 30 states and the District of Columbia.

Will Biden Deliver Green Cards To Indian American Physicians? NRI Doctors Organize Protest Rally In DC

Every 7th patient in the United States is being treated by physicians of Indian origin alone. They are sought after and admired for their skills, dedication and compassion. Yet, when it comes to obtaining Residencies, work permits and Green Card, they are not treated fairly.

A growing shortage of doctors and nurses in the United States over the past decade has been exacerbated by the COVID-19 crisis. Fortunately, there are thousands of trained health professionals who want to practice in the United States. One-sixth of our health care workforce in the United States is foreign-born. Immigrant nurses and doctors play a vital role in our healthcare system, and their contributions are now more crucial than ever.

Every 7th patient in the United States is being treated by physicians of Indian origin alone. They are sought after and admired for their skills, dedication and compassion. Yet, when it comes to obtaining Residencies, work permits and Green Card, they are not treated fairly.
There and many other concerns were brought to light as a group of Indian American Doctors staged a protest rally in the nation’s capital on March 17th, 2021.

Physicians and healthcare professionals from India get a raw deal thanks to the green card backlog and per-country cap even though they are virtually the backbone of the healthcare system in the United States, pointed out the group of doctors of Indian origin who held a protest in Washington, DC.

One of the issues that concerns Indian nationals on work visas in the United States is the employment-based green cards. The Biden administration’s proposed legislation could boost the number of employment-based green cards. Currently, the maximum employment-based green cards that can be issued each year is 140,000. Biden’s proposed legislation would not only eliminate the per country cap but would also allow the use of unused visa slots from previous years. It will also allow spouses and children of employment-based visa holders to receive green cards while not counting them under the annual cap limit.

“Overall, we could have retained these high skilled immigrants and their families if the backlog situation were resolved by previous administrations,” said Pooja B Vijayakumar, a consultant and researcher on immigration. “The current immigration system is broken, and I hope that this issue is taken up seriously. In the future, the Biden administration has plans to hire more foreign workers, which is great, but this should be only done once the current green card backlog issue is addressed.”

As per current regulations, citizens of no single country can claim more than 7 percent of available green cards. That policy has resulted in creating a massive green card back log for countries such as India and China. According to some estimates, Indian Americans, who qualify for skilled worker visas, including Green Cards could wait for over a hundred years to get approved for Green Cards due to this country-based cap.

Four years of the Trump administration have been tumultuous as far as immigration is concerned. According to a recent report by Pew Research Center, the number of people who received green card declined from about 236,000 in the second quarter of the 2020 fiscal year (January to March) to under 78,000 in the third quarter (April to June). By comparison, in the third quarter of fiscal 2019, nearly 266,000 people received green card.

Immigrant doctors and nurses have been fighting to save American lives, living in the US for decades, paying taxes, contributing to the economy but they have no right to participate in any kind of democratic process, the protesters said through a media note.
President Joe Biden should take executive action and offer green cards to frontline healthcare workers, they demanded. “Yes, this is about the green card backlog,” Dr Raj Karnatak, an infectious disease and critical care physician from Milwaukee, Wisconsin, told indica News when contacted.

“More than green card, this is about how frontline healthcare workers are being disrespected. How Indians are being discriminated against,” he added. “Among high-skilled immigrants in the green card backlog, there are around 20,000 frontline healthcare workers serving on the frontline during the pandemic,” he said. The pandemic, he pointed out, has been brutal to frontline healthcare workers and their families.
“Many lost their lives, and on top of the Covid-19 crisis frontline healthcare workers have to face an inhumane green card backlog due to the archaic caps that allow no country to get more than 7 percent of employment-based green cards,” he said.

Another protester Dr Pranav Singh, a pulmonary and critical care physician, was quoted as saying in the media note: “We are frontline Covid warriors, and we are here to tell how we have been shortchanged into a life of perpetual indentured servitude. Each of us has a story. We are here from all over the country asking for justice. Justice that has precluded us for decades now.”

Dr Karnatak lamented that the immigrant healthcare workers from other countries get green cards within months to a year but high-skilled immigrants from India wait decades, and the current estimated wait time is 195 years.“We are being cut in line by every other country,” he said. “An unborn child in the womb in any other country who will grow up, go to school and college, and eventually will come to the US will get his/her green card before an Indian doctor already living in the US, serving the community, fighting pandemic on the frontline, contributing to the economy, paying taxes and being a good, law-abiding citizen.

“Is this the equal opportunity that America prides itself for?” he asked. He said that due to decades of backlog, many high-skilled immigrants are not able to change jobs because they fear losing their spot in the green card line, and are virtually indentured to one employer. They can only work in the specialty occupation the visa is allotted for decades, Karnatak explained.Many healthcare workers could not serve in Covid-19 hot spots as the visas are tied to the job and employer, he pointed out. Frontline healthcare workers in the backlog have children who despite living in the US for all their lives risk aging out and have to self-deport when they turn 21, he underlined.
“Frontline healthcare workers have aging parents in India and cannot sponsor them to come to the US. High-skilled workers must think thousands of times before deciding to visit family back home due to fear of visa rejections and getting stranded, and spouses who are on the dependent visa are being discriminated against and denied EADs (work authorizations) on time,” Karnatak said.

According to the Pew report, “In fiscal 2019, more than 188,000 high-skilled foreign workers received H-1B visas. H-1Bs accounted for 22 percent of all temporary visas for employment issued in 2019. In all, nearly 2 million H-1B visas were issued from fiscal years 2007 to 2019.”
There have been several Bills introduced in both the Chambers of Congress in rec3ent years, seeking to address the backlog issues. A bipartisan group of senators had in 2020 introduced new legislation Thursday to grant 40,000 unused green card slots to foreign health care workers needed to help U.S. medical professionals fight the coronavirus pandemic. Sen. Richard J. Durbin, D-Ill., a longtime stalwart of immigration-related legislation, unveiled the bill with his colleagues, Sens. David Perdue, R-Ga., Todd Young, R-Ind., and Chris Coons, D-Del.
The bill would authorize up to 25,000 immigrant visas to go to foreign nurses and up to 15,000 for doctors who are eligible to come to the United States or who are already here on temporary work visas. These immigrant visas would lead to employment-based green cards. The legislation would also allow U.S. Citizenship and Immigration Services to give out slots from a pool of previously unclaimed green cards for the families of these medical workers.

Now with a new president in town, all eyes are on him and his proposed immigration reforms. President Joe Biden has already announced his immigration agenda and is working toward boosting refugee admissions. However, when it comes to work-based immigration, there are a lot of questions on how the Biden administration proposes to work on them, especially on employment-based green cards and H-1B visas.
The Biden administration has for now decided not to implement a rule proposed by Trump that aimed at linking H-1B visas to wages.

The administration withdrew a notice —  issued just five days before Trump’s exit — regarding compliance with a law requiring US employers to pay H-1B visa foreign workers the same or more than Americans in similar jobs by both staffing agencies and their clients. There is also a proposal to provide permanent work permits to the spouses of H-1B visa holders.The Physicians of Indian Origin believe, now is the time and that President Biden can fix the long delayed immigration issues facing hundreds of thousands of well deserving qualified Indian Americans.

How Did Covid-19 Originate? WHO Has Possible Answers

Following a month-long fact-finding mission in China, a World Health Organization (WHO) team investigating the origins of the COVID-19 pandemic concluded that the virus probably originated in bats and passed to people through an intermediate animal.

More than a year after Covid-19 touched off the worst pandemic in more than a century, scientists have yet to determine its origins. The closest related viruses to SARS-CoV-2 were found in bats more than 1,000 miles from the central Chinese city of Wuhan, where the disease erupted in late 2019. Initially, cases were tied to a fresh food market and possibly the wildlife sold there. Other theories allege the virus accidentally escaped from a nearby research laboratory, or entered China via imported frozen food. Amid all the posturing and finger-pointing, governments and scientists agree that deciphering the creation story is key to reducing the risk of future pandemics.

Following a month-long fact-finding mission in China, a World Health Organization (WHO) team investigating the origins of the COVID-19 pandemic concluded that the virus probably originated in bats and passed to people through an intermediate animal. But fundamental questions remain about when, where and how SARS-CoV-2 first infected people.

To trace the virus’s origin, it’s crucial to pin down exactly when the first cases occurred in people. The WHO team established that the first person known to have COVID-19 was an office worker in Wuhan with no recent travel history, who began showing symptoms on 8 December 2019, says Peter Ben Embarek, a food-safety scientist at the WHO in Geneva, Switzerland, who led the investigation. But the virus was probably spreading in the city before that, because it was well-established by later that month, he says.

While the World Health Organization (WHO) report on the origins of the novel coronavirus was released on March 30th, 2020, the draft report has said that the laboratory origin theory of SARS-Cov-2 — that it was leaked from a laboratory — is “extremely unlikely”. According to a report by CNN, which says that it has reviewed the draft report, the virus started spreading probably a month or two before December 2019, when it first came into notice.

Markets that sold animals — some dead, some alive — in December 2019 have emerged as a probable source of the coronavirus pandemic in a major investigation organized by the World Health Organization (WHO).That investigation winnowed out alternative hypotheses on when and where the pandemic arose, concluding that the virus probably didn’t spread widely before December or escape from a laboratory. The investigation report, released today, also takes a deep look at the likely role of markets — including the Huanan market in Wuhan, to which many of the first known COVID-19 infections are linked.Of the four possible scenarios on how Covid-19 spread, the draft says the most likely way the pandemic started would have been through an intermediate wild animal which may have been captured and raised on a farm, via a bat, which is considered the most likely origin. However, the report says “the possible intermediate host of SARS-CoV-2 remains elusive”.

Another way the virus could have spread may have been through direct transmission form an infected animal, such as a bat or a pangolin. The report also considers the possibility of the virus having spread from frozen or chilled food, though it says “there is no conclusive evidence for foodborne transmission of SARS-CoV-2 and the probability of a cold-chain contamination with the virus from a reservoir is very low”.
The report, prepared by a joint team of Chinese and international researchers, also looked at the role of Huanan seafood market in Wuhan and said that since there’s evidence of the virus circulating even before the outbreak at the market, which may be ascribed to the crowds gathered there, “Huanan market was not the original source of the outbreak”. The report advises more testing of blood samples taken and stored before the first report of outbreak in December 2019 as well as more testing of animals from Southeast Asia.

“We could show the virus was circulating in the market as early as December 2019,” says the WHO’s Peter Ben Embarek, who co-led the investigation. He adds that this investigation is far from the last. “A lot of good leads were suggested in this report, and we anticipate that many, if not all of them, will be followed through because we owe it to the world to understand what happened, why and how to prevent it from happening again”.

Eddie Holmes, a virologist at the University of Sydney in Australia, says that the report does a good job of laying out what’s known about the early days of the pandemic — and notes that it suggests next steps for study. “There was clearly a lot of transmission at the market,” he says. “To me, looking at live-animal markets and animal farming should be the focus going forward.”

Nevertheless, exactly what happened at the Huanan market remains unknown. Genomic analyses and inferences based on the origins of other diseases suggest that an intermediate animal — possibly one sold at markets — passed SARS-CoV-2 to humans after becoming infected with a predecessor coronavirus in bats. But inconclusive doesn’t mean impossible. Analysts say, there will be more work to come. “This report is a very important beginning, but it is not the end.”

AAPI Congratulates Dr. Vivek Murthy After He Is Confirmed By Senate As US Surgeon General

(Chicago, IL: March 27th, 2021) “We congratulate Dr. Vivek Murthy on his confirmation with bipartisan support by the United State Senate on Tuesday, March 23rd, 2021 for the second time  as the Surgeon General of the United States,” Dr. Sudhakar Jonnalagadda, President of American Association of Physicians of Indian Origin (AAPI) said here today.

Dr. Vivek H. Murthy, who as U.S. Surgeon General under President Obama had served as the United States Surgeon General and advocated a “healthier and more compassionate America,” was confirmed last week by the US Senate with seven Republican Senators joining the 50 Democrats, with 57-43 votes in the Senate, giving him bipartisan support. While Dr. Vivek Murthy says ending the coronavirus pandemic is his top priority, he’s also raised concerns over a relapsing opioid overdose crisis. “I’m deeply grateful to be confirmed by the Senate to serve once again as your surgeon general,” Murthy said in a statement. “We’ve endured great hardship as a nation over the past year, and I look forward to working with you to help our nation heal and create a better future for our children.

While offering AAPI’s whole hearted support in his efforts to lead the nation out of the Covid pandemic and opioid crisis, Dr. Jonnalagadda thanked President Joe Biden for placing his trust in Dr. Murthy, a member of AAPI to be America’s top doctor.
“The appointment and now the confirmation by the US Senate of Dr. Murthy, including other experienced and competent senior officials to the US Health Department, will help round out Biden’s team charged with addressing the pressing COVID-19 crisis, that has taken over 500,000 American lives,” Dr. Sajani Shah, Chair of AAPI BOT said.

While describing the leadership of Dr. Murthy as America’s Doctor, which is “cementing of the reputation of physicians of Indian origin have across America,” Dr. Anupama Gotimukula, President-Elect of AAPI, that represents over 100,000 physicians of Indian origin in the United States, said, “We are proud of Dr. Vivek Murthy and his many accomplishments and look forward to working together in his efforts, as the nation and the entire world seeks to find best possible solutions to tackle the pandemic that has taken the lives of millions of people around the world.”

Lauding Dr. Murthy “who has been a key coronavirus adviser to President-Elect Biden, regularly briefing him on the pandemic during his campaign and the transition,” Dr. Ravi Kolli, Vice President of AAPI said, “Dr. Murthy was part of Biden’s public health advisory committee as the pandemic first took hold in the US and has been serving as a co-chair of the President-elect’s Covid-19 advisory board during the transition. His ethics, quiet leadership style and impeccable credentials make him the smart choice for this leadership role.”

“Dr. Vivek Murthy represents the next generation of Indian American physicians,” Dr. Amit Chakrabarty, Secretary of AAPI said.  “Dr. Murthy was America’s youngest-ever top doctor, and he was also the first surgeon general of Indian-American descent, when appointed by President Barack Obama in 2014. Now that he has been confirmed by the Senate, Dr. Murthy will play a key role in the administration’s response to many daunting healthcare issues, including the pandemic that has taken the lives of hundreds of thousands of Americans.”
“Having a wide range of experiences and passion for science-based approach, Dr. Vivek Murthy will bring in new perspectives to the many healthcare issues that require immediate attention and concrete action plan,” said Dr. Satheesh Kathula, Treasurer of AAPI.  Offering fullest cooperation from the Indian American Physician community, he said, “We at AAPI, look forward to working closely with Dr. Murthy and his team to end this deadly pandemic.”
Dr. Murthy 43, has said Americans need a leader who works with the people for the progress of the country. As surgeon general under Obama, Murthy helped lead the national response to the Ebola and Zika viruses and the opioid crisis, among other health challenges.

Dr. Murthy’s commitment to medicine and health began early in life. The son of immigrants from India, he discovered the art of healing watching his parents – Hallegere and Myetriae Murthy – treat patients like family in his father’s medical clinic in Miami, Florida.
“I am proud of our community of Indian physicians for all the progress that we have made over the years, and I know that AAPI has been a critical force in making this process possible. The advice you shared and assistance you kindly offered were important pieces of this journey,” Dr. Vivek Murthy, stated in a letter to Dr. Jayesh B. Shah, a past president of AAPI, who along with AAPI’s Legislative Affairs Chair, Dr. Sampat Shivangi and other senior leaders of AAPI had led several delegations to US Senators, lobbying for his confirmation in 2014, when he was appointed by President Obama.

While expressing pride at the confirmation of Dr. Murthy, Dr. Jonnalagadda pointed out to US President Joe Biden’s remarks, describing the Indian American physician to be the US Surgeon General as a “renowned physician” who could help guide Americans safely out of a still ranging coronavirus pandemic. For more details on AAPI, please visit: www.aapiusa.org

Dr. Vivek Murthy Confirmed By Senate As US Surgeon General, Will Focus On Covid, Opioids

The US Senate voted Tuesday to confirm Vivek Murthy to be President Biden’s surgeon general, handing the administration one of its top public health officials amid the coronavirus pandemic.

Dr. Vivek H. Murthy, who as U.S. Surgeon General under President Obama had served as the United States Surgeon General and advocated a “healthier and more compassionate America,” was confirmed by the US Senate on Tuesday, March 23rd for the second time as the Surgeon General of the United States. While Dr. Vivek Murthy says ending the coronavirus pandemic is his top priority, he’s also raised concerns over a relapsing opioid overdose crisis.

“I’m deeply grateful to be confirmed by the Senate to serve once again as your surgeon general,” Murthy said in a statement. “We’ve endured great hardship as a nation over the past year, and I look forward to working with you to help our nation heal and create a better future for our children.”

According to the Office of the Surgeon General, the so-called nation’s doctor is tasked with providing Americans with the best scientific information to “improve their health and reduce the risk of injury” while overseeing the Public Health Service Commissioned Corps’ more than 6,000 uniformed public health officers.

The vote on Murthy was 57-43, giving him bipartisan support. Biden’s coronavirus response can already count on plenty of star players, but Murthy has a particular niche. As a successful author he’s addressed issues of loneliness and isolation that have been exacerbated by the pandemic. GOP Sens. Bill Cassidy (La.), Susan Collins (Maine), Roger Marshall (Kan.), Lisa Murkowski (Alaska), Rob Portman (Ohio), Mitt Romney (Utah) and Dan Sullivan (Alaska) joined Democrats in supporting his nomination on Tuesday.

But getting the support of every Democratic senator wasn’t always guaranteed. Sen. Joe Manchin (D-W.Va.) told reporters last month that he hadn’t made a decision, but ultimately ending up voting for him Tuesday.

“Murthy has confirmed his commitment to remaining non-partisan as Surgeon General and reaffirmed his belief that the vast majority of gun-owning Americans are responsible and follow the law. For these reasons, I believe Dr. Murthy is qualified to be Surgeon General and I look forward to working with him to address the numerous issues facing our nation,” Manchin said in a statement.

 Covid-19 has taken the lives of several members of Murthy’s extended family. He told senators during his confirmation hearing that he wants to help individuals and families protect themselves by conveying “clear, science-based guidance” to the general public. Persuading Americans to keep up such protective measures as wearing masks could well be his toughest challenge. Murthy served as co-chair of the Biden transition team’s coronavirus advisory board, and is said to enjoy a close personal relationship with the president.

Murthy’s family roots are in India, but as a youngster he lived in Miami. His father had a medical clinic, where both parents worked. The son spent weekends helping out and says that’s where he discovered the art of healing. “As a child, I watched them make house calls in the middle of the night and wake up early to visit patients in the hospital before heading to their office,” he told senators. “I have tried to live by the lessons they embodied: that we have an obligation to help each other whenever we can, to alleviate suffering wherever we find it, and to give back to this country that made their lives, and my life, and the lives of my children possible.”

Murthy’s style evokes the bedside manner of an empathetic physician. He “effectively conveys compassion and credibility at a time of great need for just that,” said Chris Jennings, a longtime health policy adviser to Democrats.

From his previous stint as surgeon general, Murthy says he is most proud of his efforts to call attention to the opioid epidemic, the consequences of which were not fully understood at the time. After dipping slightly, opioid deaths have again risen, driven by street formulations laced with the powerful painkiller fentanyl. “We cannot neglect the other public health crises that have been exacerbated by this pandemic, particularly the opioid epidemic, mental illness and racial and geographic health inequities,” Murthy told senators.

Murthy has drawn opposition from gun rights advocates because of his longstanding assessment that mass shootings amount to a public health problem. But he told senators that while he supports the government studying gun violence as a problem, “my focus is not on this issue, and if I’m confirmed it will be on Covid, on mental health and substance use disorder.”

“He served our country with distinction, bringing much needed added attention to some of our nation’s most pressing public health challenges,” said Howard P. Forman, M.D., M.B.A., professor of diagnostic radiology, economics, and public health, and director of the M.D./M.B.A. Program. Forman served as a mentor to Murthy during his time at Yale. “We are all excited to see what the future holds for him, but I am confident that he will continue to be a very positive force for health and health care improvements.”

When President Obama nominated him as Surgeon General in 2013, Murthy immediately came under fire from the National Rifle Association and its allies in Congress for his view that gun violence should be seen as a public health issue. But more than 100 medical and public health organizations around the country supported his nomination.

During the 2008 campaign, Murthy founded Doctors for Obama, an effort to increase engagement by physicians in the political process. After Obama’s election, the group became Doctors for America, which advocated for comprehensive health care reform. In 2011, Obama appointed Murthy to serve on the Presidential Advisory Council on Prevention, Health Promotion, and Integrative and Public Health within the U.S. Department of Health and Human Services.

“For the grandson of a poor farmer from India to be asked by the President to look out for the health of an entire nation was a humbling and uniquely American story. I will always be grateful to our country for welcoming my immigrant family nearly 40 years ago and giving me this opportunity to serve,” he wrote on Facebook on Friday. He also offered thanks for “the privilege of a lifetime. I have been truly humbled and honored to serve as your Surgeon General. I look forward to working alongside you in new ways in the years to come. Our journey for a stronger, healthier America continues.”

Murthy advised Biden for several months during the campaign on the coronavirus pandemic and vowed to focus on the mental health impact if he was confirmed.  “We know a lot of what we need to do, we just aren’t doing it. We have for example, programs that we could be investing in schools to help provide mental health counseling to kids to detect symptoms of mental illness early. We can train more mental health providers,” Murthy said.

 While nominating Murthy to the job he had held under Obama, Biden had said in December 2020, that the Indian American Doctor would have expanded responsibilities under his administration amid the coronavirus pandemic. “He will be a key public voice on the COVID response to restore public trust and faith in science and medicine,” Biden said, adding one of the reasons he nominated Murthy is because when he speaks people listen. “They trust you,” he said. “You have a way of communicating, they can just see it in your eyes.”

As India Sees Surge, Reports Of ‘Double Mutant’ Coronavirus Variant Causes Alarm

A unique “double mutant” coronavirus variant — with a combination of mutations not seen anywhere else in the world — has been found in India, the Health Ministry of India has reported. However, it is still to be established if this has any role to play in increased infectivity or in making COVID-19 more severe.

India is seeing a substantial number of coronavirus variants. But it is unclear whether these are contributing to a new surge in cases there.

On Wednesday, India reported 47,262 new cases, the highest jump since November. Coronavirus-related fatalities are also increasing with 275 deaths reported on Wednesday, the most India has seen this year.

Several virus variants have appeared in thousands of samples collected across Indian states. Some of the samples have contained viruses with two concerning mutations, one first identified in the U.K. and another in South Africa.

Genome sequencing of a section of virus samples by a consortium of 10 labs across the country, called the Indian SARS-CoV-2 Consortium on Genomics (INSACOG), revealed the presence of two mutations, E484Q and L452R together, in at least 200 virus samples from Maharashtra, as well as a handful in Delhi, Punjab and Gujarat.

Mutations in the virus per se are not surprising but specific mutations that help the virus evolve to thwart vaccines or the immune system, or are linked to a spike in cases or in disease severity, are of interest. While the two mutations have been individually identified in other variants of SARS-CoV-2 globally, and have been associated with a reduction in vaccine efficacy as well as infectivity, their combined effect and biological implication has not yet been understood. In the days ahead, the INSACOG will submit details of this variant to a global repository called GISAID and, if it merits, classify it as a “Variant of Concern” (VOC).

India has not yet conducted studies on how vaccine efficacy is influenced by variants, except for limited laboratory trials, but international studies have shown reduced efficacy of vaccines — particularly those by Pfizer, Moderna and Novavax — to certain variants. However, the vaccines continue to be significantly protective in spite of this.

So far, only three global VOCs have been identified: the U.K. variant (B.1.1.7), the South African (B.1.351) and the Brazilian (P.1) lineage. So far, of 10,787 samples from international passengers, 771 instances of these VOCs have been identified in 18 States of the country. After the new double variant has been submitted to GISAID, it will be categorised under a formal lineage, and will have its own name.

The identification of a new variant does not yet imply new public health measures, the Health Ministry said: “It would require the same epidemiological and public health response of increased testing, comprehensive tracking of close contacts, prompt isolation of positive cases & contacts as well as treatment as per National Treatment Protocol” by the States/UTs.

Separately, genome variation studies from Kerala have revealed the presence of other mutations associated with the ability to help the coronavirus evade neutralising antibodies.

“The N440K mutation that is associated with immune escape has been found in 123 samples from 11 districts. This was earlier found in 33% of samples from Andhra Pradesh, and in 53 of 104 samples from Telangana. This has also been reported from 16 other countries, including the U.K., Denmark, Singapore, Japan and Australia. As of now, these can at best be said to be variants under investigation,” noted the Ministry.

Anurag Agrawal, Director, Institute of Genomics and Integrative Biology, said: “Presence of a VOC or suspected VOC does not automatically mean that they are causing the outbreak, but rather suggests caution and implementation of public health measures for containment. This must of course be paralleled with investigation into the VOC — known and suspected — in terms of transmissibility, inhibition by antibodies of recovered people, and inhibition by antibodies of vaccinated people. Doing this together will help formulate the best health policy.”

The INSACOG was to genome sequence about 5% of the positive samples from all States but has so far managed about 1%. This, as The Hindu has previously reported, was due to restrictions on reagents and a paucity of samples sent from the States to the sequencing centers.

The Effect of Covid: Weight Gain For all Americans

I f you’re like most Americans, the past year has been a time of fear, anxiety and often profound tedium—but also of worsening dietary habits. Take 328 million people and confine them to their homes for weeks and months on end and they’re going to start eating more and exercising less. That means, no surprise, weight gain. A study published March 22 in JAMA took a crack at determining just how many pounds the average American packed on in between February and June 2020, and came up with about 7.08 lb. (3.24 kg).

Even before the pandemic began, the researchers, all from the University of California, San Francisco, were involved in a program known as the Heart eHealth Study, in which 250,000 volunteers share their blood pressure, electrocardiograms, weight and more by entering them into a phone app or connecting the phone to Bluetooth-enabled devices if they own them. There is no set frequency with which the volunteers are expected to participate, but the more often they log on and contribute their readings, the more data the researchers can collect. The goal is to learn more about the lifestyles and patterns of underlying health that lead to heart disease and how it might be possible to reverse them before trouble starts. When, in mid-March and early-April of last year, 45 states issued shelter-in-place orders, it got the research team wondering about what the sudden shift to a more sedentary lifestyle would do to eating habits and body mass.

To determine this, the team selected a broadly representative sample group from their existing pool of heart health subjects: 269 people from 37 states, with a median age of 51.9 years, and close to evenly divided between men and women. Over the course of four months, from Feb. 1, 2020—before pandemic-related social restrictions began—to June 1, 2020, the investigators collected a total of 7,444 weight readings from their sample pool. Over that time, the subjects gained an average of 0.59 lb. (0.27 kg) every 10 days.

That was unsurprising, to an extent, given the fact that so many Americans were forced to adapt to a much less active lifestyle. But it was especially troubling because so many of the subjects included in this study had actually been losing weight before the four month period began, says Dr. Gregory Marcus, a cardiologist, UCSF professor of medicine, and a coauthor of the study. “This means that their healthy behavior was not just interrupted, it was actually reversed.”

Equally worrisome, the 250,000 people from whom the 269 were selected were by no means precisely representative of the entire population. The mere fact that they enrolled in the Heart eHealth Study and that some own the bluetooth-enabled scales, ECGs and blood pressure cuffs that help them participate means that they are surely more health-conscious than much of the rest of the population. Merely to have their data included in the new weight study, they had to step on the scale a minimum of twice in the four-month study period, something that many other people may not do for months at a time.

“It might be that the general population has actually experienced more weight gain than our sample group has,” says Marcus. “It might be that this is just the tip of the iceberg.” As data from the Heart eHealth program continue to pour in, Marcus and his colleagues are keeping an eye on the 269 subjects and maintaining a record of their readings. They have not decided whether they will publish a follow-up study on their weight-gain or loss, but, says, Marcus, “It will be interesting to see what happens after all of the shelter in place orders are lifted.”

Biden Aims For “Independence From This Virus” By 4th of July

President Joe Biden pledged in his first prime-time address to make all adults eligible for vaccines by May 1 and raised the possibility of beginning to “mark our independence from this virus” by the Fourth of July.

One year after the nation was brought to a near-standstill by the coronavirus, President Joe Biden pledged in his first prime-time address to make all adults eligible for vaccines by May 1 and raised the possibility of beginning to “mark our independence from this virus” by the Fourth of July. He offered Americans fresh hope and appealed anew for their help. Speaking in the White House East Room Thursday night, Biden honored the “collective suffering” of Americans over the past year in his 24-minute address and then offered them a vision for a return to a modicum of normalcy this summer. “We are bound together by the loss and the pain of the days that have gone by,” he said.

“We are also bound together by the hope and the possibilities in the days in front of us.” He predicted Americans could safely gather at least in small groups for July Fourth to “make this Independence Day truly special.” But he also cautioned that this was a “goal” and attaining it depends on people’s cooperation in following public health guidelines and rolling up their sleeves to get vaccinated as soon as eligible. Only that, he said, can bring about an end to a pandemic that has killed more than 530,000 Americans and disrupted the lives of countless more. “While it was different for everyone, we all lost something,” Biden said of the sacrifices of the yearlong-and-counting pandemic.

The speech came just hours after Biden signed into law a $1.9 trillion relief package that he said will help defeat the virus, nurse the economy back to health and deliver direct aid to Americans struggling to make ends meet. Some cash distributions could begin arriving in the bank accounts of Americans this weekend. “This historic legislation is about rebuilding the backbone of this country,” Biden said as he signed the bill in the Oval Office. Most noticeable to many Americans are provisions providing up to $1,400 in direct payments and extending $300 weekly emergency unemployment benefits into early September. Also included are expanded tax credits over the next year for children, child care and family leave — some of them credits that Democrats have signaled they’d like to make permanent — plus spending for renters, food programs and people’s utility bills. In his Thursday night address, Biden said that as vaccine supplies continue to increase, he will direct states and territories to make all adults eligible for vaccination by May 1.

The U.S. is expecting to have enough doses for those 255 million adults by the end of that month, but Biden warned the process of actually administering those doses would take time, even as his administration looks to instill confidence in the safety of the vaccines to overcome hesitance. “Let me be clear, that doesn’t mean everyone’s going to have that shot immediately, but it means you’ll be able to get in line beginning May 1,” he said.

Biden announced an expansion of other efforts to speed vaccinations, including deploying an additional 4,000 active-duty troops to support vaccination efforts and allowing more people — such as medical students, veterinarians and dentists — to deliver shots. He is also directing more doses toward some 950 community health centers and up to 20,000 retail pharmacies, to make it easier for people to get vaccinated closer to their homes.

Biden added that his administration is planning to launch a nationwide website to help people find doses, saying it would address frustrations so that there would be “no more searching day and night for an appointment.” Even as he offered optimism, Biden made clear that the July 4 timetable applied only to smaller gatherings, not larger ones, and requires cooperation from Americans to continue to wear face coverings, maintain social distancing and follow federal guidelines meant to slow the spread of the virus in the near term. He also called on them roll up their sleeves to get vaccinated as soon as they’re eligible. This is “not the time to not stick with the rules,” Biden said, warning of the potential for backsliding just as the nation is on the cusp of defeating the virus. “I need you, the American people,” he added. “I need you. I need every American to do their part.”

Biden’s initial prime-time speech was “a big moment,” said presidential historian and Rice University professor Douglas Brinkley. “He’s got to win over hearts and minds for people to stay masked and get vaccinated, but also recognize that after the last year, the federal government hasn’t forgotten you.” Biden’s remarks were central to a pivotal week for the president as he addresses the defining challenge of his term: shepherding the nation through the twin public health and economic storms brought about by the virus.

COVID-19 Vaccine Rollout By India Has ‘Rescued The World’ From Pandemic

India is called the pharmacy of the world during the COVID-19 pandemic.The rollout of the COVID-19 vaccines by India in collaboration with leading global institutions has ‘rescued the world’ from the deadly coronavirus.

 

The rollout of the COVID-19 vaccines by India in collaboration with leading global institutions has ‘rescued the world’ from the deadly coronavirus and the contributions by the country must not be underestimated, a top American scientist has said.

India is called the pharmacy of the world during the COVID-19 pandemic with its vast experience and deep knowledge in medicine. The country is one of the world’s biggest drug-makers and an increasing number of countries have already approached it for procuring coronavirus vaccines.

Dr Peter Hotez, Dean of the National School of Tropical Medicine at Baylor College of Medicine (BCM) in Houston during a recent webinar said that the two mRNA vaccines may not impact the world’s low and middle income countries, but India’s vaccines, made in collaboration with universities across the world such as BCM and the Oxford University, have “rescued the world” and its contributions must not be underestimated.

During the webinar, “COVID-19: Vaccination and Potential Return to Normalcy – If and When”, Dr Hotez, an internationally-recognised physician-scientist in neglected tropical diseases and vaccine development, said that the COVID-19 vaccine rollout is ‘India’s gift’ to the world in combating the virus.

India’s drugs regulator gave emergency use authorization to Covishield, produced by Pune-based Serum Institute of India after securing license from British pharma company AstraZeneca, and Covaxin, indigenously developed jointly by Hyderabad-based Bharat Biotech and Indian Council of Medical Research scientists. The webinar was organized by Indo American Chamber of Commerce of Greater Houston (IACCGH).

“This is something very special and I see it myself because I’m on weekly teleconferences with our colleagues in India, you make a recommendation, and within days it’s done and not only done, but it’s done well and with incredible rigor and thought and creativity,’ Dr Hotez said, stressing that he felt compelled to make this statement because ‘India’s huge efforts in combating global pandemic is a story that’s not really getting out in the world.’ Dr Hotez, considered as the authority on vaccinations, is working on an affordable coronavirus vaccine in collaboration with Indian pharmaceutical companies.

There is increasing evidence that vaccines not only “interrupt symptomatic illness and keep you out of the hospital” but halts asymptomatic transmission as well. However, the troubling news is that the vaccines work well against the UK B.1.1.7 variant, which is now accelerating across the US, but doesn’t work quite as well against the variant coming out of South Africa.

It is likely that all the vaccines will require a booster for two reasons: the durability of protection for the vaccines is unknown and to create an added immune response that’s better tailored towards the South African variant.

Consul General of India in Houston, Aseem Mahajan, along with a distinguished panel of doctors participated in this webinar, that tracked the possibilities of a return to some semblance of normality due to the accelerated roll out of vaccines across the country.

Appreciating Dr. Hotez for commending India’s efforts in getting vaccines to the world, Consul General Mahajan, said, “in keeping with “our tradition of sharing with the world,” India has exported vaccines to many countries across the world.

India has provided 56 lakh doses of coronavirus vaccines under grants assistance to a number of countries. The vaccines were sent to Sri Lanka, Bhutan, Maldives, Bangladesh, Nepal, Myanmar and Seychelles.

There has also been a boost in the collaborative medical partnerships emerging between the US and India during this pandemic. In addition, India is one of the fourth largest destinations in Asia for medical devices manufacturing and many US companies have expressed interest in collaborating on this front,’ Mahajan said.

IACCGH Founding Secretary/Executive Director Jagdip Ahluwalia said that “India’s response to the COVID crisis, as acknowledged by Dr Hotez, falls in line with Chamber’s vision. Since its inception, 21 years ago, India would be a future global player in key areas like technology, medicine, manufacturing and international trade. This belief has been proved time and again particularly in the last decade.’ Chamber President Tarush Anand expressed pride that India has risen to this global challenge by leveraging the brilliance of its scientific community and extensive manufacturing capabilities in the most efficient manner to help the world recover from a deadly pandemic.

Describing vaccines as “one of the highest expressions of science in pursuit of humanitarian goals,” Chief Radiation Oncology Officer and moderator Dr Vivek Kavadi noted that over 28 million people had contracted the virus in the US and more than half a million Americans had tragically died. Lives and businesses had been upended but the breakthrough on the vaccine front has been one reason for cautious optimism.

More than 73 million vaccine doses have been administered to date, 15 per cent of the population has received 1 dose while 7 per cent have received both doses, Dr Kavadi said.

COVID Relief Bill Could Permanently Alter Social Safety Net

The $1.9 trillion COVID-19 relief package is being hailed as a generational expansion of the social safety net, providing food and housing, health care and is a broad-based attack on the cycle of poverty.

 

With more than $6 billion for food security-related programs, more than $25 billion in emergency rental assistance, nearly $10 billion in emergency mortgage aid for homeowners, and extensions of already-expanded unemployment payments through early September, the package is full of provisions designed to help families and individuals survive and recover from pandemic-induced economic hardships.

“When you stand back and look at it, that’s when you really can appreciate the sheer scope of it,” said Ellen Vollinger, legal director for the Food Research & Action Center, a food-security advocacy group. “The scope is both impressive and much needed.”

Several aspects seem targeted at restructuring the country’s social safety net and actually lifting people out of poverty. It’s the kind of ambition and somewhat old school Democratic Party ideal that has observers referencing former President Franklin Delano Roosevelt and the New Deal.

“We haven’t seen a shift like this seen since FDR. It’s saying families are too big to fail, children are too big to fail, the elderly are too big to fail,” said Andre Perry, senior fellow in the Metropolitan Policy Program at the Brookings Institution. “It’s a recognition that the social safety net is not working and was not working prior to the pandemic.”

Biden himself, when signing the package into law Thursday, referenced it as an overt attempt to redraw the country’s economic fault lines in a way that’s bigger than the pandemic. “This historic legislation is about rebuilding the backbone of this country and giving people in this nation, working people and middle-class folks, the people who built the country — a fighting chance,” Biden said.

And House Speaker Nancy Pelosi, D-Calif., called it “one of the most transformative and historic bills any of us will ever have the opportunity to support.”

Perry in particular pointed to the expansion of the child tax credit system as a potentially foundational change. The legislation provides families with up to $3,600 this year for each child and also expands the credit to millions of families currently making too little to qualify for the full benefits. “That is really going to put a dent in child poverty,” Perry said.

In promoting the child tax credit expansion, Democrats rallied around an analysis that predicted it would cut nationwide child poverty by 45%.

The legislation extends through September last year’s 15% increase in benefits offered by the Supplemental Nutrition Assistance Program (SNAP) program, commonly known as food stamps. It also provides extra funds to administer the expanded SNAP program and to expand access to SNAP online purchasing.

The package also includes what amounts to the biggest expansion of federal help for health insurance since the Obama-era Affordable Care Act more than 10 years ago. Several million people could see their health insurance costs reduced, and there’s also an incentive for states to expand Medicaid coverage, if they haven’t already done so. Those changes, however, won’t be as immediate as the direct cash injections in other areas.

Housing advocates give generally positive reviews, saying the massive relief packages for both renters and home owners should be enough to stave off the debts incurred so far. “This is an appropriate response for an unprecedented time. Clearly there’s a tremendous need to avoid an eviction tsunami,” said Diane Yentel, president of the National Low Income Housing Coalition.

But she also warned that the economic hardships, and need for assistance, will extend past the end of the pandemic. “Many of the jobs that low-income workers have lost won’t come back right away,” she said.

Yentel called on Biden to extend the national moratorium on evictions via executive order. The current moratorium, imposed by the Centers for Disease Control as part of the national health emergency, is being challenged in multiple court cases and expires at the end of March.

Many of the legislation’s changes are temporary, but advocates and Democratic legislators are talking openly about making some of them permanent. “Getting something out of the code is often times harder than getting something into the code,” House Ways and Means Committee Chairman Richard Neal, D-Mass., told reporters Tuesday, referring to the relief bill’s expansion of the child tax credit. He added, “What we did is unlikely to go away.”

At this point, the child tax credit expansion would expire at the end of the year without some sort of congressional intervention. But permanently enshrining those changes into law could be a battle. Congress’ nonpartisan Joint Committee on Taxation has estimated the child tax credit’s cost at $110 billion, making it one of the single most expensive items in the whole package. Extending that over multiple years would be extremely costly, and would likely draw serious opposition, especially from Republicans.

Senate Minority Leader Mitch McConnell, R-Ky, called Democrats’ expansion of those credits “sweeping new government benefits with no work requirements whatsoever,” suggesting the shape of the GOP opposition strategy ahead. But the provision is projected to lift millions of families out of poverty, and progressives believe there will be tremendous pressure on Republicans to allow the change.

Many also want to preserve the bill’s temporarily beefed up earned income tax credit, and its improved tax breaks for caring for children and dependents and for paid sick and family leave. A study by the Tax Policy Center concluded that the relief package would reduce federal taxes in 2021 by an average of $3,000 per household. Low- and moderate-income households (making $91,000 or less) would receive nearly 70 percent of the tax benefits, the study concluded.

“The question will be do they want child poverty to go back up again” by letting that credit expire, said Steve Wamhoff, director of federal tax policy for the liberal Institute on Taxation and Economic Policy.

(Associated Press writer Josh Boak contributed to this report.)

One Year After The Pandemic Was Declared, 1 In 10 Americans Have Been Fully Vaccinated

Exactly one year after the World Health Organization declared the novel coronavirus a pandemic and about three months since the first Americans outside of clinical trials got shots, one in 10 people in the US are fully vaccinated against Covid-19.

The US Centers for Disease Control and Prevention reported on its website that at least 33.9 million Americans are protected with either a one-dose or two-dose vaccine. One vaccine expert is concerned that as case numbers fall and days get warmer and longer, many people will forgo getting a shot.

“I think we are going to get fooled.” Dr. Paul Offit, director of the Vaccine Education Center at Children’s Hospital of Philadelphia, said. “I think what’s going to happen is you’re going to see that as we enter the summer months, numbers are going to go down, people will think great, we’re good.” If the United States doesn’t reach 80% of the population having immunity via inoculations because people lost interest in being vaccinated, another surge is possible, he said.

But the rise in cases late this year could be less significant if more than 260 million get their shots. “I think when next winter comes, because this virus isn’t going away, (if we get to 80% vaccinated) we’ll see a bump instead of a surge,” Offit said at a virtual event hosted by the Aspen Institute, an educational and policy studies organization, and Leaps.org, a science media platform. “And that’d be the test of how well we’ve done with getting this in hand.”

Preliminary CDC data shows 2020 deadliest year for US

Largely because of the pandemic, 2020 appears to have been the deadliest year in the recorded history of the United States — at least since 1900, according to early data from the CDC.

The health agency said in an email that its analysis suggests 2020 was the deadliest year in recorded history in terms of total number of deaths, and there was a 15% increase in the US death rate last year because of the pandemic.

“We are working on a future report, but the underlying data on which the report is based are already available from our website,” a CDC spokesperson wrote in the email.

For now, provisional data online shows that last year, 3,362,151 people died from all causes in the United States. Among those deaths, 378,292 involved Covid-19, according to the CDC data. With the US population being around 330 million people, about 3.3 million deaths represents 1% of the nation’s total population.

Total deaths last year were 18% higher than expected relative to recent years, according to the provisional data on the CDC’s website.

Overall, “2020 will have been the deadliest by far as long as we’ve kept records and almost certainly as long as the US has existed,” Bob Anderson, chief mortality statistician for the CDC, told CNN on Thursday. But, he added, you have to account for population growth and also aging of the population.

The longest year

More than 29 million cases and 530,000 deaths have been reported in the United States since March 11, 2020. The virus plunged America into grief and crisis. Several rounds of steep surges in infections prompted local and state leaders from coast to coast to order safety restrictions — in some cases, curfews — hoping to curb the deadly spread. Waves of Covid-19 patients crippled health care systems.

“After a year of this fight, we are tired, we are lonely, we are impatient,” CDC Director Dr. Rochelle Walensky said in a statement Thursday. “There have been too many missed family gatherings, too many lost milestones and opportunities, too many sacrifices.”

On this day last year, Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, told a congressional hearing that “things are going to get much worse before they get better.”

“But I did not in my mind think that much worse was going to be 525,000 deaths,” he said Thursday on NBC’s “Today” show. Now, the country is at a pivotal point.

Case numbers, after plateauing at high levels, may be beginning to decline again, Walensky said at a White House briefing Wednesday. Average hospital admissions and Covid-19 deaths were also down over the past week, she added.

“While these trends are starting to head in the right direction, the number of cases, hospitalizations and deaths still remain too high and are somber reminders that we must remain vigilant as we work to scale up our vaccination efforts across this country,” Walensky said.

Some experts have warned another possible surge could be weeks away, fueled by a highly contagious variant spreading across the country. Michael Osterholm, director of the Center for Infectious Disease Research and Policy at the University of Minnesota, said the US is at a “perfect-storm moment.” The B.1.1.7 variant — first reported in the United Kingdom — has “transmission unlike I’ve seen any at all since this pandemic began” in some areas, particularly in Florida, Texas and Georgia.

“And, remember, this is coming at us at the very same time we’re opening up America as if there is nothing else happening,” Osterholm said on CNN’s “New Day.” He added, “I think the dynamics of the virus right now, I’m afraid, are going to beat us at the vaccination game.”

What will help now, while the country works to boost its vaccination numbers, are the precautions that have been touted by officials for months: face masks, social distancing, avoiding crowds, washing hands.

And it’s especially crucial, according to experts, that Americans heed this guidance, even as more governors announce it’s time to begin loosening Covid-19 restrictions and paving the way for a return to normal.

Covid-19 model foresees more deaths with Americans increasingly on the move

A Covid-19 forecast from a group at the University of Washington said Thursday that with Americans more on the move, with fewer people wearing masks and with coronavirus variants infecting more people, the death toll in the United States by July 1 will be tens of thousands higher than previously predicted.

The researchers project 598,523 Americans will have died of Covid-19 by July 1, more than 22,000 fatalities higher than a forecast released four days ago.

“Over the last week the US has seen the largest one-week increase in mobility since the pandemic began,” the Institute for Health Metrics and Evaluation team wrote in an analysis containing data through March 8. “This huge jump in mobility means 22 states have mobility levels within 10% of the pre-COVID-19 baseline.”

Mask use has dropped from 75% in January to 73% in the first days of March, the IHME team said. The latest projection is based on a scenario that accounts for continued spread of the B.1.1.7 virus variant in some locations and scaling up of Covid-19 vaccination in the United States over the next few months. Under this “most likely” scenario, the projected total of deaths each day in the United States could drop from 1,395 to 86 and about 75,000 people will die between now and July.

South Africa has had by far Africa’s worst experience with the virus. The country of 60 million people has had more than 1.5 million confirmed cases, including more than 50,000 deaths. “You can imagine, I was really, really frightened. I had all the symptoms. except dying,” she said, with a survivor’s grim smile. Her recuperation period was lengthy. “I had shortness of breath and tightness of the chest. It lasted for six months,” she said. “I didn’t think it would ever go away.”

At the same time, people are looking back at where they were when they first understood how drastically life would change. On March 11, 2020, confirmed cases of COVID-19 stood at 125,000, and reported deaths stood at fewer than 5,000. Today, 117 million people are confirmed to have been infected, and according to Johns Hopkins, more than 2.6 million people have died.

On that day, Italy closed shops and restaurants after locking down in the face of 10,000 reported infections. The NBA suspended its season, and Tom Hanks, filming a movie in Australia, announced he was infected.

On that evening, President Donald Trump addressed the nation from the Oval Office, announcing restrictions on travel from Europe that set off a trans-Atlantic scramble. Airports flooded with unmasked crowds in the days that followed. Soon, they were empty.

And that, for much of the world, was just the beginning.

(CNN’s Homero De la Fuente, Christopher Rios, Lauren Mascarenhas, Elizabeth Stuart and Gisela Crespo contributed to this report.)

It Will Be At Least A Year Before Life Returns To The Way It Was Before COVID-19

A year after COVID-19 forced the first lockdowns, school and business closures and event cancellations across the country, most Americans are not optimistic about a quick return to the way things were before the outbreak. And the public is even less optimistic about when the job situation may return to its pre-pandemic level.

How we did this

Despite recent increases in the shares of Americans who have been vaccinated against COVID-19 – and who say they plan to get vaccinated – just 9% of the public says it will be less than six months before most businesses, schools, places of worship and other public activities operate about as they did before the outbreak. Roughly a third (34%) say this will take between six months and a year.

Nearly six-in-ten (57%) say it will be a year or more before things mostly operate as they did before the pandemic struck the U.S., including 14% who expect it will take more than two years, according to a new Pew Research Center survey, conducted March 1-7 among 12,055 adults.

For the most part, expectations about when life will return to the way it was before the pandemic do not vary widely across demographic groups or by partisanship.

Women (59%) are somewhat more likely than men (53%) to believe that it will take more than a year for public activities to return to the level they were before the outbreak.

Nearly two-thirds of Black Americans (64%) say it will be a year or longer, compared with smaller shares of White (56%), Asian (56%) and Hispanic adults (51%).

Upper-income Americans are the most optimistic about when life when will return to normal: 49% predict that schools, businesses and other public activities will fully reopen in a year or sooner. Fewer middle-income (43%) and lower-income Americans (40%) say the same.

Similar shares of Republicans and Republican-leaning independents (57%) and Democrats and Democratic leaners (56%) say it will take more than a year for life to return to normal in the country. But Republicans are more likely than Democrats to believe it will be more than two years (17% vs. 10%).

When it comes to the nation’s job situation, Americans are even more pessimistic. About eight-in-ten Americans say they expect it will take one to two years (46%) or more than two years (35%) for the job situation to recover to where it was before the outbreak. Just 19% believe it will recover in less than a year.

There are modest demographic differences in these predictions. For example, those who live in rural areas (40%) are slightly more likely than those who live in suburban (34%) or urban areas (31%) to say the job recovery will take more than two years.

While partisans are largely in agreement that it will take more than a year for employment to reach the level it was at before the pandemic, Republicans are more pessimistic: 44% expect jobs to return in more than two years, compared with about a quarter of Democrats (26%).

When is this finally going to end? That’s the question on many minds after a year of living through the COVID-19 pandemic.

But public health experts say we do have an answer, and you’re not going to like it: COVID-19 is never going to end. It now seems poised to become an endemic disease — one that is always a part of our environment, no matter what we do.

“We’ve been told that this virus will disappear. But it will not,” Dr. William Schaffner, a professor at the Vanderbilt University School of Medicine and medical director of the National Foundation For Infectious Diseases, tells CBS News.

The World Health Organization declared COVID-19 a pandemic on March 11, 2020. A year later, the virus has infected 118 million people worldwide and killed over 2.6 million, including more than 530,000 Americans, according to data compiled by Johns Hopkins University. But researchers say there’s simply no track record of infectious diseases being completely eradicated, and everything about COVID-19 shows that it will be no different.

“The more infectious a microbe is, the harder it is to control,” Dr. Tom Frieden, the CEO of Resolve To Save Lives and a former CDC director, tells CBS News. “COVID is very challenging to control, and the new variants suggest that we may end up playing kind of a game of cat and mouse.”

Prior to COVID, people were already used to living with endemic diseases. The flu is one example. Measles is another. Both continue to spread and kill people every year despite decades of vaccination and containment.

Even the virus that causes COVID-19 is just a new type of coronavirus; other coronaviruses had long been circulating and in some cases could cause the common cold. COVID itself has already gone through mutations that made it more contagious and potentially deadlier.

One Year Of Living In The Shadow Of A Pandemic

Today, March 11, marks one year since the World Health Organization declared Covid-19, the disease caused by the novel coronavirus, a pandemic. In the first months of 2020, as the unprecedented health crisis rapidly crossed borders — China, Italy, Spain, South Korea, Japan and soon, the United States — it started to take the shape of a looming, global threat. Something beyond an epidemic.

As I researched, I was surprised to learn that there was no universally agreed-upon definition of “pandemic.” But an increasing number of medical experts and public health officials I spoke with were telling me that the rapidly unfolding situation fit the bill.

Loosely speaking, a pandemic is an outbreak of a virus that can cause illness or death, where there is sustained person-to-person transmission of that virus, and evidence of its spread in different geographic locations. Check, check and check.

Still, to call it a pandemic felt momentous and weighty. It was not a decision CNN (or I, personally) took lightly — we didn’t want to panic people — be we felt we had to call it what it was. And so we did that on March 9.

To be fair, WHO had been sounding the alarm steadily for nearly six weeks, since January 30, 2020, when the director general, Tedros Adhanom Ghebreyesus, declared the situation a “public health emergency of international concern” — the highest level of health alert under international law. The definition is “an extraordinary event that may constitute a public health risk to other countries through international spread of disease and may require an international coordinated response.”

For this symbolic anniversary, I spoke to Maria Van Kerkhove, WHO’s technical lead for the coronavirus response, to reflect on the year of the pandemic and beyond.

Different countries, different responses, different outcomes

Van Kerkhove — who said WHO tries to do for the world what the US Centers for Disease Control and Prevention does for the US — told me the goal of a public health emergency of international concern is to raise the alarm before you’re in an actual pandemic, when there’s still time to possibly prevent and, at any rate, prepare for what is to come. Similarly, for more than a year now, WHO has been trying to change the trajectory of the pandemic through, among other things, expertise, guidance, advice and support as well as frequent news conferences.

While every country has responded to the emerging threat in its own way, some countries took the early warnings more seriously, she said.

“It wasn’t about rich or poor countries. It was about experience. It was about those countries that knew the threat that this was; they heeded our warnings,” said Van Kerkhove. That experience came from dealing with previous infectious outbreaks, such as SARS, MERS and Ebola. And those countries quickly implemented strong public health measures, mobilized community health workers, contact tracers and lab technicians.

Van Kerkhove points to places like South Korea, Japan and Nigeria — all of which managed to keep transmission of this novel virus relatively under control.

For me, South Korea has been one of the clearest examples of success. It reported its first case of Covid-19 on January 20, 2020, hours before the United States confirmed its first case on January 21.

But the two countries have ended up in wildly divergent places: The US has more than 29 million total reported cases and more than half a million deaths. South Korea? Fewer than 100,000 cases and less than 2,000 deaths. You can’t dismiss that as the US having a higher population than South Korea, because when you look at the per capita deaths per 100,000 population, the US has more than 161 compared with South Korea’s 3.

Van Kerkhove said South Korea learned lessons from the 2015 MERS outbreak. “What they learned from that was to rebuild their system and enhance their public health system, which was utilized during this pandemic,” she said.

As an example, she pointed to what unfolded in the city of Daegu, when there was a big outbreak linked to church activity in February. “The case numbers were seemingly out of control,” she said. “And Korea turned it around.”

How did they do it? By being strategic and leveraging the tools they had at their disposal, Van Kerkhove said. “They looked at the situation that they were in. They enhanced their cluster investigation. … They ramped up their screening capacity, their testing capacity. They used quarantine effectively and they brought that outbreak under control. But at one point in time, it seemed almost impossible — and they turned it around,” she said.

She added that other countries have turned things around too, for example, Cambodia, Thailand, Rwanda, and South Africa, even with the emergence of a more-contagious variant there. “The resilience of people is what is encouraging and inspiring,” she said.

What has often struck me is that while infectious disease outbreaks typically crush poorer countries, this novel coronavirus has disproportionately affected many of the world’s wealthiest nations. Consider there are close to 9,000 cases per 100,000 people in the United States. Compare that to India, where it’s about a 10th of that, even though they have some of the most population-dense areas in the world.

As they say, money can’t buy everything, especially good health. “You can have really, really good medical systems in countries … the best treatments in the world. But that doesn’t make up for the fundamentals of public health,” Van Kerkhove said.

Variants and vaccines

Now that we are in the second year of the pandemic, the cavalry in the form of vaccines has arrived. But with it, a more contagious and, possibly in some cases, a more deadly enemy. New variants of the virus are decimating cities in Brazil; different variants have raged through the United Kingdom and South Africa. And they are establishing themselves in this country, too.

This can be addressed by providing better vaccine access to underserved countries. According to the People’s Vaccine Alliance, a global vaccine watchdog group, rich nations are now vaccinating one person every second while the majority of the poorest nations have yet to administer a single dose.

But that’s changing, thanks to COVAX, a global initiative that promotes equitable access for developing nations to Covid-19 vaccines. Led by the WHO and other organizations, COVAX delivered 20 million vaccine doses to 20 countries last week during the first week of distribution, according to WHO Director-General Tedros. An additional 14.4 million vaccine doses are slated to go out this week to an another 31 countries. “We are all part of this global community. Every life on this planet matters,” said Van Kerkhove. “Everyone on this planet deserves to be protected.”

Shot by shot, the world is beginning to see some hope. And those countries that did heed the WHO’s warnings, and followed public health guidance, are giving us a glimpse into a post pandemic life.

“I have glimmers of hope in many countries around the world,” Van Kerkhove said, pointing to places such as Australia, New Zealand, China and Japan. “I see societies that are opened up. I see sporting events that are happening. I see a resilient community that is living their life, that has driven transmission down in some situations to zero.”

Van Kerkhove, I and many others have been humbled by this virus — a virus that taught us that rich and poor doesn’t matter, borders don’t matter, and that unexpected things can and do happen. She and I both hope that all nations, but especially Western ones, use the unfortunate lessons we’ve all been forced to learn to put the systems in place so that we are in a better position to meet the next unexpected event, the next pandemic, the next infectious pathogen — because surely this one won’t be the last.

(CNN Health’s Andrea Kane and Amanda Sealy contributed to this report.)

Cholesterol, Hypertension, Diabetes On The Rise In India

While alcohol intake and thyroid issues among Indians seem to have reduced over the past year, a new health report has detailed a concerning increase in levels of blood pressure, cholesterol, and diabetes, despite fitness and health becoming a nationwide area of interest during the Covid-19 lockdown.

As per the Health Risk Assessment (HRA) Score, 1 in 2 Indians is either in the ‘High Risk’ or ‘Borderline’ category. This is a massive 12 per cent improvement from last year’s figures where 62 per cent Indians fell into the ‘Unhealthy’ category.

According to GOQii’s latest India Fit Report 2021, majority of people can become healthy by making few adjustments to their lifestyle. Reduction in commute time and lockdown probably allowed Indians to focus more on their health and making their immune system stronger. From a gender wise perspective, men are healthier in comparison to women. From an age wise perspective, the younger generation is unhealthier in comparison to the older generation.

Blood Pressure

About 15 per cent of users have reported high BP in 2020 in comparison to 13.4 per cent in 2019. This figure, according to the report, has steadily increased over the last 4 years. About 35 per cent users also reported this disease runs in the family which is a significant figure. Blood pressure cases among older adults are just triple of those in adults. Safe to say, then, that people above 45 are at more risk of having hypertension.

Diabetes

An analysis conducted by a full-stack digital ecosystem for diabetes care and management revealed that the average pre-pandemic fasting sugar levels in January till mid-February was 138 mg/dl whereas in March till mid-April it rose to 165 mg/dl. One-third claim this disease runs in the family. The percentage of those suffering from diabetes went triple, from adults to older adults.

Cholesterol

About 13 per cent users reported high cholesterol, a figure that has remained stable for the past two years. On the other hand, only 4 per cent mentioned they had heart issues which is a major decrease from 8.6 per cent in 2019.

Alcohol

Figures for drinking have reduced for almost all of the age groups and across a majority of cities. Many reasons can be accounted for the same. To start with, the biggest reason can be the onset of the nationwide lockdown because of the Covid-19 pandemic. Travelling was restricted and all the major places where usually people used to drink earlier like cafes, restaurants, bars etc. were shut down. All of these cumulatively decreased the drinking of the people as the only option they were left with was to drink at home, which was not a feasible option for a lot of people. Some comfortably did that, while a majority were not that comfortable in drinking amid their family members and hence the number reduced this year.

As compared to last year’s data, there is a significant reduction in the number of people falling sick in every age category this year. This could be due to the increased awareness in people regarding immunity levels through healthy lifestyle and nutrition food choices. The dip in pollution levels across the nation could also be a reason for this.

The report also revealed that stress levels remained high throughout the year. The survey outcome highlighted a rise in stress index from 4.98 in Mid-year to 5.11 at end of the year. Forty-five per cent are currently plagued with depression.

City-wise, Surat, Jaipur and Patna are the top 3 healthiest cities in India, respectively, as revealed by the survey whereas Lucknow, Kolkata and Chennai are the unhealthiest. (IANS)

GAPIO Organizes 2021 Global Indian Physicians Congress

The Global Association of Physicians of Indian Origin (GAPIO), a non-profit organization, and leading association for the Indian medical diaspora organised its annual Global Indian Physicians Congress on February 27th – 28th 2021. The Congress is an important event in the medical calendar where the exchange of knowledge from subject specialists from across the world takes place. This year’s virtual conference provided an international forum to delegates to share their knowledge and exchange ideas on clinical skill development, solutions to contemporary health issues and modernizing the approach to delivering healthcare.

Dr Harsh Vardhan, the Hon’ble Health Minister, Ministry of Health and Family Welfare was Chief Guest. In a video message, Dr. Harsh Vardhan praised GAPIO, as a shining example of the talent and caliber of Indian physicians who have made remarkable contributions in various fields of medicine across the globe.

Praising the contribution of medical professionals in the fight against the COVID-19 pandemic, Dr Harsh Vardhan said, “As the world faced the unprecedented crisis of COVID19, it has been our doctors, nurses, and healthcare workers who have cemented their position as the foremost champions of humanity, saving humankind as it was staring at an existential crisis.” The Minister also praised India’s efforts domestically and internationally and commended the physicians, nurses, and scientists involved in fighting the pandemic. India can greatly benefit from GAPIO’s support, he emphasized and concluded by complimenting the awardees for their outstanding work.

“I am so proud to be part of GAPIO, a great organization with the mission to bring together 1.4 million physicians of Indian origin on one professional platform,” said GAPIO Secretary General USA and Chairman and Publisher of Parikh World Wide Media and ITV Gold 24×7 TV Channel in the U.S., Padma Shri Dr. Sudhir Parikh, at the Congress. “This was a great event. From the time it was started in 2011, GAPIO is now in 53 countries. Not only does it provide a professional platform to more than 1 million Indian physicians, it also brings all the resources they have to offer to impact the much greater philanthropic work we can do in India and around the world,” Dr. Parikh told News India Times.

Since its inception in 2011 GAPIO has endeavored to bring 1.4 million physicians of Indian origin across the world on a single platform to facilitate the exchange of knowledge, skills and research. This was the 11th edition of the Congress. More than 5000 participants from USA, UK, Australia, Canada, Middle East, Africa, UAE, India and other countries participated in the Congress, making it one of the largest such events in the world.

The GAPIO Congress featured highly qualified medical professionals and leaders from around the world, and an award ceremony for those who have excelled in their areas of expertise, including young physicians.

Founder President of GAPIO and Chairman of Apollo Hospitals Group Dr. Prathap C Reddy, said, “The exemplary work by the awardees is an inspiration for others to emulate. The spirit of the physicians of Indian origin to excel in India and overseas is what we hope to recognize.
There are countless examples of pathbreaking work across the globe that would make every Indian proud. COVID-19 has once again shown the important role played by physicians of Indian origin in handling global health crises. The valuable lessons learnt from these clinical leaders will form part of the deliberations. The need for innovation and cross-systemic learning is more important than ever before. Apart from the COVID-19 pandemic, India and the world at large are facing an epidemic of non-communicable diseases – NCDs like diabetes, heart disease and cancer. We seek involvement of everyone to overcome this biggest challenge to mankind posed by COVID-19 and NCDs.”

President of GAPIO and Group Medical Director, Apollo Hospitals Group and Senior Consultant Pediatric Gastroenterologist and Hepatologist Dr. Anupam Sibal, said, “From supporting liver transplantation to pioneering cardiac surgery to establishing high-end lab services to excelling in rheumatology to introducing geriatric care to performing complex arthroplasty in a rural setting, the awardees represent the spectrum of path-breaking achievements.

“Remarking on the young physician’s category, Vice President GAPIO and CEO cum Chairman of Columbia Asia Group of Hospitals Dr. Nandakumar Jairam, said, “The awardees in the Young category represent the aspirations of the Young Indian Physician who is willing to take on challenges to improve the delivery of care, while excelling in academics and research. Research and innovation can improve the delivery of quality healthcare in India to the last mile. As the country braces to overcome its myriad health challenges, this Congress will help identify methodologies most suitable to skill and scale the healthcare workforce in the country.

Dr. Sudhir Parikh, Secretary General of GAPIO and Chairman and Publisher of Parikh World Wide Media and ITV Gold 24×7 TV Channel in USAsaid, “Global health challenges need global solutions, and we believe through GAPIO we will evolve constructive and tangible ways of ensuring that healthcare is affordable and accessible to all citizens.

The award winners in the Distinguished Category, each of whom receives Rs. 100,000, a citation, and a trophy include:

  • Pravin Agarwal (Mr Pravin Agarwal Foundation) for Dr. Prathap C Reddy Philanthropy award
  • Rohini Handa for the Dr. IA Modi Award
    • Navin Dang for GAPIO Excellence in Diagnostics Award
  • Maligail Ramkrishna Girinath for GAPIO Karl Storz Surgical Excellence Award
  • VS Natarajan for GAPIO Lifetime achievement award.
    Dr. Madan Mohan Reddy received the GAPIO Special Appreciation Award for his pathbreaking work in delivering orthopedic care including joint replacements in villages.

The award winners in Young Category each of whom receives Rs. 50,000, a citation and a trophy, include:

  • Sonali M Khobragade and Dr. Purvi Parikh (joint winners) for Dr. IA Modi Award
  • Nishat Hussain Ahmed for GAPIO Excellence in Diagnostics Award
  • Susovan Banerjee for GAPIO Excellence in Radiology/ Radiation Therapy Award
  • Bhavuk Garg for GAPIO Karl Storz Surgical Excellence Award.

Karl Storz provides an endoscope to the winner of the Storz Surgical Excellence Award.

Speakers at the well-attended event included

Dr. Sathyaki Nambala, India, senior consultant and chief of Cardiac Surgery, Apollo Hospital, Bangalore;

Dr. Jatin Shah, USA, professor of surgery at Cornell Medical College, New York;

Kiran Mazumdar Shaw, India, founder, chairperson and managing director of Biocon Limited;

Dr. Arun Garg, Canada, consultant medical biochemist at Royal Columbian Hospital, Canada and President of Canada India Network Society (CINS);

Dr. Sanjay Patole, Australia, senior neonatologist, KEM Hospital for Women in Perth, Western Australia;

Dr. Sandeep Guleria, India, senior consultant, Renal Transplant surgeon at Apollo Hospital, New Delhi;

Dr. OM Ganda, USA, senior physician and medical director, Lipid Clinic – Joslin Diabetes Center, and also associate professor of Medicine, Harvard Medical School;

Dr. Venkataraman Sundareswaran, USA, fellow – Mitsubishi Chemical Holdings Corporation at World Economic Forum;

Dr. Mani Menon, USA, robotic surgeon and one of the foremost Urologists in the United States; and

Dr. Senthil Seniyappan, UK, consultant paediatric endocrinologist, Alder Hey Children’s Hospital, Liverpool.

AAPI Recommits To Its Seven Pillars of Lifestyle Magic NObesity Revolution – Wear Yellow Campaign On World Obesity Day

Obesity has been identified as a leading cause for early death as it leads to hypertension, diabetes, hyperlipidemia, heart attacks, strokes, some kinds of cancer and adversely affecting almost all organs in the human body. Describing Obesity as a major disease, World Health Organization (WHO) has recognized that PREVENTION is the most feasible option for curbing the obesity epidemic. Parents, schools, communities, states and countries can help make the Healthy choice the Easy choice.

American Association of Physicians of Indian Origin (AAPI), the largest ethnic medical organization in the United States has been in the forefront for the past several years, spreading this message of healthy living.  Continuing with the goal of creating awareness by educating the public and healthcare professionals, AAPI has initiated several programs and campaigns, creating awareness on Obesity and ways to prevent it. As per World Health Organisation (WHO), since 1975, the rate of obesity has tripled. People from all ages and both developed and developing countries are affected by obesity.

“Today, March 4th is being observed across the world across as the World Obesity Day, AAPI, who has been a leader in Obesity campaign, urges and want to encourage practices among people that can help them in achieving and maintaining a healthy weight,” said Dr. Sudhakart Jonnalagadda, President of AAPI.  “I am grateful to the several AAPI leaders and the dozens of AAPI Chapters from across the nation for taking on this role of educating to empower, and for participating in and spreading this noble message, and creating awareness on the need for Living Well.”

Historically, AAPI has been observing January 7th, 2021 as the Global Wear Yellow Day for Obesity Awareness & Health, showcasing Yellow for Energy, Motivation, Hope, Optimism, Joy and Happiness. AAPI’s theme and campaign is: AAPI’s Workplace Wellness – BMI Day; focusing on the Seven Pillars of Lifestyle Magic NObesity Revolution – Wear Yellow.  I want to stress today that it is a conscious choice by every one of us to “Be Healthy, Be Happy.” And, the  “Secret to Living Longer is to Eat half, Walk double, Laugh triple and Love without measure.”

Major contributors for the success of AAPI’s obesity awareness campaign over the years include, Dr. Uma Koduri, who had organized the pilot programs for childhood obesity in USA since 2013, childhood obesity in India in 2015 and Veteran obesity in USA in 2017 with the help of Drs. Sanku Rao, Jayesh Shah, Aruna Venkatesh for childhood obesity, Vikas Khurana, Satheesh Kathula for Veteran obesity, and Janaki Srinath, Uma Chitra, Avanti Rao for childhood obesity in India.

Presently, AAPI Obesity Committee’s Chair is Dr. Uma Koduri and co-chairs are Drs. Padmaja Adusumili (Veteran obesity), Pooja Kinkabwala (Childhood obesity) and Uma Jonnalagadda (Adult obesity) with chief advisors Dr. Kishore Bellamkonda and Dr. Lokesh Edara.

“AAPI has embarked on an ambitious plan, launching Global Obesity Awareness Campaign 2021,” said Dr. Uma Koduri, Founder of NObesity Revolution, Chair of National AAPI Obesity Committee, and Founding President of AAPI Tulsa Chapter. According to Dr. Koduri, “AAPI began the *GO YELLOW* campaign on Jan 7th with the mission to educate the public on: *G – Get your BMI* (measure height, weight and calculate your BMI…ask google to calculate for you ���); and, *O*- *Own your Lifestyle.  It’s up to you. No one can do it for you*. Loose weight, exercise, eat healthy – whole food, plant predominant diet. *YELLOW – energy, motivation hope,  optimism, joy and happiness*.”

“I am proud to announce today that we have been successful in successful in making this a global a reality by 12-12-2020 by covering 100 cities in USA, 100 cities in India and 100 countries around the World, including on the 7th continent on Earth, the Antarctica,” Dr. Koduri, who has been in the forefront of the obesity awareness campaign for years now, explained. “What had started off in 2011 at 11-11-11-11-11-11 seconds as AAPI Health Walkathons were held in all 5 Continents – Australia, Asia, Africa, Europe and North America was successfully completed in 2020 by Obesity Walkathons by Dr. Suresh Reddy in the remaining 2 Continents – South America and Antarctica,” Dr. Koduri added.

 

“While following in the footsteps of American Heart Association initiatives, “National Wear Red Day, on the first Friday in February,” which has become an annual campaign to raise awareness about heart disease in women, AAPI is leading a campaign to create awareness on Obesity,” said Dr. Sajani Shah, Chairwoman of AAPI BOT.

Dr. Anupama Gotimukula, President-Elect of AAPI said, “With obesity proving to be a major epidemic affecting nearly one third of the nation’s population, we have a responsibility to save future generations by decreasing childhood obesity. And therefore, we at AAPI are proud to undertake this national educational tour around the United States, impacting thousands of children and their families.”

According to Dr. Ravi Kolli, Vice President of AAPI, “AAPI has it’s chapters in almost every city and town of USA. With this extensive network around the nation, we should be able to spread the message on obesity by following the template plan. We are also exploring the use of social media and phone ‘apps’ as healthy lifestyle tools.”

“As a professional organization that represents the interests of over 100,000 physicians of Indian origin, who are practicing Medicine in the United States, one of our primary goals is to educate the public on diseases and their impact on health. The Obesity campaign by AAPI is yet another major role we have been focusing on,” said Dr. Amit Chakrabarty, Secretary of AAPI.

Dr. Satheesh Kathula, Treasurer of AAPI, said, “AAPI has taken this initiative as a “main stream” issue in both children and adults, in the US and in India. AAPI has helped organize several childhood obesity and veterans obesity programs across the US. We have the right team to take this project forward. I urge all AAPI members, their families and the members of the larger society to make a commitment today to adapt the motto: Experience the Lifestyle Magic, making this Year 2021 and beyond to be Healthy and Prosperous For You and For Every One Around You.”

“The impact and role of AAPI in influencing policy makers and the public is ever more urgent today. AAPI being the largest ethnic medical organization in USA and the second largest organized medical association after AMA, we have the power and responsibility to influence the state and the public through education for health promotion and disease prevention. Hence AAPI is trying ‘To Educate to Empower’ as ‘An Ounce of Prevention is Worth a Pound of Cure.’ In this context, AAPI is in the process of getting Wear Yellow for Obesity Awareness Proclamation from the White House so it can be implemented nationwide. So far, we got official proclamations from   Mayors from several States,” he added.

AAPI is a forum to facilitate and enable Indian American Physicians to excel in patient care, teaching and research and to pursue their aspirations in professional and community affairs. For more details on AAPI’s Global Obesity Awareness Campaign,   please visit: www.aapiusa.org

CDC Says Fully Vaccinated People Can Gather Privately Without Masks

People who are fully vaccinated against the new coronavirus can gather privately in small groups without masks or physical distancing, the Centers for Disease Control and Prevention said, relaxing safety guidelines for inoculated individuals under some circumstances.

The CDC said Monday that fully vaccinated people should continue to take precautions in most circumstances to prevent the spread of the virus that causes Covid-19. People who are fully immunized should continue to wear masks and keep their distance from others in public or while visiting unvaccinated people at higher risk for severe cases of Covid-19, the CDC said. The agency said vaccinated people should continue to hold off on long trips by plane or train.

“Our guidance must balance the risk to people who have been fully vaccinated, the risks to those who have not yet received the vaccine, and the impact on the larger community transmission of Covid-19,” CDC Director Rochelle Walensky said at a media briefing.

The updated guidance comes as government officials, businesses and individuals try to map a path back toward normalcy, one year after the pandemic first shut down much public life and business as usual across the country. New cases, hospitalizations and deaths related to Covid-19 have fallen in recent weeks following a winter surge, and the effort to inoculate Americans against the virus is ramping up.

Here is the statement issued by CDC on March 8th:

This is the first set of public health recommendations for fully vaccinated people. This guidance will be updated and expanded based on the level of community spread of SARS-CoV-2, the proportion of the population that is fully vaccinated, and the rapidly evolving science on COVID-19 vaccines.

For the purposes of this guidance, people are considered fully vaccinated for COVID-19 ≥2 weeks after they have received the second dose in a 2-dose series (Pfizer-BioNTech or Moderna), or ≥2 weeks after they have received a single-dose vaccine (Johnson and Johnson [J&J]/Janssen ).

The following recommendations apply to non-healthcare settings.

Fully vaccinated people can:

  • Visit with other fully vaccinated people indoors without wearing masks or physical distancing
  • Visit with unvaccinated people from a single household who are at low risk for severe COVID-19 disease indoors without wearing masks or physical distancing
  • Refrain from quarantine and testing following a known exposure if asymptomatic

For now, fully vaccinated people should continue to:

  • Take precautions in public like wearing a well-fitted mask and physical distancing
  • Wear masks, practice physical distancing, and adhere to other prevention measures when visiting with unvaccinated people who are at increased risk for severe COVID-19disease or who have an unvaccinated household member who is at increased risk for severe COVID-19 disease
  • Wear masks, maintain physical distance, and practice other prevention measures when visiting with unvaccinated people from multiple households
  • Avoid medium- and large-sized in-person gatherings
  • Get tested if experiencing COVID-19 symptoms
  • Follow guidance issued by individual employers
  • Follow CDC and health department travel requirements and recommendations

Top American Pandemic Expert Lists 9 Govt Actions Behind Plummeting Covid Cases in India

There has been a global puzzlement at how India has managed to dramatically lower the spread of Covid-19 cases and fatality rates over the last few months, with some experts calling it a “mystery”, but American scientist Yaneer Bar-Yam has said credit should go to the government for being able to identify and leverage its strengths to limit the spread of the infection.

Bar-Yam, who specialises in quantitative analysis of pandemics, said underlying factors such as previous successful response efforts in pandemics, less urbanisation that limits travel and rates of community transmission, limited travel and localised tourism were all important in mitigating the impact of Covid-19.

But he pointed out that swift government action of “restricting/regulating movement to increasing public health capacity to meet the increasing demands of the pandemic,” were equally essential as India seems to have done enough to emerge successful in limiting the impact of the virus.

In September last year, India was confirming nearly 1 lakh cases a day, but that figure has dropped to approximately 12,000 as the country has effectively flattened the curve. The case fatality rate has also dropped sharply.

Highlighting steps taken by the government, Bar-Yam said that in particular decisions to impose severe restrictions on travel, stop gatherings, targeted localized lockdowns, school closures, had proven effective in controlling the outbreak. Other major steps like effective public communication, improvements in case identification, rapid ramping of industrial production of masks and other personal protective equipment (PPE) and testing capacity, have also contributed, he added.

Bar-Yam said that India’s success showed that time and travel are key to controlling pandemics. “The message to go out from India therefore is ‘restrict travel in areas wherein cases are there, isolate cases and don’t allow them to transmit infection’,” he wrote.

In a paper published on his website endcoronavirus.org, he listed the nine major government actions because of which India had managed to tame the infection as well as it has:

  1. He described the zoning of the country into three zones – red, orange and green – for localised lockdowns as probably the most effective step taken by the government last April. While severe restrictions were imposed in affected districts, there was partial lifting of restrictions in unaffected districts, along with the opening up of some sectors to meet the economic challenge.
  2. Restriction on travel was the second most important step, as travel was regulated through issue of e-pass with checks on state borders across the country. The regulation of travel continues into 2021 as travel has not been fully de-regulated, he said.
  3. Isolation and contact tracing of individuals who test positive to Covid-19, and quarantining of primary high-risk contacts has been an effective strategy.
  4. The government shut down all colleges and schools for an extended period, and the recent reopening has been partial and only in the context of the very low number of cases recently.
  5. Bar-Yam said highlighted the contribution of the Indian industry, which he said responded like never before by producing masks and personal protective equipment at great pace not only to meet the country’s requirements, but also to supply to the world.
  6. India has gone from a single lab that could perform RT-PCR tests for Covid-19 to over 2300 in a short span of time, and this number has reduced the test result return time and also strengthened isolation and quarantine strategy.
  7. From cautionary caller tunes on phones to heavy fines for not wearing masks, spreading public awareness about Covid-19 risks has been a major initiative of the government, and this has meant the population more willingly accepted restriction guidelines.
  8. The American scientist also praised the response in high-density urban areas, which posed the greatest challenge, but the refinement of lockdowns, travel restrictions, rapid case identification, and communication found in other locations, has helped limited the spread.
  9. He said that the vaccination drive, which is the largest in the world, is also expected to have an increasingly significant impact on the outbreak control in India.

Johnson & Johnson’s Covid-19 Vaccine Approved For Use

Centers for Disease Control and Prevention vaccine advisers voted Sunday, Feb 28th to recommend the Johnson & Johnson Covid-19 vaccine for the US. It is the first of the three authorized Covid-19 vaccines that comes in a single dose.

In a unanimous 22-0, a panel of advisers to the Food and Drug Administration recommended that the COVID-19 vaccine developed by Johnson & Johnson be authorized for emergency use in adults during the pandemic.

The vote in favor of the vaccine, which requires only one shot for protection, was taken to answer this question: Do the benefits of the Johnson & Johnson vaccine outweigh its risks for use in people 18 years of age and older. The FDA typically follows the advice of its expert advisers. If the agency agrees, the Johnson & Johnson vaccine would be the third one cleared for use in the U.S.

A quick decision is expected given the state of the pandemic. The FDA authorized the Pfizer-BioNTech and Moderna COVID-19 vaccines one day after the same panel recommended them for clearance during separate meetings last December.

Two weeks ago, Dr. Mathai Mammen, Janssen’s global head of research and development, said if the vaccine is authorized for emergency use, “Our plan is to have supply immediately upon launch.” Even those who got moderate cases of Covid-19 in the trial tended to develop a milder course and fewer symptoms, said Dr. Mathai Mammen. From one month after the shot, all hospitalizations and deaths occurred in the placebo group.

The Johnson & Johnson vaccine was tested in an international study of about 40,000 people, half of whom got the vaccine and half of whom got a placebo. The study found the company’s vaccine to be 66% effective overall in preventing moderate to severe COVID-19 disease. For disease judged severe or critical, the effectiveness was 85%. The study was conducted in the U.S., South America and South Africa.

The main study included in the company’s application found that 28 days or more after immunization, the Johnson & Johnson vaccine prevented hospitalizations and death related to COVID-19.  The overall efficacy figures are lower than Pfizer’s 95% for preventing COVID-19 disease and 94% for Moderna.

As the pandemic has drawn on, the coronavirus has mutated. Variants first seen in South Africa and Brazil, where the Johnson & Johnson vaccine was tested, mutated in ways that help them evade the immune response prompted by vaccines developed against the original form of the virus.

The vaccine was tested in more than 44,000 people in the US, South Africa and Latin America. Globally, it was 66.1% effective against moderate to severe/critical Covid-19 at least four weeks after vaccination, according to an FDA analysis. In the US, it is considered 72% effective, and offered 86% protection against severe forms of the disease.

Among more than 6,000 study participants who were queried within a week of vaccination, the most common side effects were pain at the site of injection (49%), headache (39%), fatigue (38%) and muscle pain (33%). These side effects were mostly mild or moderate.

The authorization of Johnson & Johnson’s vaccine would help expand the supply of COVID-19 shots. The company said 4 million doses of vaccine would be available in the U.S. as soon as the FDA gives its OK. A total of 20 million doses would be ready by the end of March, and Johnson & Johnson has committed to deliver 100 million doses under its contract with the federal government by the end of June.

The CDC’s Advisory Committee on Immunization Practices is a group of vaccine and public health experts that helps set guidelines for the CDC concerning the best practices with vaccinations. Members voted unanimously, with one recusal for a potential conflict of interest, to recommend the vaccine. They did not make any recommendations about specific groups who should receive the vaccine.

“I just want to state explicitly how very grateful I am that we now have three highly effective vaccines,” said ACIP member Dr. Matthew Daley of the Institute for Health Research with Kaiser Permanente Colorado.

The vaccine, made by Johnson & Johnson’s Janssen vaccine arm, can be kept at regular refrigerator temperatures, which experts said would make it much easier to distribute than vaccines made by Moderna and Pfizer/BioNTech.

“During a pandemic, the data show that the best utilization of resources is to employ all available vaccines with acceptable vaccine efficacy. This will save cost and lives,” the CDC’s Dr. Sara Oliver told the ACIP meeting. A single-dose vaccine has an advantage, particularly in settings where a second dose “would be challenging.” For example, it could be used to help protect the homeless, people in the justice system, and those with limited access to health care like people who are homebound or live in rural areas, Oliver said.

Overall, non-fatal serious adverse events were infrequent, according to the FDA’s analysis, and there were no reported cases of anaphylaxis following vaccination in the trial. There have been a small number of severe allergic reactions with the Moderna and Pfizer/BioNTech vaccines. For example, in the first week of the Pfizer vaccine rollout, there were only 29 cases out of 1.9 million doses administered, according to the CDC. More research is needed to now for sure, but the FDA analysis also hinted that the J&J vaccine may help prevent asymptomatic infections.

“These are three highly efficacious vaccines,” said Dr. Anthony Fauci, the director of the National Institute of Allergy and Infectious Diseases. “I can tell you I have been fully vaccinated with one that was available. It was the Moderna. If I were not vaccinated now and I had a choice of getting a J&J vaccine now or waiting for another vaccine, I would take whatever vaccine would be available to me as quickly as possible.”

“We want to get as many people vaccinated as quickly and expeditiously as possible,” Fauci said Sunday on CNN’s State of the Union. “So this is good news because we have another very good vaccine in the mix.”

The US has ordered 100 million doses and the company has been manufacturing it while it has been testing the vaccine. Typically, companies wait to make the vaccine after its been approved, but that changed during the pandemic.  Johnson & Johnson says it can meet its 100 million dose commitment by June.

What It Will Take to Get Life Back to Normal

At last, Covid vaccine shots are going into arms in significant numbers, but too many people could still fall through the cracks. Vaccines have brought the United States tantalizingly close to crushing the coronavirus within its borders. After months of hiccups, some 1.4 million people are now being vaccinated every day, and many more shots are coming through the pipeline. The Food and Drug Administration has just authorized a third vaccine — a single-dose shot made by Johnson & Johnson — while Pfizer and Moderna are promising to greatly expand the supply of their shots, to roughly 100 million total doses per month, by early spring.

If those vaccines make their way into arms quickly, the nation could be on its way to a relatively pleasant summer and something approaching normal by autumn. Imagine schools running at full capacity in September and families gathering for Thanksgiving.

But turning that “if” into a “when” will require clearing additional hurdles so that everyone who needs to be vaccinated gets vaccinated. This is especially true for racial minorities, who are being disproportionately missed by the vaccination effort.

There’s plenty of disagreement among experts as to why America is still having problems with vaccine uptake. Some officials have suggested that the main cause is that too many people are hesitant to get the vaccine. Others point the finger at overcautious public health officials who they say have undersold the promise of the vaccines. Still others point to long lines at clinics as proof that far more people want the vaccine than can actually get it.

There is probably some truth to all of these hypotheses, and the underlying problems are not new. Vaccine hesitancy had been growing steadily in America long before the current pandemic, so much so that in 2019 the World Health Organization ranked it as one of the leading global health threats. At the same time, poor health care access and other logistical constraints, such as a lack of public transportation and limited internet access, have long impeded public health efforts in low-income communities.

To maximize the number of Americans getting vaccinations, policymakers need to tackle each of these crises with greater urgency than they have so far.

As supply increases, health officials should mount ambitious vaccination campaigns modeled on ones that have worked to curb diseases in other countries. That will mean not relying solely on web portals for scheduling vaccine appointments. It will mean going block by block and door to door, through high-risk communities especially. It will mean setting up employee vaccination sites at schools, grocery stores, transit hubs and meatpacking plants, and community clinics at houses of worship, with local leaders promoting and running them.

“The easier you can make it for people to get vaccinated, the more likely your program will be to succeed,” said Dr. Walter Orenstein, a former director of the national immunization program at the Centers for Disease Control and Prevention. “It’s really that simple.”

Outreach efforts cost money. But they’re far less expensive than allowing the pandemic to fester. Congress has appropriated some money to help states with vaccine rollout. It should offer more, and states should put as much of those resources as possible toward vaccination efforts that meet people where they are.

Health officials should also recognize that vaccine hesitancy has many root causes — deliberate disinformation campaigns, mistrust of medical authorities in marginalized communities, ill-considered messaging by health officials. The best way to counter that is with campaigns that are locally led, that clearly outline the benefits of vaccination and that frame getting the shot as not just a personal choice but a collective responsibility.

Doctors and scientists can help those pro-vaccine messages stick by minding their own public communications. It’s crucial to be transparent about what vaccines will and won’t do for society — overselling now will only sow more mistrust later.

That said, underselling is its own problem. It’s true that these vaccines will not immediately restore the world to total normalcy. But they will eventually allow people to hug their loved ones, to return to their offices — and to be protected from dying from or becoming seriously ill with Covid-19. Health officials should be clear about that.

Policymakers at the highest levels of government should press social media companies and e-commerce sites to curb the most aggressive purveyors of vaccine disinformation.

To not only quell this pandemic but to try to prevent the next one, America will need to improve its health system and its public health apparatus, both of which have significant holes. “The problem with a lot of the response is that it was predicated on the idea that we have a good system in place for doing adult immunizations across the country,” said Dr. Peter Hotez, a vaccine expert at Baylor College of Medicine. “The fact is, we really don’t.”

In the end, lawmakers and the people who vote them into office will have to address the much broader problems that this pandemic has exposed.

 

GOPIO Manhattan Chapter Educates the Public On Covid 19 and The Vaccines

The COVID-19 pandemic has led to a dramatic loss of human life worldwide and presents an unprecedented challenge to public health, food systems and the world of work. The economic and social disruption caused by the pandemic is devastating. Coronavirus has affected day to day life and is slowing down the global economy. It has rapidly affected our day to day life, businesses, disrupted the world trade and movements. The distribution and administration of Covid vaccine in the United States and around the e3ortld have given us hope, but there are several unanswered questions and skepticism about the efficacy of the vaccines. 
Second in a series of webinars, a timely discussion organized virtually by Global Organization of Persons of Indian Origin (GOPIO) Manhattan Chapter in collaboration with the Indian Consulate in New York on Friday, February 26th provided answers to these most important questions.
Attended by people from around the globe, the webinar led by Hana Akselrod, MD, MPH attempted to answer questions raised by laymen on the pandemic, how it spreads and ways to prevent and mitigate the spread. Currently an Assistant Professor of Medicine in the Division of Infectious Diseases at the George Washington University School of Medicine and Health Sciences, Dr. Akselrod has been active in medical education, serving as a faculty mentor in the Quality Improvement and the Clinical Public Health curriculum programs, conducting research on HIV and aging as part of the DC Center for AIDS Research (CFAR) and DC Cohort Longitudinal HIV study. During an hour long presentation, she provided an overview of the epidemic and the efficacy of the vaccines in common man’s language.
In his opening remarks, Consul General of India in New York, Randhir Jaiswal congratulated GOPIO for organizing the much needed webinar on Covid 19 and for educating the community on such a timely and vital topic with a thoughtful session by experts in healthcare field. While acknowledging the challenges faced by humanity due to COVID, Ambassador expressed hope and said, “There is optimism in the New Year and we hope to put this pandemic away.” Ambassador lavished praises on GOPIO and its leadership for the many initiatives. “GOPIO has helped NRIs in several ways, facilitating travel, organizing prescription medicine and providing living accommodation to many stranded due to Covid. I am appreciative and thank GOPIO for their constant efforts to be on the forefront.” 
Ambassador Randhir Jaiswal referred to India’s massive undertaking under the leadership of Prime Minister Narendra Modi, India has undertaken, what is likely to be the world’s largest Covid-19 vaccination campaign, joining the ranks of wealthier nations where the effort is already underway. India has plans to vaccinate 300 million people, roughly the population of the United States. Praising the two India-based pharmaceutical companies for manufacturing the vaccines in record time, Mr. Jaiswal said, “We are sharing our vaccines with other countries who need. It gives us pride that we can share our scientific knowledge with the world.” While acknowledging that the mutations are posing additional threats, he assured, “We are pushing the pandemic away in India and around the world.”
Dr. Asha Samant, in her opening remarks, described the current period experienced by humanity due to COVID as “a dark period in human history.”  Dr. Arnab Ghosh, a physician in Memorial Sloan Kettering (MSK) specializing in adult Bone Marrow Transplantation, moderated the lively session. “While admitting that “we do not have answers to many questions to Covid that has changed our lives in all possible ways,” he said, “Where to find vaccines? GOPIO is seeking to find answers.” 
Dr. Thomas Abraham, Chairman if GOPIO-International shared greetings to the Manhattan Chapter leaders and panelists from GOPIO International. “India has done a great deal of service to the world by being a leader in supplying vaccines to as many as 33 nations around the world. Referring to how the pandemic has impacted human lives for over a year now, Dr. Abraham pointed to how the City of New York was among the worst hit and that life is returning to near normal, especially with strict guidelines and the arrival of the vaccines. 
In her opening remarks, Dr. Hana Akselrod shared with the audience about her upbringing as an immigrant to the US from Russia and how she overcame the hurdles and has been able to achieve the dreams and aspirations of her immigrant parents.  She shared about the proximity of the George Washington University where she teaches and researches on epidemiogy, to the divers population and the centers of power in Washington, DC.  “We at George Washington University have successful initiated several programs befitting the local community, using the golden standard of community services,” she said.  
While acknowledging that the US is responsible for a high percentage of mortality, she stated, it may be due to the fact that many nations do not test and some are not transparent in reporting the actual cases of the virus. “The Covid virus is under reported in several nations, including in the US. We have one of the highest mortality rates in the world.” Expressing hope that, especially with the holiday season behind us, and that many states who were resistant to preventing measures have caught up now, and have contributed to the reduction of cases with the virus, she said. 
How do we get out of this? She suggested that everyone follows the common preventable methods recommended by CDC, including hand hygiene, masking, social distance, ventilating, and being prepared to stake a step back. “Vaccination will give herd immunity, if 60 percent of the population is immunized,” she said. However, if the efficacy of the vaccine is less than 100 percent, more people need to be vaccinated to achieve herd immunity.
Transmission is far from safe levels, she said. Until we have a population that is immune and has herd immunity, it is a challenge to contain it. “We have extensive studies on the spread and prevention of Covid,” she said. “Preventive measures are important. Vaccination is likely to make us achieve herd immunity.” 
 “Now, we are more concerned about the variants, which have not impacted much as of now. Low income, lack of education and lack of access to medical care are some of the cause of disparity in Covid infection and mortality rates,” she explained. 
How does the virus spread? Dr. Hana Akselrod said, COVID-19 is thought to spread mainly through close contact from person to person, including between people who are physically near each other (within about 6 feet). People who are infected but do not show symptoms can also spread the virus to others. Pathogens that are spread easily through airborne transmission require the use of special engineering controls to prevent infections.
She explained on how the virus spreads thorough the Spike protein. Multiple SARS-CoV-2 variants are circulating globally, she said. Several new variants emerged in the fall of 2020, most notably:
In the United Kingdom (UK), a new variant strain of SARS-CoV-2 (known as 20B/501Y.V1, VOC 202012/01, or B.1.1.7 lineage) emerged with an unusually large number of mutations. This variant has since been detected in numerous countries around the world, including the United States (US) and Canada.
To understand how COVID-19 vaccines work, it helps to first look at how our bodies fight illness, Dr. Hana Akselrod pointed out. “When germs, such as the virus that causes COVID-19, invade our bodies, they attack and multiply. This invasion, called an infection, is what causes illness. Virus can affect all parts of the body. Inflammation, heart disease and lungs mostly impacted. Inflammatory damage process that may cause blood clots. 
While assuring the audience that COVID-19 vaccines can help our bodies develop immunity to the virus that causes COVID-19 without us having to get the illness, she said, “Different types of vaccines work in different ways to offer protection, but with all types of vaccines, the body is left with a supply of “memory” T-lymphocytes as well as B-lymphocytes that will remember how to fight that virus in the future.” To a question on which is the best of the three vaccines available in the US, she said, “The best vaccine is the one that is available to you now.” 
Exploding how each vaccine works and helps gain immunity, on the reactions to Vaccine, Dr. Hana Akselrod said, “Mostly they have found to be safer with minor side effects with some larger effects, most of which are not life threatening. CDC has an app to report the reactions to vaccine,” she added. 
While admitting that there are many who are skeptical about the vaccines, not only among the scientific community and among the general public, she stressed the need for effective communication and educating the public. While prominent and scientific leaders have taken on the role, she emphasized the need for education by individual physicians and healthcare workers, who can play a critical role in educating the efficacy of the vaccines. To another question, she said, “Vaccines are not causing infertility among women. There is no proof to it,” she added.  
Mr. Shivender Sofat, GOIO Manhattan President thanked the panelists and participants to the timely and very important discussion on COVID and vaccination. In accordance with the mission, the Manhattan Chapter has taken several initiatives in the recent past. He referred to the Community Feeding every month organized by the Chapter. He urged the community to support the initiative by being a volunteer and or a sponsor.

When Will The Vaccine Be Available To Children In US?

Children in high school — roughly ages 14-18 in the United States — should be able to get the vaccine “sometime this fall,” Fauci told NBC’s “Meet the Press” on Sunday last week. The mass vaccination of school-age children will allow millions of children to return sooner to in-person learning and ease the burden on millions of parents now caring for their offspring at home.

The United States could start vaccinating older children against Covid-19 by the fall and younger ones by year-end or early 2022, the White House’s top pandemic advisor Anthony Fauci said Sunday.

The mass vaccination of school-age children will allow millions of children to return sooner to in-person learning and ease the burden on millions of parents now caring for their offspring at home.

School reopenings, an intensely debated matter, have varied sharply across the country, with some private and religious schools opening before public schools and teachers in some areas protesting any early return.

But the decision Saturday by the US Food and Drug Administration to grant emergency use authorization to a new single-dose vaccine from Johnson & Johnson has boosted the prospects for earlier reopenings. “We now have three really efficacious vaccines,” Fauci said on ABC’s “This Week.”

With vaccines becoming available t​o protect against COVID-19, we’ve made a big step toward slowing down  the virus that causes this deadly disease. The first vaccines released are authorized for use in adults and teens who are at least 16 years old. High-risk groups such as frontline workers and elderly people are first in line to receive the vaccines, with other adults and teens likely to have access later this spring.

Research shows these new vaccines to be remarkably effective and safe. The American Academy of Pediatrics urges teens and adults to get the COVID-19 vaccine as soon as it is available to them.

Before COVID-19 vaccines become available for younger teens and children, clinical trials need to be completed. This is to ensure they are safe and effective for these age groups. Children are not little adults; we can’t just assume a vaccine will have the same effect on a child as it does for someone older.

While there are current studies that include children as young as 12 years of age, it is critical that children of all ages be included in more trials as quickly as possible.

The COVID-19 pandemic continues to take a terrible toll on children’s lives. We need more data on vaccines for children so they can be protected from this virus and the pandemic can be controlled. Once this information is available, the AAP will review it and make vaccine recommendations for children and adolescents.

For now, none of the three authorized vaccines in the US (also including Pfizer/BioNTech and Moderna) has been cleared for children under 16, but trials on children are under way.

A New Phase for Eye Foundation of America, Founded By Dr. V K Raju

Renowned ophthalmologist and president and founder of the Eye Foundation of America, Dr. VK Raju’s crusade for the past four decades has been to achieve his vision of a world without avoidable blindness. In 1977, he began traveling home to India to offer his services as an ophthalmologist to those who could not afford, or access, desperately needed eye care. The Eye Foundation of America founded by an Indian-American physician, is entering a new phase in its mission of ending avoidable blindness by collaborating with GAPIO (Global Association of Physicians of Indian Origin) and AAPI (American Association of Physicians of India Origin). These preventive services and medical and surgical interventions were delivered in the form of eye camps in the early days, and the EFA was initially founded to allow for easier transfer of state-of-the-art equipment and medicine from the United States to India. As the Foundation matured, it became so much more. The EFA is now a global organization responsible for treating millions of patients, performing hundreds of thousands of surgeries, and training hundreds of eye care professionals to join in the global fight against preventable blindness. The EFA’s work spans 30 countries over several continents. One focus of current outreach efforts is in the prevention of diabetes. Diabetes-related complications typically strike during the prime of life and include the development of cataracts at an earlier age than normal, a two-fold increased risk of glaucoma, and small blood vessel damage (i.e., diabetic retinopathy). Retinopathy can cause blindness; however, early detection and treatment can prevent blindness in up to 90% of cases. The International Diabetes Foundation estimates that 20% of the diabetic world population resides in India, approximately 61.3 million diabetics. In 2018, 34.2 million Americans had diabetes. There are 229,000 people with diabetes in West Virginia and 8.3% of adults are borderline diabetic. West Virginia is ranked the #2 state for deaths involving diabetes. According to Dr. Raju, the prevalence of diabetes among Indians in India and West Virginians in the United States continues to rise rapidly, and in many ways, the diabetes epidemic in West Virginia is similar to that of India, as the populations share similar characteristics: they tend to be rural, poor, and underserved. Born in Rajahmundry, Andhra Pradesh, Raju earned his medical degree from Andhra University and completed an ophthalmology residency and fellowship at the Royal Eye Group of Hospitals in London. The Indian American physician is board certified in ophthalmology, and is a Fellow of the Royal College of Surgeons and the American College of Surgeons. He moved to the United States in 1976 and has since resided in Morgantown, West As Dr. Raju points out, prevention is more beneficial than disease management, and lifestyle changes can be preventive. His organization’s programs, which aim at prevention through education and lifestyle modifications, include the 100,000 Lives campaign in India and the WV Kids Farmer’s Market Program in West Virginia. A child in India undergoes vision screening Project in Aragonda, Andhra Pradesh. Photo courtesy Eye Foundation of America The goal in India is to reach at least 100,000 rural diabetic Indians suffering with or at risk of diabetic retinopathy, where it is believed that 51% of diabetics are undiagnosed due to lack of access to medical care. The World Health Organization (WHO) estimates that one child goes blind every minute and that 1.4 million children are blind worldwide. Many blind children reside in rural areas and live in poverty, thus restricting their access to preventative services and medical care. The prevalence of blindness is 10 times greater in India than in the U.S. and many cases of pediatric blindness can be prevented, Dr. Raju contends. However, 70–80% of children do not have access to an ophthalmologist. In an effort to provide affordable and accessible eye care, the EFA has helped to build the Goutami Eye Institute, which has a wing dedicated exclusively to children, and has launched an initiative to screen newborns for retinopathy of prematurity (ROP). Approximately 3.5 million infants are born premature in India each year. The incidence of ROP is increasing in India due to improved neonatal survival, and ROP is the leading cause of infant blindness. The Goutami Eye Institute has screened more than 8,000 babies and treated over 600.

Roivant Grows Computational Drug Discovery Engine with Acquisition of Silicon Therapeutics

Roivant Sciences today announced it has entered into a definitive agreement to acquire Silicon Therapeutics for $450 million in Roivant equity, with additional potential regulatory and commercial milestone payments.

Silicon Therapeutics has built a proprietary industry-leading computational physics platform for the in silico design and optimization of small molecule drugs for challenging disease targets. The platform includes custom methods based on quantum mechanics, molecular dynamics and statistical thermodynamics to overcome critical bottlenecks in drug discovery projects, such as predicting binding energies and conformational behavior of molecules.

Silicon Therapeutics’ computational platform is powered by a proprietary supercomputing cluster and custom hardware enabling accurate all-atom simulations at biologically meaningful timescales. This computational platform is tightly integrated with experimental laboratories equipped for biophysics, medical chemistry and biology in order to facilitate the rapid progression of drug candidates by augmenting simulations with biophysical data. The company has used these capabilities to discover multiple drug candidates.

The acquisition of Silicon Therapeutics bolsters and complements Roivant’s targeted protein degradation platform. That platform will be powered by VantAI’s advanced machine learning models trained on proprietary degrader-specific experimental data and by Silicon Therapeutics’ proprietary computational physics capabilities, which help address many of the modality-specific challenges of degrader design and optimization. Integrating Silicon Therapeutics and VantAI will enable Roivant to distinctively capture the power of both computational physics and machine learning-based approaches to drug design; for instance, by incorporating proprietary computational physics simulations as training data for VantAI’s degrader-specific deep learning models.

The combination of Silicon Therapeutics and VantAI also gives Roivant distinctive advantages in designing other types of novel small molecule drugs against difficult targets, such as allosteric inhibitors, molecular glues and high-affinity ligands. Silicon Therapeutics’ drug discovery efforts are led by Drs. Woody Sherman, Huafeng Xu and Chris Winter, who will join Roivant’s drug discovery leadership.

Dr. Sherman is a recognized leader in computational chemistry and biomolecular simulations who spent 12 years as a senior scientific executive at Schrödinger, where he served as vice president and global head of applications science. Dr. Sherman is an authority in the emerging field of physics-driven drug design who has developed novel methods for free energy simulations, conformational modulation, virtual screening, improved force fields, lead optimization and precision selectivity design.

Dr. Xu is a pioneer in novel molecular dynamics methods who spent 12 years at D. E. Shaw Research where he led development of the methods and software for free energy calculations that are now widely used in the pharmaceutical industry, including the Anton chip and Desmond software.

Dr. Winter is an accomplished drug discovery biologist who has delivered 11 targeted cancer therapies into clinical development. Before joining Silicon Therapeutics, Dr. Winter served as Sanofi Oncology’s head of discovery biology. He joined Sanofi from Blueprint Medicines, where he served as head of biology. Prior to Blueprint, Dr. Winter held senior research positions at Merck Research Laboratories and Exelixis.

“We are delighted to integrate Silicon Therapeutics into Roivant as we continue to expand our capabilities in computationally-powered drug discovery,” said Matt Gline, chief executive officer of Roivant Sciences. “We intend to leverage our established development apparatus as we rapidly advance promising compounds from our drug discovery engine into clinical studies.”

“Silicon Therapeutics was founded with a vision of transforming the pharmaceutical industry through use of technology,” said Lanny Sun, co-founder and chief executive officer of Silicon Therapeutics. “By joining forces with Roivant, we can significantly accelerate making this vision a reality. Roivant has an impressive track record in clinical execution and building and deploying technology platforms to power pharmaceutical research, development and commercialization.”

“The combination of Silicon Therapeutics’ integrated approach, platform and highly capable team with Roivant’s technologies and commitment to transforming the pharmaceutical industry represents a new and exciting paradigm in drug discovery and development,” said Roger Pomerantz, M.D., F.A.C.P., chairman of the board of directors of Silicon Therapeutics.
The acquisition is subject to customary closing conditions including receipt of requisite regulatory approvals.

Roivant’s mission is to improve the delivery of healthcare to patients by treating every inefficiency as an opportunity. Roivant develops transformative medicines faster by building technologies and developing talent in creative ways, leveraging the Roivant platform to launch Vants – nimble and focused biopharmaceutical and health technology companies.

Another Sad Milestone For US, As Covid Claims 500,000 Lives

After a year that has darkened doorways across the U.S., the pandemic surpassed a milestone Monday that once seemed unimaginable, a stark confirmation of the virus’s reach into all corners of the country and communities of every size and makeup.

The United States has recorded its unfathomable 500,000th death from Covid-19 paradoxically at a moment of rare hope in the pandemic. Yet the tragic landmark has occurred even as the United States makes all efforts under the Biden-Harris administration to stop the spread and prevention of Covid pandemic across the nation.

 

The toll, accounting for 1 in 5 deaths reported worldwide, has far exceeded early projections, which assumed that federal and state governments would marshal a comprehensive and sustained response and individual Americans would heed warnings.

The symbolic power of the half a million figure emphasizes the horror of the nightmare that seized the country a year ago. On February 23, 2020, ex-President Donald Trump crowed that “we have it very much under control” and “we’ve had no deaths,” revealing his unpreparedness for the disaster that was about to unfold on his watch.

 

In a contrast to the former President, who rarely shouldered the nation’s collective grief, President Joe Biden and first lady Jill Biden plan to mark the 500,000th American death from Covid-19 with a candle-lighting ceremony at the White House Monday that will include Vice President Kamala Harris and her husband Doug Emhoff.

 

The crisis swept away one President — who didn’t sufficiently prioritize the health of his nation over his own political prospects — and is now testing another, who is vowing this week to be “laser focused” on a $1.9 trillion Covid relief package designed to hasten the end of the pandemic and to ease its awful economic consequences.

 

A warning from Dr. Anthony Fauci on CNN Sunday that Americans could be wearing masks into 2022 came as leading medical associations pleaded for extended vigilance from people exhausted by months of self-isolating and the punishing economic impact of the worst public health calamity in 100 years. But the national dichotomy between fear and hope was exemplified by an announcement that more vaccines than ever are being sent to states and a fast ebbing of new cases of the novel coronavirus across most of the country.

 

“It’s terrible, it’s really horrible,” Fauci, the government’s top infectious diseases specialist, told CNN’s Dana Bash on “State of the Union.” “People decades from now are going to be talking about this as a terribly historic milestone in the history of this country, to have these many people to have died from a respiratory-borne infection,” Fauci said.

Reasons for hope amid fresh warning signs

“It’s very hard for me to imagine an American who doesn’t know someone who has died or have a family member who has died,” said Ali Mokdad, a professor of health metrics at the University of Washington in Seattle. “We haven’t really fully understood how bad it is, how devastating it is, for all of us.”

Experts warn that about 90,000 more deaths are likely in the next few months, despite a massive campaign to vaccinate people. Meanwhile, the nation’s trauma continues to accrue in a way unparalleled in recent American life, said Donna Schuurman of the Dougy Center for Grieving Children & Families in Portland, Oregon.

 

Perhaps more than at any previous moment of the current crisis, there are reasons for optimism that even if normality is months away, the hopelessness of the darkest winter in modern American history may be lifting.

 

New Covid-19 cases are falling sharply across the country, amazingly down by a quarter week-on-week. Deaths, a lagging indicator, are also beginning to ease. The vaccine effort is cranking up and is likely to overcome a slowdown caused by a blitz of winter weather by the middle of the week. More than 63 million vaccine doses have been administered and Biden says there will be enough shots available for every American by the end of July. More studies suggest that the Moderna and Pfizer vaccines authorized in the US may also prevent infection and not just symptomatic disease, a key factor in ending the pandemic. The arrival of spring in a few weeks, and warmer weather that makes it harder for the virus to spread, may bring more than the usual sense of renewal this year.

Still, there are many reasons to be cautious. The arrival in the US of viral variants from the UK and South Africa underscores how the country is in a race against time to vaccinate before the virus mutates further. New US Centers for Disease Control and Prevention data on Sunday showed 1,700 cases in the US of the fast-spreading variants, which experts fear could dominate home-grown infections within weeks. And the struggle to open schools after some kids have been stuck in nearly a year of online learning is a lesson in just how difficult it will be to get the economy and the country fully and safely open again.

 

The uncertainty was one reason why Fauci said that it was “possible” mask wearing might still be necessary into 2022, depending on the level of virus that remains in the community over the next year or so. “When it goes way down, and the overwhelming majority of the people in the population are vaccinated, then I would feel comfortable in saying, we need to pull back on the masks, we don’t need to have masks,” Fauci said.

AAPI’s Global Healthcare Summit 2021 To Be Held in Vaizag, Andhra Pradesh

The 14th annual Global Healthcare Summit (GHS) 2021, organized by the Association of American Physicians of Indian Origin (AAPI) in collaboration with the Indian Ministry of Health and Family Welfare, will be held at the prestigious Novotel, Visakhapatnam, India from April 30th to May 3rd, 2021.

 

The groundbreaking Summit from April 30th to May 3rd, 2021 will discuss ways to bring the most innovative, efficient and cost effective healthcare solutions for India.

 

“Harnessing the power of Indian doctors worldwide, the AAPI Global Healthcare Summit platform has evolved with the support of prominent global and Indian medical associations,” says Dr. Sudhakar Jonnalgadda, President of AAPI. In addition, several international healthcare industry partners are looking for opportunities to participate at this event for greater collaboration on Research & Development and philanthropic engagements, he adds.

 

According to him, “Senior leaders from leading healthcare organizations such as pharmaceuticals, device and medical equipment manufacturers and major medical teaching institutions, hospitals and from the Ministries – Health, External/Overseas Affairs and regulatory bodies are collaborating with AAPI with the ultimate goal to provide access to high quality and affordable healthcare to all people of India.”

 

While elaborating on the themes and areas that are going to be covered during the Summit, Dr. Sajani Shah, Chair of AAPI BOT, says, “In our efforts to realize the core mission of AAPI, which is to share the best from leading experts from around the world, to collaborate on clinical challenges, research and development, philanthropy, policy and standards formulation, the Summit in Visakhapatnam will have clinical tracks that are of vital to healthcare in India.”

 

Chronic diseases, notably diabetes, cardiovascular, hypertension, COPD, oncology, maternal and infant mortality, and emerging ones – trauma and head injury, transplant and minimally invasive robotic surgeries are only some of those that are going to be covered during this Summit. An exclusive Healthcare CEO forum brings the healthcare industry perspective, with senior Government officials, both Union and State providing the legislative wisdom. Hands-on workshops provide supervised skill transfer.

 

Dr. Prasad Chalasani, Chair of AAPI GHS USA 2021 says, “With over 200 physicians from the United States, the Summit is expected to be attended by nearly 1,000 delegates from around the world. AAPI Global Healthcare Summit (GHS) will have many new initiatives and also will be carrying the torch of ongoing projects undertaken by AAPI’s past leaders.”

 

Dr. Ravi Raju, Chair of GHS India, “Healthcare in India is one of the largest sectors, in terms of revenue and employment.  India is making significant improvements in the healthcare infrastructure and is building modern medical facilities throughout India. Indian doctors have made tremendous progress in the 21st century and India is now being touted as a medical tourism hub”

 

While elaborating the objectives of the Summit, Dr. Anupama Gotimukula, President-Elect of AAPI, says, “This innovative Summit is aimed at advancing the accessibility, affordability and the quality of world-class healthcare to the people of India. Among other areas, the Summit will focus on prevention, diagnosis, treatment options and share ways to truly improve healthcare transcending global boundaries.”

 

According to Dr. Ravi Kolli, Vice President of AAPI, “This international health care summit is a progressive transformation from the first Indo-US Healthcare Summit launched by AAPI USA in 2007. Since then, AAPI has organized 13 Indo – US/Global Healthcare Summits and developed strategic alliances with various organizations.”

 

Dr. Amit Chakrabarty, Secretary of AAPI, says, “It is these learning and relationships that have now enabled AAPI and participating organizations to plan ahead and prepare for an outstanding event that is expected to have over 300 very prominent and talented physicians and surgeons of Indian origin from around the world and are very passionate about serving their homeland, Mother India.”

 

Dr. Satheesh Kathula, Treasurer of AAPI, says, “With the changing trends and statistics in healthcare, both in India and US, we are refocusing our mission and vision, AAPI would like to make a positive and meaningful impact on the healthcare delivery system both in the US and in India,”

 

“Being organized at this critical phase, GHS 2021 is aimed at exploring possibilities for greater collaboration and cooperation between the physicians and health care providers in India with those of Indian origin and major health-care providers abroad,” Dr. Jonnalagadda said. For more information, please visit www.aapiusa.org 

 

Dr. Amit Chakrabarty And Colleagues Volunteer In Odisha Pandemic Relief Efforts

“There are very few Doctors from the state of Odisha in the United States,” says Dr. Amit Chakrabarty, Secretary of American Association of Physicians of Indian Origin (AAPI), the largest ethnic medical association in the US. “I am one of the very few physicians from my home state, who are active and members of Odisha Doctors International Association (ODIA) and working towards expanding ODIA with members from across the globe. As the Treasurer of Odisha Society of Americas Health and Wellness Group, I am honored to work collaboratively with other members for the cohesive work the organization has been doing during the pandemic, while representing the great and historical state of Odisha at the national AAPI leadership”

 

Among the several initiatives, Dr. Chakrabarty and his colleagues in the US from the state of Odisha have initiated and established a new organization, Doctors of ODIA collaborating with local organizations and to provide healthcare to Odisha people, as pandemic impacts their livelihood.

 

Dr. Chakrabarty, the multi-talented, generous and hardworking leader of AAPI says, “With a deep sense of commitment to serve the people of Odisha, we have, under the leadership of Dr. Debashis Ray of Georgia, now expanded our organization to international standards with participation of 37 countries.”

 

Lamenting that Odisha has always been “under-represented and underserved and relatively a poor state in India with regards to medical collaborations in this country,” Dr. Chakrabarty says, “We are a small group of dedicated people who want to make a difference for our home state. For this reason I have put my heart and soul to make our state Medical Organization a great Resource to help our home state.”

 

The group of Doctors at Odisha Doctors International Association recently organized an international webinar on February 6th for the general public benefitting the local population in the state of Odisha to educate and answer the questions on Covid and vaccines. “I believe, we can make a huge difference by providing the people of Odisha necessary services and supplies hat will go a long way in the upliftment of the health status of the people of the state of Odisha.”

 

“The launch of the Covid 19 vaccine amidst the crisis and havoc created by the pandemic gives us all HOPE,” says Dr. Chakrabarty. “Team ODIA geared up to present in extensive details about the Coronavirus, the new mutant viruses and the different types of COVID-19 vaccines and global experience with the vaccine so far, answering the questions and concerns surrounding the Covid 19 vaccine.”

 

The global seminar lasting over three hours was inaugurated by Mr. Dhamendra Pradhan, Union Minister for Petroleum and Natural Gas and was attended across zoom Facebook and YouTube in large numbers Odisha actor and humanitarian and ODIA brand ambassador Mr. Sabyasachi Mishra graced the seminar by his presence.

 

Physician teams of ODIA from 11 countries and presenters included from state of Odisha. Dr.  Niranjan Mishra, Department of Public Health, who showed the audience on the efficient ways Odisha has been planning the vaccine rollout. Other participants were from UK Australia, New Zealand, Malaysia, Singapore, India, Ireland, UAE, Oman, Maldives, in addition to USA.

 

In October of 2020 the Health and Wellness group of The Odisha Society of America’s donated a mobile Covid screening unit to the Health and Family Welfare department of the Government of Odisha. “The purpose of this unit is to provide screening at multiple places during the Covid pandemic and be available for use by the government in remote and rural areas of the state. The organization’s brand ambassador actor has represented us at all of our projects in Odisha and helped carry forward our Mission during the pandemic with sheer care and diligence,” says Dr. Chkarabarty. “Our second mobile Covid screening donated by one of our senior founder member of Health and Wellness group is also complete and has been in use by the Government of Odisha since the end of December 2020.”

 

In December 2020 the Health and Wellness group supported the Government of Odisha with 500 Dr. Diaz adult fingertip Pulse oximeters, to be used by healthcare workers in Odisha in remote areas lacking adequate triaging facilities, helping those  severely compromised by Covid. “Our mission and vision is to continue to provide medical necessities and healthcare related  support to the people of Odisha in future,” adds Dr. Chakrabarty.

 

“As an active member of ODIA, I am happy and immensely satisfied that I could be part of this noble organization that is committed to serve the poorest of the poor in India,” says, Dr. Chakrabarty, whose leadership qualities have come to be recognized by the larger AAPI general body, who have elected him to be the national AAPI Secretary in 2020, and he is looking forward to serve the largest ethnic medical organization as the Vice President and beyond, with his vision to take AAPI to newer heights.

“It is amazing how quickly these two years have passed by. With the help of Dr. Annu Terkonda, I helped revive the Indian Medical Council of St Louis (IMCStL), that had been dormant for more than 8 years to become one of the most vibrant chapters of the American Association of Physician of Indian Origin (AAPI), culminating in hosting the National AAPI governing body meeting during our upcoming Diwali Gala,” said Dr. Amit Chakrabarty, President of IMCStL 2018 and 2019, and currently the National AAPI Secretary said, after receiving an Award recognizing his contributions to the growth of AAPI and the revival of Indian Medical Council of St Louis.  Dr. Suresh Reddy, Immediate Past President of AAPI honored Dr. Amit Chakrabarty during the Mini Convention held in Chicago on Saturday, September 26th, 2020.

 

Dr. Amit Chakrabarty, who was honored with the National AAPI Distinguished Service Award 2018 and the President’s Award for Services in 2019 by the Indian American Urological Society, says, “I consider myself to be a leader and shine in the fact that I can get people motivated.  I lead by example that motivates people.  I am fun loving and have always striven to brush off any obstacles that come in the way.”

 

Dr. Chakrabarty has been the President of two AAPI subchapters, namely Alabama Association of Physicians of Indian Origin 2012-2014 and Indian Medical Council of St Louis 2018-2020 reviving them from obscurity and inactivity to make them one the most vibrant chapters of AAPI.  Under his leadership, Alabama AAPI produced 13 out of the last 15 Regional directors and the St Louis Chapter hosted the most productive and successful AAPI governing body within 3 years of its revival from 10 years of inactivity. He also serves as the Chairman, Board of Trustees, Huntsville India Association and was the President, Indian Cultural Association of Birmingham, and led an Indian Delegation to Japan at the International Youth Year in 1985.

 

It’s been a long journey with American Association of Physicians of Indian Origin (AAPI) for Dr. Amit Chakrabarty, from being an ordinary member of the largest ethnic medical society in the United States to a Regional Leader, currently serving as the Vice Chair of the Board of Trustees (BOT) of national AAPI, and now looking forward to lead the organization that he calls as his second family and has come to adore.  “Since my membership to AAPI In 1997, for more than two decades I have been a dedicated foot soldier for the American Association of Physicians of Indian Origin,” Dr. Amit Chakrabarty a Consultant Urologist, Poplar Bluff Urology, Past Chairman of Urologic Clinics of North Alabama P.C., and the Director of Center for Continence and Female Pelvic Health.

 

In his endeavor to play a more active role and commit his services for the growth and expansion of AAPI that represents the interests of over 100,000 Indian American physicians, Dr. Amit Chakrabarty, the Alabama-based Indian American Physician wants this noble organization to be “more vibrant, united, transparent, politically engaged, ensuring active participation of young physicians, increasing membership, and enabling that AAPI’s voice is heard in the corridors of power.”

 

A Patron Member of AAPI for 25 years, Dr. Chakrabarty has been an active AAPI Governing Body Member for over a decade. He has served AAPI in several capacities.  He has served with distinction as an AAPI Regional Director from 2004 to 2006. There is hardly any Committee of AAPI that he was not part of in the past two decades. He was the Chair of AAPI Ethics and Grievances Committee in 2011-2012, and had served as the Chair of AAPI Journal Resource Committee in 2012-2013. He has served as a Member of AAPI IT committee, Journal Committee, Website Committee, Bylaws Committee, Alumni Committee, Ethics and Grievances Committee, and AAPI Charitable Foundation. “I have attended more than 100 AAPI events including Annual conventions, Governing Body meetings, Global Summits and Pravasi Bharatiya Divas in the past 20 years,” he recalls.

 

A multi-talented physician, Dr. Chakrabarty has not only showcased his musical talents at almost every major AAPI event, he was the Founder and Creator of AAPI’s Got Talent, at AAPI Annual Convention 2010 in Washington DC. He was the Founder and Conductor of “Mehfil” @ AAPI Annual Convention in Atlanta 2008, and has been conducting the ever popular AAPI’s Got Talent and Mehfil every year at Annual Conventions. “I love people and having good times,” he describes self. “I rarely get depressed or feel down with any failures and bounce right back.  I believe in seeing the silver lining in each cloud.  If life gives me lemons, I make lemonade!”

 

Dr. Chakrabarty has been a dreamer and devoted his talents for charity and noble deeds from childhood onwards. “Since my childhood I have been motivated for philanthropic activities that includes several school fund raising activities, organizing inter college meets in college forming a musical group in India and here primarily for fund raising.” And, as an ardent and active member of AAPI, Dr. Chakrabarty has continued these noble deeds as an adult.

 

One of the major goals for AAPI in recent years has been the financial stability of AAPI. Describing fund raising as his strength, he points out to his special talents and skills in raising money for AAPI in the past two decades. He says with pride that “I have been a leader in Fund Raising for AAPI and the several causes we have committed to support.”

He organized and raised funds during AAPI-Mahadevan show in Atlanta, raising almost $300,000 for AAPI in 2013. Other concerts/events he has helped organize and raise funds include: The 10 city Sukhwinder Singh Tour, 9 City Talat Aziz Fund, Pankaj Udhas Show, Hema Malini Concert, , as well as towards AAPI Hurricane Harvey Fund by conceiving and organizing “musical performance by my group Geetanjali Music.”

 

In addition, “I had spearheaded a fund rising in 2013 at Huntsville, Alabama collecting almost $80,000 for AAPI scholarship fund and National AAPI childhood obesity awareness program. Many of these events/concerts I had organized myself, spending my own money for travel and logistics.”  Contributing his personal money as seed money for AAPI, he had single-handedly spearheaded planning a fund-raising tour called “DADA vs DADA” for AAPI Charitable Foundation in 2005. The show did not take place due to Hurricane Katrina devastating the region.

 

Recognizing the role of Young Physicians in AAPI, Dr. Chakrabarty wants to invest heavily in Medical Student/Residents and Young Physician (MSR/YPS) section of AAPI and in giving them leadership roles in mainstream AAPI, which will create more enthusiasm in our young members towards their parent organization.  Without them there will be no AAPI in 20 years. “Give some prime time slots in the main convention to AAPI YPS, at least one night main stage should be devoted to and managed by them,” he suggests.

 

Realizing how hard it is for the physicians in India to come to the US for training, Dr. Chakrabarty “raised almost $100,000 for the Society of Indian American Clinical Urology for a scholarship fund for Clinical Indian Urologists to come for a month training in US.”  He participated in two back to back fund raising shows 2015 and 2016 for the Hindu Temple of St. Louis raising more than $ 300,000 each year, featuring

Geetanjali musical group’s performance.

 

A physician with compassion, brilliance, and dedication, Dr. Chakrabarty has excelled in every role he has undertaken. As an educator at AAPI’s CMEs and Workshops, he has authored several articles/publications in Medical Journals, Chair of Entertainment Committee, and as a Founder member of  Geetanjali Music Group (www.geetanjalimusic.com) that performs fund raising shows in several AAPI governing body and state chapter meetings, this AAPI leader has given his best for AAPI.

Another goal he wants to pursue for AAPI is to “Continue partnership in health care education and provide economic and material aid across the globe, working towards making AAPI, along with Indian physicians in other countries, a global health leader. I want AAPI to be a part of the decision-making process of World Health Organization and United Nations health policies especially those affecting south Asians.”

 

Dr. Chakrabarty says, he wants to have AAPI Charitable Foundation to be the main frame of AAPI make it more accountable. Making our noble efforts known to the society is important, he says, “We need to make their services more prominently advertised. Anytime we do press conference we use primarily them as example of what we are doing but we do not give them the support that they need.”

 

As a leader of AAPI, Dr. Chakrabarty wants to “form a separate political action committee (PAC) and make it financially sound so that AAPI can hire lobbyists on Capitol Hill who will help to move forward policies that are important to AAPI. VISA issues for our colleagues should top the list.”

 

A Gandhian at heart, Dr. Chkarabarty says, “I have always believed in Gandhiji’s principles “Satyameva Jayate” (Truth always wins). I am a Bengali from Odisha and have lived in small AAPI subchapters like Alabama and Missouri, I have no special state or chapter affiliation, I take pride in reaching across the aisle and have friends from all states and backgrounds not only in AAPI but also in my personal life participating in all ethnic festivities as my friends from Huntsville can testify.”

 

“I have the diverse experience to achieve each of these goals,” Dr. Chakrabarty says with confidence. “Having been a member and leader of AAPI for over two decades, I have perfected the skills necessary to move AAPI forward through the office of AAPI’s national Secretary. My mission/goal in life is to leave back a legacy of work that people will remember me fondly and proudly after I am gone.”

The COVID-19 Virus Is Mutating. What Does That Mean for Vaccines?

As we enter the second year of living with the new coronavirus SARS-CoV-2, the virus is celebrating its invasion of the world’s population with yet more mutated forms that help it to spread more easily from person to person.

 

One, first detected in the U.K. in December, has already raised alarms about whether the COVID-19 virus is now escaping from the protection that vaccines just being rolled out now might provide. The variant has also been found in the U.S. Already, U.K. officials have tightened lockdowns in England, Scotland and Wales, and over the holidays, more than 40 countries banned travelers from the region in an effort to keep the new strain from spreading to other parts of the world.

 

Health officials are also concerned about a different strain found in South Africa that could become more resistant to vaccine protection. This variant includes a few mutations in key areas that antibodies, generated by the vaccine, target.

 

Exactly how the new strains affect people who are infected—such as whether they develop more severe symptoms—and whether they can lead to more hospitalizations and deaths, aren’t clear yet. But scientists are ramping up efforts to genetically sequence more samples from infected patients to learn how widespread they are. So far, there are enough hints to worry public health experts.

 

The fact that SARS-CoV-2 is morphing into potentially more dangerous strains isn’t a surprise. Viruses mutate. They must, in order to make up for a critical omission in their makeup. Unlike other pathogens such as bacteria, fungi and parasites, viruses have none of the machinery needed to make more copies of themselves, so they cannot reproduce on their own. They rely fully on hijacking the reproductive tools of the cells they infect in order to generate their progeny.

 

Being such freeloaders means they can’t be picky about their hosts, and must make do with whatever cellular equipment they can find. That generally leads to a flurry of mistakes when they sneak in to copy their genetic code; as a result, viruses have among the sloppiest genomes among microbes.

 

The bulk of these mistakes are meaningless—false starts and dead ends—that have no impact on humans. But as more mistakes are made, the chances that one will make the virus better at slipping from one person to another, or pumping out more copies of itself, increase dramatically.

 

Fortunately, coronaviruses in particular generate these genetic mistakes more slowly than their cousins like influenza and HIV—scientists sequencing thousands of samples of SARS-CoV-2 from COVID-19 patients found that the virus makes about two errors a month. Still, that’s led so far to about 12,000 known mutations in SARS-CoV-2, according to GISAID, a public genetic database of the virus. And some, by sheer chance, end up creating a greater public health threat.

 

Just a few months after SARS-CoV-2 was identified in China last January, for example, a new variant, called D614G, superseded the original strain. This new version became the dominant one that infected much of Europe, North America and South America. Virus experts are still uncertain over how important D614G, named for where the mutation is located on the viral genome, has been when it comes to human disease. But so far, blood samples from people infected with the strain show that the virus can still be neutralized by the immune system.

 

That means that the current vaccines being rolled out around the world can also protect against this strain, since the shots were designed to generate similar immune responses in the body. “If the public is concerned about whether vaccine immunity is able to cover this variant, the answer is going to be yes,” says Ralph Baric, professor or epidemiology, microbiology and immunology at University of North Carolina Chapel Hill, who has studied coronaviruses for several decades.

 

The so-called N501Y variant (some health officials are also calling it B.1.1.7.), which was recently detected in the U.K. and the U.S., may be a different story. Based on lab and animal studies, researchers believe this strain can spread more easily between people. That’s not a surprise, says Baric, since to this point, most of the world’s population has not been exposed to SARS-CoV-2.

 

That means that for now, the strains that are better at hopping from one person to another will have the advantage in spreading their genetic code. But as more people get vaccinated and protected against the virus, that may change. “Selection conditions for virus evolution right now favor rapid transmission,” he says. “But as more and more of the human population become immune, the selection pressures change. And we don’t know which direction the virus will go.”

 

In a worst case scenario, those changes could push the virus to become resistant to the immune cells generated by currently available vaccines. The current mutants are the virus’ first attempts to maximize its co-opting of the human population as viral copying machines. But they could also serve as a backbone on which SARS-CoV-2 builds a more sustained and stable takeover.

 

Like a prisoner planning a jailbreak, the virus is biding its time and chipping away at the defenses the human immune system has constructed. For example, the virus may mutate in a way that changes the makeup of its spike proteins—the part of the virus where the immune system’s antibodies attempt to stick to in order to neutralize the virus. And that one mutation may not be enough to protect the virus from those antibodies. But two or three might.

 

The biggest concern right now, says Baric, is that there are already two or three variants of SARS-CoV-2 that have mutations in just such places, “where additional mutations can make a more significant change in terms of transmissibility or virulence.”

The best way to monitor that evolution is by sequencing the virus in as many people who are infected, as often as possible.

 

Only by tracking how SARS-CoV-2 is changing can scientists hope to stay ahead of the most dangerous and potentially more lethal mutations. In Nov., the U.S. Centers for Disease Control (CDC) launched a sequencing program that will ask each state to send 10 samples every other week from people who have been infected, in order to more consistently track any changes in SARS-CoV-2’s genome. But it’s a voluntary program. “It’s still not a national effort, it’s voluntary, and there is no dedicated funding for it,” says Baric.

 

“Come on, we’re in the 21st century—let’s enter the 21st century.”

Without substantial federal funding dedicated specifically to sequencing SARS-CoV-2 genomes, most of the work in the U.S. is currently being done by scientists at academic centers like the Broad Institute of MIT and Harvard and the University of Washington. Since early last year, the CDC has been working to better characterize SARS-CoV-2 viruses from patient samples in partnership with some of these academic labs, as well as state and local health departments and commercial diagnostic companies, in the SARS-CoV-2 Sequencing for Public Health Emergency Response, Epidemiology and Surveillance (SPHERES) consortium.

 

“If we sequence one out of 200 cases then we’re missing a lot of information,” says Baric. “If we’re sequencing about 20% of cases, then we might start to see something and we would be in the ball game to find new variants. We probably could be doing a better job of that here in the U.S.”

 

Other countries are also working on this effort. The U.K. has long been a leader in genetic sequencing, and likely because of their efforts were able to identify the new variant relatively quickly after it emerged. Globally, scientists have also been posting genetic sequences from SARS-CoV-2 to the public GISAID database.

 

Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, and chief medical advisor to President-elect Joe Biden, says that his teams are sequencing and studying the new variants to better understand what effect they might have on disease, how close they might be to causing more severe illness and, more importantly as more people get vaccinated, whether the new variants can escape the protection of the vaccines we know work today.

The good news is that if the mutant strains do become resistant to the current vaccines, the mRNA technology behind the Pfizer-BioNTech and Moderna should enable the companies to develop new shots without the same lengthy developing and testing that the originals required. “The mRNA platform is eminently flexible to turn around,” says Fauci.

 

If a new vaccine were needed, it would be treated by the Food and Drug Administration as a strain change in the virus target, similar to how flu shots are modified every year. “You could get that out pretty quickly,” says Fauci, after showing in tests with a few dozen people that the new vaccine produced satisfactory amounts of antibodies and protection against the mutant virus.

 

Tracking every change the virus makes will be critical to buying the time needed to shift vaccine targets before SARS-CoV-2 leaps too far ahead for scientists to catch up. “We are taking [these variants] seriously and will be following them closely to make sure we don’t miss anything,” says Fauci.

Universal Health Coverage Is Within Our Reach

A rare opportunity has presented itself: physicians, hospitals, insurers and employers have come together to agree on a common path forward to cover the uninsured through an Affordable Coverage Coalition that is the first of its kind. As a group, we recognize that universal health coverage is a goal we all must support, especially during a public health crisis with the magnitude of COVID-19.

 

Our AMA strongly believes that everyone should have access to meaningful and affordable health insurance coverage. We and our partners in the newly formed coalition also believe we can achieve universal health coverage by offering increased financial help to patients to help them afford their coverage, incentivizing states that have not yet done so to expand Medicaid, taking steps to automatically enroll low-income patients in no-cost health insurance coverage, and minimizing the loss of health insurance coverage resulting from pandemic-related unemployment.

 

Major consensus

These and other steps can help achieve universal coverage, a goal that has eluded our nation for decades, as outlined by the Affordable Coverage Coalition. This new partnership is notable for several reasons, but perhaps the most important is the fact it represents a consensus by all the major players in health care about the best way ahead.

 

That path aligns with AMA’s plan to cover the uninsured, which is based on longstanding AMA policy in support of expanding access to and choice of affordable, quality health insurance coverage. The AMA plan recognizes that affordable coverage options available due to the Affordable Care Act (ACA)—subsidized ACA marketplace coverage and the Medicaid expansion—are more critical than ever, serving as a needed safety net for those who have lost their employer-sponsored health insurance coverage due to job losses resulting from the COVID-19 pandemic.

 

Covering the uninsured also is a key component in any strategy to eliminate longstanding inequities in our health care system that have yielded devastating health outcomes for Black, Latino and Indigenous communities, members of the LGBTQ community, and other historically marginalized groups.

 

The steps we and our partners in the Affordable Coverage Coalition recommend include:

Expanding eligibility for and increasing the size of premium tax credits and cost-sharing reductions to help more people afford their premiums and cost-sharing responsibilities in the ACA marketplaces.

 

Establishing an “insurance affordability fund” to provide support for reinsurance programs to offset the costs of covering higher-risk patients, or otherwise lower premiums and cost-sharing for ACA marketplace enrollees.

Automatically enrolling—and renewing—those who are eligible for Medicaid and no-premium ACA marketplace plans.

 

Adequately funding navigator, outreach and enrollment programs to increase public awareness of and enrollment in ACA marketplace coverage and Medicaid/CHIP.

Providing incentives for additional states to expand Medicaid in order to close the low-income coverage gap.

 

Taking steps to prevent people who have lost or are at risk of losing employer-provided health coverage from becoming uninsured.

 

Physicians know that patients who are uninsured delay or skip the care they need, and often live sicker and die younger. While millions of Americans have gained coverage resulting from the ACA, our work to cover the uninsured is not done. The AMA believes that now is the time to invest not only in fixing the law, but also in enhancing it.

The agreement of the Affordable Coverage Coalition outlined above will further that mission. Our AMA remains firmly committed to improving health insurance coverage and health care access so that patients receive timely, high-quality care, preventive services, medications and other necessary treatments. We now have an opportunity to help make that happen.

Worried About The UK Or South African Strains? India Has 240 Strains

With the fifth consecutive day of rising Covid-19 cases in the country, fears of India on the brink of a second Covid-19 wave appear to be gaining ground. From reporting under 10,000 fresh cases last week, India’s daily fresh Covid-19 cases climbed back to over 14,000 on Saturday — with the bulk of new cases emanating from the five states of Kerala, Maharashtra, Punjab, Chhattisgarh and Madhya Pradesh.

While Kerala, which gained global fame in the initial days of the pandemic for effectively controlling the spread of the novel coronavirus, is now the second worst affected state, the worst affected, Maharashtra, is not just battling a laxity on adherence to Covid-19 protocols but also a multiplicity of strains of the novel coronavirus.

 

According to Dr Shashank Joshi, member of Maharashtra’s Covid Task Force, India has 240 new strains of SARS-Cov-2 in circulation, which is causing a resurgence in the number of positive cases, especially in Maharashtra. Adding to the concern, Dr Randeep Guleria, Director of the Delhi-based All India Institute of Medical Sciences (AIIMS), said that these new strains could be highly contagious and more lethal.

 

The presence of hundreds of new strains also makes it difficult to attain herd immunity, Guleria added as at least 80% of India’s population will need to be infected with Covid-19. Moreover, there’s the possibility that the new strains could also cause re-infection among those who have recovered from Covid-19, negating the presence of antibodies they have developed.

 

Reinforcing the need “to go back to aggressive measures of testing, contact tracing and isolating infections”, Guleria, while speaking with NDTV said the virus variants have an “immune escape mechanism”, which allows them to circumvent either vaccination-imbued or disease-caused immunity. However, he added, getting vaccinated may still be the best shot in controlling Covid-19 — as even if their efficacy against new variants is less, the infection will be milder.

Uninsured Rates Among Young People Dropped Under ACA: Urban Institute From PIERCE Healthcare

Young adults were among the most likely to be uninsured prior to the Affordable Care Act, but the law’s Medicaid expansion had a significant impact on those rates, according to a new study.

 

Research published by Urban Institute, a left-leaning think tank, this week shows the uninsured rate for people aged 19 to 25 declined from 30% to 16% between 2011 and 2018, while Medicaid enrollment for this population increased from 11% to 15% in that window.

 

The coverage increases were felt most keenly between 2013 and 2016, when many of the ACA’s key tenets were carried out, including Medicaid expansion and the launch of the exchanges, according to the study.

 

“Before the ACA, adolescents in low-income households often aged out of eligibility for public health insurance coverage through Medicaid or the Children’s Health Insurance Program as they entered adulthood,” the researchers wrote. “Further, young adults’ employment patterns made them less likely than older adults to have an offer of employer-sponsored insurance coverage.”

States that expanded Medicaid saw greater declines in the number of young people without insurance, the study found.

 

On average, the uninsured rates among young people declined from nearly 28% in 2011 to 11% in 2018, according to the analysis. In non-expansion states, however, the uninsured rate decreased from about 33% to nearly 21%.

 

In expansion states, Medicaid enrollment for people aged 19 to 25 rose from 12% in 2011 to close to 21%, according to the study, while enrollment in non-expansion states remained flat.

 

Urban’s researchers estimate that Medicaid expansion is linked to a 3.6 percent point decline in uninsurance among young people overall, and had the highest impact on young Hispanic people. Uninsurance decreased by 6 percentage points among Hispanic young people, the study found, and that population had the largest uninsured rate prior to the ACA.

 

“The effects of Medicaid expansion on young adults’ health insurance coverage and health care access provide evidence of the initial pathways through which Medicaid expansions could improve young adults’ overall health and trajectories of health throughout adulthood,” the researchers wrote.

 

“Beyond coverage and access to preventive care, Medicaid expansion may affect young adults’ health care use in ways not examined in our report. Thus, ensuring young adults have health insurance coverage and access to affordable care is a critical first step toward long-term health,” they wrote.

Covid-19 Cases Are Declining Sharply In USA

For the first time since November, average new daily coronavirus infections in the U.S. fell under 100,000 — well below the average infection rate in December and January, according to data from Johns Hopkins University.

The seven- day average of new infections dropped below 100,000 on Friday, continuing at that level through Sunday, according to the Johns Hopkins Coronavirus Resource Center. Researchers reported 83,321 new infections and 3,361 new deaths Sunday.

These figures are well below the average daily infection rate of 200,000 for December and nearly 250,000 in January.

A grim new forecast confirms what experts caution amid declining Covid-19 cases and hospitalizations: when it comes to the pandemic, the US is not yet out of the woods. Another 130,000 Americans are projected to die of the virus over the next three and a half months, according to the latest model from the University of Washington’s Institute for Health Metrics and Evaluation.

And while Covid-19 numbers may be trending in the right direction now, there are four key factors that will determine how the next months unfold, the IHME said in a briefing accompanying its model.

The first two are what will likely help the pandemic numbers continue a downward trajectory: increasing vaccinations and declining seasonality — the pattern of lower transmission that’s likely in the US during the spring and summer months.

“Two factors, however, can slow or even reverse the declines that have begun,” the IHME team said.  The first factor is the spread of the B.1.1.7 variant, which was first identified in the UK and experts warned could become the dominant strain in the US by spring. Data from the US Centers for Disease Control and Prevention shows more than 980 cases of the variant have so far been detected across 37 states.

The second factor, according to the IHME team, is “increased behaviors that favor COVID-19 transmission. Transmission has been contained over the winter through mask wearing, decreased mobility, and avoidance of high-risk settings such as indoor dining,” the team said. “As daily case counts decline and vaccination increases, behaviors are likely to change towards increased risk of transmission.”

That’s why experts say now is not the time for the US to let down its guard, even as a growing list of governors loosen Covid-19 restrictions.  New Jersey Gov. Phil Murphy said the state rolled back Covid-19 restrictions on youth sports, allowing parents or guardians of young athletes to attend. On the same day, Maine’s governor issued an executive order expanding gathering limits for houses of worship.

Indoor dining — with capacity limits — resumed in New York City ahead of the Valentine’s Day holiday, with New York Gov. Andrew Cuomo announcing Friday he was extending bar and restaurant closing times to 11 p.m. statewide.

Despite lingering concerns, officials are hopeful the continued ramping up of vaccinations is beginning to shift the pandemic’s course in a positive direction.  So far, about 37 million Americans have received at least their first dose of the two-part Covid-19 vaccines available to the US market, CDC data shows. About 13 million Americans are now fully vaccinated.

The IHME expects 145 million adults to be vaccinated by June 1, it said in a statement, which would prevent 114,000 deaths. “Our vaccine supply is going up, the positivity rate is going down and we’re getting one step closer to winning the war against COVID each day,” Cuomo said in a statement, referring to New York’s vaccinations.

The state has so far administered 90% of the first dose vaccines it’s received from the federal government and more than 80% of first and second doses, the governor said.

In California, officials announced millions of people will be added to the vaccination priority list, including residents “at high risk with developmental and other disabilities” and residents with serious underlying health conditions. The plan, which will begin mid-March, broadens the ages of eligible individuals from 65 and older to ages 16 through 64 who are in those categories.

Protein Slowing Down Covid Spread In Asia?

A team of scientists from the National Institute of Biomedical Genomics in Kalyani, West Bengal, have found a biological reason for the slower spread of a mutant of coronavirus in Asia compared to the West. They explained how higher levels of a human protein — neutrophil elastase — helps the virus to enter the human cell, multiply and also spread faster from infected individuals.

However, this protein is kept in check by the biological system, which produces another protein called alpha-1 antitrypsin (AAT). AAT deficiency leads to higher levels of neutrophil elastase in the cells, which in turn helps in faster spread of the virus. This deficiency is known to be much higher in Europe and America than among Asians. The study has been published in the journal Infection, Genetics and Evolution.

The team of scientists led by Nidhan Biswas and Partha Majumder observed that the rate of the spread of the mutant virus — D614G — has been non-uniform across geographical regions. The researchers say that, “…in order to reach 50% relative frequency, the 614G subtype took significantly longer time in East Asia (5.5 months) compared to Europe (2.15 months) as well as North America (2.83 months).”

The researchers linked the differential spread to an additional cleavage site created by the D614G mutant virus, for entry into the human cell.

“However, some naturally-occurring mutations in the AAT-producing gene results in deficiency of the AAT protein,” said Majumder. “This deficiency is known to be much higher in the Caucasians of Europe and America than among Asians. While we used AAT deficiency data from East Asia, along with North America and Europe, for the study, considering the pace at which the coronavirus is spreading, the numbers are representative of other Asian regions too, including India.”

Per their data, AAT deficiency is the least in East Asian countries — 8 per 1,000 individuals in Malaysia, 5.4 per 1,000 in South Korea, 2.5 in Singapore. On the other hand, 67.3 in per 1,000 individuals in Spain are AAT deficient, 34.6 in the UK and 51.9 in France and in the US it is prevalent in 29 individuals among 1,000.

WHO-AYUSH Ministry Of India Sign Deal On Traditional Medicine

The Ministry of AYUSH and the World Health Organization’s South East Asian Regional Office (WHO-SEARO) signed a Letter of Exchange on Monday for the deputation of an AYUSH expert to WHO’s regional traditional medicine programme in New Delhi.

Vaidya Rajesh Kotecha, Secretary, Ministry of AYUSH and Dr Poonam Khetrapal Singh, Regional Director of WHO South-East Asia Region, signed the agreement.

The initiative has been taken to support the WHO-SEARO implementing the regional traditional medicine action plan, with particular emphasis on the safe and effective use of traditional medicine service including Ayurveda and other Indian traditional systems of medicine and its appropriate integration into national health care systems.

Efforts will also be made to strengthen capacities of SEAR countries in the area of traditional medicine, said ministry officials in a statement.

This partnership will be part of joint efforts of Ministry of AYUSH and WHO in helping countries in the South-East Asia Region to develop policies and to implement action plans to strengthen the role of traditional medicine.

At the ceremony to mark the start of this partnership, WHO South East Asia Regional Director, Dr Poonam Khetrapal Singh said, “The close collaboration of WHO and the Government of India goes back many decades, to the Basic Agreement both parties concluded on July 16, 1952, to fulfil mutual responsibilities in a spirit of friendly cooperation. Today’s agreement will formally extend this cooperation into the area of traditional medicine, which is a valuable tool in our shared quest to achieve universal health coverage.”

Secretary Kotecha said that AYUSH has already had various interactions with WHO in the field of Ayurveda, Yoga and other Indian traditional systems of medicine and these Indian systems are getting more popular and being accepted as medicinal systems in South-East Asian countries, Africa, Europe, Latin America and others.

As a major outcome of this partnership, Ministry of AYUSH and WHO would be working to identify various challenges faced by the member states of SEAR (region) in regulating, integrating and further promoting traditional systems of medicine in the respective countries.

Ministry of AYUSH and WHO will assist member states to develop appropriate policy, regulation framework, exchange of information, activities performed for integration of traditional medicine in public health and dissemination of information to the community, said the AYUSH secretary.

The Ministry of AYUSH and the WHO SEAR office also agreed to launch a public health research project on COVID-19. The project is jointly supported by WHO-SEARO and the Ministry of AYUSH.

4 Steps to Walk Away From Loneliness

There are plenty of times where we may be alone—working remotely, commuting solo, or even living by ourselves. Just because we’re by ourselves doesn’t mean we feel lonely. Sometimes we thrive in this “alone time,” allowing us to do activities we enjoy on our own.

But many of us don’t like to admit we all feel lonely from time to time.

According to a 2018 survey by Cigna, nearly half of Americans reported sometimes or always feeling alone, and one in five people reported never feeling close to people.

The American Psychological Association (APA) defines loneliness as “…discomfort or uneasiness from being or perceiving oneself to be alone….” The APA cites various reasons for loneliness, such as a lack of companionship or a lack of desired closeness in relationships.

Certain situations, such as moving to a new city, or a major life change, such as divorce, can contribute to feelings of loneliness. Any events that may negatively impact your social circles may make you feel lonely.

Mental health conditions can also play a factor. Someone with social anxiety may struggle to interact with others, even though they may crave human connection.

“Humans need social connections,” explained Lisa W. Coyne, PhD, psychologist and senior clinical consultant at the Child and Adolescent OCD Institute (OCDI Jr.) at McLean Hospital. “When we don’t have them, it’s harder for us to handle things on our own. There are some issues and problems in this world that are best dealt with as a community.”

We can even feel alone when we’re surrounded by other people. For example, you may feel alone if traveling to a country where the language is unfamiliar to you. Often, teens who feel misunderstood by their parents and siblings may feel lonely at home.

“Some of us are introverts,” Coyne said, “but at the same time, we have a herd mentality. We need connections to survive.”

Confronting Loneliness

Regardless of the reason, loneliness is painful. Even worse, it can lead to mental health issues, such as depression and Alzheimer’s disease, and physical conditions, including heart disease and cancer.

We can take steps, however, to cope with loneliness and even change our state of mind.

Step 1: Practice Gratitude

Studies have shown that acts of gratitude can help us feel more positive and have stronger relationships.

Think of the people in your life you appreciate. They may include someone from the past who had a major impact on your life, such as a mentor in your youth. Or they could be someone you see more frequently, such as the friend who recently helped you move.

Consider sending this person a handwritten card or letter, reaching out by email, or calling to express your appreciation. Not only will you likely brighten someone’s day with your action, but you will make yourself happier by fostering the connection and being kind.

Even silently recognizing a good person or situation in your life can develop a sense of gratitude.

Keeping a gratitude journal, in which you write about what you feel grateful for, can improve your mental health. Gratitude journaling helps us realize what we have in our lives as opposed to what we lack.

For a more targeted approach to gratitude journaling, follow the Three Good Things exercise in which you write about three good things (large or small) that happened throughout your day. Try the practice daily for a set period of time, such as one week, and note if your sense of loneliness has shifted.

Love and Isolation in the Time of COVID

Drs. Jacqueline Olds and Richard Schwartz help us understand how the COVID-19 pandemic is causing an increase in feelings of loneliness, while simultaneously creating difficulties in couples’ relationships from too much closeness.

Step 2: Participate in Meaningful Activities

By pursuing your passions, your mind and spirit are engaged, decreasing feelings of loneliness. By joining a recreational sports team, library book club, volunteer effort, or other activities you enjoy, you are also more likely to meet others who have shared interests.

If you find that you don’t see your friends as often as you’d like, consider setting up a recurring virtual gathering. Having a date and time planned in your calendar (for example, 2pm every other Tuesday) will encourage everyone to meet automatically and make it easy to maintain your connections with each other.

Step 3: Remember That You Are Unique

Feeling “less than” can contribute to feelings of loneliness.

Try to avoid comparing yourself to others. It is only human to look at someone else and feel sad when their surface-level feelings or apparent situation seem happier than our own.

“We have pretty critical minds,” said Coyne. “Our mind has evolved to be our threat detector. And our brain is going to be keeping an eye on things like: Are you doing all the things to connect? Are you keeping up with the Joneses?”

With these questions, she explained, some information can be useful—and some is not. “The only way to really tell is to defuse—step back and notice—that my mind is having a field day with my social interactions,” Coyne said. “And that gives me the liberty to ask: Is this helping me? Or can I organize my thoughts and mental energy in another way?”

Sometimes, if we get hooked on negative social evaluations, we can get stuck in organizing our behavior around avoidance. “As a result, you might not behave in a way that benefits you the most and instead you’re feeding negative personal judgment,” Coyne explained.

Alone and lonely are not the same; finding moments of solitude is healthy for the mind and body

Such comparisons can create a sense of distance from others. However, that increases our sense of isolation. It’s important to realize we never know what is going on in someone else’s life.

We all have good times as well as challenging periods in our lives—and keeping this universal truth in mind can help us feel connected. On the other hand, remember that you are unique: There is no one else on earth like you. It can be satisfying to recognize that you are doing what you can with what you have.

Step 4: Connect With Yourself

Solitude is different from loneliness because it is the state of being alone without necessarily feeling lonely. The word often implies there is an opportunity for reflection or doing things we enjoy.

While there are various ways you can reduce loneliness through connecting to others, consider the relationship you have with yourself and how you can enrich it. If you can do this, you may feel less isolated.

“Change your criteria for success,” said Coyne. “Don’t ask: Am I keeping up with whoever is in my social circles? Am I keeping up in a way that my mind says is comparable to others? Instead, ask yourself: Am I being true to myself today? Have I been kind or a good friend? Did I do things that are consistent with what I value?” Engaging in small mental choices and small habitual changes over time can give you a sense of self-efficacy, esteem, and comfort with yourself.

Set aside a period of time each day to check in with yourself. You could meditate, pray, practice yoga, or read a couple of pages of a spiritual text. This practice can be done in as little as five minutes, but it’s helpful to do it every day so it becomes a healthy habit.

Connecting with yourself doesn’t mean turning inward and calling it a day. We’ve all heard it before, but it’s so important to exercise and eat a balanced diet with plenty of fruits and vegetables. What we eat directly affects our body and mind.

If you are experiencing anxiety or depression, consider cutting back on alcohol because it can make you feel worse. Additionally, getting enough sleep—7-9 hours per night for adults—is one of the most important things we can do for our health.

Even if You Feel Lonely—You Are Not Alone!

If you are feeling lonely, reach out to an understanding loved one. If your feelings of loneliness don’t go away or feel unbearable, or if you are feeling anxious or depressed, contact a mental health professional.

“How do you know if you’re taking care of yourself and your social relationships in a way that’s vital to you?” asked Coyne. “A good way to look at it is to ask yourself some of these questions: Are you avoiding doing things? How’s your mood? Do you feel disconnected? Do you feel guilty for not talking to friends, or are you talking yourself into social situations?” All of these can be signs that you need to take steps toward developing good, intimate, and authentic relationships.

Consider taking the step of making connections through a support group. Support groups address a variety of issues, from specific mental health conditions to various challenges, including grief and physical illness. Many groups are free and available online.

If you need help right away, contact a hotline. The National Suicide Prevention Lifeline is 1.800.273.8255. Even if you’re feeling lonely, know that you are not alone.

National Nutrition Month® 2021: Eat Right for Life Stages

Newswise — CHICAGO –For National Nutrition Month® 2021, the Academy of Nutrition and Dietetics recommends people adjust their eating habits to address the nutritional needs of their bodies during all stages of life.

“What works for you in your twenties won’t necessarily work for you in your fifties. As you age and evolve, so do your health and nutrition needs. It’s important to eat right for life,” said registered dietitian nutritionist Colleen Tewksbury, a national spokesperson for the Academy of Nutrition and Dietetics in Philadelphia, Pa.

In March, the Academy focuses attention on healthful eating through National Nutrition Month®. This year’s theme, Personalize Your Plate, promotes creating nutritious meals to meet individuals’ cultural and personal food preferences. The Academy encourages everyone to make informed food choices and develop sound eating and physical activity habits they can follow all year long.

The new 2020-2025 Dietary Guidelines for Americans provide authoritative advice to help people of all ages meet their dietary needs while limiting added sugars, sodium and saturated fat. The federal guidelines are issued and updated every five years.

“A registered dietitian nutritionist, a food and nutrition expert, can translate the recommendations of the Dietary Guidelines to help people of all ages find the healthful eating plan that works best for them. Modest changes like healthful food choices and regular physical activity can help people manage or reduce their risk for chronic diseases such as type 2 diabetes, obesity or heart disease,” Tewksbury said.

To find a registered dietitian nutritionist near you, use the Academy’s online Find an Expert service.

Registered dietitian nutritionists can show people how to use MyPlate, which provides practical, consumer-friendly tips to follow the key recommendations of the Dietary Guidelines. MyPlate recommends visualizing your plate as nutrient-rich sections with one quarter reserved for grains, another with protein-rich foods and the remaining half with fruits and vegetables along with a serving of low-fat or fat-free dairy.

In addition to maintaining healthful eating habits throughout life, Tewksbury recommends the following tips:

  • Teens to 20s— Build bone density by eating and drinking calcium-rich foods and beverages such as fat-free or low-fat dairy milk or yogurt or calcium-fortified soy beverages. Non-dairy sources of calcium include fortified cereals, beans, some leafy greens and canned salmon with bones.
  • 20s to 30s— Reduce your risk of chronic diseases such as obesity, Type 2 diabetes and heart disease by eating more dietary fiber, including whole grains, legumes, fruits, vegetables, nuts and seeds. Women of childbearing age should include sources of folate, such as beans and peas and dark-green leafy vegetables, and eat foods fortified with folic acid such as breads, cereals and other grain products. A folic acid supplement may also be needed and should be discussed with a health care provider.
  • 30s to 40s— Continue to eat a variety of nutritious foods, especially plenty of fruits and vegetables, whole grains and beans, peas and lentils for vitamins, minerals, antioxidants and dietary fiber.
  • 40s to 50s— Fine tune your healthful eating habits and continue to incorporate regular physical activity as your body changes due to fluctuating hormones and slowing metabolism. Also continue to focus on ways to limit foods and beverages with added sugars, salt and saturated fat.
  • 60s and beyond — Continue to include a variety of protein-rich foods to maintain bone strength and incorporate strength-building activities to maintain muscle. Good sources of protein include seafood, lean cuts of meat, eggs, beans, tofu and nuts. Animal-based protein foods also provide vitamin B12, which is a concern for some older adults. Foods also may be fortified with vitamin B12 or a supplement may be recommended by your health care provider.

National Nutrition Month®

National Nutrition Month® was initiated in 1973 as National Nutrition Week, and it became a month-long observance in 1980 in response to growing interest in nutrition. The second Wednesday of March is Registered Dietitian Nutritionist Day, an annual celebration of the dedication of RDNs as the leading advocates for advancing the nutritional status of Americans and people around the world. This year’s observance will be March 10.

As part of National Nutrition Month®, the Academy’s website will host resources to spread the message of good nutrition and the importance of an overall healthy lifestyle for all. Follow National Nutrition Month® on the Academy’s social media channels including Facebook and Twitter using #NationalNutritionMonth.

Representing more than 100,000 credentialed nutrition and dietetics practitioners, the Academy of Nutrition and Dietetics is the world’s largest organization of food and nutrition professionals. The Academy is committed to improving the nation’s health and advancing the profession of dietetics through research, education and advocacy. Visit the Academy at www.eatright.org.

Age-Related Macular Degeneration: Poised For A New Treatment Era

Newswise — SAN FRANCISCO – For more than a decade, ophthalmologists have treated wet age-related macular degeneration (AMD) with eye injections given every month or two, and dry AMD with antioxidant vitamins. These treatments were groundbreaking when introduced, offering hope for the first time that this sight-threatening disease could be slowed, and in some cases stopped or even reversed. As we mark February as AMD Awareness Month, the American Academy of Ophthalmology is highlighting what the next decade may hold for the 11 million Americans suffering from AMD.

The good news is that AMD treatment continues to evolve to the benefit of patients. Ophthalmologists expect to soon have more effective options to protect people from going legally blind from AMD.

“While our current treatments have made a huge difference in the lives of hundreds of thousands of people, new treatments offer hope to patients whose AMD previously could not be treated,” said Sunir J. Garg, MD, FACS, a retina specialist and clinical spokesperson for the American Academy of Ophthalmology. “New treatments will also help patients receive beneficial treatment more conveniently than ever before.”

The following is a review of the most promising research.

Dry AMD

Dry AMD can be divided into three forms: early, intermediate, and late. For those with intermediate disease, a formulation of antioxidant vitamins called the AREDS2 formula can help many patients reduce their risk of vision loss. But for those with late-stage disease, also called geographic atrophy, there is no treatment available. However, there are several promising clinical trials underway.

  • Targeting the immune system A part of the immune system called the “complement cascade” has long been identified as a culprit in AMD. Two new drugs that target the complement cascade and stop it from attacking the retina have recently advanced to late-stage clinical trials. One (pegcetacoplan, APL-2) targets a complement protein called C3, the other drug candidate (Zimura, avacincaptad pegol) targets a different protein in the cascade, C5. Like currently available treatments for wet AMD, these drugs are injected directly into the patient’s eye. Already proven safe in people, researchers are now investigating whether they can substantially improve vision. Results are expected in about a year.
  • Replacing vision cells Another concept under investigation is the possibility of replacing some cells that begin to die in late dry AMD. These retinal pigment epithelial cells can be produced from stem cells and then placed under the retina during a surgical procedure. Trials have shown that cell replacement did not have unexpected side effects. Additional trials are now evaluating whether it can actually improve vision. Even though intriguing investigations are progressing, stem cell treatments still have a long way to go before approval.

Wet AMD

Before anti-VEGF treatments were introduced about 15 years ago, people with wet AMD were almost certain to develop severe vision loss or blindness. While clinical trials show that anti-VEGF injections have allowed more than 90 percent of patients to keep their vision, in the real world the percentage is closer to 50 percent. That’s because people aren’t being treated as regularly as they should. The problem is most people need an injection every four to eight weeks to keep their vision. This can be a difficult schedule to maintain for many elderly patients struggling with other maladies and reliant on others to get them to their ophthalmology visits.

Some of the most exciting research today is looking at better alternatives to frequent injections. It’s not just about convenience; the hope is that a more consistent treatment will also help people keep more of their vision.

  • New delivery methods One promising approach that could be available soon is a refillable drug reservoir. The device, about the size of a grain of rice, is surgically implanted in the eye, just under the eyelid. After the device is filled with a concentrated version of the anti-VEGF drug Lucentis, it delivers drug to the back of the eye over time. Instead of an injection every six to eight weeks, patients might get a fill up once or twice a year at the doctor’s office. The device can be refilled using a special needle. The latest studies show many people treated this way were able to go 15 months in between treatments.
  • Gene therapy Gene therapy offers the hope of a potential “one-and-done” treatment. Researchers are using already proven gene therapy methods to deliver a treatment that enables the eye to make its own anti-VEGF medicine. Two different methods are under investigation: One injects the gene therapy underneath the retina in a surgical procedure; the other injects it into the eye just like a routine anti-VEGF treatment is done in the doctor’s office. There are four different drug candidates under investigation for wet AMD and one for dry AMD. Despite the promise of gene therapy, the long-term effectiveness remains to be seen. Among the challenges it faces is the likely sky-high cost of such a treatment.
  • New targets Anti-VEGF treatments are effective because they target one key factor that contributes to wet AMD, vascular endothelial growth factor (VEGF). But what if a drug could target two key contributing factors to the development of AMD? That’s the idea behind the drug faricimab. It targets both VEGF and the protein angiopoietin-2. It’s injected into the eye like a standard anti-VEGF treatment, but it lasts longer. The latest research shows patients could go up to four months in between treatments. However, this data is so new that it has not yet been published in a peer-reviewed journal.

“This is an exciting time for clinical research for age-related macular degeneration that gives hope to many of our patients,” said Rahul N. Khurana, a retina specialist and clinical spokesperson for the American Academy of Ophthalmology. “For dry AMD patients suffering from vision loss, there may be treatments on the horizon. For wet AMD, there are new delivery options with longer duration of action and new molecular targets that may lead to more effective therapies.”

The American Academy of Ophthalmology is the world’s largest association of eye physicians and surgeons. A global community of 32,000 medical doctors, we protect sight and empower lives by setting the standards for ophthalmic education and advocating for our patients and the public. We innovate to advance our profession and to ensure the delivery of the highest-quality eye care. Our EyeSmart® program provides the public with the most trusted information about eye health. For more information, visit aao.org.

As Biden Reopens ACA Enrollment, Are You Eligible To Sign Up Or Switch Health Plans?

For people who’ve been without health insurance during the pandemic, relief is in sight.

In January, President Biden signed an executive order to open up the federal health insurance marketplace for three months starting Monday so uninsured people can buy a plan and those who want to change their marketplace coverage can do so.

Consumer advocates applauded the directive. Since 2016, the number of Americans without health insurance has been on the rise, reaching 30 million in 2019. The economic upheaval caused by the novel coronavirus has made a bad situation worse, throwing millions off their insurance plans.

 

Biden’s move is in stark contrast to the Trump administration’s approach. As COVID-19 took hold last spring and the economy imploded, health experts pleaded with the Trump administration to open up the federal marketplace so people could buy insurance to protect themselves during the worst public health emergency in a century. The administration declined, noting that people who suddenly found themselves without coverage because they lost their jobs were able to sign up on the marketplace under ordinary rules. They also cited concerns that sick people who had resisted buying insurance before would buy coverage and drive up premiums.

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The Biden administration is promising to spend $50 million on outreach and education to get the word out about the new special enrollment period. That’s critical, experts say. Though the number of people signing up for Affordable Care Act plans has generally remained robust, the number of new consumers enrolling in the federal marketplace has dropped every year since 2016, according to KFF, corresponding to funding cuts in marketing and outreach. (KHN is an editorially independent program of KFF.)

“There are a lot of uninsured people who even before COVID were eligible for either hefty marketplace subsidies or for Medicaid and not aware of it,” says Sabrina Corlette, a research professor at Georgetown University’s Center on Health Insurance Reforms. A marketing blitz can reach a broad swath of people and hopefully draw them in, regardless of whether they’re uninsured because of COVID or not, she says.

Here are answers to questions about the new enrollment option.

Q: When can consumers sign up, and in which states?

The sign-up window will be open for three months, from Monday through May 15. Uninsured residents of any of the 36 states that use the federal healthcare.gov platform can look for plans during that time and enroll.

Nearly all of the states and the District of Columbia that operate their own marketplaces are establishing special enrollment periods similar to the new federal one, though they may have somewhat different time frames or eligibility rules. In Massachusetts, for example, the sign-up window remains open until May 23, while in Connecticut, it closes March 15. Meanwhile, Colorado has reopened enrollment in its marketplace for residents who lack insurance, but most people already enrolled in one of the state’s marketplace plans won’t be allowed to switch to a different plan until the regular open enrollment period in the fall.

At this point, only Idaho has not announced plans to reopen its marketplace for enrollment, says Corlette. It may yet do so, however.

Q: Can people who lost their jobs and health insurance many months ago sign up during the new enrollment period?

Yes. The enrollment window for people in states that use the federal marketplace is open to anyone who is uninsured and would normally be eligible to buy coverage on the exchange (people who are serving prison or jail terms and those who are in the country without legal permission aren’t allowed to enroll).

People with incomes up to 400% of the federal poverty level (about $51,500 for one person or $106,000 for a family of four) are eligible for premium tax credits that may substantially reduce their costs

Typically, people can buy a marketplace plan only during the annual open enrollment period in the fall or if a major life event gives them another opportunity to sign up, in what’s called a special enrollment period. Losing job-based health coverage is one event that creates a special sign-up opportunity; so is getting married or having a baby. But usually people must sign up with the marketplace within 60 days of the event.

With the new special enrollment period, how long someone has been uninsured isn’t relevant, nor do people have to provide documentation that they’ve lost job-based coverage.

“The message is quite simple: Come and apply,” says Sarah Lueck, a senior policy analyst at the Center on Budget and Policy Priorities.

Q: What about people who are already enrolled in a marketplace plan? Can they switch their coverage during this new enrollment period?

Yes, as long as their coverage is through the federal marketplace. If, for example, someone is enrolled in a gold plan now on HealthCare.gov, but wants to switch to a cheaper bronze plan with a higher deductible, that’s allowed. As mentioned above, however, some state-operated marketplaces may not make that option available, so check your state’s website. You can find a list of the websites for state exchanges here.

 

Q: Many people have lost significant income during the pandemic. How do they decide whether a marketplace plan with premium subsidies is a better buy for them than Medicaid?

They don’t have to decide. During the application process, the marketplace asks people for income information. If their annual income is below the Medicaid threshold (for many adults in most states, that’s 138% of the federal poverty level –which works out to be about $18,000 for an individual), they will be directed to the state’s Medicaid program for coverage. If people are eligible for Medicaid, they can’t get subsidized coverage on an ACA exchange.

 

People can sign up for Medicaid anytime; there’s no need to wait for an annual or special enrollment period.

Those already enrolled in a marketplace plan whose income changes should go back into the marketplace and update their income information as soon as possible. They may be eligible for larger premium subsidies for their marketplace plan or, if their income has dropped significantly, newly eligible for Medicaid. (Likewise, if their income has increased and they don’t adjust their marketplace income estimates, they could be on the hook for overpayments of their subsidies when they file their taxes.)

Q: What about people who signed up under the federal COBRA law to continue their employer coverage after losing their job? Can they drop it and sign up for a marketplace plan?

Yes, people in federal marketplace states can take that step, health experts say. Under COBRA, people can be required to pay the full amount of the premium plus a 2% administrative fee. Marketplace coverage is almost certainly cheaper.

Normally, if people have COBRA coverage and they drop it midyear, they can’t sign up for a marketplace plan until the annual fall open enrollment period. But this special enrollment period will give people that option.

(Kaiser Health News is a nonprofit, editorially independent program of the Kaiser Family Foundation, and is not affiliated with Kaiser Permanente)

 

Medicare Covers Annual PSA-Based Screenings

In the early 1990s, the annual prostate-specific antigen (PSA) screening test for men 50 years of age and older reduced prostate cancer (PCa) mortality by 50%. Unfortunately, in 2012, based on a flawed PCa screening trial (Screening for Prostate Cancer in Older Patients [PLCO], NCT00002540), the United States Preventive Services Task Force (USPSTF) recommended against PCa screening.

By 2018, the USPSTF upgraded the recommendation for PSA-based PCa screening from grade D to C (but maintained a grade D for men 70 years and older). These recommendations are largely followed by frontline primary care physicians, and currently 50% of primary care doctors are not offering their patients annual PCa screening.

The US data indicate that the lack of PCa screening has increased the number of patients with PCa, PCa metastasis, and PCa mortality, especially in men 70 years and older. The American Cancer Society reported 161,360 new cases of PCa and 26,730 deaths due to PCa in 2017 compared to 191,930 new cases and 33,330 deaths in 2020, respectively.

In 2010, Medicare spent $11.8 billion on PCa treatment which increased to 15.3 billion by 2018, largely due to treatment of advanced PCa. As PCa specialists, we have reviewed our local experience with PCa and have published our results in US urology peer reviewed journals (7 papers and 13 letters).

Our most recent paper, A trend toward aggressive prostate cancer,1 showed that the number of prostate biopsies have decreased by 45% while the diagnosis of PCa has increased threefold. Our data (and other US data) have highlighted 3 highrisk groups for PCa—African American (AA) men, men with a family history of PCa and healthy men age 70 and above.

The PLCO PCa screening randomized trial on which the USPSTF based its recommendations against PSA-based PCa screening was contaminated (90% of the men in the non-screening arm were screened) and had only 4% AA men. In the US, AA men represent about 12% of the population and in large cities represent over 30%.

Based on our data and that of other US groups, we strongly believe that annual PCa screening (PSA and digital rectal exam) should be offered to all men 55 years and older. PCa screening should especially be offered to high-risk men—AA men, men with a family history of PCa, and healthy men 70 years and older. Currently, due to enhanced risk assessment tools (both MRI imaging and genetic tests) and the ability to offer men active surveillance, overtreatment of PCa has been significantly reduced. According to current Medicare policy, Medicare covers an annual PSA-based PCa screening for men 50 years and older.

Our goal is to highlight this coverage policy so that PSA-based PCa screening can be increased in order to diagnose and cure early PCa, thereby reducing PCa morbidity, mortality, and cost associated with late-stage treatment. Navin Shah, MD; and Vladimir Ioffe, MD / Greenbelt, Maryland REFERENCE 1. Shah N, Ioffe V. A trend toward aggressive prostate cancer. Rev Urol. 2020;2

(Picture: Medicare FAQ)

The Impact of the U.S. Re-engaging with the World Health Organization

Newswise — The United States will begin participating in an international collaboration to distribute COVID-19 vaccines more equitably around the world after President Joe Biden reversed the Trump administration’s withdrawal from the World Health Organization on his first day in office.

Richard Marlink, the director of Rutgers Global Health Institute, discusses the impact COVAX, the global collaboration to accelerate the development, production, and equitable access to COVID-19 tests, treatments, and vaccines, will have on ending the COVID-19 pandemic and strengthening global health.

What is the significance of the U.S. move to reverse its withdrawal from the World Health Organization?

Part of it is symbolic. It was one of the very first acts of Biden’s presidency, and that sends an important message that the U.S. is prioritizing global health and a multilateral approach.

But in practical terms, the U.S. contributes significant funding and leadership resources to the World Health Organization. Historically, the U.S. has been the WHO’s largest donor. We are in the worst pandemic the world has seen in 100 years, and we will need all the world’s strongest resources to pull ourselves out of it.

One very concrete example is that the U.S. has finally agreed to participate in COVAX, which is co-led by the WHO. This commitment by the U.S. will strengthen efforts to distribute vaccines in countries that otherwise have no or very limited access.

COVID-19 has killed more people in the U.S. than in any other country, and most U.S. citizens are not yet vaccinated. Why is it a good thing to divert attention and resources to other countries?

There are two very good reasons to do this: one altruistic and the other selfish. First of all, it’s the right thing to do. All lives are valuable; someone who was fortunate enough to be born in a wealthy country should not have better access to health and quality health care than one who was not.

Second, the lack of a global vaccine strategy actually lengthens the pandemic. It is not possible to eradicate a virus this infectious in just one country. SARS-CoV-2 and its variants have demonstrated that they are fast, efficient travelers. As long as this virus continues infecting people, it will continue mutating, creating the more infectious variants. That puts all of us at risk. We won’t be protected until all countries are protected.

Given the criticisms the World Health Organization has faced for its response to the pandemic, is staying involved ultimately going to benefit the U.S.?

U.S. participation makes the World Health Organization stronger and gives us a seat at the table in creating important solutions, now and for the future. What improvements can we make to our pandemic alert system? How do we prepare for the next pandemic? How do we build resilience?

With the rate of global travel and instant worldwide communication we have today, unilateralism is not only ill-advised; it’s impossible. We’re all breathing the same air, so to speak. And infectious diseases are just one example of how global health issues affect us all.

What other issues are most in need of worldwide solutions?

Well, first, the impact of this pandemic will go far beyond the more than the 100 million people infected. By the time it’s over, how many businesses will have closed? How many more people will be food insecure or suffering mental health impacts? How many children will have suffered education losses because virtual education wasn’t a viable option for them, and how many will have dropped out? These are far-reaching problems with long-term effects on health in every country.

Second, there are the issues that existed long before the pandemic, and have even grown worse during the pandemic. Disparities in access to health care, or to the conditions necessary for good health, are limiting entire communities — and many countries — from realizing their potential. These disparities have economic and social costs, not to mention the fact that it is heartbreaking to know that there are places in the world where people are dying of completely curable and preventable conditions.

The U.S. can and should be a leader in solving these problems. The best way to do that is to work with the primary organization that’s set up to address human health across all borders, worldwide. Most health problems know no borders. We are all in this together.

New CDC Director Outlines 6 Big Fixes Needed To Crush COVID-19

As newly appointed Centers for Disease Control and Prevention (CDC) Director Rochelle P. Walensky, MD, MPH, steps into her new role leading the agency, the to-do list is long. Stay on top of breaking news, discover great discussions and never miss an update with our new and improved channels and tools.

Help get a pandemic under control. Create an equitable health system. Bolster public health infrastructure. Improve communication and combat misinformation circulating on social media and elsewhere. Build relationships with people at the state, community and tribal levels. Boost internal morale for scientists at the agency. Assess the collateral damage of the past year, including falling behind on childhood immunizations. And more.

Dr. Walensky, who heads to the CDC after serving as a professor of medicine at Harvard Medical School and practicing as an infectious disease physician at Massachusetts General Hospital and Brigham and Women’s Hospital, is ready for the challenge.

“I’m calling it my midcareer residency. I’m going to dive in. I got called during a code and when you get called during a code, your job is to be there to help,” Dr. Walensky told viewers during a JAMA Network™ livestreamed interview on the eve of her officially taking over as the CDC’s new director.

Combating COVID-19

On her first day on the job, Dr. Walensky announced that as a protective public health measure, she will extend the order that temporarily halts residential eviction until at least March 31. She said in a statement that the pandemic is a historic threat to the nation’s health and that it has “triggered a housing affordability crisis that disproportionately affects some communities.” Learn more with the AMA about why eviction moratorium key weapon in the pandemic fight.

In the livestreamed interview led by Howard Bauchner, MD, editor-in-chief of JAMA and senior vice president of AMA scientific publications and multimedia applications, Dr. Walensky talked about key areas that need improvement to help crush the pandemic and secure longer-lasting public health gains.

Vaccines. President Joe Biden is aiming to have the nation reach 100 million doses administered within his first 100 days in office, a goal she believes is attainable. Dr. Walensky said more thought should be devoted to vaccine eligibility to hit the sweet spot between supply on the shelf and the number of people eligible.

Vaccinators. Dr. Walensky said the U.S. must ensure there are enough people who can administer vaccinations, which means looking broadly for help from medical military, Public Health Service Commissioned Corps members, medical students and nursing students, dentists, veterinarians and more.

Vaccination sites. A four-pronged approach to reach people is being worked on: Community vaccination centers, such as stadiums and gymnasiums; mobile units to do the outreach to communities that otherwise wouldn’t be reached; federally qualified health centers; and a pharmacy program.

Collaboration. The federal government needs to work with the states, offering support and resources available from the national level to help get vaccines distributed. Dr. Walensky said the role of the federal government will be to step in and ask each state “What is the help you need?”

Public health investment. The pandemic has laid bare the nation’s frail public health infrastructure. “We need to fix that public health infrastructure and we need resources to do it,” Dr. Walensky said. “One of my challenges is to make sure Congress knows and understands that we are in this because we had warning for many, many other public health scares over the last 20 years and we didn’t fix our public health infrastructure and our data infrastructure.”

Agency morale. Internally, Dr. Walensky said she needs to figure out how to make sure the CDC’s many talented scientists—who fortunately have not left in a mass exodus—understand and feel the value that should be given to them.

“They’ve been diminished. I think they’ve been muzzled. Science hasn’t been heard. This top-tier agency, world renowned, hasn’t really been appreciated over the past four years … I have to fix that,” she said. “I need to make sure that those voices get heard again—that I’m leading with trust.”

Public communication. Lastly, the CDC must better communicate with the American people: “I want to be able to convey in layman’s terms what the science shows, when guidelines change. … And not just me, but subject-matter experts who can convey that.” Subscribe to the “Conversations with Dr. Bauchner” podcast. Each week, he interviews leading researchers and thinkers in health care about their recent JAMA articles.

The AMA has created a COVID-19 vaccine resource center that features an array of information relevant to physicians about the development and distribution of COVID-19 vaccines. The AMA also partnered with the CDC and the Food and Drug Administration to provide a series of educational webinars that help explain the process of vaccine development and offer a deeper dive into the data to understand safety and efficacy results. These webinars are also available on the AMA COVID-19 vaccine resource center.

(Picture: AP News)

Heart Disease and Sudden Cardiac Arrests, Focus Indians and Indian Immigrants “Saving Lives” Strategies & Collaborations for Better Outcomes

February is the “American Heart Month” to raise awareness of heart disease and promote “Healthy Heart” lifestyles. Heart disease is the number one Global Public Health problem. South Asians are at a four-times greater risk of heart disease than their western counterparts and have a greater chance of having a heart attack before 50 years of age. Heart attacks strike South Asian Men and Women at younger ages, and as a result, both morbidity and mortality are higher among them compared to any other ethnic group. They tend to develop heart disease ten years earlier than other groups.

Almost one in three in this group may die from heart disease before 65 years of age. In India, heart disease remains the number one cause of death. Common risk factors are smoking and a diet high in sugar, salt, refined grains, and fat. A large number of South Asians appear to have “insulin resistance”, a condition in which the body does not utilize insulin efficiently, resulting in Diabetes, which leads to a significant number of heart-related problems. Lack of adequate exercise, stress, and genetic predisposition are also contributing factors.

Body Mass Index (BMI), a measure that determines if a person’s weight is healthy, often falls into “skinny fat” category in South Asians,who may have an acceptable BMI, but carry more of their weight in their abdomen. The fat surrounding their internal organs (visceral fat) increases the risk of having a serious heart attack. More than one-third of South Asian men and about 17% of South Asian women have “Metabolic Syndrome”, with high blood pressure, high blood sugar levels, excess fat around the waist, and abnormal cholesterol levels that increase Heart Disease risk, Stroke, and Diabetes.

The triglyceride levels tend to be higher with lower levels of HDL-good cholesterol. South Asians also tend to have smaller luminal diameters of the coronary (Heart) arteries and higher grade obstructions of multiple vessels that can lead to the “death” of parts of heart muscle during a “Heart Attack”. “Cardiac Arrest” is when the heart stops beating due to any underlying condition or cause. Some 350,000 cases occur each year outside of a hospital in the United States, and the survival rate is less than 12 percent.

Immediate Bystander CPR (Cardiopulmonary Resuscitation) can double or triple the chances of their survival. There is insufficient data on the prevalence of Sudden Cardiac Arrest among South Asians living in the United States or Indians in India. Given the fact that South Asians tend to have more heart problems, it is presumed that the incidence of Sudden Cardiac Arrests might be higher in them compared to the general population in the United States.

It is evidence-based information that women, in general, have a different pattern of heart symptoms and seek emergency medical help less often than men, and may receive less treatment for the same condition in both primary care and secondary prevention. In an observational study of Out-of-Hospital Cardiac arrests (OHCA) reported in Indian Print Media, published recently (2020) in the Journal of Indian College of Cardiology, the important role of mass media was recognized in raising public awareness of cardiac arrests and encouraging bystander CPR help to improve outcomes. (The Author is a Co-Author of this study).

To collect available information on OHCA in India, a pilot project called WACAR (Warangal Area Out-of-Hospital Cardiac Arrest Registry) was initiated during January-December 2018 to understand OHCA in a regional setting in the State of Telangana.(The Author is the CoInvestigator of the WACAR Study, which was published (2020) in the Indian Heart Journal). The study, which was based on an internationally accepted Utstein template, included 814 subjects of OHCA.

With the available collected data, results of the study showed that Heart disease with pre-existing conditions such as high blood pressure, diabetes, and tobacco addiction led to sudden cardiac arrests in a majority of cases. The study addressed the need for a reliable Cardiac Arrest Registry with accurate and detailed data of all OHCAs.

The data is essential to develop a comprehensive community cardiac care plan involving EMS(Emergency Medical Services), Bystander CPR, Public Access Defibrillators (devices to reverse dangerous heart rhythms), and faster access to emergency interventions in tertiary cardiac care hospitals. A recently completed project in India to improve outcomes after heart attacks is the “HeartRescue India” project (2015-2020) in Bengaluru, Karnataka.

The University of Illinois College of Medicine and UI Health in partnership with Ramaiah Medical College and Hospital in Bengaluru initiated this groundbreaking program in India. The project was funded by the Medtronic Foundation. The purpose of this project was to reduce deaths due to sudden cardiac arrests and improve access and quality of care for heart attack patients in Bengaluru.

The program implemented interventions with successful outcomes across the three settings of cardiac care: (1) communities, (2) pre-hospital EMS, and (3) a network of hospitals within a 10- kilometer catchment area in Bengaluru. The project is a unique, comprehensive Indian Cardiac Care Model, tailored to the local community’s needs, efficiently utilizing available resources and workforce. COVID-19 Pandemic has slowed down the progress of global health initiatives. With the administration of the COVID-19 Vaccine combined with robust international public health measures, it’s possible to regain the lost momentum of these “life-saving” programs.

The following recommendations will enhance the “Heart Health” of a community: 1. Prevention: A. Increasing awareness through Community Education about Heart Disease, Stroke, Sudden Cardiac Arrests, High Blood Pressure, and Diabetes B. Targeted CPR-training Programs for Communities and High School Students 2. Early diagnosis: Community Health Screenings and Personal Counselings and 3. Timely interventions Mental health-promoting strategies with an individualized holistic approach need to be encouraged.

In summary, it’s critical to initiate “Community Heart Health” programs with preventive strategies, retard the progression of heart disease with early diagnosis and individualized treatment plans, and implement measures to enhance neurological and other functional outcomes after sudden cardiac arrests. The latter involves providing immediate resuscitation help with high-quality bystander CPR, early defibrillation, and faster transportation to tertiary cardiac care hospitals.

Needless to say, a concerted effort is needed to achieve the goals by all involved stakeholders, Governmental and non-Governmental, with individual participation! Acknowledgement: Terry Vanden Hoek, MD, Bellur S. Prabhakar, MSc, Ph.D. (University of Illinois College of Medicine, Chicago, Illinois, USA), Srinivas Ramaka, MD (Srinivasa Heart Center, Warangal, Telangana, India) and Aruna C. Ramesh, MD (Ramaiah Medical College & Hospital, Bengaluru, Karnataka, India) were actively in studies referred in the article.

(Dr. Vemuri S. Murthy, an Adjunct Faculty in the Department of Emergency Medicine @ The University of Illinois College of Medicine, Chicago, Illinois, USA and Visiting Professor in India, is an Advocate of Resuscitation education, training and research in USA and India.His current work involves Cardiac Arrest Registries and Cardiac Health-promoting Projects with Indo-US collaborations.)

Pandemic’s Deadliest Month In US Ends With Signs Of Progress

The deadliest month of the coronavirus outbreak in the U.S. ended with some encouraging signs of progress: new COVID-19 cases and hospitalizations were plummeting, while vaccinations were picking up speed.  The critical question remains whether America can stay ahead of the fast-spreading mutations of the virus, report Michael Kunzelman and Michelle Smith.

The U.S. death toll has climbed past 443,000, with over 95,000 lives lost in January alone. Deaths are running at about 3,150 per day on average, down slightly, by about 200, from their peak in mid-January.

U.S. Teachers: The pandemic has cut instruction time in America’s schools by as much as half, and many middle school and high school teachers have given up on covering all the material they normally do. Instead, they are cutting lessons. English teachers are deciding which books to skip. History teachers are condensing units. Science teachers are often doing without experiments. Certain topics must be taught because they will appear on important exams. But teachers are largely on their own to make difficult choices on what to prioritize and what to sacrifice, Michael Melia reports.

Italy Reopening: Much of Italy is gingerly reopening from pre-Christmas closures. The Vatican Museums welcomed a trickle of visitors to the Sistine Chapel and locals ordered their cappuccinos at outdoor tables for the first time in weeks. While many European countries remain in hard lockdowns amid surging infections and virus variants, most Italian regions graduated to the coveted “yellow” category of risk.

But Italy is by no means out of the woods. The country is averaging around 12,000-15,000 new confirmed cases and 300-600 COVID-19 deaths each day. But it appears to have avoided the severe post-Christmas surges in Britain and elsewhere thanks to tightened restrictions over the holidays. Trisha Thomas and Elisa Colella report from Rome.

Tanzania’s health ministry says it has no plans to accept COVID-19 vaccines, just days after the president of the country of 60 million people expressed doubts about the vaccines without offering evidence. The East African government has been widely criticized for its approach to the pandemic.

World Health Organization experts have visited an animal disease center in the Chinese city of Wuhan as part of their investigation into the origins of the pandemic.

(Picture: AP News)

COVID-19 Cases In India Underreported By More Than 20 Million

Newswise — CHICAGO — A new study, led by professors at the University of Chicago and Duke University, found that COVID-19 cases in the southern state of Karnataka, India, are nearly 95 times greater than reported.

The study – led by Prof. Anup Malani from the University of Chicago’s Law School and Pritzker School of Medicine, and Prof. Manoj Mohanan from Duke University – suggests that 44.1 percent of the population in rural areas and 53.8 percent in urban areas in the southern state of Karnataka tested positive for antibodies to COVID-19 by the end of August 2020.

The findings, published today in JAMA, are based on data collected from a representative sample of households in 20 districts in the state, suggest that Karnataka alone had approximately 31.5 million cases of COVID-19 by then, relative to 8 million reported nationally in India until now.

Funded by ACT Grants in India and supported by IDFC Institute, the study collected data on antibodies for recent and past COVID-19 infection using a test that targets the RBD spike protein and better identifies exposure to the SARS-CoV-2 virus rather than other coronaviruses.  A unique feature of the study is that it also tested the same individuals for current infections using the RT-PCR test.  This pairing allows the study to both report current levels of immunity and forecast future immunity because most of today’s infected population will, in a few weeks, join tomorrow’s immune population.

“Our data shows evidence of high levels of active infections and transmission, especially in urban areas of Mysore and coastal districts during our study period – where 9.7 percent to 10.5 percent of individuals tested positive for current infection,” Malani said.

The study found that rural areas had nearly the same level of exposure to COVID-19 as urban areas.  Although cities were more densely populated, rural area face additional risk because agriculture is an essential sector and exempt from many lockdown restrictions.

The study also demonstrated the feasibility, in resource-constrained settings, of conducting pooled sample RT-PCR testing where multiple samples are tested simultaneously and individual samples are further tested if a ‘pool’ tests positive. It also demonstrated the feasibility of simultaneously measuring current and past infection in a population-representative sample even in rural areas of a lower-middle income country.

The University of Chicago is a leading academic and research institution that has driven new ways of thinking since its founding in 1890. As an intellectual destination, the University draws scholars and students from around the world to its campuses and centers around the globe. The University provides a distinctive educational experience and research environment, empowering individuals to challenge conventional thinking and pursue field-defining research that produces new understanding and breakthroughs with global impact.

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Dr. Raj Panjabi to Lead Malaria Initiative By Biden Administration

President Joe Biden has appointed Dr. Raj Panjabi, an Indian American physician and social entrepreneur originally from Liberia, to lead his Malaria Initiative, which runs programs in sub-Saharan Africa and Southeast Asia.

“After being sworn in this morning, I’m honored to share that I’ve been appointed by Joe Biden as the president’s Malaria Coordinator to lead the US president’s Malaria Initiative,” Panjabi wrote on Twitter Feb. 1. “I’m grateful for this chance to serve.”

“In the face of unprecedented crises, I am humbled by the challenges our country and our world faces to build back better. But as I have learned in America: we are not defined by the conditions we face, we are defined by how we respond,” Panjabi added in another tweet.

“My family and I arrived in America 30 years ago after fleeing civil war in Liberia. A community of Americans rallied around my family to help us build back our lives. It’s an honor to serve the country that helped build back my own life as part of the Biden-Harris Administration,” he wrote. “I’ve seen the relief on the faces of parents whose children survived malaria because they were treated with medicines and by health workers backed by its support,” he said.

Raj Panjabi fled Liberia during the country’s civil war at age nine, becoming a refugee in the US. He returned to Liberia as a medical student and in 2007, co-founded Last Mile Health. He has served as an assistant professor of medicine at the Harvard Medical School, an associate physician at the Brigham and Women’s Hospital and the CEO and co-founder of Last Mile Health, according to his profile on LinkedIn.

Raj Panjabi and the Last Mile Health team played a key role in the 2013-16 West Africa Ebola epidemic, helping train over a thousand frontline and community health workers and support the government of Liberia to lead its national Ebola Operations Centre. Raj Panjabi delivered testimony on the Ebola epidemic at the US Senate Foreign Relations Subcommittee.

As a doctor and public health professional who has cared for patients alongside the staff of the president’s Malaria Initiative, led by USAID and co-implemented with the Centers for Disease Control and Prevention, Panjabi said: “I’ve been inspired by how they’ve responded to fight malaria, one of the oldest and deadliest pandemics, and saved lives around the world.”

He shared that this cause really hits home for him. “My grandparents and parents were infected with malaria while living in India. As a child in Liberia, I fell sick with malaria, and as a doctor serving in Africa, I have seen this disease take too many lives,” he said.

“I’ve seen how the Malaria Initiative and its partners have responded with resolve in the countries where it operates. I’ve seen the relief on the faces of parents whose children survived malaria because they were treated with medicines and by health workers backed by its support,” he went on to explain.

Panjabi is the co-founder and CEO of the nonprofit Last Mile Health, which tackles the “last mile” — the final, critical step of delivering products or services to consumers — a conundrum for businesses and in health care, where last-mile problems hit poor regions especially hard, according to the organization’s website.

After escaping a civil war in his home country of Liberia at age 9, Panjabi returned as a 24-year-old medical student to serve the people he had left behind and co-founded Last Mile Health.

Last Mile Health partners with government to deploy, support, and manage networks of community health professionals and to integrate them into the public health system. With training in maternal and child health, family planning, treatment adherence and surveillance of epidemics, together with mentoring from nurse supervisors, these community health workers deliver quality healthcare to remote communities, the foundation noted.

In 2016, TIME Magazine named Panjabi to its annual list of the “100 Most Influential People in the World.” In 2017, he was named by Fortune magazine to its list of “The World’s 50 Greatest Leaders.

1 In 3 Adults Anxious, Depressed Due To Pandemic: Study

One in every three adults, particularly women, younger adults and those of lower socioeconomic status, are experiencing psychological distress related to Covid-19, a new study suggests.

The study, published in the journal PLOS ONE, indicates that women are more likely to experience psychological distress than men is consistent with other global studies that have shown that anxiety and depression are more common in women.

“The lower social status of women and less preferential access to healthcare compared to men could potentially be responsible for the exaggerated adverse psychosocial impact on women,” according to the researchers, including Tazeen Jafar from the Duke-NUS in Singapore.

For the study, the team performed a meta-analysis of 68 studies conducted during the pandemic, encompassing 2,88,830 participants from 19 countries, to assess risk factors associated with anxiety and depression among the general population.

They found that, among the people most affected by Covid-19-related anxiety or depression, women, younger adults, individuals of lower socioeconomic status, those living in rural areas and those at high risk of Covid-19 infection were more likely to experience psychological distress.

Younger adults, aged 35 and under, were more likely to experience psychological distress than those over the age of 35.

Although the reasons for this are unclear, previous studies have suggested that it might be due to younger people’s greater access to Covid-19 information through the media.

This current study also confirmed that longer media exposure was associated with higher odds of anxiety and depression, the researchers said.

Other factors associated with psychological distress included living in rural areas; lower education, lower income or unemployment; and being at high risk of Covid-19 infection. However, having stronger family and social support and using positive coping strategies were shown to reduce the risk of psychological distress.

“Understanding these factors is crucial for designing preventive programmes and mental health resource planning during the rapidly evolving Covid-19 outbreak,” Jafar said.

(Picture: USC News)

Coconut Oil Is The Best Hair Oil

Coconut oil is natures hair care miracle, offering 10-fold benefits when it comes to hair health. While its numerous hair advantages are well known, here are the top 5 benefits that make coconut oil indispensable.

  1. Coconut Oil Is The Ultimate Hair Protector

No one does the job of shielding hair better than coconut oil. Living in a warm and sunny environment has its own set of problems for hair. Every exposure to sun causes hair to lose moisture and shine, increasing dryness. But not when there’s coconut oil to protect it. A Research Gate study reveals that coconut oil seeps 10 layers deep into the hair shaft and forms a layer of protection that continually hydrates your hair. It also has SPF and anti-oxidant abilities to safeguard from sun damage. Additionally, chemical damage from shampoos and other styling products, including heat damage, can be averted by applying coconut oil prior to exposure.

  1. Coconut Oil Restores Hair Health From Within

As you tire out from superficial hair care products that do more damage than good in the long run, remember that coconut oil seeps into the deepest part of the hair shaft and rejuvenates the hair follicles to restore hair health from the inside out. The fatty acids and vitamins of this oil go deep into the hair to moisturize and hydrate the hair follicles to combat dryness.

  1. Coconut Oil Is A Scalp Saviour

Humidity and extreme climatic changes are not friends to our scalp. With abundant anti-fungal and anti-bacterial properties, coconut oil has the ability to prevent and treat multiple scalp issues including dandruff, dryness, and other infections. It also efficiently removes sebum build-up, a critical factor causing greasiness in the scalp and hair.

  1. Coconut Oil Effectively Removes Frizz

While we wish everyday were a good hair day, the reality is often quite different. Frizz, which is a result of moisture being sucked out of hair, generally happens when the harsh chemicals in some shampoos deplete the hair of its natural moisture. During the drying process, moisture is sucked out, especially in humid climes leading to frizzy hair. Applying a few drops of coconut oil to freshly washed, damp hair, ensures that the moisture stays locked in and your hair stays frizz free.

  1. Coconut Oil is Natural and Environmental Friendly

Coconuts trees, common as they are in the tropics, literally grow abundantly all around us. Hence, coconut oil is natural, local, available in plenty and perfectly suited to our hair’s multi-faceted needs, Let us ditch the multitude of exorbitantly priced, non-biodegradable and unnecessary hair products, and replace it with the all-natural goodness of coconut oil and do our part in protecting the environment. Our hair, our bank account and our planet will thank us for it. (Picture: Dr. Axe)

AAPI Legislative Day Planned For May 19th on Capitol Hill

(Washington, DC: January 30, 2021) Healthcare continues to be the center of the nation’s focus, especially as the nation is seeking ways to effectively combat the deadly virus, COVID-19, AAPI’s annual legislative day, comes to be a vital part of AAPI’s growing influence and having its united voice heard in the corridors of power. “We are excited to announce that our next Legislative Day is on Wednesday, May 19th in Washington, DC,” said Dr. Sudhakar Jonnalagadda, President of AAPI. “We expect to have the participation from dozens of key Congressmen and Senators. The annual Legislative Day will be a unique opportunity for AAPI to be part of the decision making process on matters related to healthcare.”

“Our daytime program begins at 9:00 am and will include lunch in the U.S. House of Representatives. We will conclude in the afternoon, giving participants the opportunity to meet their own Congressman/Senator on their own time. That evening, we are planning for a reception and dinner with several dignitaries at the Indian Embassy,” summarized Dr. Jonnalgadda.

AAPI represents the interests of over 80,000 physicians and 30,000 medical students and residents of Indian heritage in the United States. Dr. Sajani Shah, Chair of AAPI BOT said, “The mission AAPI, the largest ethnic organization of physicians, is to provide a forum to facilitate and enable Indian American physicians to excel at inpatient care, teaching and research, and to pursue their aspirations in professional and community affairs.  The Executive Committee is working hard, enabling AAPI’s voice to be heard in the corridors of power, and thus taking AAPI to new heights.”

 “AAPI Legislative day is a flagship annual event that is eagerly awaited to rekindle and renew our energy in bringing up the issues that we need to bring to the attention of national policy makers and leaders of the US Congress on Capitol Hill,” said Dr. Sampat Shivangi, chair of AAPI Legislative Affairs Committee. “A tradition of more than two decades which has brought many important transformations in National Healthcare policies that have helped Physicians of Indian Origin. Now, it is the need of the day to renew our friendship with new leadership under President Joe Biden and Vice President Kamala Harris and brief the leadership on issues that are important to us.” According to Dr. Shivangi, “The legislative day is also time to meet and interact with Indian Ambassador to USA Hon. Taranjit Singh Sandhu and the Embassy officials during an evening dinner to be hosted by the Ambassador. I look forward to see many of our friends in Washington, DC on May 19th.” Dr. Shivangi added.

 “AAPI has been seeking to collectively shape the best health care for the people of US, with the physician at the helm, caring for the medically underserved as we have done for several decades when physicians of Indian origin came to the US in larger numbers,” says Dr. Anupama Gotimukula, president-elect of AAPI. “During the annual Legislative Conference, among others, AAPI will discuss: Increased Residency Slots, Immigration Reform, Medicare and Medicaid Reimbursements, Tort Reform, Repeal of the Individual Mandate, Lowering the Cost of Prescription Drugs, and, The South Asian Heart Health Awareness and Research Act of 2017,” she added.”

“AAPI is once again in the forefront in bringing many burning health care issues facing the community at large and bringing this to the Capitol and to the US Congress,” says Ravi Kolli, Vice President of AAPI. Dr. Kolli urged his “AAPI colleagues and everyone interested in or connected with providing health care to attend this event and ensure that our concerns and needs are heard by our lawmakers and ensure that they act on them.”

Stating that the “US is currently experiencing a physician shortage, which will be exacerbated by retiring baby boomers, affecting thousands of patients’ access to a physician, and ultimately the health care they need, AAPI strongly supports, the much needed “Immigration Reform, particularly with the focus on H-1 and J-1 visas are used by many South Asian American physicians, playing an important role in providing critical health care across the country,” Dr. Amit Chakrabarty, Secretary  of AAPI, pointed out. 

“The conference will focus on Immigration Reform and ways for AAPI members to be part of the process in the implementation of the health care reform in this country,” adds Dr. Satheesh Kathula, Treasurer of AAPI. “While medical school enrollment has climbed 2% annually over the past five years through new schools and expansion of existing schools, the number of residency slots funded by Medicare has been capped at about 100,000 since 1997,” he added.

Dr. Sudhakar Jonnalagadda says that “AAPI continues to discover her own potential to be a player in shaping the healthcare of each patient with a focus on health maintenance than disease intervention. To be a player in crafting the delivery of health care in the most efficient manner. To strive for equality in health globally. The annual Legislative Day is another way to impact Healthcare policy and programs in a most effective way. Come and join us on Capitol Hill on May 19th.” For more information on AAPI and its several noble initiatives benefitting AAPI members and the larger society, please visit: www.aapiusa.org

Dr. Mathai Mammen, J&J’s Global Head Of Research And Development, Is Confident Of Its Covid Vaccine

A third Covid-19 vaccine, one made by Johnson & Johnson, could be authorized for use in the United States in the near future. The vaccine was made through a collaboration of J&J’s Belgium-based vaccine division, Janssen Pharmaceutical, and Beth Israel Deaconess Medical Center, and it works a bit differently.

The company will apply for an EUA “middle to late next week,” Dr. Mathai Mammen, Janssen’s global head of research and development, said during a call with reporters last week. The call was held along with officials from the National Institutes of Health. Janssen is the vaccine arm of Johnson & Johnson. If the vaccine is authorized for emergency use, Mammen said, “Our plan is to have supply immediately upon launch.” 

Once an application is submitted, “The FDA really looks very, very carefully at the data in each age group and in each demographic group,” Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, said during the call.

 

Data about the single-shot vaccine released, and the company is now collating its data to apply to the US Food and Drug Administration for emergency use authorization. Here’s what’s known about how it works and how it will fit into the mix of vaccines.

How effective is it?

Johnson & Johnson’s Covid-19 single-shot vaccine was shown to be 66% effective in preventing moderate and severe disease in a global Phase 3 trial, the company announced Friday.

The vaccine is 85% effective overall at preventing hospitalization and death in all regions where it was tested.

Its efficacy against moderate and severe disease ranged from one country to another: 72% in the US, 66% in Latin America and 57% in South Africa. This was measured starting one month after the shot.

In South Africa, 95% of cases in the trial were due to a variant known as B.1.351, which is known to be more contagious and carries mutations that may make the virus less susceptible to the antibody immune response — including antibodies prompted by vaccination.

Even those who got moderate cases of Covid-19 in the trial tended to develop a milder course and fewer symptoms, said Dr. Mathai Mammen, Janssen’s global head of research and development. From one month after the shot, all hospitalizations and deaths occurred in the placebo group.

How it works

The J&J vaccine is what is known as a non-replicating viral vector vaccine, using a common cold virus called adenovirus 26. Scientists made this vaccine by taking a small amount of genetic material that codes for a piece of the novel coronavirus and integrating it with a weakened version of adenovirus 26. J&J scientists altered this adenovirus so it can enter cells, but it cannot replicate and make people sick. 

AstraZeneca uses a similar platform, but its adenovirus comes from a chimpanzee. The adenovirus carries the genetic material from the coronavirus into human cells, tricking them into making pieces of the coronavirus spike protein — the part it uses to attach to cells. The immune system then reacts against these pieces of the coronavirus.

“So you’re not being infected with the virus that can give you Covid-19 when you get this vaccine. It just has some of the harmless Covid virus proteins on its surface,” explained Dr. William Schaffner, an internist and infectious disease specialist with Vanderbilt University’s Department of Health Policy. “So essentially it’s a sheep in wolf’s clothing, and when your immune system sees it, it responds to it and creates protection against it and in the future, against the real virus that causes Covid-19.”

The technology used in the Covid-19 vaccine has worked with the Ebola vaccine by Janssen.

How is it different from the other Covid-19 vaccines?

Dr. Paul Offit, the director of the Vaccine Education Center at Children’s Hospital of Philadelphia, said the Moderna, Pfizer and J&J Covid-19 vaccines all take a similar approach, but there is a small difference with the J&J approach.

“In the case of the Moderna and Pfizer vaccine you’re just giving the gene in a lipid nanoparticle or a fat droplet,” Offit said. “In the case of J&J you’re giving the gene in a virus that can’t reproduce itself.”

The J&J vaccine is the only Covid-19 vaccine so far to be given in a single dose. Moderna and Pfizer’s use two. Like Moderna’s, it can also be kept at regular refrigerated temperatures and does not need a deep freeze like Pfizer’s.

How does a single-dose shot affect the rollout?

A single dose and would be much easier to administer and would mean more people could be vaccinated, as none would need to be set aside to give someone a second shot. 

“This advantage goes up in neon,” said Schaffner who believes adding a vaccine like this would “really accelerate” vaccination efforts in the US and around the world.

“If it’s a single-dose vaccine, then a billion vaccine doses would translate into a billion people vaccinated,” said Dr. Dan Barouch of Harvard Medical School, who helped develop Johnson & Johnson’s vaccine candidate on CNN’s Coronavirus Fact vs. Fiction podcast.

The cold-chain advantage 

J&J’s other advantage is that it can be stored at regular refrigerator temperatures, unlike the Pfizer vaccine, which needs special deep freezers. The vaccine is stable for up to three months at 36 degrees F to 46 degrees F, the company said. That means health care facilities would not have to buy extra equipment to safely store the vaccine.

“If they’re successful, these vaccines would especially be popular in the developing world, because they would be easy to store and administer,” said Dr. Rafi Ahmed, the director of the Vaccine Center at Emory University.

The vaccines would also be popular in rural communities in the US and regular doctor’s offices that may not have access or the budget to afford specialized equipment.

“In other words, we could bring the vaccine to the people,” Schaffner said, “rather than bringing the people to the vaccine.”

What happens next?

The company will request what’s known as an emergency use authorization, or an EUA, from the FDA in early February. The data will get a close look from the FDA and advisers to the US Centers for Disease Control and Prevention.

While the FDA is reviewing the data, it schedules a public meeting of its Vaccines and Related Biological Products Advisory Committee. The committee is made up of independent science and public health experts who will discuss the J&J data and make a recommendation to the agency.

Once an application is submitted, “The FDA really looks very, very carefully at the data in each age group and in each demographic group,” Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, said during a call on Friday.

After the meeting, FDA staff members consider the committee input along with the agency’s evaluation of the company’s data and will make a decision about whether the vaccine should by authorized.

Shortly after an EUA, the CDC’s Advisory Committee on Immunization Practices, also known as ACIP, goes through the data, too.

Once the CDC committee has made a recommendation and it has been approved by the CDC director, the company plans to ship the vaccines immediately and it can go into arms right away.

How long does the authorization process take?

The process for the Johnson & Johnson vaccine should be about the same as it was for the Moderna and Pfizer vaccines, according Offit, who is a member of the FDA’s VRBPAC.

With the Pfizer vaccine, it took a little over three weeks from the time the company submitted its data to an EUA. With the Moderna vaccine, it took a little more than two weeks.

If the vaccine is authorized for emergency use, “our plan is to have supply immediately upon launch,” Mammen said.

How many doses are there?

The US has ordered 100 million doses and the company has been manufacturing it while it has been testing the vaccine. Typically, companies wait to make the vaccine after its been approved, but that changed during the pandemic.  Johnson & Johnson says it can meet its 100 million dose commitment by June.

Dr. Mammen’s mission is to work with the best research and development professionals in the world to make meaningful medicines that impact the lives of patients, their families and communities.

Prior to joining Janssen in June 2017, Dr. Mammen was Senior Vice President at Merck Research Laboratories, responsible for research in the areas of Cardiovascular, Metabolic and Renal Diseases, Oncology/Immuno-Oncology and Immunology. Jointly with his team, he initiated numerous new programs and progressed eight into early clinical development. He also nucleated a new discovery site in the San Francisco Bay Area.

Prior to Merck, Dr. Mammen led R&D at Theravance, a company he co-founded in 1997 based on his work at Harvard University. Under his leadership, the Theravance team of 200 scientists nominated 31 development candidates in 17 years, created three approved products (Breo®, Anoro®, Vibativ®), two additional assets that have successfully completed Phase 3 studies and a pipeline containing 11 further development-stage compounds in 2016. In 2014, he and the Theravance Leadership Team separated Theravance into two publicly traded companies: Innoviva (INVA) and Theravance Biopharma (TBPH).

Dr. Mammen has more than 150 peer-reviewed publications and patents and serves on various boards and advisory committees. He received his M.D. from Harvard Medical School/Massachusetts Institute of Technology (HST program) and his Ph.D. in Chemistry from Harvard University’s Department of Chemistry, working with George Whitesides. He received his BSc in Chemistry and Biochemistry from Dalhousie University in Halifax, Nova Scotia.

(Courtesy: CNN’s Amanda Sealy, Jacqueline Howard and Maggie Fox)

Prism Health Lab Opens Their Sixth Location in Chicago

Chicago IL: Prism Health Lab has developed its sixth COVID-19 testing location in order to provide Chicagoland’s various communities with access to safe, easily accessible, and affordable testing options. 

 The locations, which offer no-cost testing and are open to all, are part of a joint effort with State Rep. Theresa Mah and Ald. Byron Sigcho (25th) to bring permanent testing sites to communities that need them the most. Prism Health Lab’s 6th site, located at the Chicago Public Library in Chinatown at 2100 S Wentworth Ave, is permanent.  

“The goal of having these locations is to do everything we can to eliminate the barriers to our health care for our Chinese and Latinx community, particularly our immigrant community,” Sigcho-Lopez said.

 “Our immigrant communities, particularly our Spanish-speaking and Chinese immigrant community, are disproportionately suffering from COVID-19,” Mah said. “Making testing more widely available is part of what we can do to help people protect themselves and, ultimately, our communities.”

 “We are happy to be here with members of this diverse community because we’re dedicated to getting everyone one step closer to life before COVID-19,” said Zul Kapadia, CEO & President of Prism Health Lab. “We have faith that grassroots initiatives like ours will be recognized, and as we transition into the Biden Administration, we hope our voices – the voices of Chicago’s communities – will be heard when executing the vaccine roll-out.”

 Prism Health Lab’s testing sites offer a wide range of services & support, and can accommodate patients who speak English, Spanish, Cantonese, and Mandarin. Insurance is not required and there is no copay or deductible.

Prism Health Lab testing sites are open from 9 a.m. – 5 p.m. Monday – Friday and 11a.m. – 4 p.m. on Saturday in the following areas:

Laramie & 18th, Cicero, IL
Peterson & Western, West Ridge, Chicago, IL
Archer & Wentworth, Chinatown, Chicago, IL
Lake & Bryn Mawr, Roselle, IL
Schaumburg & Plum Grove, Schaumburg, IL
Touhy & Niles Center, Holiday Inn, Skokie, IL

 To make an appointment, visit prismhealthlab.com/appointment or call (800) 325-1812.

(Photographs and Press release by: Asian Media USA)

Last Mile Delivery of COVID-19 Vaccines––A Logistical Nightmare

The world has been reeling hard from the COVID-19 pandemic, crossing over two million deaths across the world. Paul Offit, a vaccine developer at the Children’s Hospital of Philadelphia and a member of the Food and Drug Administration (FDA), explains that there are two ways out of a pandemic: “one is hygienic measures–which we don’t seem very good at–and two is the vaccine.” That said, the government has thrown in everything to help build vaccines as all other measures have been unable to contain the virus efficiently. 

 

Eighteen billion dollars have been invested through government funds and Operation Warpspeed to expedite the process of vaccine development. Scientists and researchers have worked hand-in-hand with industry and regulatory authorities and were able to perform almost a miracle of getting an effective vaccine ready in fewer than twelve months. Pfizer and Moderna developed vaccines from the messenger RNA (mRNA) that codes for the SARS-CoV-2 spike protein. Phase 3 clinical trials have proven that the Moderna vaccine has 94.1% efficacy and the Pfizer vaccine has 95% efficacy. Despite its high efficacy rate, the process of vaccination is going to have numerous hurdles as the supply chain management process takes long before the vaccine is actually administered to the user.  This involves transporting the vaccines from factories to national storage facilities to clinics through flights, trains, and trucks. 

 

The major problem in this process is going to arise at the last-mile delivery stage, particularly in remote villages and less developed areas where there may not be as much infrastructure available for transportation. Another significant limitation is that these vaccines need to be stored at extremely low temperatures throughout the process. For example, the Pfizer vaccine needs to be stored at -70 degrees Celsius, and the Moderna vaccine needs to be stored at -20 degrees Celsius. As a result, these vaccines need to be stored in specialized freezers and packaged with dry ice. However, studies have shown that only 25 to 30 countries have this ultra cold storage facility. It is therefore going to be a significant challenge for the rest of the countries that do not have this technology for the storage of vaccines and for people to gain access to vaccines for COVID-19. 

 

To overcome the lack of infrastructure networks for storage and transportation, drones can be effective tools. Drones have been effectively used in the healthcare field for the delivery of medications, bandages, etc. Similarly, they can be an ideal solution to deliver COVID-19 vaccines in a cost-effective and efficient way. Drones are beneficial because they are small and compact, and they require minimal infrastructure like roads, airports, and rail lines. They are also less expensive due to low maintenance costs, consume less energy, and are battery operated which is great for sustainability. 

 

Drone technologies are improving each year, enhancing the speed (75 mph) and endurance (8+ hours). By attaching a cold storage box with stored vaccines, it is possible to maintain storage requirements while also delivering vaccines to every corner of the world, regardless of the geographical location or access to transportation of that location. One drawback to utilizing drones is that they can only carry a limited amount of weight, and the cold storage system adds a significant weight. To counter this issue, we will need a large number of drones that can carry the limited baggage they can transport. Vaccines can be initially transported using available infrastructure to the major locations that have an established infrastructure. From these centers, drones can then perform the last-mile delivery to locations that do not have established transport  infrastructures. Drones are one of the most feasible ways to help get the vaccines delivered to everyone, regardless of geography or other socioeconomic factors. The US Government has also realized this, and recently the FAA issued new regulations that will allow small commercial drones to fly short distances over people and at night without a waiver. Small drones will also be permitted to fly over moving vehicles under limited conditions. The new rules mark a significant step forward by the US government towards a future of commercial drone deliveries, which can hopefully translate into getting vaccines for every person in the world.

 

(Kritika Singh is an aspiring pre-medical undergraduate student at Rutgers University as part of the Honors College, double majoring in Biological Sciences and Public Health. Her research focus is on bringing technology and medicine together to aid patients in underserved areas. She has previously worked as a research intern at Nair Hospital, a tertiary care center in Mumbai, India, to study HIV epidemiology and co-infection rates with other significant illnesses. She has also worked as a UI/UX design intern at the Mount Sinai AppLab in New York, where she helped develop a smartphone app that uses surface area for estimating weight of infants and determining their corresponding medication dosages for emergency pediatric settings. Currently, she is a New Jersey Vaccine Advocate, striving to promote health and wellness in local underserved communities by combating vaccine hesitancy among the population. She is a journalist for The Examiner, the pre-health journal of Rutgers University, and has served as an Editor of The Podium, which was her high school newspaper. She is also a Contact Tracer for COVID-19 at the Montville Township Health Department. Outside of academics, Kritika is passionate about yoga, music, and landscape photography. She runs voluntary classes for yoga to raise money for children with autism. She has played the piano for over eight years and enjoys performing for the elderly at assisted living centers.) 

Sources:

https://wamu.org/story/20/08/27/covid-19-vaccine-may-pit-science-against-politics/

https://www.gasworld.com/restarting-global-economy-depends-on-tackling-last-mile-of-vaccine-journey-new-report-says/2020172.article

https://www.softboxsystems.com

https://www.scientificamerican.com/article/the-covid-cold-chain-how-a-vaccine-will-get-to-you/

https://www.dronesinhealthcare.com

https://spectrum.ieee.org/automaton/robotics/drones/faa-drone-rules-what-recreational-and-commercial-pilots-need-to-know

 

 

AAPI Sends Best Wishes To President Biden & Vice President Harris

Chicago, Il: January 20, 2021) “On behalf of the American Association of Physicians of Indian Origin (AAPI), I want to congratulate and offer our best wishes to our President Joe Biden and Vice President Kamala Harris on the occasion of their solemn swearing ceremony as they commit the nation to unity, prosperity and strengthening of democratic values,” Dr. Sudhakar Jonnalgadda, President of AAPI said here today. Describing these as “critical times” for the nation, Dr. Jonnalagadda said, “We, the members of the medical fraternity are encouraged by President Biden beginning his presidency with paying tributes to the 400,000 Americans who have lost their lives to COVID and thanking the services of the healthcare professionals who are at the forefront of the fight against the pandemic.”

In her congratulatory note, Dr. Sajani Shah, Chair of AAPI BOT, while wishing the new Administration the very best as Biden and Harris were sworn in as President and Vice President of the United States, assume office on January 20th, 2021, praised Biden for pledging “to be a president who seeks not to divide, but to unify; who doesn’t see red states and blue states, only sees the United States.”

 

“America’s leadership is vital on the issues that matter to us all, from climate change to COVID,” said Dr. Anupama Gotimukula, President-Elect of AAPI, in a message. She praised Vice President Kamala Harris, who has “made history by being elected to be the first ever woman and of South Asian heritage to become the Vice President of the United States.” Referring to her Indian origins, Dr. Gotimukula described the election of Kamala Harris as “Inspiring and is of immense pride for all Indian-Americans and to all women.”

Describing the 202 elections and the oath ceremony today on Capitol Hilly as a demonstration of the resilience of American democracy, Dr. Ravi Kolli, Vice President of AAPI said, “I do hope that the new Biden-Harris administration will be guided by its deep concern for building a society marked by authentic justice and freedom, while fostering understanding, reconciliation and peace within the US and among the nations of the world.”

“The overrepresentation of Indians in the field of medicine is striking – in practical terms, one out of seven doctors in the United States is of Indian Heritage. The nominations of dozens of leading experts in the new administration by Biden, including our own Dr. Vivek Murthy as the US Surgeon General makes us all proud,” said, Dr. Amit Chakrabarty, Secretary of AAPI said.

Describing the numerous efforts by AAPI during the pandemic, Dr. Satheesh Kathula, Treasurer of AAPI, pointed out, “AAPI as an organization has helped and is continuing to help the communities, especially during COVID-19 pandemic. I am confident that under President Biden’s administration the vaccine distribution will take place at a faster pace to end this pandemic. It is really great to see the diversity in the government. AAPI will continue to advise the new administration when needed

Established in 1982, with the lofty ideal to bring together Physicians of Indian Origin in the United States under a single umbrella organization, and be their Voice in this adopted land of ours, American Association of Physicians of Indian Origin (AAPI) is a non-political umbrella organization which has over 100 local chapters, specialty societies and alumni organizations. Almost 10%-12% of medical students entering US schools are of Indian origin. AAPI represents the interests of over 80,000 physicians and 30,000 medical students and residents of Indian heritage in the United States. With their hard work, dedication, compassion, and skills, they have thus carved an enviable niche in the American medical community. AAPI’s role has come to be recognized as vital among members and among lawmakers. 

 While offering fullest cooperation to the Biden administration, Dr. Sudhakar Jonnalagadda said,  “The American Association of Physicians of Indian Origin (APPI) the largest ethnic medical organization in the country has taken several proactive steps in educating their members and the general public about the disease, the preventive steps that needs to be taken at this time and most importantly, they are using all their contacts and resources at the hospital administrative and government level to facilitate treatment protocols to be in place at the various hospitals around the country.” For more information on AAPI, please visit: www.aapiusa.org

(Biden Harris. Picture Courtesy  of Whitehouse.gov)

“To Heal, We Must Remember”

One of the great tragedies of the past year, as some 400,000 Americans lost their lives to Covid-19, was not only that many victims died alone — their loved ones robbed of the chance to say goodbye — but that the pain of that loss was whitewashed by a President who chose to minimize and deny it.

In a somber ceremony at the Lincoln Memorial on Tuesday night that was his first stop in Washington, President-elect Joe Biden signaled that honoring that grief and the terrible toll of the last year would be at the very heart of his administration. Elected because of his empathy and his compassion for Americans, who are suffering through a confluence of crises that have created a time of great uncertainty, Biden spoke just a few words as the sun set over the National Mall, casting a rosy glow in the twilight. 

The President-elect told Americans he shared in their grief — with his own understanding deepened by the loss of his first wife and daughter in a car accident as a young man and the loss of his son Beau to cancer at the age of 46.

“It’s hard sometimes to remember, but that’s how we heal. It’s important to do that as a nation,” Biden said in brief remarks before 400 lights were illuminated along the edges of the Lincoln Memorial Reflecting Pool, marking the more than 400,000 Americans who have died from Covid-19. 

There are always plenty of reasons to take advantage of Sam’s Club’s curbside Pickup, from the stores’ enormous selection to the great member prices.

He and his wife, Jill Biden, watched in silence, alongside Vice President-elect Kamala Harris and her husband, Doug Emhoff, as the reflections of the lights glimmered in the water. Hundreds of towns, cities and communities across the country joined in the tribute, lighting up buildings from the Empire State Building in New York to the Space Needle in Seattle. Cardinal Wilton Gregory, the archbishop of Washington, delivered the invocation and gospel singer Yolanda Adams performed “Hallelujah” after Biden spoke.

Harris spoke briefly at the memorial, noting that “for many months, we have grieved by ourselves. Tonight, we grieve and begin healing together.”

“Though we may be physically separated, we, the American people, are united in spirit and my abiding hope, my abiding prayer, is that we emerge from this ordeal with a new wisdom: to cherish simple moments, to imagine new possibilities and to open our hearts just a little bit more to one another,” Harris said.

The President-elect arrived in Washington, DC, on Tuesday for the start of his inaugural ceremonies at a dark moment in American history, preparing to take his oath of office as the US passes 400,000 coronavirus deaths and is more divided than at any time since the Civil War.

As he departed for the nation’s capital earlier in the day, Biden gave an emotional farewell to his home state of Delaware, his voice breaking at times as he thanked the state’s residents for believing in him and standing with him throughout his career.

“I’ll always be a proud son of the state of Delaware,” Biden said at the Delaware National Guard headquarters in New Castle County. “Excuse the emotion,” he said, tears streaming down his face, “but when I die, Delaware will be written on my heart and the hearts of all of us — all the Bidens. We love you all. You’ve been there for us in the good and the bad.” 

He gave a moving tribute to his son Beau, who died of brain cancer in 2015 at the age of 46, stating that he had hoped to see his son become president one day. “We should be introducing him as president,” he said. 

The President-elect also noted the historical arc of his career witnessing the civil rights struggle as well as signs of progress in the United States. He said he came home to Wilmington, Delaware, from law school after Dr. Martin Luther King Jr. was assassinated — inspired by the turmoil to become a public defender. In 2009, he made the journey to Washington with Barack Obama, who became the nation’s first Black president. And he is returning to Washington, DC, this week “to meet a Black woman of South Asian descent, to be sworn in as President and vice president of the United States. That’s America,” he said Tuesday. 

The nation’s continuing struggles for equality and racial justice also drew Biden into the 2020 presidential race. He has said he decided to seek the highest office after watching President Donald Trump’s dismissive handling of the deadly White supremacist rally in Charlottesville, Virginia, when he said there were “very fine people on both sides.”

(Picture: Market Watch)

India Begins World’s Largest Vaccination Program

India on Saturday began one of the most ambitious and complex initiatives in its history: the nationwide rollout of coronavirus vaccines to 1.3 billion people, an undertaking that will stretch from the perilous reaches of the Himalayas to the dense jungles of the country’s southern tip.

The campaign is unfolding in a country that has reported more than 10.5 million coronavirus infections, the second-largest caseload after the United States, and 152,093 deaths, the world’s third-highest tally. India’s rollout, among the first in a major developing country, comes as millions of people in the United States, Britain, Israel, Canada and the European Union have received at least one dose.

The first dose was administered to a health worker at All India Institute of Medical Sciences in Delhi, after the prime minister, Narendra Modi, kickstarted the campaign with a national televised speech as 3,000 centers nationwide were set to inoculate a first round of health care workers. About 300,000 people were set to receive the vaccines on Saturday alone, followed by millions more health care and frontline workers by spring. “Everyone was asking as to when the vaccine will be available,” Mr. Modi said. “It is available now. I congratulate all the countrymen on this occasion.”

Covishield and another vaccine called Covaxin were authorized for emergency use in India this month. Neither Covaxin’s manufacturer, Bharat Biotech, nor the Indian Council of Medical Research, which contributed to the vaccine’s development, has published data proving that it works. In a Covaxin consent form at District Hospital Aundh, one of a handful of sites in Pune where the vaccine was being administered, the manufacturer noted that clinical efficacy was “yet to be established.”

At Kamala Nehru Hospital in Pune, a city of about 3.1 million southeast of Mumbai, 100 long-stemmed red roses were stacked neatly on a table beside a bottle of hand sanitizer. Each person registered to receive the Covishield vaccine, developed by AstraZeneca and Oxford University and manufactured by the Pune-based Serum Institute of India, was to get a rose.

Dr. Rajashree Patil, one of the health workers who received the Covishield vaccine at Kamala Nehru Hospital, said she was both excited and nervous. After contracting the coronavirus while working in the government hospital’s emergency room in May, she spent 12 days in a Covid ward at another hospital, having lost her senses of smell and taste and experiencing extreme fatigue. “I’m a little bit worried. Actually we’re on a trial basis,” Dr. Patil said. “But I am happy we are getting it so we can one day be corona-free.”

Another doctor who received the Covishield vaccine at that hospital, Usha Devi Bharmal, said that she had wanted to get a shot to dispel people’s fears about coronavirus vaccines. “There are rumors on social media,” she said, adding that she hoped to help show that vaccines are a “positive thing.”

Mr. Modi has pledged to inoculate 300 million health care and frontline workers, including police officers and, in some cases, teachers, by July. But so far the Indian government has purchased only 11 million doses of Covishield and 5.5 million doses of Covaxin.

Indian television stations showed Dr. Randeep Guleria, the director of the All India Institute of Medical Sciences in New Delhi and a prominent government adviser on Covid-19, receiving a jab on Saturday. It was unclear whether Mr. Modi was vaccinated.

India’s vaccination effort faces a number of obstacles, including a growing sense of complacency about the coronavirus. After reaching a peak of more than 90,000 new cases per day in mid-September, the country’s official infection rates have dropped sharply. Fatalities have fallen about 30 percent in the last 14 days, according to a New York Times database.

City streets are buzzing. Air and train travel have resumed. Social distancing and mask-wearing standards, already lax in many parts of India, have slipped further. That alarms experts, who say the real infection rate is probably much worse than official numbers suggest. 

 (Picture Courtesy: ITV Hub)

WHO’s Rare Rebuke Of China On Covid

The World Health Organization took the rare step of criticizing China on Tuesday, using its first press conference of the new year to express disappointment that Beijing has still not given permission to United Nations investigators to probe the origins of the coronavirus pandemic. 

WHO Director-General Tedros Adhanom Ghebreyesus told reporters that several scientists on the U.N. agency’s team researching the pandemic’s source had left their home countries on Monday and Tuesday, after the Chinese government had agreed to allow their entry. But while team members were en route, Tuesday, the WHO was told that Chinese officials had not yet finalized the necessary permissions for their arrival, Dr. Tedros said. 

Some members were still waiting for visas, said Mike Ryan, executive director of WHO’s emergencies program, and at least one member has begun returning home.

China played down World Health Organization (WHO) concern about a delay in authorisation for a visit by team of experts looking into the origins of the coronavirus pandemic, saying arrangements were being worked out.

The head of the WHO, Tedros Adhanom Ghebreyesus, said on Tuesday he was “very disappointed” that China had not authorised the entry of the team for the investigation, which he said was a WHO priority. “We are eager to get the mission underway as soon as possible,” he said. 

The coronavirus disease was first detected in the Chinese city of Wuhan in late 2019 and has since spread around the world.

Much remains unknown about its origins and China has been sensitive about any suggestion it could have done more in the early stages of the pandemic to stop it.

Foreign ministry spokesperson Hua Chunying, told a regular news briefing in Beijing that the problem was “not just about visas” for the team.

Asked about reports that the dates had been agreed upon, she said there had been a “misunderstanding” and the two sides were still in discussions over the timing and other arrangements and “remain in close communication”.

“There’s no need to overinterpret this,” she said. 

China’s experts were also busy dealing with a renewed spurt of coronavirus infections, with many locations entering a “wartime footing” to stop the virus, she said.

The delay by Chinese authorities fuels concern that Beijing is obstructing international efforts to trace the origins of a pandemic that has now killed over 1.8 million people worldwide.

The 10-strong team of international experts had been due to set off in early January as part of a long-awaited mission to investigate early cases of the disease.

China has been seeking to shape the narrative about when and where the pandemic began, with senior diplomat Wang Yi saying “more and more studies” showed that it emerged in multiple regions.  WHO emergencies chief Mike Ryan has previously called this “highly speculative”. 

China has also dismissed criticism of its handling of early cases although some including US President Donald Trump have questioned its actions during the outbreak.

The WHO, too, has been criticised for being too deferential to China through the course of the pandemic, and has been blamed by other countries for initially downplaying the severity of the crisis. Trump said last year that the superpower would terminate its relationship with the WHO unless it “demonstrated independence” from China. The US President also called for a “transparent” investigation and criticised the terms under which Chinese experts conducted a first phase of research.

The mission is due to be led by Peter Ben Embarek, the WHO’s top expert on animal diseases that cross the species barrier, who went to China on a preliminary mission last July.

Is The COVID-19 Vaccine Safe For Nursing Mothers?

Newswise — New Rochelle, NY, January 12, 2021–The Academy of Breastfeeding Medicine (ABM) does not recommend cessation of breastfeeding for individuals who are vaccinated against COVID-19. In a new statement, the ABM suggests that lactating women discuss the risks and benefits of vaccination with their health care provider, within the context of their risk of contracting COVID-19 and of developing severe disease, according to the peer-reviewed journal Breastfeeding MedicineClick here to read the ABM statement now.

This is a challenging topic because the vaccine trials excluded lactating women. Thus, there are no clinical data regarding the safety of the Pfizer/BioNtech or the Moderna vaccine in nursing mothers. According to the ABM statement, “there is little biological plausibility that the vaccine will cause harm, and antibodies to SARS-CoV-2 [the virus that causes COVID-19] in milk may protect the breastfeeding child.”

“Without clinical data, the Academy of Breastfeeding Medicine relied on biological plausibility and expert opinion to craft a statement on considerations for mRNA COVID-19 vaccines in lactation,” says Alison Stuebe, MD, President of ABM. “The available information is reassuring; however, pregnant and lactating people deserve better than plausibility to guide medical decisions. Henceforward, phase 3 clinical trials should routinely include pregnant and lactating participants. It’s time to protect pregnant and breastfeeding individuals through research, not from research.”

Arthur I. Eidelman, MD, Editor-in-Chief of Breastfeeding Medicine, states: “The publication of the balanced ABM statement will serve as an immediate guide for clinicians and families in deciding to proceed with Covid-19 vaccination of nursing mothers.”

Breastfeeding Medicine, the official journal of the Academy of Breastfeeding Medicine, is an authoritative, peer-reviewed, multidisciplinary journal published 10 times per year in print and online. The Journal publishes original scientific papers, reviews, and case studies on a broad spectrum of topics in lactation medicine. It presents evidence-based research advances and explores the immediate and long-term outcomes of breastfeeding, including the epidemiologic, physiologic, and psychological benefits of breastfeeding. Tables of content and a sample issue may be viewed on the Breastfeeding Medicine website.

The Academy of Breastfeeding Medicine is a worldwide organization of medical doctors dedicated to the promotion, protection, and support of breastfeeding. Our mission is to unite members of the various medical specialties with this common purpose. For more than 20 years, ABM has been bringing doctors together to provide evidence-based solutions to the challenges facing breastfeeding across the globe. A vast body of research has demonstrated significant nutritional, physiological, and psychological benefits for both mothers and children that last well beyond infancy. But while breastfeeding is the foundation of a lifetime of health and well-being, clinical practice lags behind scientific evidence. By building on our legacy of research into this field and sharing it with the broader medical community, we can overcome barriers, influence health policies, and change behaviors.

Mary Ann Liebert, Inc., publishers is known for establishing authoritative peer-reviewed journals in many promising areas of science and biomedical research. A complete list of the firm’s 90 journals, books, and newsmagazines is available on the Mary Ann Liebert, Inc., publishers website.

(picture courtesy: Science) 

A Rift In The Retina May Help Repair The Optic Nerve

Newswise — In experiments in mouse tissues and human cells, Johns Hopkins Medicine researchers say they have found that removing a membrane that lines the back of the eye may improve the success rate for regrowing nerve cells damaged by blinding diseases. The findings are specifically aimed at discovering new ways to reverse vision loss caused by glaucoma and other diseases that affect the optic nerve, the information highway from the eye to the brain.

“The idea of restoring vision to someone who has lost it from optic nerve disease has been considered science fiction for decades. But in the last five years, stem cell biology has reached a point where it’s feasible,” says Thomas Johnson, M.D., Ph.D., assistant professor of ophthalmology at the Wilmer Eye Institute at the Johns Hopkins University School of Medicine.

The research was published Jan. 12 in the journal Stem Cell Reports.

A human eye has more than 1 million small nerve cells, called retinal ganglion cells, that transmit signals from light-collecting cells called photoreceptors in the back of the eye to the brain. Retinal ganglion cells send out long arms, or axons, that bundle together with other retinal ganglion cell projections, forming the optic nerve that leads to the brain.

When the eye is subjected to high pressure, as occurs in glaucoma, it damages and eventually kills retinal ganglion cells. In other conditions, inflammation, blocked blood vessels, or tumors can kill retinal ganglion cells. Once they die, retinal ganglion cells don’t regenerate.

“That’s why it is so important to detect glaucoma early,” says Johnson. “We know a lot about how to treat glaucoma and help nerve cells survive an injury, but once the cells die off, the damage to someone’s vision becomes permanent.”

Johnson is a member of a team of researchers at the Johns Hopkins Wilmer Eye Institute looking for ways scientists can repair or replace lost optic neurons by growing new cells. 

In the current study, Johnson and his team grew mouse retinas in a laboratory dish and tracked what happens when they added human retinal ganglion cells, derived from human embryonic stem cells, to the surface of the mouse retinas. They found that most of the transplanted human cells were unable to integrate into the retinal tissue, which contains several layers of cells.

“The transplanted cells clumped together rather than dispersing from one another like on a living retina,” says Johnson.

However, the researchers found that a small number of transplanted retinal cells were able to settle uniformly into certain areas of the mouse retina. Looking more closely, the areas where the transplanted cells integrated well aligned with locations where the researchers had to make incisions into the mouse retinas to get them to lie flat in the culture dish. At these incision points, some of the transplanted cells were able to crawl into the retina and integrate themselves in the proper place within the tissue.

“This suggested that there was some type of barrier that had been broken by these incisions,” Johnson says. “If we could find a way to remove it, we may have more success with transplantation.”

It turns out that the barrier is a well-known anatomical structure of the retina, called the internal limiting membrane. It’s a translucent connective tissue created by the retina’s cells to separate the fluid of the eye from the retina.

After using an enzyme to loosen the connective fibers of the internal limiting membrane, the researchers removed the membrane and applied the transplanted human cells to the retinas. They found that most of the transplanted retinal ganglion cells grew in a more normal pattern, integrating themselves more fully. The transplanted cells also showed signs of establishing new nerve connections to the rest of the retinal structure when compared with retinas that had intact membranes.

“These findings suggest that altering the internal limiting membrane may be a necessary step in our aim to regrow new cells in damaged retinas,” says Johnson.

The researchers plan to continue investigating the development of transplanted retinal ganglion cells to determine the factors they need to function once integrated into the retina.

Other researchers involved in the study include Kevin Zhang, Caitlyn Tuffy, Joseph Mertz, Sarah Quillen, Laurence Wechsler, Harry Quigley and Donald Zack of the Johns Hopkins University School of Medicine.

This work was funded by the National Eye Institute (K12EY015025, K08EY031801, R01EY002120, P30EY001765), the ARVO Dr. David L. Epstein Award, Research to Prevent Blindness, the American Glaucoma Society, the Johns Hopkins Physician Scientist Training Program, and generous gifts from the Guerrieri Family Foundation, the Gilbert Family Foundation, and the Marion & Robert Rosenthal Family Foundation. The authors declare no competing interests.

(Picture Credit: Thomas Johnson and Johns Hopkins Medicine. Transplanted retinal ganglion cells marked with a fluorescent tag.)

Pfizer, Moderna Vaccines May Vanquish Covid Today, Cancer Tomorrow

The night is darkest just before dawn, they say. Dark it certainly is right now. The more contagious variants of SARS-CoV-2 coming out of the U.K. and South Africa will make the pandemic worse before mass vaccination can make it better.

But take another look at some of these new vaccines. And then contemplate the dawn to come — not just its first rays in the coming months but also the bright light of future years and decades. It looks increasingly plausible that the same weapons we’ll use to defeat Covid-19 can also vanquish even grimmer reapers — including cancer, which kills almost 10 million people a year.

The most promising Covid vaccines use nucleic acids called messenger RNA, or mRNA. One vaccine comes from the German firm BioNTech SE and its U.S. partner Pfizer Inc. The other is from the U.S. companyModerna Inc. (its original spelling was ModeRNA, its ticker is MRNA). Another is on the way from CureVac NV, also based in Germany.

Ordinary vaccines tend to be inactivated or weakened viruses which, when injected into the body, stimulate an immune response that can later protect against the live pathogen. But the process of making such vaccines requires various chemicals and cell cultures. This takes time and provides opportunities for contamination.

mRNA vaccines don’t have these problems. They instruct the body itself to make the offending proteins — in this case, the ones that wrap around the viral RNA of SARS-CoV-2. The immune system then homes in on these antigens, practicing for the day when the same proteins show up with the coronavirus attached.

Therein lies mRNA’s bigger promise: It can tell our cells to make whatever protein we want. That includes the antigens of many other diseases besides Covid-19.

In its day-to-day function, mRNA takes instructions from its molecular cousin, the DNA in our cell nuclei. Stretches of the genome are copied, which the mRNA carries into the cytoplasm, where little cellular factories called ribosomes use the information to churn out proteins.

BioNTech and Moderna shortcut this process, by skipping the whole fiddly business in the nucleus with the DNA. Instead, they first figure out what protein they want — for example, a spike on the coat around a virus. Then they look at the sequence of amino acids that makes this protein. From that they derive the precise instructions the mRNA must give.

This process can be relatively fast, which is why it took less than a year to make the vaccines, a pace previously unimaginable. It’s also genetically safe — mRNA can’t go back into the nucleus and accidentally insert genes into our DNA.

Researchers since the 1970s have had a hunch that you can use this technique to fight all sorts of maladies. But as usual in science, you need huge amounts of money, time and patience to sort out all the intermediary problems. After a decade of enthusiasm, mRNA became academically unfashionable in the 1990s. Progress seemed halting. The main obstacle was that injecting mRNA into animals often caused fatal inflammation.

Enter KatalinKariko — a Hungarian scientist who immigrated to the U.S. in the 1980s and has heroically devoted her entire career to mRNA, through its ups and downs. In the 1990s, she lost her funding, was demoted, had her salary cut and suffered other setbacks. But she stuck with it. And then, after battling cancer herself, she made the crucial breakthrough.

In the 2000s, she and her research partner realized that swapping out uridine, one of mRNA’s “letters,” avoided causing inflammation without otherwise compromising the code. The mice stayed alive.

Her study was read by a scientist at Stanford University, Derrick Rossi, who later co-founded Moderna. It also came to the attention of UgurSahin and OzlemTureci, two oncologists who are husband and wife and co-founded BioNTech. They licensed Kariko’s technology and hired her. From the start, they were most interested in curing cancer.

Today’s weapons against cancer will one day seem as primitive an idea as flint axes in a surgery room. To kill a malignant tumor, you generally zap it with radiation or chemicals, damaging lots of other tissue in the process.

The better way to fight cancer, Sahin and Tureci realized, is to treat each tumor as genetically unique and to train the immune systems of individual patients against that specific enemy. A perfect job for mRNA. You find the antigen, get its fingerprint, reverse-engineer the cellular instructions to target the culprit and let the body do the rest.

Take a look at the pipelines of Moderna and BioNTech. They include drug trials for treating cancers of the breast, prostate, skin, pancreas, brain, lung and other tissues, as well as vaccines against everything from influenza to Zika and rabies. The prospects appear good.

Progress, admittedly, has been slow. Part of the explanation Sahin and Tureci give is that investors in this sector must put up oodles of capital and then wait for more than a decade, first for the trials, then for regulatory approvals. In the past, too few were in the mood.

Covid-19, fingers crossed, may turbo-charge all these processes. The pandemic has led to a grand debut of mRNA vaccines and their definitive proof of concept. Already, there are murmurs about a Nobel Prize for Kariko. Henceforth, mRNA will have no problems getting money, attention or enthusiasm — from investors, regulators and policymakers.

That doesn’t mean the last stretch will be easy. But in this dark hour, it’s permissible to bask in the light that’s dawning.

(Story Courtesy: Business Standard; Picture Courtesy: Moneyweb)

India To Begin Rollout of CovidVaccine

The nationwide Covid vaccination rollout will begin on January 16, with an estimated 3 crore healthcare workers and frontline workers identified to get the jab in the initial phase. They will be followed by those above 50 years of age and those under-50 with co-morbidities. And for the vaccine distribution effort, an unprecedented official machinery is being cranked up.

India has recorded the second-highest number of Covid-19 infections in the world, after the US.Since the pandemic began it has confirmed more than 10.3 million cases and nearly 150,000 deaths.

The country’s drugs regulator has given the green light to two vaccines – one developed by AstraZeneca with Oxford University (Covishield) and one by Indian firm Bharat Biotech (Covaxin), India’s first domestic pharmacy to get nod for vaccine distribution in India, with more than 1.3 billion people.

The Drug Controller General of India has approved the company’s application to conduct a Phase I and II clinical trial of Covaxin, which was developed along with the Indian Council of Medical Research’s National Institute of Virology, the company said in a statement on Monday.

Bharat Biotech, which makes the vaccine in partnership with ICMR, said it found that the “serious adverse reaction” was “not related to vaccine or placebo”.

January 16 has been chosen as the launch date for Covid-19 vaccination since it falls after the festivals of lohri, makarsankranti, maghbihu and pongal. The government didn’t say why festivals were a factor in choosing the date.

The effort: 20 central government ministries, including the Railways, Power, Defence and Civil Aviation, among others, are being used to roll out the vaccination programme which will initially target 30 crore healthcare and frontline workers, along with the high-risk population.

The roles: Each ministry has a specific role — Railways will conduct vaccination sessions at its hospitals and other premises, apart from doing their brand promotion on its tickets; Power to ensure uninterrupted electricity supply at vaccine storage facilities and vaccination sites; Defence to ensure supply of vaccines in remote and inaccessible areas; IT to utilise its village-level Common Service Centres for vaccination registrations and ensure telecom companies send SMS and voice messages on vaccination; and Civil Aviation to ensure proper transportation logistics, including temperature regulation.

State level: State PWDs are being tasked with the logistics such as identification of vaccination centres and supply of drinking water while state police forces will provide security to vaccine consignments and ensure crowd management at vaccination centres. State education departments will launch an awareness campaign to explain why children aren’t being inoculated in the first phase while the Panchayat level apparatus will be used for registration of healthcare workers.

The challenges: A shortage of vaccine supply in the first phase itself, admitted to by Serum Institute of India CEO Adar Poonawalla — whose company’s vaccine, Covishield, will be the first to roll out — who said the shortage of vaccine will be felt for the first six months of 2021 after which it will ease off. Low internet penetration along with the mandatory requirement of pre-registration — no on-the-spot registrations allowed — for vaccination, lack of cold chain facilities coupled with their uneven spread and vaccine hesitancy are some of the challenges India’s vaccination drive will encounter.

P Chidambaram writes on the pandemic, vaccine and controversy: “There was, I suspect, a tinge of business between the SII and Bharat Biotech. Happily, both Mr Adar Poonawalla and Mr Krishna Ella buried the hatchet in a couple of days and promised to cooperate and work together. That is the way frontline companies, especially in research and development, should conduct their affairs, with a right mix of public good and private profit.”

(Picture Courtesy: Bloomberg News)

Dr. SudhakarJonnalagadda ReceivesPravasiBharatiyaSamman Award

Dr. SudhakarJonnalagadda, President of the American Association of Physicians of Indian Origin (AAPI), was conferred The PravasiBharatiyaSamman Award (PBSA) during the 16th edition of the annual PravasiBharatiya Divas (PBD) Convention, held virtually on January 9th, 2021. The PravasiBharatiyaSamman Awards were conferred by the Hon’ble President at the PBD Convention in the valedictory session of the PravasiBharatiya Divas celebrations.

 

The PravasiBharatiyaSamman Award (PBSA) is the highest honor conferred on Non-Resident Indians, Persons of Indian Origin or an organization/institution established and run by the Non-Resident Indians or Persons of Indian Origin in recognition of their outstanding achievements both in India and abroad.

 

Dr. Jonnalagadda was chosen for the prestigious award by the government of India in the field of Medicine and for his great leadership of AAPI, the largest ethnic medical organization in the US, especially during the Pandemic.

 

Dr. Jonnalagadda, said, “I wanted to express my sincere gratitude and appreciation to the government of India for selecting me for the prestigious award. In recognizing me, the government has recognized all the medical professionals who have been in the forefront fighting Covid, including those who have laid their lives at the services of treating patients infected with the deadly virus. This award will strengthen the medical fraternity to recommit our efforts, skills and talents for the greater good of humanity. Congratulations to all of my co-awardees.”

Dr. SudhakarJonnalagadda assumed office as the 37th President of American Association of Physicians of Indian Origin (AAPI) on Saturday, July 11, 2020, and committed himself to “make AAPI stronger, more vibrant, united, transparent, politically engaged, ensuring active participation of young physicians, increasing membership, and enabling that AAPI’s voice is heard in the corridors of power” .

 

AAPI is the largest Medical Organization in the United States, representing the interests of the over 100,000 physicians and Fellows of Indian origin in the United States, serving the interests of the Indian American physicians in the US and in many ways contributing to the shaping of the healthcare delivery in the US for the past 39 years. “AAPI must be responsive to its members, supportive of the leadership and a true advocate for our mission,” he said.

 

Dr. Jonnalagadda was born in a family of physicians. His father was a Professor at a medical college in India and his mother was a teacher. He and his siblings aspired to be physicians and dedicate their lives for the greater good of humanity. “I am committed to serving the community and help the needy. That gives me the greatest satisfaction in life,” he said.  Ambitious and wanting to achieve greater things in life, Dr. Jonnalagadda has numerous achievements in life. He currently serves as the President of the Medical Staff at the Hospital. And now, “being elected as the President of AAPI is greatest achievement of my life,”

 

As the President of AAPI, the dynamic physician from the state of Andhra Pradesh, wants to “develop a committee to work with children of AAPI members who are interested in medical school, to educate on choosing a school and gaining acceptance; Develop a committee to work with medical residents who are potential AAPI members, to educate on contract negotiation, patient communication, and practice management; Develop a committee to work with AAPI medical students, and to provide proctorship to improve their selection of medical residencies.”

 

A Board-Certified Gastroenterologist/Transplant Hepatologist, working in Douglas, GA, Dr. Jonnalagadda is a former Assistant Professor at the Medical College of Georgia. He was the President of Coffee Regional Medical Staff 2018, and had served as the Director of Medical Association of Georgia Board from 2016 onwards. He had served as the President of Georgia Association of Physicians of Indian Heritage (GAPI) 2007-2008, and was the past chair of Board of trustees, GAPI. He was the chairman of the Medical Association of Georgia, IMG cection, and was a Graduate, Georgia Physicians Leadership Academy (advocacy training).

 

His vision for AAPI is to increase the awareness of APPI globally and help its voice heard in the corridors of power.  “I would like to see us lobby the US Congress and create an AAPI PAC and advocate for an increase in the number of available residency positions and green cards to Indian American Physicians so as to help alleviate the shortage of Doctors in the US.”

IAPC Seminar ByAlberta And British Columbia Chapters On Global Economy In The Post-Covid Era

“Covid pandemic globally impacted meticulously by various factors like globalization severely disrupted, the digital revolution accelerated, and inequality in all the sectors drastically increased,” said Dr. EtayankaraMuralidharan, Ph.D. (School of Business, MacEwan University, Edmonton, Canada.), commencing the Zoom conference on Saturday, January 9th, 2021.

 

As a part of IAPC’s Web series Town Hall meetings, Alberta and British Columbia Chapters together was hosting the seminar on the subject “Global Economy in Post Covid Era.” The meeting was presided by Dr. Joseph Chalil( Chairman, IAPC), and Dr. P.V Baiju ( IAPC Director board member) was the moderator for the seminar.

 

Dr. Muralidharan presented the vivid aspects of the Covid consequences and how the world is adopting and reshaping globalization with social media resources like Zoom or webinar. He narrated the income inequality and income mobility and the means to change the objective or methods of operation in the governmental, organizational, and individual levels. He presented in turn how organizations contribute to social inequalities and how the firms need to develop CSR practices, reshape work designs, and to align compensation

 

The other panelist and economic expert, Dr. S. Mohammed IrshadPh D. (Jamsetji Tata School of Disaster Studies, Tata Institute of Social Sciences, Mumbai, India presented how the Covid pandemic pushed the economy down. Major countries are on the brink of economic recession, and the global economy is going to trail Pre pandemic trajectory for many years to come. He explained how economic resilience or accountable capitalism or how government stimulus can help overcome it.

 

The subject matter experts, after their presentations, tactfully answered the various questions raised by the audience. It was condensed that already pre Covid recession was creeping in, and the unexpected pandemic boosted the factors of recession. It is still uncertain how long the peril will continue.

 

BinoyKaruvayil, VP of the IAPC Alberta chapter, welcomed the guests and all the participants from the various chapters in Canada and the USA. Miss NeethuSivaram of the British Columbia Chapter well managed the event as the MC. Anjaleena Jose, the budding singer with her melodious voice, inspired the participants with her patriotic song ‘ VandeMataram.’

 

Dr. Joseph Chalil thanked the guests and the Chapter members of the hosting Chapters. Chairman also released the colorful “IAPC Alberta Chronicle Vol 2” and congratulated Chief editor Rajesh Peter and the editorial team. Founder Chairman GinsmonZacharia, General Secretary Biju Chacko, Treasurer Reji Philip, BoD member Thampanoor Mohan, Vice President C G Daniel, Treasurer Innocent Ulahannan were also active participants of the Zoom Meeting.  With the vote of thanks by Anitha Naveen, Secretary BC chapter, the productive and informative session was concluded.

AAPI Welcomes 2021 In Style

At AAPI’s New Year Celebrations, Gurudev Sri Sri Ravishankar Praises The Sacrifices Of Indian American Physicians, Hoping For End to Covid in 2021

“Let me congratulate the great work done by the physicians around the world, and especially the American Association of Physicians of Indian Origin (AAPI) members,” said Gurudev Sri Sri Ravishnakar in a live message via Zoom from his home in India to the members of American Association of Physicians of Indian Origin (AAPI) at a colorful New Year 2021 Welcome Event organized by AAPI on Friday, January 1st. Recognizing the leadership of AAPI, led by Dr. Sudhakar Jonnalagadda and the executive committee, he commented them “for their service to humanity, putting their own life at risk, doing so much for the society.”
Acknowledging that the past year 2020 has been a period of immense challenges for Humanity, Sri Sri Ravishnakar acknowledged the sacrifices and heroic efforts and contributions of physicians of Indian origin. “Healthcare professionals, particularly the Physicians of Indian Origin have put their life at risk, and have served humanity well,” he said.
“I wish you all a brighter and happier New Year in 2021,” hoping that “we will find answers for the problem of covid-19.” Stressing that “What matter is the need for Inner Strength,” Sri Sri told Indian American physicians that “I’m sure you all recognize the value of mental health and Inner Strength. May all you be very strong physically and mentally.” Showering his spiritual blessings on each of them, he said, “I want to wish you all a very happy new year and lots of blessings for you to continue to serve the society the way you have been doing.”
In his New Year message, Dr. Jonnalagadda, President of AAPI said, “All across the world, people are looking forward to welcoming 2021 and bidding goodbye to the challenging year that was 2020, which will be a year seared in all our memories. It’s been a year that has fundamentally challenged long established certainties about what we think is safe and what we believe is healthy in all areas of our lives.”
Pointing to the record time in which healthcare professionals and leaders have been able to make, distribute and administer vaccines around the world in order to combat and mitigate the deadly virus, he said, “The innovative ways healthcare professionals have learnt and begun to practice Medicine gives humanity HOPE. A New Year is a powerful occasion: It’s a time when we reflect on our gratitude for the past and our hopes for the future. And it’s a chance to welcome a fresh start to reinvigorate our enthusiasm for chasing goals and dreams. As we wave goodbye to the old and embrace the New Year with hope, dreams, and ambition. A Very Happy New Year full of Blessings, Happiness, Health and Prosperity!”
The event was coordinated and presented by Dr. Anajana Samaddar, Chair of AAPI’s Women’s Forum and Dr. Udaya Shivangi, Event Chair.
The celebrations included contemporary and classic music live from India by a talented and much acclaimed team of artists led by Gautham Bharadwaj & Niranjana, who were the only band chosen from India to perform at the 2012 London Olympics. The team performed live to the delight of a large audience from across the US with melodies in several Indian languages.

For more details on year round activities and programs, please visit: www.aapiusa.org

Why Does Early Treatment of COVID Matter?

Hooray for COVID Vaccines:  An Ounce of Prevention of COVID is Worth a Pound of Cure.  Let’s Use That Same Rationale for People Who Already Have COVID. 
To be a proponent for early treatment of coronavirus infection shouldn’t automatically mean there is a disregard for the much-needed prevention efforts represented by the mRNA vaccines.  This should not be an “either-or” argument.  Though there are some who have concerns about the rapid release and production of these novel vaccine interventions, no one can question that we are indeed in a public health crisis and an urgent and expedited effort is what is absolutely warranted (i.e., Operation Warp Speed is actually a fitting name for the rapid response).  We get it.  However, the broad media coverage on the vaccines seems to obscure any discussion or consideration of formal early treatment interventions for the COVID-positive patient before hospitalization is absolutely required.  Early treatment intervention of COVID has the potential to save lives, reduce hospital burden and reduce the need to limit a hospital’s capacity to render other standards of care such as routine surgical interventions. 
The death rate of COVID is actually much lower than the actual infection rate, something like only 2% or a little less than 3% maximum.  This is a good thing, unless the death rate includes one of your loved ones; then 2% doesn’t seem so negligible.  Regardless, complications of COVID can be really challenging for clinicians and downright scary for the rest of the public.  It’s been stated at least 10% of COVID survivors develop after effects for up to 6 months or more.  Early treatment intervention could potentially reduce the risk of these complications by reducing the progression of COVID to the most serious symptoms and a drastic dash to the local E.D. requiring hospital admission as a minimum, intubation for mechanical ventilation as a maximum.
The reports abound of hospital capacities stretched to their limits and physicians and other clinicians pushed beyond their normal capacities to perform, amidst caring for patients who were originally told to go home and manage on their own, until they have difficulty breathing (of course).  Really?  This is not the best we can do nor should it be the only consideration.  
Let’s take the Ohio State University (OSU) COVID-athlete study into perspective: 26 student athletes who recovered from COVID.  Some had symptoms and some actually were asymptomatic (meaning no headache, fever, sniffles or cough, etc.).  Myocarditis was observed in 4, or 15%, of these student athletes and in 8, or 30%, the student athletes were observed to have developed cardiac scar tissue.  If this is the impact of COVID on young and healthy student athletes (some of whom never developed symptoms), just waiting around until you can’t breathe really shouldn’t be the only outpatient option.  
Rather than waiting around for approval from the National Institutes of Health (NIH) or the Centers for Disease Control (CDC), physicians should at least begin to treat the symptoms of COVID in recognition of the over-activation of the inflammatory response is a signal for an advancement of the COVID assault on our bodies.  The forecasted intention should be to prevent the COVID-triggered advancement in inflammatory response. So, doctors, what’s the rationale for awaiting a rushed emergency room visit versus a purposeful effort to prevent the mad dash to the E.R. in the first place?   Shouldn’t we be activated in preventing this progression of an unchecked inflammatory response (especially since we already know how to keep it from happening)?  We must believe in ourselves and standardize an approach to common COVID symptoms using the current medications already in our FDA-indicated/FDA-approved arsenal.
If we were living in a house and heard the alarm sound from the smoke detector, there is no way we would say that there has to be a flame before we take any action (whatsoever).  There is no way you would acknowledge that the smoke will transition from a flame to a full-on blaze and only then determine the fire department should be called.  Doctor, you would pursue a focused effort to ensure the origin of the smoke was determined and then implement swift action to address whatever caused the smoke in the first place.  We would want to make sure the smoke never, ever became a flame and the flame allowed to become the dreaded blaze.  Yes, without a doubt, we Early Interventionists are grateful for the new COVID vaccines.  The vaccines are a brilliant and valiant effort at a much-needed, long-awaited prevention effort to interrupt the plaque of COVID across our great nation and our world.  Nevertheless, these COVID vaccines are not destined for people who already have COVID (at home or in the hospital); the people who are sick at home need prevention too- prevention from hospitalization.  Today, as we exhale and celebrate the release of the vaccine to prevent COVID, there are tens of thousands of Americans who are already COVID-positive and not yet hospitalized.  By the way, are you wondering about the great mutations?

If You Defend the Body, the Strain Won’t Matter 
 
Treating symptomatic expressions of COVID, before hospital admission, bypasses the need for a specific COVID regimen per se.  If your patient has a fever, you address it.  If there is evidence of pulmonary dysfunction (like coughing or symptoms of bronchitis, for instance), you would treat it with the standard go-to corticosteroid that you normally would (i.e., prednisone or methylprednisolone).  If there is a concern that steroids could further suppress the immune response, then boost the immune system as a precaution.  Is anybody concerned that there is now a whole multiple of new COVID strains reported?  If we focus on active management of the symptoms (within FDA-indications and -approval, of course) we have a strong likelihood of avoiding the most severe consequences of the infection.  Perhaps if we can limit the development of COVID complications in the body, the variations of the strain shouldn’t matter.  These efforts are only until the rest of the country has access to the vaccines.  However, if essential workers and long-term care, or nursing home, residents are the appropriate priority, there has to be a mitigation plan for treating COVID patients until all who want to be vaccinated can receive the vaccine.  Otherwise, are folks to simply try to avoid COVID infection until their vaccine number is called up in April?
We simply must reconsider the intentional plan that says “do nothing until…” it’s a mad panic and rush to the emergency room.  The ounce of prevention, to avoid the ambulance, is early treatment intervention of COVID before the infection progresses to the point where hospitalization is required.  As staggering as the death toll, the numbers do indeed reflect that more are infected and survive from COVID than those who die from COVID.  Nevertheless, there is little comfort in numbers when someone you love and care about is taken from you so tragically and often without any gift of closure in sharing a loving goodbye.  Early medicinal intervention in COVID infections as a measure of prevention, against the progression of COVID complications, is critical.  Different clinicians have varied approaches towards this end (i.e., Ivermectin, ICAM-similar regimens , etc.) and I have no particular preference.  I’m simply grateful they recognize the need to intervene early is undeniable.  

Take care of all who want the highly valued prevention effort of the vaccines as soon as possible, but plese don’t forget the folks who already have COVID.  Just like the flu vaccines are for people who have not yet contracted the flu, the COVID vaccines are destined for people who have not contracted the COVID infection.  Right now, prior to hospitalization, the best effort a COVID patient can obtain is probably thoughts and prayers because their told to ‘go home and come to the E.D. if you get worse or sick or have trouble breathing.  However, more and more clinicians have determined that the COVID patient deserves a valiant effort at prevention as well.  Let’s not forget, an ounce of prevention could be a great alternative to the need for a COVID ambulance.   
(By An Anonymous Healthcare Provider)

Pope Urges Coronavirus Vaccine Access For All

Pope Francis has called on world leaders to ensure unfettered access to coronavirus vaccines for everyone. In a Christmas Day address delivered online for the first time, the pontiff warned against putting up “walls” to treatments.
The pandemic meant this year the annual Urbi et Orbi message was not presented from the balcony at St Peter’s Basilica to huge crowds, as is tradition. Instead the Pope spoke from a lectern in a chamber inside the Vatican.
Pope Francis’ warning comes amid concerns that wealthier countries are buying up disproportionate doses of vaccines to the detriment of poorer ones.
“May the Son of God renew in political and government leaders a spirit of international cooperation, starting with health care, so that all will be ensured access to vaccines and treatment,” he said.
“In the face of a challenge that knows no borders, we cannot erect walls. All of us are in the same boat.” Coronavirus vaccines: Will any countries get left out?
The Pope said the effects of the health crisis showed the need for global unity was greater than ever. “At this moment in history, marked by the ecological crisis and grave economic and social imbalances only worsened by the coronavirus pandemic, it is all the more important for us to acknowledge one another as brothers and sisters.”
The pontiff called for generosity and support to victims of the pandemic, singling out women suffering domestic violence during lockdown.
Turning to other troubles in the world, the Pope called for peace and reconciliation in Syria, Yemen, Libya, Nagorno-Karabakh, South Sudan, Nigeria, Cameroon and Iraq.
He is due to visit Iraq in March in what would be the first such trip to the war-torn country by a pontiff.

Applications To Medical School Up Big. Is It The “Fauci Effect”?

“Now more than ever we need your talent, your energy, your resolve and your character.” Those were the words Anthony S. Fauci, MD, director of the National Institute of Allergy and Infectious Diseases, said last spring to new medical school graduates as part of the AMA’s “Tribute to the Medical School Class of 2020.”
FAQs about med school
Get answers to all your biggest questions about getting into medical school, the application process, the MCAT and more. 
It appears another flock of potential physicians may have been listening, however. With medical school applications up nearly 20% from last year, some are attributing that bounce to the “Fauci effect,” in essence crediting the nation’s most famous and most visible physician with inspiring a new generation.
According to the Association of American Medical Colleges (AAMC), the number of students applying to enter medical school in 2021 is up 18% from this time last year. The bump is unprecedented, and the reasons behind it are not entirely clear.
“This large of an increase is unprecedented,” said Geoffrey Young, PhD, the AAMC’s senior director of student affairs and programs. ”We can’t say for sure why so many more students have applied this year. Some students may have had more time for applications and preparing for the MCAT exam after their college courses went online. Some may have been motivated by seeing heroic doctors on the front lines of the COVID-19 pandemic.”
At Ohio University Heritage College of Osteopathic Medicine (OU), one of 37 member schools of the AMA Accelerating Change in Medical Education Consortium, the number of applications received to date—a 14% year-to -date increase—has surpassed the number received in the entire 2020 cycle, with two months before the application submission deadline.
“The fact that we as a society are dealing with this pandemic and people are seeing the challenges that our health care workforce are dealing with, and the pain and suffering of those who deal with COVID, it certainly could have fanned the flames for applicants who were thinking about a career in medicine,” said John D. Schriner, PhD, an associate dean for admissions and student affairs at OU. “They want to make a difference similar to what Dr. Fauci is saying.”
Other factors to which the spike could be attributed include an unfriendly economic climate for new graduates and more time to prepare applications.
“It is certainly encouraging to see an increase in applicants to medical school, and there are likely multiple drivers involved,” said Kimberly Lomis, MD, the AMA’s vice president for undergraduate medical education innovations. “The pandemic disrupted many students’ intended plans and has caused all to reconsider their educational and career options. Medicine needs people inclined to step up in times of crisis, and current medical students across the country demonstrated that ethos this year.”
At the November 2020 AMA Special Meeting, Dr. Fauci gave an exclusive interview to AMA Executive Vice President and CEO James L. Madara, MD. Read more about Dr. Fauci’s 2021 forecast on COVID-19 vaccines, treatments.
In interviews, Dr. Fauci has downplayed his impact on the application increase. Schriner isn’t so sure, however.
“There are a lot of great physicians who inspire students to go toward medicine and make a difference,” Schriner said. “Dr. Fauci is such an inspiring figure, a trusted figure. I think there may be something to it.”
While the factors contributing to the increase in applications are likely manyfold, the pandemic has caused an increase, Schriner says, in applicant altruism. And it has done so at a needed time— according to data published this year by the AAMC, the United States could see an estimated shortage of between 54,100 and 139,000 physicians, including shortfalls in both primary and specialty care, by 2033.
“Folks are just seeing such suffering and such sacrifice on the part of the patients and their families, and also the sacrifice and suffering made by the health care delivery team,” Schriner said. “There’s an altruistic spirit that is reflected in the increase in applications.”
Medicine can be a career that is both challenging and highly rewarding but figuring out a medical school’s prerequisites and navigating the application process can be a challenge into itself. The AMA premed glossary guide has the answers to frequently asked questions about medical school, the application process, the MCAT and more.

From Polio To The COVID Vaccine, Dr. Peter Salk Sees Great Progress

(NPR Editor’s Note: As this year winds down, we’re looking back at some people we spoke to earlier in 2020, when the coronavirus pandemic was in its early stages. Now that there’s a vaccine, we wanted to check in with someone whose family has a long history with vaccines.
When I spoke to Dr. Peter Salk back in May, he told me the tale of receiving an early polio vaccine – the one invented by his father, Dr. Jonas Salk.
“I just hated injections. And my father came home with polio vaccine and some syringes and needles that he sterilized on the kitchen stove by boiling in water, lined us kids up and then administered the vaccine,” Salk said. “Somehow the needle must have missed a nerve, and I didn’t feel it. And so that has fixed that moment in my mind.”
Peter Salk was just 9 when he got that shot in 1953 at the family home outside Pittsburgh.
At that time, polio terrorized the country every summer. In the worst single year, 1952, nearly 60,000 children were infected. Many were paralyzed, and more than 3,000 died. Frightened parents kept their children away from swimming pools, movie theaters and other public places.
The vaccine helped eradicate polio, made his father world famous, and shaped Peter Salk’s own life — he also became a doctor of infectious diseases.
Yet when we talked last spring, Peter Salk was worried about the race for a COVID-19 vaccine. He feared corners might be cut. He noted that his father, who died in 1995, needed seven years to develop a vaccine that was both effective and safe.
“What concerns me is knowing that, in the past, there have been unexpected things that have taken place with vaccines that had not been foreseen,” Salk said at the time.
Back in the 1950s, one bad batch of the polio vaccine was blamed for 10 deaths, 200 cases of paralysis and for making many Americans wary of getting the shot.
But in a recent phone chat with Salk at his home in San Diego, he was very upbeat about the COVID vaccine. “I was bowled over when the first news came out about the Pfizer, BioNTech results and being somewhere on the order of 95 percent effective,” he said. “I just had a really strong emotional reaction that I totally had not anticipated.”
He’s following the vaccine news closely and has been hugely impressed by the development of a vaccine in less than a year. There could still be hiccups, he said, but none that can’t be solved. “In my mind, so far, so good,” he said.
Dr. Salk is a bit concerned about the number of people who are reluctant, or outright opposed, to getting the vaccine. But he believes those numbers will shrink as people see the benefits. And, he said, this “vaccine hesitancy” is nothing new.
“I was surprised when I first learned a few months ago about a Gallup poll in 1954 that indicated that about half the population did not want the polio vaccine,” he said.
That was the year before the U.S. government authorized nationwide use. In the end, most everyone received it. The current pandemic has sharply curtailed Salk’s movements. He’s still a part-time professor of infectious diseases at the University of Pittsburgh, and has stopped traveling there.
He spends most of his time at home and says his aching knees, as well as the threat of the virus, keep him from getting out much in the neighborhood.
“My wife [Ellen] and I have been extremely careful during this whole period,” he said. “I’m probably going to continue to do social distancing and wear masks and take the precautions that I’ve been taking really until this thing is practically gone.”
Dr. Salk was at the front of the line when he got the polio vaccine as a kid. And he’s eager to get the new vaccine. But at age 76, and in good health overall, he said he’s content to wait his turn.
“We’re going to be somewhere down the line” when it comes to the vaccine, he said. “As far as I’m concerned, that’s fine with me. I think it’s really important to prioritize the limited supply of vaccine.”
As a nation, he predicts it could take until the end of 2021 before life returns to normal for the country as a whole. Until then, he’ll be playing it safe. “I’m not ready to throw away the mask,” he said.

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