Amy Schumer’s recent 50-pound weight loss is attributed to Cushing’s syndrome, a serious hormonal disorder that can have life-threatening complications if left untreated.
Comedian Amy Schumer, 44, has opened up about her battle with Cushing’s syndrome, a condition that has led to her significant weight loss. Schumer’s transformation has ignited discussions online, prompting her to clarify the situation in a now-deleted Instagram post. She emphasized, “I didn’t lose 30lbs — I lost 50,” while also denying any use of cosmetic procedures such as Botox or fillers.
Schumer stressed that her weight loss was not motivated by a desire to enhance her appearance but rather a necessity for her health. “Not to look hot, which does feel fun and temporary,” she explained. “I did it to survive. I had a disease that makes your face extremely puffy that can kill you, but the internet caught it and that disease has cleared.” She added, “Sorry for whatever feeling it’s giving you that I lost that weight.” Schumer also mentioned her past experiences with plastic surgery and her use of the medication Mounjaro, stating, “I’m pain free. I can [play] tag with my son.”
In her post, Schumer also touched on her hormonal changes, expressing her willingness to share more about her experiences with perimenopause. Previously, she had disclosed her diagnosis of Cushing’s syndrome, a hormonal disorder that can lead to severe swelling, fatigue, and potentially fatal complications.
Dr. Peter Balazs, a hormone and weight loss specialist based in New Jersey, provided insights into Cushing’s syndrome in an interview with Fox News Digital. He explained that the condition arises from prolonged exposure to high levels of cortisol, the body’s primary stress hormone. This excess cortisol is often a result of long-term steroid use, commonly seen in patients with autoimmune disorders.
Dr. Balazs noted that Cushing’s syndrome is characterized not only by weight gain but also by a specific redistribution of fat due to elevated cortisol levels. This can lead to fat accumulation in the abdomen, chest, upper back—often referred to as a “buffalo hump”—and the face, which may appear swollen, a condition known as “moon face.” Additionally, cortisol contributes to the breakdown of protein, resulting in thinning of the arms and legs.
Weight gain associated with Cushing’s syndrome can be involuntary and challenging to manage. Cortisol also stimulates hunger, raises blood sugar levels, and promotes fat storage, particularly in the abdominal area. Other complications of the syndrome may include high blood pressure, bone loss, and an increased risk of type 2 diabetes, as noted by the Mayo Clinic.
In addition to weight gain, individuals with Cushing’s syndrome may experience a variety of symptoms, including pink or purple stretch marks on the stomach, hips, thighs, breasts, and underarms, as well as acne, slow wound healing, and fragile skin that bruises easily. Women may notice thick, dark hair growth on the face and body, along with irregular menstrual cycles. Men may experience reduced libido, fertility issues, and erectile dysfunction.
Other symptoms can include extreme fatigue, muscle weakness, depression, anxiety, irritability, mood swings, difficulty concentrating, headaches, insomnia, skin darkening, and stunted growth in children. Those exhibiting symptoms are advised to consult their healthcare provider, especially if they are on steroid medications for conditions such as asthma, arthritis, or inflammatory bowel disease, as these can worsen the syndrome.
The Mayo Clinic emphasizes that early intervention is crucial for recovery, stating, “the sooner treatment starts, the better the chances for recovery.” For patients like Schumer, weight loss is not the primary objective; rather, it serves as a critical indicator of effective treatment. Dr. Balazs explained, “The primary goal is to normalize your high cortisol levels.” He believes that Schumer received treatment for her underlying condition first, and once her cortisol levels were stabilized, adjunct medications could assist with weight management.
Among these adjunct medications, Mounjaro is highlighted as an effective option for reducing deep abdominal fat and improving insulin sensitivity in cells. Schumer’s journey serves as a reminder of the complexities of hormonal disorders and the importance of addressing health issues promptly.
Fox News Digital’s Stephanie Giang-Paunon contributed to this report.
For further information on Cushing’s syndrome and its management, consult healthcare professionals or trusted medical resources.